A new method for the preparation of piperidin-4-ones

Michael Hoffelner, Werner Seebacher*, Usama Hassan, Andreas Leitner, Robert Weis, Robert Saf

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We describe a new reduction process for the efficient preparation of various, especially 2-substituted, piperidin-4-ones which are not accessible by other reaction pathways until now. Tetrahydropyridinylidene salts (THPS) with differing substitution pattern are the educts of this reaction. These compounds are available by mainly two different reaction sequences and they can be further modified by insertion of various substituents before the targeted piperidin-4-ones are obtained.

Original languageEnglish
Article number132189
Publication statusPublished - 18 Jun 2021


  • 2-Substituted piperidin-4-ones
  • Drug research
  • Selective reduction
  • Synthons
  • Tetrahydropyridinylidene salts

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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