We describe a new reduction process for the efficient preparation of various, especially 2-substituted, piperidin-4-ones which are not accessible by other reaction pathways until now. Tetrahydropyridinylidene salts (THPS) with differing substitution pattern are the educts of this reaction. These compounds are available by mainly two different reaction sequences and they can be further modified by insertion of various substituents before the targeted piperidin-4-ones are obtained.
- 2-Substituted piperidin-4-ones
- Drug research
- Selective reduction
- Tetrahydropyridinylidene salts
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry