A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods

B Burja, T Kuret, S Sodin-Semrl, K Lakota, Ž Rotar, R Ješe, K Mrak-Poljšak, P Žigon, G G Thallinger, J Feichtinger, S Čučnik, M Tomšič, S Praprotnik, A Hočevar

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

Original languageEnglish
Pages (from-to)188-194
JournalAutoimmunity Reviews
Volume17
Issue number2
Early online date28 Nov 2017
DOIs
Publication statusPublished - 1 Feb 2018

Fingerprint

Giant Cell Arteritis
Biomarkers
Arteries
Systemic Vasculitis
Acute-Phase Proteins
Meta-Analysis
Early Diagnosis
Pathologic Constriction
Cytokines

Keywords

  • Journal Article
  • Review

Fields of Expertise

  • Human- & Biotechnology
  • Information, Communication & Computing

Treatment code (Nähere Zuordnung)

  • Basic - Fundamental (Grundlagenforschung)
  • Experimental

Cite this

A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods. / Burja, B; Kuret, T; Sodin-Semrl, S; Lakota, K; Rotar, Ž; Ješe, R; Mrak-Poljšak, K; Žigon, P; Thallinger, G G; Feichtinger, J; Čučnik, S; Tomšič, M; Praprotnik, S; Hočevar, A.

In: Autoimmunity Reviews, Vol. 17, No. 2, 01.02.2018, p. 188-194.

Research output: Contribution to journalArticleResearchpeer-review

Burja, B, Kuret, T, Sodin-Semrl, S, Lakota, K, Rotar, Ž, Ješe, R, Mrak-Poljšak, K, Žigon, P, Thallinger, GG, Feichtinger, J, Čučnik, S, Tomšič, M, Praprotnik, S & Hočevar, A 2018, 'A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods' Autoimmunity Reviews, vol. 17, no. 2, pp. 188-194. https://doi.org/10.1016/j.autrev.2017.11.022
Burja, B ; Kuret, T ; Sodin-Semrl, S ; Lakota, K ; Rotar, Ž ; Ješe, R ; Mrak-Poljšak, K ; Žigon, P ; Thallinger, G G ; Feichtinger, J ; Čučnik, S ; Tomšič, M ; Praprotnik, S ; Hočevar, A. / A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods. In: Autoimmunity Reviews. 2018 ; Vol. 17, No. 2. pp. 188-194.
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AU - Kuret, T

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AU - Lakota, K

AU - Rotar, Ž

AU - Ješe, R

AU - Mrak-Poljšak, K

AU - Žigon, P

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AU - Feichtinger, J

AU - Čučnik, S

AU - Tomšič, M

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AU - Hočevar, A

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N2 - Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

AB - Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

KW - Journal Article

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