A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods

B Burja; T Kuret; S Sodin-Semrl; K Lakota; Ž Rotar; R Ješe; K Mrak-Poljšak; P Žigon; G G Thallinger; J Feichtinger; S Čučnik; M Tomšič; S Praprotnik; A Hočevar

doi:10.1016/j.autrev.2017.11.022

A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods

B Burja, T Kuret, S Sodin-Semrl, K Lakota, Ž Rotar, R Ješe, K Mrak-Poljšak, P Žigon, G G Thallinger, J Feichtinger, S Čučnik, M Tomšič, S Praprotnik, A Hočevar

Research output: Contribution to journal › Article › peer-review

Abstract

Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

Original language	English
Pages (from-to)	188-194
Journal	Autoimmunity Reviews
Volume	17
Issue number	2
Early online date	28 Nov 2017
DOIs	https://doi.org/10.1016/j.autrev.2017.11.022
Publication status	Published - 1 Feb 2018

Keywords

Journal Article
Review

Fields of Expertise

Human- & Biotechnology
Information, Communication & Computing

Treatment code (Nähere Zuordnung)

Basic - Fundamental (Grundlagenforschung)
Experimental

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10.1016/j.autrev.2017.11.022

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Burja, B., Kuret, T., Sodin-Semrl, S., Lakota, K., Rotar, Ž., Ješe, R., Mrak-Poljšak, K., Žigon, P., Thallinger, G. G., Feichtinger, J., Čučnik, S., Tomšič, M., Praprotnik, S., & Hočevar, A. (2018). A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods. Autoimmunity Reviews, 17(2), 188-194. https://doi.org/10.1016/j.autrev.2017.11.022

Burja, B, Kuret, T, Sodin-Semrl, S, Lakota, K, Rotar, Ž, Ješe, R, Mrak-Poljšak, K, Žigon, P, Thallinger, GG, Feichtinger, J, Čučnik, S, Tomšič, M, Praprotnik, S & Hočevar, A 2018, 'A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods', Autoimmunity Reviews, vol. 17, no. 2, pp. 188-194. https://doi.org/10.1016/j.autrev.2017.11.022

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doi = "10.1016/j.autrev.2017.11.022",

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AU - Burja, B

AU - Kuret, T

AU - Sodin-Semrl, S

AU - Lakota, K

AU - Rotar, Ž

AU - Ješe, R

AU - Mrak-Poljšak, K

AU - Žigon, P

AU - Thallinger, G G

AU - Feichtinger, J

AU - Čučnik, S

AU - Tomšič, M

AU - Praprotnik, S

AU - Hočevar, A

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N2 - Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

AB - Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

KW - Journal Article

KW - Review

U2 - 10.1016/j.autrev.2017.11.022

DO - 10.1016/j.autrev.2017.11.022

M3 - Article

C2 - 29196244

SN - 1568-9972

VL - 17

SP - 188

EP - 194

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

IS - 2

ER -

A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods

Abstract

Keywords

Fields of Expertise

Treatment code (Nähere Zuordnung)

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