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• Article

  A Toolbox of Diverse Promoters Related to Methanol Utilization: Functionally Verified Parts for Heterologous Pathway Expression in Pichia pastoris

  Vogl, T., Sturmberger, L., Kickenweiz, T., Wasmayer, R., Schmid, C., Hatzl, A-M., Gerstmann, M. A., Pitzer, J., Wagner, M., Thallinger, G. G., Geier, M. & Glieder, A., 19 Feb 2016, In : ACS Synthetic Biology . 5, 2, p. 172-86 15 p.

  Research output: Contribution to journal › Article

  • Pichia
  • Methanol
  • alcohol oxidase
  • Genes
  • Biosynthetic Pathways

• Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans

  Fiorentini, F., Geier, M., Binda, C., Winkler, M., Faber, K., Hall, M. & Matteiv, A., 2016, In : ACS Chemical Biology. p. 1039 1048 p.

  Research output: Contribution to journal › Article

• Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation

  Geier, M., Braun, A., Fladischer, P., Stepniak, P., Rudroff, F., Hametner, C., Mihovilovic, M. & Glieder, A., 2013, In : The FEBS journal. 280, 13, p. 3094-108

  Research output: Contribution to journal › Article

• Engineered bidirectional promoters enable rapid multi-gene co-expression optimization

  Vogl, T., Kickenweiz, T., Pitzer, J., Sturmberger, L., Weninger, A., Biggs, B. W., Köhler, E-M., Baumschlager, A., Fischer, J. E., Hyden, P., Wagner, M., Baumann, M., Borth, N., Geier, M., Ajikumar, P. K. & Glieder, A., 4 Sep 2018, In : Nature Communications . 9, 1, p. 3589

  Research output: Contribution to journal › Article

  Open Access

  • genes
  • Synthetic Biology
  • Libraries
  • Genes
  • Metabolic Networks and Pathways

• First functional expression of cytochrome P450 3A4 in Pichia pastoris

  Geier, M., Schmid, C. & Glieder, A., 2013, In : Chimica Oggi. 31, 3, p. 24-27

  Research output: Contribution to journal › Article

• Methanol independent induction in Pichia pastoris by simple derepressed overexpression of single transcription factors

  Vogl, T., Sturmberger, L., Fauland, P. C., Hyden, P., Fischer, J. E., Schmid, C., Thallinger, G. G., Geier, M. & Glieder, A., 1 Apr 2018, In : Biotechnology and Bioengineering. 115, 4, p. 1037-1050

  Research output: Contribution to journal › Article

  • Transcription factors
  • Pichia
  • Methanol
  • Transcription Factors
  • Carbon

• Screening for cytochrome P450 expression in Pichia pastoris whole cells by P450-carbon monoxide complex determination

  Gudiminchi, R. K., Geier, M., Glieder, A. & Camattari, A., Jan 2013, In : Biotechnology Journal. 8, 1, p. 146-152 7 p.

  Research output: Contribution to journal › Article

  • Pichia
  • Carbon Monoxide
  • Cytochrome P-450 Enzyme System
  • Yeasts
  • Cytochrome P-450 CYP2D6
• Chapter

  Protein Engineering Using Eukaryotic Expression Systems

  Geier, M. & Glieder, A., 2013, Protein Engineering Handbook - Volume 3. Weinheim, Germany: Wiley-VCH , p. 47-72

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• Comment/debate

  Erratum to: Engineered bidirectional promoters enable rapid multi-gene co-expression optimization (Nature Communications, (2018), 9, 1, (3589), 10.1038/s41467-018-05915-w)

  Vogl, T., Kickenweiz, T., Pitzer, J., Sturmberger, L., Weninger, A., Biggs, B. W., Köhler, E. M., Baumschlager, A., Fischer, J. E., Hyden, P., Wagner, M., Baumann, M., Borth, N., Geier, M., Ajikumar, P. K. & Glieder, A., 1 Dec 2018, In : Nature Communications . 9, 1, 4566.

  Research output: Contribution to journal › Comment/debate

  Open Access

  • files
  • genes
  • Publications
  • Genes
  • communication
• Conference contribution

  Human flavin monooxygenase 2: Heterologous expression in E. coli and API modification

  Winkler, M., Geier, M., Bachler, T., Hanlon, S. P., Kittelmann, M., Glieder, A., Lütz, S. & Wirz, B., 2014, New Biotechnology. ., p. S82-S82

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• Patent

  COMPACT AND OPTIMIZED METABOLIC PATHWAY DESIGN IN PICHIA PASTORIS

  Geier, M., Glieder, A. & Fauland, P., 6 May 2016, IPC No. C12N 15/ 09 A I, Patent No. WO2016066711, Priority date 28 Oct 2014, Priority No. EP20140190702

  Research output: Patent

  • Pichia
  • Metabolic Networks and Pathways
  • Yeasts
  • Gene Expression
• Poster

  ACIB and CHEM21: Towards greener and more sustainable pharmaceutical manufacturing processes

  Geier, M., Killinger, M., Wiltschi, B., Gruber-Khadjawi, M., Lypetska, K., Strohmeier, G., Breinbauer, R., Turrini, N., Faber, K. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• Efficient expression and purification of human flavin-containing monooxygenases (hFMOs): first steps towards the elucidation of FMO3 crystal structure

  Fiorentini, F., Geier, M., Winkler, M., Binda, C. & Mattevi, A., 2013.

  Research output: Contribution to conference › Poster

• Exploiting recombinant Pichia pastoris for drug metabolite synthesis: Towards an efficient CYP3A4-based whole-cell catalyst

  Geier, M., Schmid, C. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• Generating a Platform of Human Non-CYP Drug Metabolizing Enzymes for API Modification

  Geier, M., Bachler, T., Eggimann, F., Rodrigues, D., Hanlon, S., Wirz, B., Kittelmann, M., Lütz, S., Glieder, A. & Winkler, M., 2014.

  Research output: Contribution to conference › Poster

• Human flavin monooxygenase 2: Heterologous expression in E. coli and API modification

  Winkler, M., Geier, M., Bachler, T., Hanlon, S., Kittelmann, M., Glieder, A., Lütz, S. & Wirz, B., 2014.

  Research output: Contribution to conference › Poster

• Human Flavin Monooxygenases as a Tool for Drug Metabolite Synthesis

  Bachler, T., Hanlon, S. P., Kittelmann, M., Geier, M., Camattari, A., Glieder, A., Wirz, B., Lütz, S. & Winkler, M., 2013.

  Research output: Contribution to conference › Poster

• Integrative expression vectors for stable pathway construction in the yeast Schizosaccharomyces pombe

  Geier, M., Hatzl, A-M., Mellitzer, A. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• New tools for pathway generation employing the concepts of synthetic biology

  Geier, M., Vogl, T., Sturmberger, L., Schmid, C., Wiltschi, B. & Glieder, A., 2014.

  Research output: Contribution to conference › Poster

• Pichia pastoris with improved NADH regeneration: A novel platform strain for whole-cell biocatalysis

  Geier, M., Brandner, C. & Glieder, A., 2014.

  Research output: Contribution to conference › Poster

• Preliminary characterization of hFMO5. A human Bayer-Villiger Monooxygenase?

  Fiorentini, F., Hall, M., Winkler, M., Geier, M., Binda, C., Faber, K. & Mattevi, A., 2014.

  Research output: Contribution to conference › Poster

• Towards drug metabolite production on the multi-miligram scale: Generation of an efficient aldehyde oxidase (AOX1) based biocatalyst

  Bachler, T., Rodrigues, D. F., Kittelmann, M., Geier, M., Abad, S., Hanlon, S. P., Camattari, A., Lütz, S., Wirz, B. & Winkler, M., 2013.

  Research output: Contribution to conference › Poster
• Review article

  Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

  Wiltschi, B., Cernava, T., Dennig, A., Galindo, M., Geier, M., Gruber, S., Haberbauer, M., Heidinger, P., Acero, E. H., Kratzer, R., Luley-Goedl, C., Müller, C. A., Pitzer, J., Ribitsch, D., Sauer, M., Schmölzer, K., Schnitzhofer, W., Sensen, C. W., Soh, J., Steiner, K. & 3 others, Winkler, C. K., Winkler, M. & Wriessnegger, T., 23 Jan 2020, In : Biotechnology Advances. 40, 107520.

  Research output: Contribution to journal › Review article

  Open Access

  • Enzymes
  • Recovery
  • Biocontrol
  • Bioconversion
  • Biocatalysts

• Humane Enzyme für die Organische Synthese

  Winkler, M., Geier, M., Hanlon, S. P., Nidetzky, B. & Glieder, A., 2018, In : Angewandte Chemie. 130, p. 13592-13610

  Research output: Contribution to journal › Review article

• Human Enzymes for Organic Synthesis

  Winkler, M., Geier, M., Hanlon, S. P., Nidetzky, B. & Glieder, A., 2018, In : Angewandte Chemie / International Edition . 57, 41, p. 13406-13423 18 p.

  Research output: Contribution to journal › Review article

  • Enzymes
  • Pharmaceutical Preparations
  • Xenobiotics
  • Metabolites
  • Metabolism

• Refined Pichia pastoris reference genome sequence

  Sturmberger, L., Chappell, T., Geier, M., Krainer, F., Day, K. J., Vide, U., Trstenjak, S., Schiefer, A., Richardson, T., Soriaga, L., Darnhofer, B., Birner-Gruenberger, R., Glick, B. S., Tolstorukov, I., Cregg, J., Madden, K. & Glieder, A., 10 Oct 2016, In : Journal of Biotechnology. 235, p. 121-131 11 p.

  Research output: Contribution to journal › Review article

  • Pichia
  • Genes
  • Genome
  • Chromosomes
  • Open Reading Frames