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• Article

  A Toolbox of Diverse Promoters Related to Methanol Utilization: Functionally Verified Parts for Heterologous Pathway Expression in Pichia pastoris

  Vogl, T., Sturmberger, L., Kickenweiz, T., Wasmayer, R., Schmid, C., Hatzl, A-M., Gerstmann, M. A., Pitzer, J., Wagner, M., Thallinger, G. G., Geier, M. & Glieder, A., 19 Feb 2016, In : ACS Synthetic Biology . 5, 2, p. 172-86 15 p.

  Research output: Contribution to journal › Article

  • Pichia
  • Methanol
  • alcohol oxidase
  • Genes
  • Biosynthetic Pathways

• Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans

  Fiorentini, F., Geier, M., Binda, C., Winkler, M., Faber, K., Hall, M. & Matteiv, A., 2016, In : ACS Chemical Biology. p. 1039 1048 p.

  Research output: Contribution to journal › Article

• Compact multi-enzyme pathways in P. pastoris

  Geier, M., Fauland, P. C., Vogl, T. & Glieder, A., 2015, In : Chemical Communications. 15, 51;9, p. 1643-1646

  Research output: Contribution to journal › Article

• Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation

  Geier, M., Braun, A., Fladischer, P., Stepniak, P., Rudroff, F., Hametner, C., Mihovilovic, M. & Glieder, A., 2013, In : The FEBS journal. 280, 13, p. 3094-108

  Research output: Contribution to journal › Article

• Engineering Pichia pastoris for improved NADH regeneration: A novel chassis strain for whole-cell catalysis

  Geier, M., Brandner, C., Strohmeier, G. A., Hall, M., Hartner, F. S. & Glieder, A., 2015, In : Beilstein Journal of Organic Chemistry . 11, p. 1741-8 8 p.

  Research output: Contribution to journal › Article

  • Chassis
  • NAD
  • Catalysis
  • Methanol
  • formaldehyde transketolase

• First functional expression of cytochrome P450 3A4 in Pichia pastoris

  Geier, M., Schmid, C. & Glieder, A., 2013, In : Chimica Oggi. 31, 3, p. 24-27

  Research output: Contribution to journal › Article

• Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis

  Geier, M., Bachler, T., Hanlon, S. P., Eggimann, F. K., Kittelmann, M., Weber, H., Lütz, S., Wirz, B. & Winkler, M., 2015, In : Microbial cell factories . 14, 82, p. 1-10

  Research output: Contribution to journal › Article

• Screening for cytochrome P450 expression in Pichia pastoris whole cells by P450-carbon monoxide complex determination

  Gudiminchi, R. K., Geier, M., Glieder, A. & Camattari, A., Jan 2013, In : Biotechnology Journal. 8, 1, p. 146-152 7 p.

  Research output: Contribution to journal › Article

  • Pichia
  • Carbon Monoxide
  • Cytochrome P-450 Enzyme System
  • Yeasts
  • Cytochrome P-450 CYP2D6
• Chapter

  Protein Engineering Using Eukaryotic Expression Systems

  Geier, M. & Glieder, A., 2013, Protein Engineering Handbook - Volume 3. Weinheim, Germany: Wiley-VCH , p. 47-72

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• Conference contribution

  Human flavin monooxygenase 2: Heterologous expression in E. coli and API modification

  Winkler, M., Geier, M., Bachler, T., Hanlon, S. P., Kittelmann, M., Glieder, A., Lütz, S. & Wirz, B., 2014, New Biotechnology. ., p. S82-S82

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• Patent

  COMPACT AND OPTIMIZED METABOLIC PATHWAY DESIGN IN PICHIA PASTORIS

  Geier, M., Glieder, A. & Fauland, P., 6 May 2016, IPC No. C12N 15/ 09 A I, Patent No. WO2016066711, Priority date 28 Oct 2014, Priority No. EP20140190702

  Research output: Patent

  • Pichia
  • Metabolic Networks and Pathways
  • Yeasts
  • Gene Expression
• Poster

  ACIB and CHEM21: Towards greener and more sustainable pharmaceutical manufacturing processes

  Geier, M., Killinger, M., Wiltschi, B., Gruber-Khadjawi, M., Lypetska, K., Strohmeier, G., Breinbauer, R., Turrini, N., Faber, K. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• Biotransformations for drug metabolite synthesis

  Winkler, M., Bachler, T., Geier, M., Hanlon, S. P., Eggimann, F. K., Rodrigues, D., Ferreira Antunes, M., Kittelmann, M., Glieder, A., Wirz, B. & Lütz, S., 2015.

  Research output: Contribution to conference › Poster

• Drug Metabolizing Enzymes: From Heterologous Expression to Drug Metabolite Synthesis

  Winkler, M., Bachler, T., Geier, M., Glieder, A., Hanlon, S. P., Eggimann, F. K., Rodrigues, D., Antunes, M., Kittelmann, M., Wirz, B. & Lütz, S., 2015.

  Research output: Contribution to conference › Poster

• Efficient expression and purification of human flavin-containing monooxygenases (hFMOs): first steps towards the elucidation of FMO3 crystal structure

  Fiorentini, F., Geier, M., Winkler, M., Binda, C. & Mattevi, A., 2013.

  Research output: Contribution to conference › Poster

• Exploiting recombinant Pichia pastoris for drug metabolite synthesis: Towards an efficient CYP3A4-based whole-cell catalyst

  Geier, M., Schmid, C. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• Generating a Platform of Human Non-CYP Drug Metabolizing Enzymes for API Modification

  Geier, M., Bachler, T., Eggimann, F., Rodrigues, D., Hanlon, S., Wirz, B., Kittelmann, M., Lütz, S., Glieder, A. & Winkler, M., 2014.

  Research output: Contribution to conference › Poster

• Human flavin monooxygenase 2: Heterologous expression in E. coli and API modification

  Winkler, M., Geier, M., Bachler, T., Hanlon, S., Kittelmann, M., Glieder, A., Lütz, S. & Wirz, B., 2014.

  Research output: Contribution to conference › Poster

• Human Flavin Monooxygenases as a Tool for Drug Metabolite Synthesis

  Bachler, T., Hanlon, S. P., Kittelmann, M., Geier, M., Camattari, A., Glieder, A., Wirz, B., Lütz, S. & Winkler, M., 2013.

  Research output: Contribution to conference › Poster

• Integrative expression vectors for stable pathway construction in the yeast Schizosaccharomyces pombe

  Geier, M., Hatzl, A-M., Mellitzer, A. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• New tools for pathway generation employing the concepts of synthetic biology

  Geier, M., Vogl, T., Sturmberger, L., Schmid, C., Wiltschi, B. & Glieder, A., 2014.

  Research output: Contribution to conference › Poster

• Pichia pastoris with improved NADH regeneration: A novel platform strain for whole-cell biocatalysis

  Geier, M., Brandner, C. & Glieder, A., 2014.

  Research output: Contribution to conference › Poster

• Preliminary characterization of hFMO5. A human Bayer-Villiger Monooxygenase?

  Fiorentini, F., Hall, M., Winkler, M., Geier, M., Binda, C., Faber, K. & Mattevi, A., 2014.

  Research output: Contribution to conference › Poster

• Towards drug metabolite production on the multi-miligram scale: Generation of an efficient aldehyde oxidase (AOX1) based biocatalyst

  Bachler, T., Rodrigues, D. F., Kittelmann, M., Geier, M., Abad, S., Hanlon, S. P., Camattari, A., Lütz, S., Wirz, B. & Winkler, M., 2013.

  Research output: Contribution to conference › Poster
• Review article

  Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

  Wiltschi, B., Cernava, T., Dennig, A., Galindo, M., Geier, M., Gruber, S., Haberbauer, M., Heidinger, P., Acero, E. H., Kratzer, R., Luley-Goedl, C., Müller, C. A., Pitzer, J., Ribitsch, D., Sauer, M., Schmölzer, K., Schnitzhofer, W., Sensen, C. W., Soh, J., Steiner, K. & 3 others, Winkler, C. K., Winkler, M. & Wriessnegger, T., 23 Jan 2020, In : Biotechnology Advances. 40, 107520.

  Research output: Contribution to journal › Review article

  Open Access

  • Enzymes
  • Recovery
  • Biocontrol
  • Bioconversion
  • Biocatalysts

• Refined Pichia pastoris reference genome sequence

  Sturmberger, L., Chappell, T., Geier, M., Krainer, F., Day, K. J., Vide, U., Trstenjak, S., Schiefer, A., Richardson, T., Soriaga, L., Darnhofer, B., Birner-Gruenberger, R., Glick, B. S., Tolstorukov, I., Cregg, J., Madden, K. & Glieder, A., 10 Oct 2016, In : Journal of Biotechnology. 235, p. 121-131 11 p.

  Research output: Contribution to journal › Review article

  • Pichia
  • Genes
  • Genome
  • Chromosomes
  • Open Reading Frames