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  • Johannes Khinast
2013

Inline monitoring and a PAT strategy for pharmaceutical hot melt extrusion

Wahl, P., Treffer, D. F., Mohr, S., Roblegg, E., Koscher, G. & Khinast, J., 2013, In : International Journal of Pharmaceutics. 455, p. 159-168

Research output: Contribution to journalArticle

Investigation of the Leaching Behavior of a Pd-Catalyst Supported on 3-Mercaptopropyl-Functionalized Silica Gel

Gruber-Wölfler, H., Feenstra, P., Lichtenegger, G. J., Khinast, J. & Radl, S., 2013.

Research output: Contribution to conferencePoster

Large-scale CFD–DEM simulations of fluidized granular systems

Jajcevic, D., Siegmann, E., Radeke, C. & Khinast, J., 19 Jul 2013, In : Chemical Engineering Science.

Research output: Contribution to journalArticle

Laterally Controlled Immobilization Of Organometallic Pd-Catalysts On Flat and Porous Si-Wafers

Lichtenegger, G. J., Gruber-Wölfler, H. & Khinast, J., 23 Sep 2013.

Research output: Contribution to conference(Old data) Lecture or Presentation

Manufacturing of Low Fill Weight Capsules Using a Nozzle Dosator Capsule Filling Machine

Llusa, M., Faulhammer, E., Khinast, J., Lawrence, S., Biserni, S., Calzolari, V. & Fink, M., 2013, (Accepted/In press) Manufacturing of Low Fill Weight Capsules Using a Nozzle Dosator Capsule Filling Machine. .

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Microscopic Models for the Prediction of Liquid Transfer in Granular Flows

Radl, S., Mohan, B., Girardi, M., Sundaresan, S. & Khinast, J., 2013.

Research output: Contribution to conferencePoster

Microstructure of Calcium Stearate Matrix Pellets: A Function of the Drying Process

Schrank, S., Kann, B., Windbergs, M., Glasser, B. J., Zimmer, A., Khinast, J. & Roblegg, E., 2013, In : Journal of Pharmaceutical Sciences . 102, 11, p. 3987-3997

Research output: Contribution to journalArticle

Monitoring Blending of Pharmaceutical Powders with Multipoint NIR Spectroscopy

Scheibelhofer, O., Balak, N., Wahl, P., Koller, D. M., Glasser, B. J. & Khinast, J., 2013, In : AAPS PharmSciTech . 14, 1, p. 234-244

Research output: Contribution to journalArticle

Nano-Extrusion: Herstellung einer festen nanopartikulären Formulierung durch das Verarbeiten von Nanosuspensionen mittels Schmelzextrusion

Baumgartner, R., Khinast, J. & Roblegg, E., 2013, 9. Minisymposium Verfahrenstechnik, 17.04.-18.04.2013, Montanuniversität Leoben, Book of Abstracts. Leoben: Verlag der Montanuniversität Leoben, p. 97-101

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File

Nano-Extrusion (NANEX): A One-step Process for Manufacturing Solid API Nanoparticle-Formulations Directly from the Liquid Phase

Baumgartner, R., Khinast, J. & Roblegg, E., 2013.

Research output: Contribution to conferencePoster

Nano-Extrusion (NANEX): Manufacturing of Solid-Nanoparticle Formulations Directly from the Liquid Phase via Hot-Melt Extrusion

Baumgartner, R., Khinast, J. & Roblegg, E., 2013.

Research output: Contribution to conferencePoster

Open Access
File

On the Filling Rate of a Liquid Bridge Between Wet Particles

Radl, S., Khinast, J. & Sundaresan, S., 3 Nov 2013.

Research output: Contribution to conference(Old data) Lecture or Presentation

Optical coherence tomography for non-destructive analysis of coatings in pharmaceutical tablets

Markl, D., Hannesschläger, G., Sacher, S., Khinast, J. & Leitner, M., 2013, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials. Ferraro, P. (ed.). ., Vol. 8792. p. 879202-879202 (SPIE Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Optical Coherence Tomography for non-destructive Tablet Coating Characterization

Markl, D., Hannesschläger, G., Leitner, M., Sacher, S. & Khinast, J., 13 Feb 2013.

Research output: Contribution to conference(Old data) Lecture or Presentation

PAT for Pharmaceutical Extrusion: In-line Monitoring of Drug Content with NIR

Wahl, P., Markl, D., Treffer, D. F., Sacher, S., Koscher, G., Roblegg, E. & Khinast, J., 10 Jun 2013.

Research output: Contribution to conference(Old data) Lecture or Presentation

Practical lecture: What does the engineer think when designing extruders?

Eitzlmayr, A., Koscher, G. & Khinast, J., 18 Sep 2013.

Research output: Contribution to conference(Old data) Lecture or Presentation

Simulation of Mixing in Hot Melt Extruders Using Smoothed Particle Hydrodynamics

Eitzlmayr, A., Radl, S., Koscher, G. & Khinast, J., 3 Nov 2013.

Research output: Contribution to conference(Old data) Lecture or Presentation

Simulation of Mixing in Hot Melt Extruders Using Smoothed Particle Hydrodynamics

Eitzlmayr, A., Radl, S., Koscher, G. & Khinast, J., 2013, North American Mixing Forum 2013 - Core Programming Area at the 2013 AIChE Annual Meeting. American Institute of Chemical Engineers, p. 66-67

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Spatially resolved monitoring of powder mixing processes via multiple NIR-probes

Scheibelhofer, O., Balak, N., Koller, D. M. & Khinast, J., 2013, In : Powder Technology. 243, p. 161-170

Research output: Contribution to journalArticle

spin flash dryer - characterization for pharmaceutical application

Gursch, J., Dujmovic, D., Hohl, R., Redlinger-Pohn, J. D., Brozio, J., Krumme, M., Rasenack, N. & Khinast, J., 2013.

Research output: Contribution to conferencePoster

Strategy of Assessing Continuous Manufacturing Feasibility Based on Process and Materials Knowledge

Hohl, R. & Khinast, J., 4 Mar 2013.

Research output: Contribution to conference(Old data) Lecture or Presentation

Supervisory Control System for Monitoring a Pharmaceutical Hot Melt Extrusion Process

Markl, D., Wahl, P., Menezes, J. C., Koller, D. M., Kavsek, B., Francois, K., Roblegg, E. & Khinast, J., 2013, In : AAPS PharmSciTech . 14, 2, p. 1-11

Research output: Contribution to journalArticle

Synthesis, Catalytic Activity and Heterogeneity Studies of an Immobilized Bis(oxazoline) - Palladium Catalyst

Gruber-Wölfler, H., Lichtenegger, G. J. & Khinast, J., 29 Sep 2013.

Research output: Contribution to conference(Old data) Lecture or Presentation

The effect of capsule-filling machine vibrations on average fill weight

Llusa, M., Faulhammer, E., Khinast, J., Lawrence, S., Biserni, S. & Calzolari, V., 2013, In : International Journal of Pharmaceutics. 454, 1, p. 381–387

Research output: Contribution to journalArticle

The Effect of Capsule-Filling Machine Vibrations on Average Fill Weight of Capsules

Faulhammer, E., Khinast, J., Llusa, M., Lawrence, S. M., Biserni, S. & Calzolari, V., 2013.

Research output: Contribution to conferencePoster

The Effect of the Ratio between the Powder Bed’s Height and the Length of the Dosing Chamber and the Speed of Capsule Filling on Plug Density and Capsule Weight Variability

Llusa, M., Faulhammer, E., Khinast, J., Scharrer, G., Lawrence, S., Biserni, S. & Calzolari, V., 2013, (Accepted/In press) The Effect of the Ratio between the Powder Bed’s Height and the Length of the Dosing Chamber and the Speed of Capsule Filling on Plug Density and Capsule Weight Variability. .

Research output: Chapter in Book/Report/Conference proceedingConference contribution

The Influence of Ethanol on Hot Melt Extruded Micropellets Containing Compritol® and Precirol® as Additives

Jedinger, N., Koscher, G., Khinast, J. & Roblegg, E., 2013.

Research output: Contribution to conferencePoster

The Influence of Process Parameters on the Properties of PLGA-Microparticles Produced by the Emulsion Extraction Method

Kiss, N., Brenn, G., Suzzi, D., Scheler, S., Jennewein, H., Wieser, J. & Khinast, J., 2013, In : AIChE Journal. 59, 6, p. 1868-1881

Research output: Contribution to journalArticle

Thinking Continuously: A Microreactor for the Production and Scale-up of Biodegradable, Self-assembled Nanoparticles

Petschacher, C., Eitzlmayr, A., Besenhard, M., Wagner, J., Barthelmes, J., Bernkop-Schnürch, A., Khinast, J. & Zimmer, A., 2013, In : Polymer Chemistry. 4, p. 2342-2352

Research output: Contribution to journalArticle

Transport Rates of Adhering Liquid Films in Sheared Particle Beds

Mohan, B., Khinast, J. & Radl, S., 3 Nov 2013.

Research output: Contribution to conference(Old data) Lecture or Presentation

Open Access
File

Untersuchung des Einflusses von Alkohol auf lipophile schmelzextrudierte Pellets

Jedinger, N., Koscher, G., Khinast, J. & Roblegg, E., 2013, 9. Minisymposium der Verfahrenstechnik, 17. und 18. April 2013, Montanuniversität Leoben, Book of Abstracts. Leoben: Verlag der Montanuniversität Leoben, p. 138-142

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2012

(Multiawesome) Multispectral Multiprobe Monitoring

Scheibelhofer, O., Hohl, R., Sacher, S., Menezes, J. C. & Khinast, J., 18 Sep 2012.

Research output: Contribution to conference(Old data) Lecture or Presentation

Analysis of drug-packaging interactions via molecular dynamics (MD) simulation

Feenstra, P., Brunsteiner, M. & Khinast, J., 2012, Extractables & Leachables Europe 2012. Shawbury, Shrewsbury, Shropshire SY4 4NR, UK: Smithers Information Ltd., p. 12-1-12-10

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Analysis of drug-packaging interactions via molecular dynamics (MD) simulations

Feenstra, P., Brunsteiner, M. & Khinast, J., 12 Dec 2012.

Research output: Contribution to conference(Old data) Lecture or Presentation

Application of DEM spray models for the optimization of tablet coating processes

Toschkoff, G., Just, S., Funke, A., Djuric, D., Knop, K., Kleinebudde, P., Scharrer, G. & Khinast, J., 25 Aug 2012.

Research output: Contribution to conference(Old data) Lecture or Presentation

Application of enhanced DEM simulations for the improvement of a given tablet coating process.

Toschkoff, G., Just, S., Funke, A., Djuric, D., Knop, K., Kleinebudde, P., Scharrer, G. & Khinast, J., 28 Oct 2012.

Research output: Contribution to conference(Old data) Lecture or Presentation

Characterizing critical protein powder parameters for optimization of further processing

Wahl, V., Leitgeb, S. & Khinast, J., 2012.

Research output: Contribution to conferencePoster

Characterizing critical protein powder parameters for optimization of further processing

Wahl, V., Leitgeb, S. & Khinast, J., 2012, Book of Abstracts. ., p. 137-140

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Continuous Pharmaceutical Hot-Melt Extrusion & Hot-Die Face Pelletizing

Treffer, D. F., Eitzlmayr, A., Smola, C-M., Koscher, G., Roblegg, E. & Khinast, J., 28 Oct 2012.

Research output: Contribution to conference(Old data) Lecture or Presentation

Continuous Pharmaceutical Hot-Melt Extrusion & Hot-Die Face Pelletizing

Treffer, D. F., Eitzlmayr, A., Smola, C-M., Koscher, G., Roblegg, E. & Khinast, J., 2012, (Accepted/In press) 2012 AIChE Annual Meeting. .

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Continuous Pharmaceutical Manufacturing with Hot Melt Extrusion

Markl, D., Wahl, P., Khinast, J., Kavsek, B., Francois, K. & Lederer, P., 9 May 2012.

Research output: Contribution to conference(Old data) Lecture or Presentation

Continuous Powder Flow Monitoring via Near-Infrared Hyperspectral Imaging

Scheibelhofer, O., Koller, D. M., Kerschhaggl, P. & Khinast, J., 2012.

Research output: Contribution to conferencePoster

Continuous Powder Flow Monitoring via Near-Infrared Hyperspectral Imaging

Scheibelhofer, O., Koller, D. M., Kerschhaggl, P. & Khinast, J., 2012, 2012 IEEE International Instrumentation and Measurement Technology Conference (I2MTC 2012) Proceedings. ., p. 748-753

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Continuous Sonocrystallization of Acetylsalicylic Acid (ASA): Control of Crystal Size

Eder, R. J-P., Schrank, S., Besenhard, M., Roblegg, E., Gruber-Wölfler, H. & Khinast, J., 2012, In : Crystal growth & design. 12, 10, p. 4733–4738

Research output: Contribution to journalArticle

Demonstration of a Pharmaceutical Hot Melt Extrusion Process with SIPAT

Markl, D., Kavsek, B., Wahl, P., Koller, D., Francois, K. & Khinast, J., 22 Jan 2012.

Research output: Contribution to conference(Old data) Lecture or Presentation

DEM simulation of continuous tablet coating: Effects of tablet shape and fill level on inter-tablet coating variability

Suzzi, D., Toschkoff, G., Radl, S., Machold, D., Fraser, S., Glasser, B. J. & Khinast, J., 2012, In : Chemical Engineering Science. 69, p. 107-121

Research output: Contribution to journalArticle

Depth of Scrutiny for Monitoring Powder flow via Near-Infrared Spectroscopy

Scheibelhofer, O., Koller, D. M., Kerschhaggl, P. & Khinast, J., 2012.

Research output: Contribution to conferencePoster

Detailed analysis of air flow and spray loss in a pharmaceutical coating process

Toschkoff, G., Suzzi, D., Tritthart, W., Reiter, F., Schlingmann, M. & Khinast, J., 2012, In : AIChE Journal. 58, 2, p. 399-411

Research output: Contribution to journalArticle

Developing a PAT Strategy for Pharmaceutical Hot Melt Extrusion

Wahl, P., Treffer, D. F., Markl, D., Koscher, G., Roblegg, E. & Khinast, J., 2012.

Research output: Contribution to conferencePoster