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2019

Can we predict trends in tribo-charging of pharmaceutical materials from first principles?

Brunsteiner, M., Zellnitz, S., Pinto, J. T., Karrer, J. & Paudel, A., 1 Nov 2019, In : Powder Technology. 356, p. 892-898 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Ionization potential
Drug products
Pharmaceutical Preparations
Discrete Fourier transforms
Electronic structure

Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings

Koutsamanis, I., Eder, S., Beretta, M., Witschnigg, A., Paudel, A., Nickisch, K., Friedrich, M., Eggenreich, K. & Roblegg, E., 10 Jun 2019, In : International Journal of Pharmaceutics. 564, p. 90-97 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Female Contraceptive Devices
Membranes
Polymers
Hormone Replacement Therapy
Silicones

IMPACT OF RELATIVE HUMIDITY AND POWDER FILLING LEVEL ON THE ELECTROSTATIC CHARGING BEHAVIOUR OF DIFFERENT CAPSULE TYPES

Wutscher, T., Zellnitz, S., Kobler, M., Buttini, F., Andrade, L., Daza, V., Mercandelli, A., Biserni, S., Ecenarro Probst, S., Khinast, J. & Paudel, A., 1 Apr 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 32, 2, p. A9-A10

Research output: Contribution to journalAbstractResearchpeer-review

Insights into DPI sensitivity to humidity: An integrated in-vitro-in-silico risk-assessment

Radivojev, S., Pinto, J. T., Fröhlich, E. & Paudel, A., 1 Aug 2019, In : Journal of Drug Delivery Science and Technology. 52, p. 803-817 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Dry Powder Inhalers
Humidity
Budesonide
Computer Simulation
Powders

Pvp-h2o2 complex as a new stressor for the accelerated oxidation study of pharmaceutical solids

Modhave, D., Barrios, B. & Paudel, A., 1 Sep 2019, In : Pharmaceutics . 11, 9, 457.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Excipients
Peroxides
Pharmaceutical Preparations
Hydrogen Peroxide
Povidone

Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs

Radivojev, S., Zellnitz, S., Paudel, A. & Froehlich, E., 10 Feb 2019, In : International Journal of Pharmaceutics. 556, p. 45-56 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Inhalation
Pharmaceutical Preparations
Particle Size
Computer Simulation
Solubility

Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate

Zellnitz, S., Pinto, J., Brunsteiner, M., Schröttner, H., Khinast, J. & Paudel, A., 2019, In : Pharmaceutical research. 36, 6, p. 80 11 p., 36:80.

Research output: Contribution to journalArticleResearchpeer-review

Use of PBPK Modeling to Evaluate the Performance of Dissolv It, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products

Hassoun, M., Malmlöf, M., Scheibelhofer, O., Kumar, A., Bansal, S., Selg, E., Nowenwik, M., Gerde, P., Radivojev, S., Paudel, A., Arora, S. & Forbes, B., 4 Mar 2019, In : Molecular pharmaceutics. 16, 3, p. 1245-1254 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Pharmacokinetics
Lung
Pharmaceutical Preparations
Aerosols
Ethylene Oxide
2018

Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs

Bäckman, P., Arora, S., Couet, W., Forbes, B., de Kruijf, W. & Paudel, A., 15 Feb 2018, In : European Journal of Pharmaceutical Sciences. 113, p. 41-52 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhalation Exposure
Computer Simulation
Lung
Pharmaceutical Preparations
Aerosols

Assessment of Dry Powder Inhaler Carrier Targeted Design: A Comparative Case Study of Diverse Anomeric Compositions and Physical Properties of Lactose

Pinto, J. T., Zellnitz, S., Guidi, T., Roblegg, E. & Paudel, A., 1 Jun 2018, In : Molecular pharmaceutics. 15, 7, p. 2827-2839

Research output: Contribution to journalArticleResearchpeer-review

Dry Powder Inhalers
Lactose
Adhesives
Gas Lasers
Surface Properties

COMBINATIONAL APPROACH FOR ADVANCED UNDERSTANDING OF A LOW-DOSE CAPSULE FILLING PROCESS FOR INHALATION APPLICATION

Faulhammer, E., Stranzinger, S., Calzolari, V., Biserni, S., Loidolt, P., Paudel, A. & Khinast, J., Apr 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 31, 2, p. A7-A7

Research output: Contribution to journalAbstractResearchpeer-review

Density fluctuations in amorphous pharmaceutical solids. Can SAXS help to predict stability?

Laggner, P. & Paudel, A., 2 May 2018, In : Colloids and Surfaces / B. 168, p. 76-82 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Sulfamerazine
Small Angle Scattering
Simvastatin
Nanostructures
Dermatoglyphics

Formulation performance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization

Hörmann, T., Jäger, N., Funke, A., Mürb, R-K., Khinast, J. G. & Paudel, A., 20 Dec 2018, In : International Journal of Pharmaceutics. 553, 1-2, p. 408-421 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Nimodipine
Polymers
Vacuum
Temperature
Fourier Transform Infrared Spectroscopy
adhesives
sulfates
drugs
aerodynamics
powders

Key acceptability attributes of orodispersible films

Scarpa, M., Paudel, A., Kloprogge, F., Hsiao, W. K., Bresciani, M., Gaisford, S. & Orlu, M., Apr 2018, In : European journal of pharmaceutics and biopharmaceutics. 125, p. 131-140 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Carboxymethylcellulose Sodium
Mouth
Polymers
Molecular Weight
Literature

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing

Khinast, J., Leane, M., Pitt, K., Reynolds, G. K., Dawson, N., Ziegler, I., Szepes, A., Crean, A. M., Agnol, R. D., Broegmann, B., Charlton, S., Davies, C., Gamble, J., Gamlen, M., Hsiao, W. K., Khimyak, Y., Kleinebudde, P., Moreton, C., Oswald, M., Page, S. & 5 othersPaudel, A., Sahoo, R., Sheehan, S., Stamato, H. & Stone, E., 2018, In : Pharmaceutical development and technology. p. 964-977 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Industry
Particle Size
Pharmaceutical Preparations
Proxy
Drug Compounding

MODEL INFORMED DEVELOPMENT OF DRY POWDER INHALER (DPI) FORMULATIONS AND PROCESSES

Paudel, A., Zellnitz, S., Arora, S., Benque, B., Brunsteiner, M., Faulhammer, E., Loidolt, P. & Khinast, J. G., Apr 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 31, 2, p. A9-A9

Research output: Contribution to journalAbstractResearchpeer-review

Dry Powder Inhalers
Surface Properties
Capsules
Weights and Measures
Lactose

Pharmaceutical-grade oral films as substrates for printed medicine

Wimmer-Teubenbacher, M., Planchette, C., Pichler, H., Markl, D., Hsiao, W. K., Paudel, A. & Stegemann, S., 2018, In : International Journal of Pharmaceutics. 547, 1-2, p. 169-180 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Printing
Medicine
Pharmaceutical Preparations
Polymers
Polarization Microscopy
Open Access
Molecular Dynamics Simulation
Solubility
Excipients
Polymers
Pharmaceutical Preparations

Study of a low-dose capsule filling process by dynamic and static tests for advanced process understanding

Paudel, A., Stranzinger, S., Faulhammer, E., Scheibelhofer, O., Calzolari, V., Biserni, S. & Khinast, J., 5 Apr 2018, In : International Journal of Pharmaceutics. 540, 1-2, p. 22-30 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Powders
Capsules
Weights and Measures
Vibration
Lactose
2016

Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Paudel, A., Llusa, M., Mohr, S., Baumgartner, R., Koscher, G. & Khinast, J., 2 Aug 2016, In : Drug development and industrial pharmacy. p. 1360-1364 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Extrusion
Pharmaceutical Preparations
Feeding Methods
Powders
Suspensions

Decoupling of a low-dose dosator capsule filling process in dynamic and static mode tests

Stranzinger, S., Faulhammer, E., Srčič, S., Calzolari, V., Biserni, S., Paudel, A. & Khinast, J., 31 Mar 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Decoupling of a Low-Dose Dosator Capsule Filling Process in Dynamic and Static Mode Tests to Understand the Extend of the Effect of Powder and Process Parameters on Capsule Quality Attributes

Faulhammer, E., Stranzinger, S., Loidolt, P., Calzolari, V., Biserni, S., Srčič, S., Dreu, R., Paudel, A. & Khinast, J., 18 Nov 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Development of a design space and predictive statistical model for capsule filling of low-fill-weight inhalation products

Paudel, A., Faulhammer, E., Llusa, M., Wahl, PR., Lawrence, S., Biserni, S., Calzolari, V. & Khinast, J., 1 Feb 2016, In : Drug development and industrial pharmacy. 42, 2, p. 221-230

Research output: Contribution to journalArticleResearchpeer-review

Statistical Models
Inhalation
Capsules
Powders
Weights and Measures

Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

Paudel, A., Gomes Lopes, D., Garsuch, V., Becker, K., Zimmer, A. & Salar-Behzadi, S., 20 Aug 2016, In : International Journal of Pharmaceutics. p. 285-295

Research output: Contribution to journalArticleResearchpeer-review

Sorbitol
Ibuprofen
Sodium
Powders
Excipients

Lyophilized protein powders: A review of analytical tools for root cause analysis of lot-to-lot variability

Paudel, A., Wahl, V. & Khinast, J., Sep 2016, In : Trends in Analytical Chemistry. p. 468-491

Research output: Contribution to journalArticleResearchpeer-review

powders
freeze drying
proteins
biopharmaceuticals
process control

Multi-methodological investigation of the variability of the microstructure of HPMC hard capsules

Faulhammer, E., Khinast, J., Paudel, A., Wahl, V. & Markl, D., 25 Sep 2016, In : International Journal of Pharmaceutics. 511, 2, p. 840-854 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Capsules
Optical Coherence Tomography
Electron Scanning Microscopy
Hot Temperature
X-Rays

Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure

Planchette, C., Pichler, H., Wimmer-Teubenbacher, M., Gruber, M., Gruber-Wölfler, H., Mohr, S., Tetyczka, C., Hsiao, W. K., Paudel, A., Roblegg, E. & Khinast, J., 2016, In : International Journal of Pharmaceutics. p. 518-527

Research output: Contribution to journalArticleResearchpeer-review

Scale-up of HME Process from a Trilobed 16mm to a Bilobed 27mm Extruder; SPH Simulations and 1D Mechanistic Modelling

Matic, J., Laske, S., Paudel, A., Pfefferlé, F., Martinetti, J. L., Martel, S. & Khinast, J., 16 Nov 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Extruders
Hydrodynamics
Computational fluid dynamics
Pharmaceutical Preparations
Rubber industry

The Effect of Powder and Process Parameters on the Powder Bed Uniformity of a low-dose Capsule Filling Process

Stranzinger, S., Faulhammer, E., Srčič, S., Dreu, R., Calzolari, V., Biserni, S., Paudel, A. & Khinast, J., 7 Jul 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

2015

Accuracy of Micro Powder Dosing and Feeding via a Vibratory Sieve-Chute System

Faulhammer, E., Paudel, A., Llusa, M., Besenhard, M. & Khinast, J., 8 Dec 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Accuracy of micro powder dosing via a vibratory sieve-chute system

Faulhammer, E., Besenhard, M., Paudel, A., Khinast, J., Llusa, M., Biserni, S., Calzolari, V. & Ferrari, A., 2015.

Research output: Contribution to conferencePosterResearch

Amorphous Solid Dispersion of Poorly Soluble API By Hot Melt Extrusion (HME) and Spray Drying (SD): A Rational Screening Approach

Paudel, A., Mercuri, A., Mohr, S., Bresciani, M. & Khinast, J., 8 Nov 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Lactose
Powders
Inhalation
Capsules
Mannitol

Carrier-based Dry Powder Inhalation Part I: Impact of Carrier Modification on Capsule Filling Processability and in vitro Aerodynamic Performance

Zellnitz, S., Faulhammer, E., Wahl, V., Paudel, A. & Khinast, J., 2015, (Accepted/In press) Drug Delivery to the Lungs - DDL26 - Book of abstracts. .

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Carrier-based Dry Powder Inhalation Part II: Impact of carrier material and API processing on the inter-particulate surface interactions in adhesive mixtures for inhalation

Zellnitz, S., Faulhammer, E., Wahl, V., Khinast, J. & Paudel, A., 2015, (Accepted/In press) Drug Delivery to the Lungs - DDL26 - Book of abstracts. .

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Crystallization kinetics of inhalable size amorphous salbutamol as a function of relative humidity and temperature

Zellnitz, S., Narygina, O., Resch, C., Schröttner, H. & Paudel, A., 2015.

Research output: Contribution to conferencePosterResearch

Crystallization kinetics of inhalable size amorphous salbutamol as a function of relative humidity and temperature

Zellnitz, S., Narygina, O., Resch, C., Schröttner, H. & Paudel, A., 2015, (Accepted/In press) European Aerosol Conference (EAC 2015) - Proceeding. .

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Evaluation of the surface free energy of inhalable powders

Pinto, J., Zellnitz, S., Bresciani, M., Khinast, J., Roblegg, E. & Paudel, A., 2015.

Research output: Contribution to conferencePosterResearch

Extractables and Leachables from Filter Material and their Effect on Human Granulocyte Colony-Stimulating Factor (hG-CSF)

Wahl, V., Mohr, S., Wieser, J., Khinast, J. & Paudel, A., 11 Nov 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

EXTRACTABLES AND LEACHABLES FROM FILTER MATERIAL AND THEIR IMPACT ON PROTEIN FORMULATION

Wahl, V., Wieser, J., Mohr, S., Khinast, J. & Paudel, A., 2015, Programme & Abstracts. Ghent: ., p. 114-115

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Influence of in vitro pulmonary permeability on in silico prediction of oral inhalation products

Wu, S., Mercuri, A., Salar-Behzadi, S., Bresciani, M. & Paudel, A., 12 Sep 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Multi-methodological investigation on the variability in the microstructure of HPMC capsules

Faulhammer, E., Wahl, V., Markl, D., Khinast, J., Paudel, A. & Lawrence, S., 2015.

Research output: Contribution to conferencePosterResearch

Physical and chemical stability of different polymorphs of pharmaceutical solids

Gressl, C., Brunsteiner, M., Paudel, A., Khinast, J., Davis, A., Landis, M., Pencheva, K., Scrivens, G., Sluggett, G. & Wood, G., 16 Sep 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch