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2019

Characterization of Type IV Carboxylate Reductases (CARs) for Whole Cell-Mediated Preparation of 3-Hydroxytyrosol

Horvat, M., Fritsche, S., Kourist, R. & Winkler, M., 19 Mar 2019, In : ChemCatChem. p. 4171-4181

Research output: Contribution to journalArticleResearchpeer-review

carboxylates
Oxidoreductases
preparation
cells
aldehydes

Combined Enzymatic Decarboxylation and Pd-catalyzed Heck Coupling in Continuous Flow

Grabner, B., Schweiger, A. K., Gavric, K., Kourist, R. & Gruber-Wölfler, H., Sep 2019.

Research output: Contribution to conferencePosterResearchpeer-review

Expanding the potential of phenolic acid decarboxylase from Bacillus subtilis by use of non-conventional solvents

Schweiger, A. K., Ríos-Lombardía, N., Winkler, C. K., Schmidt, S., Morís, F., Kroutil, W., González-Sabín, J. & Kourist, R., Jul 2019.

Research output: Contribution to conferencePosterResearch

From One-pot to One-flow: A chemo-enzymatic tandem reaction in continuous flow

Grabner, B., Schweiger, A. K., Gavric, K., Kourist, R. & Gruber-Wölfler, H., Sep 2019.

Research output: Contribution to conferencePosterResearch

Hydrogen-driven cofactor regeneration for stereoselective whole-cell C=C bond reduction in Cupriavidus necator

Assil Companioni, L., Schmidt, S., Heidinger, P., Schwab, H. & Kourist, R., 19 Mar 2019, In : ChemSusChem. 12, 11, p. 2361-2365 5 p.

Research output: Contribution to journalArticleResearchpeer-review

biotransformation
Hydrogen
regeneration
hydrogen
Hydrogenase

Photo-Biocatalysis: Biotransformations in the Presence of Light

Schmermund, L., Jurkaš, V., Özgen, F. F., Barone, G. D., Büchsenschütz, H. C., Winkler, C. K., Schmidt, S., Kourist, R. & Kroutil, W., 2019, In : ACS Catalysis. 9, 5, p. 4115-4144 30 p.

Research output: Contribution to journalReview articleResearchpeer-review

Chemical reactions
Enzymes
Biotransformation
Biocatalysis
Biocatalysts

Using Deep Eutectic Solvents to Overcome Limited Substrate Solubility in the Enzymatic Decarboxylation of Bio-Based Phenolic Acids

Schweiger, A. K., Ríos-Lombardía, N., Winkler, C. K., Schmidt, S., Morís, F., González-Sabín, J. & Kourist, R., 8 Aug 2019, In : ACS Sustainable Chemistry & Engineering. 7, 19, p. 16364-16370

Research output: Contribution to journalArticleResearchpeer-review

decarboxylation
Eutectics
solubility
Solubility
substrate
2018

A light-driven enzyme cascade reaction for the synthesis of lactones

Büchsenschütz, H. C., Schultes, F., Schmidt, S. & Kourist, R., 9 Apr 2018.

Research output: Contribution to conferencePosterResearch

A light-driven enzyme cascade reaction for the synthesis of lactones.

Büchsenschütz, H. C., Schultes, F., Schmidt, S. & Kourist, R., 26 Aug 2018.

Research output: Contribution to conferencePosterResearch

Alternative Binding Mode impairs Enantioselectivity of Arylmalonate Decarboxylase

Schweiger, A. K., Enoki, J., Mügge, C. & Kourist, R., Aug 2018.

Research output: Contribution to conferencePosterResearch

Bio-based α,ω functionalized hydrocarbons from multi-step reaction sequences with bio- and metallo-catalysts based on the fatty acid decarboxylase OleTJE

Bojarra, S., Reichert, D., Grote, M., Gómez Baraibar, Á., Dennig, A., Nidetzky, B., Mügge, C. & Kourist, R., Mar 2018, In : ChemCatChem. 10, 5, p. 1192-1201

Research output: Contribution to journalArticleResearchpeer-review

decarboxylation
Carboxy-Lyases
fatty acids
Hydrocarbons
Fatty acids

Cloning and characterization of a new delta-specific L-leucine dioxygenase from Anabaena variabilis

Correia Cordeiro, R. S., Enoki, J., Busch, F., Mügge, C. & Kourist, R., 20 Oct 2018, In : Journal of Biotechnology. 284, p. 68-74 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Anabaena variabilis
Dioxygenases
Cloning
Leucine
Amino acids

Enzymatic Decarboxylation as a Tool for the Enzymatic Defunctionalization of Hydrophobic Bio-based Organic Acids

Kourist, R., Schweiger, A. & Büchsenschütz, H., 2018, Lipid Modification by Enzymes and Engineered Microbes. Bornscheuer, U. T. (ed.). AOCS Press, p. 89-118 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearch

Fatty Alcohols: enzymatically from Free fatty Acids

Horvat, M., Zabielska, J., Kourist, R. & Winkler, M., 3 Jul 2018.

Research output: Contribution to conferencePosterResearch

Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions

Schmidt, S., Castiglione, K. & Kourist, R., 6 Feb 2018, In : Chemistry - a European Journal. 24, 8, p. 1755-1768 14 p.

Research output: Contribution to journalReview articleResearchpeer-review

Enzyme immobilization
Purification
Catalysts
Enzymes

Practical considerations regarding the choice of the best high-throughput assay

Mügge, C. & Kourist, R., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 189-208 20 p. (Methods in Molecular Biology; vol. 1685).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Protein Engineering
Enzyme Assays
Enzymes

Raman Microspectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells

Aljakouch, K., Lechtonen, T., Yosef, H. K., Hammoud, M. K., Alsaidi, W., Kötting, C., Mügge, C., Kourist, R., El-Mashtoly, S. F. & Gerwert, K., 11 Jun 2018, In : Angewandte Chemie / International Edition . 57, 24, p. 7250-7254 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolites
Metabolism
Protein-Tyrosine Kinases
Microscopic examination
Cells
2017

Applied Microbiology for Chemical Syntheses

Kourist, R., Siebers, B., Gonzales-Sabín, J. & Julsing, M., 11 Oct 2017, In : Frontiers in Microbiology . 8, p. 1931

Research output: Contribution to journalEditorialResearchpeer-review

Microbiology

Biocatalysis

Kourist, R. & Bornscheuer, U. T., 1 Nov 2017, Applied Homogeneous Catalysis with Organometallic Compounds. Cornils, B., Herrmann, W., Beller, M. & Paciello, R. (eds.). Third Edition ed. Wiley-VCH

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Biotechnology
Enantioselectivity
Enzymes
Catalysts
Biocatalysis

Durch Trennen verbinden

Schmidt, S., Gröger, H. & Kourist, R., Oct 2017, In : Nachrichten aus der Chemie. 65, 10, p. 985-988 4 p.

Research output: Contribution to journalArticleResearch

Editorial Special Issue on the Occasion of Prof. Dr. Alf Pühlers 75th birthday.

Marques Alves, P., Becker, A., Blöcker, H., Chan, R. L., Chen, G. G-Q., Fussenegger, M., Kondo, A., Kourist, R., Schwab, H., Sensen, C. W., Sensen, M., Seo, J-H. & Srienc, F., 10 Sep 2017, In : Journal of Biotechnology. p. 1 1 p., doi: 10.1016/j.jbiotec.2017.07.013.

Research output: Contribution to journalEditorialResearch

Enzymatic Oxyfunctionalization Driven by Photosynthetic Water-Splitting in the Cyanobacterium Synechocystis sp. PCC 6803

Böhmer, S., Köninger, K., Gomez-Baraibar, A., Bojarra, S., Mügge, C., Schmidt, S., Nowaczyk, M. & Kourist, R., Aug 2017, In : Catalysts. 7, 8, 8 p., 240.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
water splitting
regeneration
Fueling
Oxygenation
Niacinamide

Evolving Enzymes for Biocatalysis

Bornscheuer, U. T. & Kourist, R., 2017, Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids: Production of Fuels and Chemicals. Lee, S. Y. (ed.). Cham: Springer International Publishing AG , p. 1-17 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Exploring the Substrate Scope of a Phenolic Acid Decarboxylase Variant

Schweiger, A. K., Gómez Baraibar, Á., Winkler, C. K., Kroutil, W., Schmidt, S. & Kourist, R., Jul 2017.

Research output: Contribution to conferencePosterResearch

Exploring the Substrate Scope of a Phenolic Acid Decarboxylase Variant

Schweiger, A. K., Gómez Baraibar, Á., Winkler, C. K., Kroutil, W., Schmidt, S. & Kourist, R., Sep 2017.

Research output: Contribution to conferencePosterResearch

Overcoming the incompatibility challenge in chemo-enzymatic and multi-catalytic cascade reactions.

Schmidt, S., Castiglione, K. & Kourist, R., 6 Sep 2017, In : Chemistry - a European Journal.

Research output: Contribution to journalArticleResearchpeer-review

Photobiocatalytic Nicotinamide REcycling

Winkler, C. K., Schmidt, S., Büchsenschütz, H. C., Vidimce-Risteski, V., Kourist, R. & Kroutil, W., 15 Nov 2017.

Research output: Contribution to conferencePosterResearch

Photosynthesis-driven Asymmetric reduction of c=c double bonds

Schmidt, S., Winkler, C. K., Büchsenschütz, H. C., Vidimce-Risteski, V., Kroutil, W. & Kourist, R., 15 Nov 2017.

Research output: Contribution to conferencePosterResearch

Practical Considerions Regarding the Choice of High-Throughput-Assays

Kourist, R. & Mügge, C., 1 Sep 2017, Protein Engineering- Methods and Protocols. Bornscheuer, U. & Höhne, M. (eds.). Vol. 1685. p. 189-208 18 p. (Springer Protocols Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Assays
Throughput
Enzymes
Amino Acids
Proteins

Transcriptome Profiling of the Australian arid-land Plant Eremophila serrulata for the Identification of Monoterpene synthases

Kracht, O. N., Ammann, A-C., Stockmann, J., Wibberg, D., Kalinowski, J., Piotrowski, M., Kerr, R., Brück, T. B. & Kourist, R., 2017, In : Phytochemistry. 136, p. 15-22

Research output: Contribution to journalArticleResearchpeer-review

2016

A Multi-Enzymatic Cascade Reaction for the Stereoselective Production of γ-Oxyfunctionalyzed Amino Acids

Enoki, J., Meisborn, J., Müller, A-C. & Kourist, R., 2016, In : Frontiers in Microbiology . 7, p. 425

Research output: Contribution to journalArticleResearchpeer-review

Amino Acids
Geobacillus
Enzymes
Racemases and Epimerases
Dioxygenases

A One-Pot Cascade Reaction Combining an Encapsulated Decarboxylase with a Metathesis Catalyst for the Synthesis of Bio-Based Antioxidants

Gómez Baraibar, Á., Reichert, D., Mügge, C., Seger, S., Gröger, H. & Kourist, R., 14 Nov 2016, In : Angewandte Chemie / International Edition . 55, 47, p. 14823-14827 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Carboxy-Lyases
Antioxidants
Organic solvents
Catalysts
Ruthenium

Arylmalonate decarboxylase-a highly selective bacterial biocatalyst with unknown function

Miyamoto, K. & Kourist, R., Oct 2016, In : Applied Microbiology and Biotechnology. 100, 20, p. 8621-31 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Enzymes
Carboxy-Lyases
Carboxylic Acids
malonate decarboxylase

Arylmalonate decarboxylase-catalyzed asymmetric synthesis of both enantiomers of optically pure flurbiprofen

Gaßmeyer, S. K., Wetzig, J., Mügge, C., Assmann, M., Enoki, J., Hilterhaus, L., Zuhse, R., Miyamoto, K., Liese, A. & Kourist, R., 2016, In : ChemCatChem. 8, p. 916-921 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of amino acid networks governing catalysis in the closed complex of class I terpene synthases

Schrepfer, P., Buettner, A., Goerner, C., Hertel, M., van Rijn, J., Wallrapp, F., Eisenreich, W., Sieber, V., Kourist, R. & Brück, T., 23 Feb 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 8, p. E958-67

Research output: Contribution to journalArticleResearchpeer-review

Catalysis
Terpenes
Amino Acids
Computer Simulation
Catalytic Domain

Lichtgetriebene Ganzzellbiotransformation mit rekombinanten Cyanobakterien

Nowaczyk, M. & Kourist, R., 2016, In : Biospektrum. 22, 7, p. 765-767 3 p.

Research output: Contribution to journalArticleResearch

Light-driven Enzymatic Decarboxylation

Köninger, K., Grote, M., Zachos, I., Hollmann, F. & Kourist, R., 22 May 2016, In : Journal of visualized experiments . 111

Research output: Contribution to journalArticleResearchpeer-review

Decarboxylation
Hydrogen Peroxide
Fatty Acids
Fatty acids
Enzymes

Recombinant Cyanobacteria for the Asymmetric Reduction of C=C Bonds Fueled by the Biocatalytic Oxidation of Water

Köninger, K., Gómez Baraibar, Á., Mügge, C., Paul, C. E., Hollmann, F., Nowaczyk, M. M. & Kourist, R., 25 Apr 2016, In : Angewandte Chemie / International Edition . 55, 18, p. 5582-5 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidoreductases
Oxidation
Photosynthesis
Water
NADP

Semiempirical QM/MM calculations reveal a step-wise proton transfer and an unusual thiolate pocket in the mechanism of the racemizing mutant G74C of arylmalonate decarboxylase

Busch, F., Hülsemann, N., Enoki, J., Miyamoto, K., Bocola, M. & Kourist, R., 2016, In : Catalysis Science & Technology. 6, p. 4937-4944 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Sequence-Based Screening for Rare Enzymes: New Insights into the World of AMDases Reveal a Conserved Motif and 58 Novel Enzymes Clustering in Eight Distinct Families

Maimanakos, J., Chow, J., Gaßmeyer, S. K., Güllert, S., Busch, F., Kourist, R. & Streit, W. R., 2016, In : Frontiers in Microbiology . 7, p. 1332

Research output: Contribution to journalArticleResearchpeer-review

Cluster Analysis
Enzymes
aspartate racemase
Genes
glutamate racemase
2015

A combined bioinformatics and functional metagenomics approach to discovering lipolytic biocatalysts

Masuch, T., Kusnezowa, A., Nilewski, S., Bautista, J. T., Kourist, R. & Leichert, L. I., 2015, In : Frontiers in Microbiology . 6

Research output: Contribution to journalArticleResearchpeer-review

Draft Genome Sequence of Bordetella bronchiseptica KU1201, the First Isolation Source of Arylmalonate Decarboxylase

Yoshida, S., Enoki, J., Hemmi, R., Kourist, R., Kawakami, N. & Miyamoto, K., 7 May 2015, In : Genome Announcements. 3, 3

Research output: Contribution to journalArticleResearchpeer-review

Bordetella bronchiseptica
Genome
Bacteria
Proteins
malonate decarboxylase

Engineered hydrophobic pocket of (S)-selective arylmalonate decarboxylase variant by simultaneous saturation mutagenesis to improve catalytic performance

Yoshida, S., Enoki, J., Kourist, R. & Miyamoto, K., 2015, In : Bioscience, Biotechnology and Biochemistry. 79, 12, p. 1965-1971 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression of enantioselective enzymes in cyanobacteria

Bartsch, M., Gaßmeyer, S. K., Igarashi, K., Miyamoto, M., Rögner, M., Nowaczyc, M. & Kourist, R., 2015, In : Microbial cell factories . 14, p. 53 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Genomics and Transcriptomics Analyses of the Oil-Accumulating Basidiomycete Yeast Trichosporon oleaginosus: Insights into Substrate Utilization and Alternative Evolutionary Trajectories of Fungal Mating Systems: Insights into Substrate Utilization and Alternative Evolutionary Trajectories of Fungal Mating Systems

Kourist, R., Bracharz, F., Lorenzen, J., Kracht, O. N., Chovatia, M., Daum, C., Deshpande, S., Lipzen, A., Nolan, M., Ohm, R. A., Grigoriev, I. V., Sun, S., Heitman, J., Brück, T. & Nowrousian, M., 21 Jul 2015, In : mBio. 6, 4, p. e00918

Research output: Contribution to journalArticleResearchpeer-review

Trichosporon
Basidiomycota
Genomics
Oils
Yeasts

Photobiocatalytic decarboxylation for olefin synthesis

Zachos, I., Gaßmeyer, S. K., Bauer, D., Sieber, V., Hollmann, F. & Kourist, R., 2015, In : Chemical Communications. 51, p. 1918-1921 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Photosynthetic production of enantioselective biocatalysts

Bartsch, M., Gassmeyer, S. K., Köninger, K., Igarashi, K., Liauw, P., Dyczmons-Nowaczyk, N., Miyamoto, K., Nowaczyk, M. M. & Kourist, R., 15 Apr 2015, In : Microbial cell factories . 14, p. 53

Research output: Contribution to journalArticleResearchpeer-review

Biocatalysts
Enzymes
Synechocystis
Biofuels
Cyanobacteria