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  • 2020
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Author

  • Johannes Khinast
Article

Efficient Discrete Element Method Simulation Strategy for Analyzing Large-Scale Agitated Powder Mixers

Siegmann, E., Jajcevic, D., Radeke, C., Strube, D., Friedrich, K. & Khinast, J. G., 1 Aug 2017, In : Chemie - Ingenieur - Technik. 89, 8, p. 995-1005 11 p.

Research output: Contribution to journalArticle

Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates

Eder, S., Beretta, M., Witschnigg, A., Koutsamanis, I., Eggenreich, K., Khinast, J. G., Koscher, G., Paudel, A., Nickisch, K., Friedrich, M., Froehlich, E. & Roblegg, E., 1 Nov 2017, In : AAPS PharmSciTech . 18, 8, p. 2971-2976 6 p.

Research output: Contribution to journalArticle

Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

Amidon, G. E., Anderson, B. D., Balthasar, J. P., Bergstrom, C. A. S., Huang, S-M., Kasting, G., Kesisoglou, F., Khinast, J. G., Mager, D. E., Roberts, C. J. & Yu, L., Jan 2019, In : Journal of Pharmaceutical Sciences . 108, 1, p. 2-7

Research output: Contribution to journalArticle

Filling of lactose-based formulations in a tamping-pin capsule filler

Faulhammer, E., Kruisz, J., Scheibelhofer, O., Rehrl, J., Witschnigg, A. & Khinast, J. G., May 2020, In : Drug Development and Industrial Pharmacy. 46, 5, p. 775-787 13 p.

Research output: Contribution to journalArticle

Flow of granular materials in a bladed mixer: Effect of particle properties and process parameters on impeller torque and power consumption

Boonkanokwong, V., Frank, R. P., Valliappan, P., Remy, B., Khinast, J. G. & Glasser, B. J., 1 Nov 2018, In : Advanced powder technology. 29, 11, p. 2733-2752 20 p.

Research output: Contribution to journalArticle

Heat transfer of dry granular materials in a bladed mixer: Effect of thermal properties and agitation rate

Hartmanshenn, C., Khinast, J. G., Papageorgiou, C. D., Mitchell, C., Quon, J. & Glasser, B. J., 27 Nov 2019, In : AIChE Journal.

Research output: Contribution to journalArticle

Hopper flow of irregularly shaped particles (non-convex polyhedra): GPU-based DEM simulation and experimental validation

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Pizette, P. & Xu, W., 2018, In : Chemical Engineering Science. p. 34-51

Research output: Contribution to journalArticle

Open Access

Industrial scale simulations of tablet coating using gpu based dem: A validation study

Kureck, H. G., Govender, N., Siegmann, E., Böhling, P., Radeke, C. & Khinast, J., 20 Jul 2019, In : Chemical Engineering Science. p. 462-480 19 p.

Research output: Contribution to journalArticle

Influence of Process Route on the Mechanical Properties of Polymer Based Intravaginal Drug Delivery Systems

Eggenreich, K., Schrank, S., Koscher, G., Nickisch, K., Roblegg, E. & Khinast, J., 2017, In : AIP Conference Proceedings. 1914

Research output: Contribution to journalArticle

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticle

Large-scale GPU based DEM modeling of mixing using irregularly shaped particles

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Rajamani, R. K. & Glasser, B. J., 2018, In : Advanced powder technology. p. 2476-2490

Research output: Contribution to journalArticle

LIF or dye: Comparison of different tracing methods for granular solids

Scheibelhofer, O., Kruisz, J., Rehrl, J., Faulhammer, E., Witschnigg, A. & Khinast, J., 2020, In : Powder Technology. 367, p. 20-31

Research output: Contribution to journalArticle

Liquid Transport Rates during Binary Collisions of Unequally-sized Particles

Wu, M., Khinast, J. & Radl, S., 2017, In : Powder Technology. 309, p. 95-109 14 p.

Research output: Contribution to journalArticle

Open Access
File

Local gas holdup simulation and validation of industrial-scale aerated bioreactors

Witz, C., Treffer, D. F., Hardiman, T. & Khinast, J., 2 Oct 2016, In : Chemical Engineering Science. 152, p. 636-648 13 p.

Research output: Contribution to journalArticle

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing

Khinast, J., Leane, M., Pitt, K., Reynolds, G. K., Dawson, N., Ziegler, I., Szepes, A., Crean, A. M., Agnol, R. D., Broegmann, B., Charlton, S., Davies, C., Gamble, J., Gamlen, M., Hsiao, W. K., Khimyak, Y., Kleinebudde, P., Moreton, C., Oswald, M., Page, S. & 5 others, Paudel, A., Sahoo, R., Sheehan, S., Stamato, H. & Stone, E., 2018, In : Pharmaceutical development and technology. p. 964-977 13 p.

Research output: Contribution to journalArticle

Measurement of granule layer thickness in a spouted bed coating process via optical coherence tomography

Pietsch, S., Peter, A., Wahl, P., Khinast, J. & Heinrich, S., Nov 2019, In : Powder Technology. 356, p. 139-147

Research output: Contribution to journalArticle

Measuring bulk density variations in a moving powder bed via terahertz in-line sensing

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Khinast, J. G., Zeitler, J. A. & Markl, D., 15 Feb 2019, In : Powder Technology. 344, p. 152-160

Research output: Contribution to journalArticle

Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets

Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In : Powder Technology. 325, p. 247-260

Research output: Contribution to journalArticle

Mechanistic modeling of a capsule filling process

Loidolt, P., MadImeir, S. & Khinast, J. G., 30 Oct 2017, In : International Journal of Pharmaceutics. 532, 1, p. 47-54

Research output: Contribution to journalArticle

Mechansitic modeling of a capsule filling process

Loidolt, P., Madlmeir, S. & Khinast, J., 30 Oct 2017, In : International Journal of Pharmaceutics.

Research output: Contribution to journalArticle

Micro-feeding and dosing of powders via a small-scale powder pump

Besenhard, M., Fathollahi, S., Siegmann, E., Slama, E., Faulhammer, E. & Khinast, J., 2017, In : International Journal of Pharmaceutics. 519, 1-2, p. 314-322

Research output: Contribution to journalArticle

Model-based approach to the design of pharmaceutical roller-compaction processes

Toson, P., Lopes, D. G., Paus, R., Kumar, A., Geens, J., Stibale, S., Quodbach, J., Kleinebudde, P., Hsiao, W-K. & Khinast, J., Dec 2019, In : International Journal of Pharmaceutics: X. 1, 100005.

Research output: Contribution to journalArticle

Open Access

Multi-methodological investigation of the variability of the microstructure of HPMC hard capsules

Faulhammer, E., Khinast, J., Paudel, A., Wahl, V. & Markl, D., 25 Sep 2016, In : International Journal of Pharmaceutics. 511, 2, p. 840-854 14 p.

Research output: Contribution to journalArticle

NANEX: Process design and optimization

Baumgartner, R., Matic, J., Schrank, S., Laske, S., Khinast, J. & Roblegg, E., 14 Apr 2016, In : International Journal of Pharmaceutics. 506, p. 35-45 10 p.

Research output: Contribution to journalArticle

Numerical investigation of a coarse-grain discrete element method in solid mixing in a spouted bed

Takabatake, K., Mori, Y., Khinast, J. G. & Sakai, M., 15 Aug 2018, In : Chemical Engineering Journal. 346, p. 416-426 11 p.

Research output: Contribution to journalArticle

Particle-level residence time data in a twin-screw feeder

Toson, P. & Khinast, J. G., Dec 2019, In : Data in Brief . 27, 104672

Research output: Contribution to journalArticle

Performance Characterization of Static Mixers in Precipitating Environments

Kreimer, M., Zettl, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. G. & Krumme, M., Jul 2019, In : Organic Process Research & Devlopment. 23, 7, p. 1308-1320

Research output: Contribution to journalArticle

Powder flow and mixing in different tablet press feed frames

Siegmann, E., Forgber, T., Toson, P., Martinetz, M. C., Kureck, H., Brinz, T., Manz, S., Grass, T. & Khinast, J., 1 Jan 2020, (Accepted/In press) In : Advanced powder technology.

Research output: Contribution to journalArticle

Predicting capsule fill weight from in-situ powder density measurements using terahertz reflection technology

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Zeitler, J. A., Biserni, S., Calzolari, V., Khinast, J. G. & Markl, D., 1 Dec 2019, In : International Journal of Pharmaceutics: X. 1, 100004.

Research output: Contribution to journalArticle

Open Access

Prediction of the anisotropic mechanical properties of compacted powders

Loidolt, P., Ulz, M. H. & Khinast, J., 2019, In : Powder Technology. 345, p. 589-600 12 p.

Research output: Contribution to journalArticle

Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure

Planchette, C., Pichler, H., Wimmer-Teubenbacher, M., Gruber, M., Gruber-Wölfler, H., Mohr, S., Tetyczka, C., Hsiao, W. K., Paudel, A., Roblegg, E. & Khinast, J., 2016, In : International Journal of Pharmaceutics. p. 518-527

Research output: Contribution to journalArticle

Rapid automated process development of a continuous capsule-filling process

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 30 Jul 2018, In : International Journal of Pharmaceutics. 546, 1-2, p. 154-165 12 p.

Research output: Contribution to journalArticle

Open Access

Runtime Maximization of Continuous Precipitation in an Ultrasonic Process Chamber

Zettl, M., Kreimer, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. & Krumme, M., 17 Apr 2020, In : Organic Process Research & Devlopment. 24, 4, p. 508-519

Research output: Contribution to journalArticle

Sensitivity analysis of a pharmaceutical tablet production process from the control engineering perspective

Rehrl, J., Gruber, A. F., Khinast, J. & Horn, M., 30 Nov 2016, In : International Journal of Pharmaceutics. 517, 1-2, p. 373-382 10 p.

Research output: Contribution to journalArticle