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• 100% double site saturation by individual expression of 400 muteins in Pichia pastoris

  Geier, M., 2012.

  Research output: Contribution to conference › Poster

• ACIB and CHEM21: Towards greener and more sustainable pharmaceutical manufacturing processes

  Geier, M., Killinger, M., Wiltschi, B., Gruber-Khadjawi, M., Lypetska, K., Strohmeier, G., Breinbauer, R., Turrini, N., Faber, K. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• A Toolbox of Diverse Promoters Related to Methanol Utilization: Functionally Verified Parts for Heterologous Pathway Expression in Pichia pastoris

  Vogl, T., Sturmberger, L., Kickenweiz, T., Wasmayer, R., Schmid, C., Hatzl, A-M., Gerstmann, M. A., Pitzer, J., Wagner, M., Thallinger, G. G., Geier, M. & Glieder, A., 19 Feb 2016, In : ACS Synthetic Biology . 5, 2, p. 172-86 15 p.

  Research output: Contribution to journal › Article

  • Pichia
  • Methanol
  • alcohol oxidase
  • Genes
  • Biosynthetic Pathways

• Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans

  Fiorentini, F., Geier, M., Binda, C., Winkler, M., Faber, K., Hall, M. & Matteiv, A., 2016, In : ACS Chemical Biology. p. 1039 1048 p.

  Research output: Contribution to journal › Article

• Biotransformations for drug metabolite synthesis

  Winkler, M., Bachler, T., Geier, M., Hanlon, S. P., Eggimann, F. K., Rodrigues, D., Ferreira Antunes, M., Kittelmann, M., Glieder, A., Wirz, B. & Lütz, S., 2015.

  Research output: Contribution to conference › Poster

• COMPACT AND OPTIMIZED METABOLIC PATHWAY DESIGN IN PICHIA PASTORIS

  Geier, M., Glieder, A. & Fauland, P., 6 May 2016, IPC No. C12N 15/ 09 A I, Patent No. WO2016066711, Priority date 28 Oct 2014, Priority No. EP20140190702

  Research output: Patent

  • Pichia
  • Metabolic Networks and Pathways
  • Yeasts
  • Gene Expression

• Compact multi-enzyme pathways in P. pastoris

  Geier, M., Fauland, P. C., Vogl, T. & Glieder, A., 2015, In : Chemical Communications. 15, 51;9, p. 1643-1646

  Research output: Contribution to journal › Article

• Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation

  Geier, M., Braun, A., Fladischer, P., Stepniak, P., Rudroff, F., Hametner, C., Mihovilovic, M. & Glieder, A., 2013, In : The FEBS journal. 280, 13, p. 3094-108

  Research output: Contribution to journal › Article

• Drug Metabolizing Enzymes: From Heterologous Expression to Drug Metabolite Synthesis

  Winkler, M., Bachler, T., Geier, M., Glieder, A., Hanlon, S. P., Eggimann, F. K., Rodrigues, D., Antunes, M., Kittelmann, M., Wirz, B. & Lütz, S., 2015.

  Research output: Contribution to conference › Poster

• Efficient expression and purification of human flavin-containing monooxygenases (hFMOs): first steps towards the elucidation of FMO3 crystal structure

  Fiorentini, F., Geier, M., Winkler, M., Binda, C. & Mattevi, A., 2013.

  Research output: Contribution to conference › Poster

• Engineered bidirectional promoters enable rapid multi-gene co-expression optimization

  Vogl, T., Kickenweiz, T., Pitzer, J., Sturmberger, L., Weninger, A., Biggs, B. W., Köhler, E-M., Baumschlager, A., Fischer, J. E., Hyden, P., Wagner, M., Baumann, M., Borth, N., Geier, M., Ajikumar, P. K. & Glieder, A., 4 Sep 2018, In : Nature Communications . 9, 1, p. 3589

  Research output: Contribution to journal › Article

  Open Access

  • genes
  • Synthetic Biology
  • Libraries
  • Genes
  • Metabolic Networks and Pathways

• Engineering Pichia pastoris for improved NADH regeneration: A novel chassis strain for whole-cell catalysis

  Geier, M., Brandner, C., Strohmeier, G. A., Hall, M., Hartner, F. S. & Glieder, A., 2015, In : Beilstein Journal of Organic Chemistry . 11, p. 1741-8 8 p.

  Research output: Contribution to journal › Article

  • Chassis
  • NAD
  • Catalysis
  • Methanol
  • formaldehyde transketolase

• Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

  Wiltschi, B., Cernava, T., Dennig, A., Galindo, M., Geier, M., Gruber, S., Haberbauer, M., Heidinger, P., Acero, E. H., Kratzer, R., Luley-Goedl, C., Müller, C. A., Pitzer, J., Ribitsch, D., Sauer, M., Schmölzer, K., Schnitzhofer, W., Sensen, C. W., Soh, J., Steiner, K. & 3 others, Winkler, C. K., Winkler, M. & Wriessnegger, T., 23 Jan 2020, In : Biotechnology Advances. 40, 107520.

  Research output: Contribution to journal › Review article

  Open Access

  • Enzymes
  • Recovery
  • Biocontrol
  • Bioconversion
  • Biocatalysts

• Erratum to: Engineered bidirectional promoters enable rapid multi-gene co-expression optimization (Nature Communications, (2018), 9, 1, (3589), 10.1038/s41467-018-05915-w)

  Vogl, T., Kickenweiz, T., Pitzer, J., Sturmberger, L., Weninger, A., Biggs, B. W., Köhler, E. M., Baumschlager, A., Fischer, J. E., Hyden, P., Wagner, M., Baumann, M., Borth, N., Geier, M., Ajikumar, P. K. & Glieder, A., 1 Dec 2018, In : Nature Communications . 9, 1, 4566.

  Research output: Contribution to journal › Comment/debate

  Open Access

  • files
  • genes
  • Publications
  • Genes
  • communication

• Exploiting recombinant Pichia pastoris for drug metabolite synthesis: Towards an efficient CYP3A4-based whole-cell catalyst

  Geier, M., Schmid, C. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• First functional expression of cytochrome P450 3A4 in Pichia pastoris

  Geier, M., Schmid, C. & Glieder, A., 2013, In : Chimica Oggi. 31, 3, p. 24-27

  Research output: Contribution to journal › Article

• Humane Enzyme für die Organische Synthese

  Winkler, M., Geier, M., Hanlon, S. P., Nidetzky, B. & Glieder, A., 2018, In : Angewandte Chemie. 130, p. 13592-13610

  Research output: Contribution to journal › Review article

• Human Enzymes for Organic Synthesis

  Winkler, M., Geier, M., Hanlon, S. P., Nidetzky, B. & Glieder, A., 2018, In : Angewandte Chemie / International Edition . 57, 41, p. 13406-13423 18 p.

  Research output: Contribution to journal › Review article

  • Enzymes
  • Pharmaceutical Preparations
  • Xenobiotics
  • Metabolites
  • Metabolism

• Human Flavin Monooxygenases as a Tool for Drug Metabolite Synthesis

  Bachler, T., Hanlon, S. P., Kittelmann, M., Geier, M., Camattari, A., Glieder, A., Wirz, B., Lütz, S. & Winkler, M., 2013.

  Research output: Contribution to conference › Poster

• Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis

  Geier, M., Bachler, T., Hanlon, S. P., Eggimann, F. K., Kittelmann, M., Weber, H., Lütz, S., Wirz, B. & Winkler, M., 2015, In : Microbial cell factories . 14, 82, p. 1-10

  Research output: Contribution to journal › Article

• Integrative expression vectors for stable pathway construction in the yeast Schizosaccharomyces pombe

  Geier, M., Hatzl, A-M., Mellitzer, A. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• Methanol independent induction in Pichia pastoris by simple derepressed overexpression of single transcription factors

  Vogl, T., Sturmberger, L., Fauland, P. C., Hyden, P., Fischer, J. E., Schmid, C., Thallinger, G. G., Geier, M. & Glieder, A., 1 Apr 2018, In : Biotechnology and Bioengineering. 115, 4, p. 1037-1050

  Research output: Contribution to journal › Article

  • Transcription factors
  • Pichia
  • Methanol
  • Transcription Factors
  • Carbon

• MuteinDB: the mutein database linking substrates, products and enzymatic reactions directly with genetic variants of enzymes

  Braun, A., Halwachs, B., Geier, M., Weinhandl, K., Guggemos, M., Marienhagen, J., Ruff, A. J., Schwaneberg, U., Torres Pazmiño, D. E., Rabin, V., Thallinger, G. & Glieder, A., 2012, In : Database - The Journal of Biological Databases and Curation . p. bas028-bas028

  Research output: Contribution to journal › Article

• Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes--a comparative study

  Geier, M., Braun, A., Emmerstorfer, A., Pichler, H. & Glieder, A., 2012, In : Biotechnology Journal. 7, 11, p. 1346-1358 13 p.

  Research output: Contribution to journal › Article

  • Cytochrome P-450 CYP2D6
  • Enzymes
  • Pharmaceutical Preparations
  • Pichia
  • Biotransformation

• Protein Engineering Using Eukaryotic Expression Systems

  Geier, M. & Glieder, A., 2013, Protein Engineering Handbook - Volume 3. Weinheim, Germany: Wiley-VCH , p. 47-72

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Refined Pichia pastoris reference genome sequence

  Sturmberger, L., Chappell, T., Geier, M., Krainer, F., Day, K. J., Vide, U., Trstenjak, S., Schiefer, A., Richardson, T., Soriaga, L., Darnhofer, B., Birner-Gruenberger, R., Glick, B. S., Tolstorukov, I., Cregg, J., Madden, K. & Glieder, A., 10 Oct 2016, In : Journal of Biotechnology. 235, p. 121-131 11 p.

  Research output: Contribution to journal › Review article

  • Pichia
  • Genes
  • Genome
  • Chromosomes
  • Open Reading Frames

• Screening for cytochrome P450 expression in Pichia pastoris whole cells by P450-carbon monoxide complex determination

  Gudiminchi, R. K., Geier, M., Glieder, A. & Camattari, A., Jan 2013, In : Biotechnology Journal. 8, 1, p. 146-152 7 p.

  Research output: Contribution to journal › Article

  • Pichia
  • Carbon Monoxide
  • Cytochrome P-450 Enzyme System
  • Yeasts
  • Cytochrome P-450 CYP2D6

• Steroid biotransformations in biphasic systems with Yarrowia lipolytica expressing human liver cytochrome P450 genes

  Braun, A., Geier, M., Buehler, B., Schmid, A., Mauersberger, S. & Glieder, A., 2012, In : Microbial cell factories . 11, p. 106

  Research output: Contribution to journal › Article

• Towards drug metabolite production on the multi-miligram scale: Generation of an efficient aldehyde oxidase (AOX1) based biocatalyst

  Bachler, T., Rodrigues, D. F., Kittelmann, M., Geier, M., Abad, S., Hanlon, S. P., Camattari, A., Lütz, S., Wirz, B. & Winkler, M., 2013.

  Research output: Contribution to conference › Poster