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  • 2020
  • 2019
  • 2017
  • 2016

Author

  • Johannes Khinast
2016

Lyophilized protein powders: A review of analytical tools for root cause analysis of lot-to-lot variability

Paudel, A., Wahl, V. & Khinast, J., Sep 2016, In : Trends in Analytical Chemistry. p. 468-491

Research output: Contribution to journalArticleResearchpeer-review

2019

Industrial scale simulations of tablet coating using gpu based dem: A validation study

Kureck, H. G., Govender, N., Siegmann, E., Böhling, P., Radeke, C. & Khinast, J., 20 Jul 2019, In : Chemical Engineering Science. p. 462-480 19 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Real-Time Monitoring and Ejection of out-of-Spec Tablets Via NIR Chemical Imaging

Wolfgang, M., Wahl, P., Hauseder, G., Sacher, S., Kerschhaggl, M. & Khinast, J., 14 Nov 2016.

Research output: Contribution to conferencePosterResearchpeer-review

2017

Suzuki-Miyaura coupling reactions using novel metal oxide supported ionic palladium catalysts

Lichtenegger, G. J., Maier, M., Hackl, M., Khinast, J. G., Goessler, W., Griesser, T., Kumar, V. S. P., Gruber-Woelfler, H. & Deshpande, P. A., Jan 2017, In : Journal of molecular catalysis / A. 426, p. 39-51

Research output: Contribution to journalArticleResearchpeer-review

2019

Sensitivity of a continuous hot-melt extrusion and strand pelletization line to control actions and composition variation

Hörmann, T. R., Rehrl, J., Scheibelhofer, O., Schaden, L. M., Funke, A., Makert, C. & Khinast, J. G., 20 Jul 2019, In : International Journal of Pharmaceutics. 566, p. 239-253 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

NUMERICAL STUDY ON THE EFFECT OF PARTICLE SHAPE ON MIXERS

Govender, N., Wilke, D. N., Rajamani, R. K., Pizette, P., Khinast, J. & Glasser, B. J., 2017

Research output: Other contributionResearch

Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging

Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In : International Journal of Pharmaceutics. 518, 1-2, p. 130-137

Research output: Contribution to journalArticleResearchpeer-review

Comparison of video analysis and simulations of a drum coating process

Boehling, P., Toschkoff, G., Dreu, R., Just, S., Kleinebudde, P., Funke, A., Rehbaum, H. & Khinast, J. G., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 72-81 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The effect of material attributes and process parameters on the powder bed uniformity during a low-dose dosator capsule filling process

Stranzinger, S., Faulhammer, E., Calzolari, V., Biserni, S., Dreu, R., Šibanc, R., Paudel, A. & Khinast, J., 10 Jan 2017, In : International Journal of Pharmaceutics. 516, p. 9-20 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates

Eder, S., Beretta, M., Witschnigg, A., Koutsamanis, I., Eggenreich, K., Khinast, J. G., Koscher, G., Paudel, A., Nickisch, K., Friedrich, M., Froehlich, E. & Roblegg, E., 1 Nov 2017, In : AAPS PharmSciTech . 18, 8, p. 2971-2976 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechansitic modeling of a capsule filling process

Loidolt, P., Madlmeir, S. & Khinast, J., 30 Oct 2017, In : International Journal of Pharmaceutics.

Research output: Contribution to journalArticleResearchpeer-review

2019

A novel in silico scale-up approach for hot melt extrusion processes

Matic, J., Witschnigg, A., Zagler, M., Eder, S. & Khinast, J., 31 Aug 2019, In : Chemical Engineering Science. 204, p. 257-269

Research output: Contribution to journalArticleResearchpeer-review

Particle-level residence time data in a twin-screw feeder

Toson, P. & Khinast, J. G., Dec 2019, In : Data in Brief . 27, 104672

Research output: Contribution to journalArticleResearchpeer-review

2016

Ce0.495Sn0.495Pd0.01O2 as highly stable and low-leaching catalyst in continuous Suzuki-Miyaura cross-coupling reactions

Lichtenegger, G. J., Khinast, J. & Gruber-Wölfler, H., 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Paudel, A., Llusa, M., Mohr, S., Baumgartner, R., Koscher, G. & Khinast, J., 2 Aug 2016, In : Drug Development and Industrial Pharmacy. p. 1360-1364 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Computational Fluid Dynamics-Discrete Element Method Modeling of an Industrial-Scale Wurster Coater

Boehling, P., Khinast, J. G., Jajcevic, D., Davies, C., Carmody, A., Doshi, P., Ende, M. T. A. & Sarkar, A., Jan 2019, In : Journal of Pharmaceutical Sciences . 108, 1, p. 538-550

Research output: Contribution to journalArticleResearchpeer-review

UNDERSTANDING THE MOTION OF ROTATING HARD SHELL CAPSULES IN DRY POWDER INHALERS

Benque, B. & Khinast, J., 1 Apr 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 32, 2, p. A20-A20

Research output: Contribution to journalAbstractResearchpeer-review

2016

Multi-methodological investigation of the variability of the microstructure of HPMC hard capsules

Faulhammer, E., Khinast, J., Paudel, A., Wahl, V. & Markl, D., 25 Sep 2016, In : International Journal of Pharmaceutics. 511, 2, p. 840-854 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Light in Powder - Penetration and Information

Scheibelhofer, O., Wahl, P., Larchevêque, B. & Khinast, J., 21 Mar 2016.

Research output: Contribution to conferencePosterResearch

NIR-Hyperspectral Imaging and Raman Chemical Mapping of Multilayer-Tablets

Poms, J., Scheibelhofer, O., Sacher, S. & Khinast, J., 30 Mar 2016.

Research output: Contribution to conferencePosterResearchpeer-review

2019

Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate

Zellnitz, S., Pinto, J., Brunsteiner, M., Schröttner, H., Khinast, J. & Paudel, A., 2019, In : Pharmaceutical research. 36, 6, p. 80 11 p., 36:80.

Research output: Contribution to journalArticleResearchpeer-review

2016

Process Development for Continuous Extrusion and Pelletization of a Heat and Shear-Sensitive Formulation

Hörmann, T., Laske, S., Koscher, G. & Khinast, J., 14 Nov 2016.

Research output: Contribution to conferencePosterResearchpeer-review

Feasibility study for turret speed operating points in a rotary tablet press

Martinetz, M., Aigner, I., Rehrl, J., Scheibelhofer, O., Laske, S. & Khinast, J., Mar 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

2017

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In : Chemie - Ingenieur - Technik. 89, 8

Research output: Contribution to journalArticleResearchpeer-review

2019

Performance Characterization of Static Mixers in Precipitating Environments

Kreimer, M., Zettl, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. G. & Krumme, M., Jul 2019, In : Organic Process Research & Devlopment. 23, 7, p. 1308-1320

Research output: Contribution to journalArticleResearchpeer-review

2017

DEM study of granular transport in partially filled horizontal screw conveyors

Orefice, L. & Khinast, J. G., Jan 2017, In : Powder Technology. 305, p. 347-356

Research output: Contribution to journalArticleResearchpeer-review

2020

Runtime Maximization of Continuous Precipitation in an Ultrasonic Process Chamber

Zettl, M., Kreimer, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. & Krumme, M., 17 Apr 2020, In : Organic Process Research & Devlopment. 24, 4, p. 508-519

Research output: Contribution to journalArticleResearchpeer-review

2019

Prediction of the anisotropic mechanical properties of compacted powders

Loidolt, P., Ulz, M. H. & Khinast, J., 2019, In : Powder Technology. 345, p. 589-600 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Impulse-based dynamics for studying quasi-static granular flows: Application to hopper emptying of non-spherical particles

Toson, P. & Khinast, J. G., 15 May 2017, In : Powder Technology. 313, p. 353-360 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2019
2017

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Sensitivity analysis of a pharmaceutical tablet production process from the control engineering perspective

Rehrl, J., Gruber, A. F., Khinast, J. & Horn, M., 30 Nov 2016, In : International Journal of Pharmaceutics. 517, 1-2, p. 373-382 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2020

Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective

Hsiao, W-K., Hörmann, T. R., Toson, P., Paudel, A., Ghiotti, P., Stauffer, F., Bauer, F., Lakio, S., Behrend, O., Maurer, R., Holman, J. & Khinast, J., Jan 2020, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticleResearchpeer-review

2019

Model-based approach to the design of pharmaceutical roller-compaction processes

Toson, P., Lopes, D. G., Paus, R., Kumar, A., Geens, J., Stibale, S., Quodbach, J., Kleinebudde, P., Hsiao, W-K. & Khinast, J., Dec 2019, In : International Journal of Pharmaceutics: X. 1, 100005.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2016

Effect of Bubble-Particle Interaction Models on Flow Predictions in Three-Phase Bubble Columns

Gruber, M. C., Radl, S. & Khinast, J., 26 Feb 2016, In : Chemical Engineering Science. 146, p. 226–243

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Suzuki-Miyaura coupling reactions using novel metal oxide supportedionic palladium catalysts

Lichtenegger, G. J., Maier, M. C., Hackl, M., Khinast, J., Gössler, W., Griesser, T., Phani Kumard, V. S., Gruber-Wölfler, H. & Deshpande, P. A., 1 Nov 2016, In : Journal of molecular catalysis / A. 426, p. 39-51

Research output: Contribution to journalArticleResearchpeer-review

Scale-up of HME Process from a Trilobed 16mm to a Bilobed 27mm Extruder; SPH Simulations and 1D Mechanistic Modelling

Matic, J., Laske, S., Paudel, A., Pfefferlé, F., Martinetti, J. L., Martel, S. & Khinast, J., 16 Nov 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Optimized continuous pharmaceutical manufacturing via model-predictive control

Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 16 Jun 2016, In : International Journal of Pharmaceutics. 510, p. 100-115

Research output: Contribution to journalArticleResearchpeer-review

The Effect of Powder and Process Parameters on the Powder Bed Uniformity of a low-dose Capsule Filling Process

Stranzinger, S., Faulhammer, E., Srčič, S., Dreu, R., Calzolari, V., Biserni, S., Paudel, A. & Khinast, J., 7 Jul 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Decoupling of a low-dose dosator capsule filling process in dynamic and static mode tests

Stranzinger, S., Faulhammer, E., Srčič, S., Calzolari, V., Biserni, S., Paudel, A. & Khinast, J., 31 Mar 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

A Model to Predict Liquid Bridge Formation between Wet Particles Based on Direct Numerical Simulations

Wu, M., Radl, S. & Khinast, J., 16 Feb 2016, In : AIChE Journal. 62, p. 1877-1897 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Liquid Transport in Bi-disperse Particle Beds revealed by Direct Numerical Simulations

Wu, M., Khinast, J. & Radl, S., 14 Sep 2016, p. 1-2. 2 p.

Research output: Contribution to conferenceAbstractResearch

Open Access
File
2017

Liquid Transport Rates during Binary Collisions of Unequally-sized Particles

Wu, M., Khinast, J. & Radl, S., 2017, In : Powder Technology. 309, p. 95-109 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

The Virtual Sandbox

Wu, M., Reichel, E., Eck, J., Khinast, J. & Radl, S., 31 Mar 2016, 3rd Austrian Particle Forum.

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

File
2020

Powder flow and mixing in different tablet press feed frames

Siegmann, E., Forgber, T., Toson, P., Martinetz, M. C., Kureck, H., Brinz, T., Manz, S., Grass, T. & Khinast, J., 1 Jan 2020, (Accepted/In press) In : Advanced powder technology.

Research output: Contribution to journalArticleResearchpeer-review

2019

Deriving control parameter settings from process models to control capsule fillers integrated into continuous manufacturing

Wagner, B., Cheong, S. F., Brinz, T. & Khinast, J., 2 Sep 2019, In : Drug Development and Industrial Pharmacy. 45, 9, p. 1523-1536

Research output: Contribution to journalArticleResearchpeer-review

Heat transfer of dry granular materials in a bladed mixer: Effect of thermal properties and agitation rate

Hartmanshenn, C., Khinast, J. G., Papageorgiou, C. D., Mitchell, C., Quon, J. & Glasser, B. J., 27 Nov 2019, In : AIChE Journal.

Research output: Contribution to journalArticleResearchpeer-review

2020

LBM for two-phase (bio-)reactors

Eibl, P., Rustige, S., Witz, C. & Khinast, J., 30 May 2020, (Accepted/In press) Advances in Chemical Engineering. 67 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review