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  • 2020
  • 2018
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  • 2016

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  • Johannes Khinast
2016

Lyophilized protein powders: A review of analytical tools for root cause analysis of lot-to-lot variability

Paudel, A., Wahl, V. & Khinast, J., Sep 2016, In : Trends in Analytical Chemistry. p. 468-491

Research output: Contribution to journalArticleResearchpeer-review

2017

Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging

Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In : International Journal of Pharmaceutics. 518, 1-2, p. 130-137

Research output: Contribution to journalArticleResearchpeer-review

2016

Real-Time Monitoring and Ejection of out-of-Spec Tablets Via NIR Chemical Imaging

Wolfgang, M., Wahl, P., Hauseder, G., Sacher, S., Kerschhaggl, M. & Khinast, J., 14 Nov 2016.

Research output: Contribution to conferencePosterResearchpeer-review

2017

Comparison of video analysis and simulations of a drum coating process

Boehling, P., Toschkoff, G., Dreu, R., Just, S., Kleinebudde, P., Funke, A., Rehbaum, H. & Khinast, J. G., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 72-81 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Paudel, A., Llusa, M., Mohr, S., Baumgartner, R., Koscher, G. & Khinast, J., 2 Aug 2016, In : Drug Development and Industrial Pharmacy. p. 1360-1364 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line

Martinetz, M., Kartunnen, A-P., Sacher, S., Wahl, P., Ketolainen, J., Khinast, J. & Korhonnen, O., 5 Jun 2018.

Research output: Contribution to conferencePaperResearchpeer-review

Open Access
2016

Multi-methodological investigation of the variability of the microstructure of HPMC hard capsules

Faulhammer, E., Khinast, J., Paudel, A., Wahl, V. & Markl, D., 25 Sep 2016, In : International Journal of Pharmaceutics. 511, 2, p. 840-854 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

MODEL INFORMED DEVELOPMENT OF DRY POWDER INHALER (DPI) FORMULATIONS AND PROCESSES

Paudel, A., Zellnitz, S., Arora, S., Benque, B., Brunsteiner, M., Faulhammer, E., Loidolt, P. & Khinast, J. G., Apr 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 31, 2, p. A9-A9

Research output: Contribution to journalAbstractResearchpeer-review

2016

Light in Powder - Penetration and Information

Scheibelhofer, O., Wahl, P., Larchevêque, B. & Khinast, J., 21 Mar 2016.

Research output: Contribution to conferencePosterResearch

2017

Suzuki-Miyaura coupling reactions using novel metal oxide supported ionic palladium catalysts

Lichtenegger, G. J., Maier, M., Hackl, M., Khinast, J. G., Goessler, W., Griesser, T., Kumar, V. S. P., Gruber-Woelfler, H. & Deshpande, P. A., Jan 2017, In : Journal of molecular catalysis / A. 426, p. 39-51

Research output: Contribution to journalArticleResearchpeer-review

Mechansitic modeling of a capsule filling process

Loidolt, P., Madlmeir, S. & Khinast, J., 30 Oct 2017, In : International Journal of Pharmaceutics.

Research output: Contribution to journalArticleResearchpeer-review

NUMERICAL STUDY ON THE EFFECT OF PARTICLE SHAPE ON MIXERS

Govender, N., Wilke, D. N., Rajamani, R. K., Pizette, P., Khinast, J. & Glasser, B. J., 2017

Research output: Other contributionResearch

The effect of material attributes and process parameters on the powder bed uniformity during a low-dose dosator capsule filling process

Stranzinger, S., Faulhammer, E., Calzolari, V., Biserni, S., Dreu, R., Šibanc, R., Paudel, A. & Khinast, J., 10 Jan 2017, In : International Journal of Pharmaceutics. 516, p. 9-20 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates

Eder, S., Beretta, M., Witschnigg, A., Koutsamanis, I., Eggenreich, K., Khinast, J. G., Koscher, G., Paudel, A., Nickisch, K., Friedrich, M., Froehlich, E. & Roblegg, E., 1 Nov 2017, In : AAPS PharmSciTech . 18, 8, p. 2971-2976 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Ce0.495Sn0.495Pd0.01O2 as highly stable and low-leaching catalyst in continuous Suzuki-Miyaura cross-coupling reactions

Lichtenegger, G. J., Khinast, J. & Gruber-Wölfler, H., 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Process Development for Continuous Extrusion and Pelletization of a Heat and Shear-Sensitive Formulation

Hörmann, T., Laske, S., Koscher, G. & Khinast, J., 14 Nov 2016.

Research output: Contribution to conferencePosterResearchpeer-review

NIR-Hyperspectral Imaging and Raman Chemical Mapping of Multilayer-Tablets

Poms, J., Scheibelhofer, O., Sacher, S. & Khinast, J., 30 Mar 2016.

Research output: Contribution to conferencePosterResearchpeer-review

Feasibility study for turret speed operating points in a rotary tablet press

Martinetz, M., Aigner, I., Rehrl, J., Scheibelhofer, O., Laske, S. & Khinast, J., Mar 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

2017

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In : Chemie - Ingenieur - Technik. 89, 8

Research output: Contribution to journalArticleResearchpeer-review

2018

Detailed modeling and process design of an advanced continuous powder mixer

Toson, P., Siegmann, E., Trogrlic, M., Kureck, H., Khinast, J., Jajcevic, D., Doshi, P., Blackwood, D., Bonnassieux, A., Daugherity, P. D. & am Ende, M. T., 1 Dec 2018, In : International Journal of Pharmaceutics. 552, 1-2, p. 288-300 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

DEM study of granular transport in partially filled horizontal screw conveyors

Orefice, L. & Khinast, J. G., Jan 2017, In : Powder Technology. 305, p. 347-356

Research output: Contribution to journalArticleResearchpeer-review

2018

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A combined DEM & FEM approach for modelling roll compaction process

Mazor, A., Orefice, L., Michrafy, A., de Ryck, A. & Khinast, J. G., Sep 2018, In : Powder Technology. 337, p. 3-16 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of particle shape in grinding mills using a GPU based DEM code

Khinast, J., Govender, N., Rajamani, R. K., Wilke, D. N., Wu, C-Y. & Glasser, B. J., 2018, In : Minerals engineering. p. 71-84

Research output: Contribution to journalArticleResearchpeer-review

2017

Impulse-based dynamics for studying quasi-static granular flows: Application to hopper emptying of non-spherical particles

Toson, P. & Khinast, J. G., 15 May 2017, In : Powder Technology. 313, p. 353-360 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2020

Runtime Maximization of Continuous Precipitation in an Ultrasonic Process Chamber

Zettl, M., Kreimer, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. & Krumme, M., 17 Apr 2020, In : Organic Process Research & Devlopment. 24, 4, p. 508-519

Research output: Contribution to journalArticleResearchpeer-review

2018

Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets

Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In : Powder Technology. 325, p. 247-260

Research output: Contribution to journalArticleResearchpeer-review

2017

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Sensitivity analysis of a pharmaceutical tablet production process from the control engineering perspective

Rehrl, J., Gruber, A. F., Khinast, J. & Horn, M., 30 Nov 2016, In : International Journal of Pharmaceutics. 517, 1-2, p. 373-382 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2020

Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective

Hsiao, W-K., Hörmann, T. R., Toson, P., Paudel, A., Ghiotti, P., Stauffer, F., Bauer, F., Lakio, S., Behrend, O., Maurer, R., Holman, J. & Khinast, J., Jan 2020, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticleResearchpeer-review

2016

Effect of Bubble-Particle Interaction Models on Flow Predictions in Three-Phase Bubble Columns

Gruber, M. C., Radl, S. & Khinast, J., 26 Feb 2016, In : Chemical Engineering Science. 146, p. 226–243

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Scale-up of HME Process from a Trilobed 16mm to a Bilobed 27mm Extruder; SPH Simulations and 1D Mechanistic Modelling

Matic, J., Laske, S., Paudel, A., Pfefferlé, F., Martinetti, J. L., Martel, S. & Khinast, J., 16 Nov 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Suzuki-Miyaura coupling reactions using novel metal oxide supportedionic palladium catalysts

Lichtenegger, G. J., Maier, M. C., Hackl, M., Khinast, J., Gössler, W., Griesser, T., Phani Kumard, V. S., Gruber-Wölfler, H. & Deshpande, P. A., 1 Nov 2016, In : Journal of molecular catalysis / A. 426, p. 39-51

Research output: Contribution to journalArticleResearchpeer-review

Optimized continuous pharmaceutical manufacturing via model-predictive control

Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 16 Jun 2016, In : International Journal of Pharmaceutics. 510, p. 100-115

Research output: Contribution to journalArticleResearchpeer-review

2018

Material tracking in a continuous direct capsule-filling process via residence time distribution measurements

Kruisz, J., Rehrl, J., Faulhammer, E., Witschnigg, A. & Khinast, J., 2018, In : International Journal of Pharmaceutics. 550, 1-2, p. 347-358

Research output: Contribution to journalArticleResearchpeer-review

2016

The Effect of Powder and Process Parameters on the Powder Bed Uniformity of a low-dose Capsule Filling Process

Stranzinger, S., Faulhammer, E., Srčič, S., Dreu, R., Calzolari, V., Biserni, S., Paudel, A. & Khinast, J., 7 Jul 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Decoupling of a low-dose dosator capsule filling process in dynamic and static mode tests

Stranzinger, S., Faulhammer, E., Srčič, S., Calzolari, V., Biserni, S., Paudel, A. & Khinast, J., 31 Mar 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

2017

Liquid Transport Rates during Binary Collisions of Unequally-sized Particles

Wu, M., Khinast, J. & Radl, S., 2017, In : Powder Technology. 309, p. 95-109 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2020

LBM for two-phase (bio-)reactors

Eibl, P., Rustige, S., Witz, C. & Khinast, J., 30 May 2020, (Accepted/In press) Advances in Chemical Engineering. 67 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

2018

Automation of a dosing-disc capsule filler from the perspective of reliability and safety

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 4 Mar 2018, In : Drug Development and Industrial Pharmacy. 44, 3, p. 502-510 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme

Khinast, J., Schaden, L-M., Wimmer-Teubenbacher, M., Poms, J., Laggner, P., Lohner, K., Sacher, S. & Salar-Behzadi, S., 2018, In : Pharmaceutical research.

Research output: Contribution to journalArticleResearchpeer-review

2017

Drug–Excipient Interactions in the Solid State: The Role of Different Stress Factors

Gressl, C., Brunsteiner, M., Davis, A., Landis, M., Pencheva, K., Scrivens, G., Sluggett, G. W., Wood, G. P. F., Gruber-Wölfler, H., Khinast, J. & Paudel, A., 2 Nov 2017, In : Molecular pharmaceutics. 14, 12, p. 4560-4571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Analysis of Flow and Mixing in Screw Elements of Corotating Twin-Screw Extruders via SPH

Eitzlmayr, A., Matic, J. & Khinast, J., Jun 2017, In : AIChE Journal. 63, 6, p. 2451-2463

Research output: Contribution to journalArticleResearchpeer-review

2018

Flow of granular materials in a bladed mixer: Effect of particle properties and process parameters on impeller torque and power consumption

Boonkanokwong, V., Frank, R. P., Valliappan, P., Remy, B., Khinast, J. G. & Glasser, B. J., 1 Nov 2018, In : Advanced powder technology. 29, 11, p. 2733-2752 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Local gas holdup simulation and validation of industrial-scale aerated bioreactors

Witz, C., Treffer, D. F., Hardiman, T. & Khinast, J., 2 Oct 2016, In : Chemical Engineering Science. 152, p. 636-648 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Understanding the motion of hard shell capsules in dry powder inhalers

Benque, B. & Khinast, J., 5 Nov 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Spatially Resolved Spectral Powder Analysis: Experiments and Modeling

Khinast, J., Scheibelhofer, O., Wahl, P., Larchevêque, B. & Chauchard, F., 2018, In : Applied Spectroscopy. p. 521-534

Research output: Contribution to journalArticleResearchpeer-review

2017

Micro-feeding and dosing of powders via a small-scale powder pump

Besenhard, M., Fathollahi, S., Siegmann, E., Slama, E., Faulhammer, E. & Khinast, J., 2017, In : International Journal of Pharmaceutics. 519, 1-2, p. 314-322

Research output: Contribution to journalArticleResearchpeer-review

2016

NANEX: Process design and optimization

Baumgartner, R., Matic, J., Schrank, S., Laske, S., Khinast, J. & Roblegg, E., 14 Apr 2016, In : International Journal of Pharmaceutics. 506, p. 35-45 10 p.

Research output: Contribution to journalArticleResearchpeer-review