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  • Johannes Khinast
2017

Liquid Transport Rates during Binary Collisions of Unequally-sized Particles

Wu, M., Khinast, J. & Radl, S., 2017, In : Powder Technology. 309, p. 95-109 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2019

Heat transfer of dry granular materials in a bladed mixer: Effect of thermal properties and agitation rate

Hartmanshenn, C., Khinast, J. G., Papageorgiou, C. D., Mitchell, C., Quon, J. & Glasser, B. J., 27 Nov 2019, In : AIChE Journal.

Research output: Contribution to journalArticleResearchpeer-review

Deriving control parameter settings from process models to control capsule fillers integrated into continuous manufacturing

Wagner, B., Cheong, S. F., Brinz, T. & Khinast, J., 2 Sep 2019, In : Drug Development and Industrial Pharmacy. 45, 9, p. 1523-1536

Research output: Contribution to journalArticleResearchpeer-review

2020

LBM for two-phase (bio-)reactors

Eibl, P., Rustige, S., Witz, C. & Khinast, J., 30 May 2020, (Accepted/In press) Advances in Chemical Engineering. 67 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

2018

Automation of a dosing-disc capsule filler from the perspective of reliability and safety

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 4 Mar 2018, In : Drug Development and Industrial Pharmacy. 44, 3, p. 502-510 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme

Khinast, J., Schaden, L-M., Wimmer-Teubenbacher, M., Poms, J., Laggner, P., Lohner, K., Sacher, S. & Salar-Behzadi, S., 2018, In : Pharmaceutical research.

Research output: Contribution to journalArticleResearchpeer-review

2017

Drug–Excipient Interactions in the Solid State: The Role of Different Stress Factors

Gressl, C., Brunsteiner, M., Davis, A., Landis, M., Pencheva, K., Scrivens, G., Sluggett, G. W., Wood, G. P. F., Gruber-Wölfler, H., Khinast, J. & Paudel, A., 2 Nov 2017, In : Molecular pharmaceutics. 14, 12, p. 4560-4571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Using online content uniformity measurements for rapid automated process development exemplified via an X-ray system

Wagner, B., Brinz, T. & Khinast, J., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 775-787

Research output: Contribution to journalArticleResearchpeer-review

Shedding light on coatings: Real-time monitoring of coating quality at industrial scale

Sacher, S., Wahl, P., Weissensteiner, M., Wolfgang, M., Pokhilchuk, Y., Looser, B., Thies, J., Raffa, A. & Khinast, J. G., 20 Jul 2019, In : International Journal of Pharmaceutics. 566, p. 57-66

Research output: Contribution to journalArticleResearchpeer-review

2017

Analysis of Flow and Mixing in Screw Elements of Corotating Twin-Screw Extruders via SPH

Eitzlmayr, A., Matic, J. & Khinast, J., Jun 2017, In : AIChE Journal. 63, 6, p. 2451-2463

Research output: Contribution to journalArticleResearchpeer-review

2019

At-line validation of optical coherence tomography as in-line/at-line coating thickness measurement method

Wolfgang, M., Peter, A., Wahl, P., Markl, D., Zeitler, J. A. & Khinast, J. G., 15 Dec 2019, In : International Journal of Pharmaceutics. 572

Research output: Contribution to journalArticleResearchpeer-review

2018

Flow of granular materials in a bladed mixer: Effect of particle properties and process parameters on impeller torque and power consumption

Boonkanokwong, V., Frank, R. P., Valliappan, P., Remy, B., Khinast, J. G. & Glasser, B. J., 1 Nov 2018, In : Advanced powder technology. 29, 11, p. 2733-2752 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Local gas holdup simulation and validation of industrial-scale aerated bioreactors

Witz, C., Treffer, D. F., Hardiman, T. & Khinast, J., 2 Oct 2016, In : Chemical Engineering Science. 152, p. 636-648 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Understanding the motion of hard shell capsules in dry powder inhalers

Benque, B. & Khinast, J., 5 Nov 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Spatially Resolved Spectral Powder Analysis: Experiments and Modeling

Khinast, J., Scheibelhofer, O., Wahl, P., Larchevêque, B. & Chauchard, F., 2018, In : Applied Spectroscopy. p. 521-534

Research output: Contribution to journalArticleResearchpeer-review

2017

Micro-feeding and dosing of powders via a small-scale powder pump

Besenhard, M., Fathollahi, S., Siegmann, E., Slama, E., Faulhammer, E. & Khinast, J., 2017, In : International Journal of Pharmaceutics. 519, 1-2, p. 314-322

Research output: Contribution to journalArticleResearchpeer-review

2016

NANEX: Process design and optimization

Baumgartner, R., Matic, J., Schrank, S., Laske, S., Khinast, J. & Roblegg, E., 14 Apr 2016, In : International Journal of Pharmaceutics. 506, p. 35-45 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Formulation performance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization

Hörmann, T., Jäger, N., Funke, A., Mürb, R-K., Khinast, J. G. & Paudel, A., 20 Dec 2018, In : International Journal of Pharmaceutics. 553, 1-2, p. 408-421 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Influence of Process Route on the Mechanical Properties of Polymer Based Intravaginal Drug Delivery Systems

Eggenreich, K., Schrank, S., Koscher, G., Nickisch, K., Roblegg, E. & Khinast, J., 2017, In : AIP Conference Proceedings. 1914

Research output: Contribution to journalArticleResearchpeer-review

2020

Powder flow and mixing in different tablet press feed frames

Siegmann, E., Forgber, T., Toson, P., Martinetz, M. C., Kureck, H., Brinz, T., Manz, S., Grass, T. & Khinast, J., 1 Jan 2020, (Accepted/In press) In : Advanced powder technology.

Research output: Contribution to journalArticleResearchpeer-review

2016

Particle Loaded Monolithic Materials for Separations via Planar Electrochromatography

Gruber-Wölfler, H., Braunbruck, M-G., Laskowski, R., Feenstra, P., Khinast, J. & Bart, H-J., 2016, In : Journal of planar chromatography - modern TLC. 29, 1

Research output: Contribution to journalArticleResearchpeer-review

2019

Study of the capsule-filling dosator process via calibrated DEM simulations

Madlmeir, S., Loidolt, P. & Khinast, J. G., 15 Aug 2019, In : International Journal of Pharmaceutics. 567

Research output: Contribution to journalArticleResearchpeer-review

2018

Study of a low-dose capsule filling process by dynamic and static tests for advanced process understanding

Paudel, A., Stranzinger, S., Faulhammer, E., Scheibelhofer, O., Calzolari, V., Biserni, S. & Khinast, J., 5 Apr 2018, In : International Journal of Pharmaceutics. 540, 1-2, p. 22-30 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Understanding the motion of hard-shell capsules in dry powder inhalers

Benque, B. & Khinast, J., 2019, In : International Journal of Pharmaceutics. 567

Research output: Contribution to journalArticleResearchpeer-review

2017

Efficient Discrete Element Method Simulation Strategy for Analyzing Large-Scale Agitated Powder Mixers

Siegmann, E., Jajcevic, D., Radeke, C., Strube, D., Friedrich, K. & Khinast, J. G., 1 Aug 2017, In : Chemie - Ingenieur - Technik. 89, 8, p. 995-1005 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Optimization of a Micro-Feeding Unit in a Continuous Pharmaceutical Process Line

Hörmann, T., Tausendschön, J., Schmid, T., Koscher, G. & Khinast, J., 21 Apr 2016.

Research output: Contribution to conferencePosterResearchpeer-review

Mechanistic Modeling of Capsule Filling Processes

Loidolt, P. & Khinast, J., 19 Apr 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

2019

The need for new control strategies for particulate matter in parenterals

Poms, J., Sacher, S., Nixdorf, M., Dekner, M., Wallner-Mang, S., Janssen, I., Khinast, J. G. & Schennach, R., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 739-750 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A system and a method for constant micro dosing and feeding of powder material

Fathollahi, S., Khinast, J., Klein, T., Besenhard, M. & Slama, E., 11 Apr 2018

Research output: PatentResearch

2017

Crystal Engineering in Continuous Plug-Flow Crystallizers

Neugebauer, P., Besenhard, M., Khinast, J. & Scheibelhofer, O., 10 Oct 2017, In : Crystal Growth and Design.

Research output: Contribution to journalArticleResearchpeer-review

2018

Understanding the Motion of Hard-shell capsules in Dry Powder Inhalers

Benque, B. & Khinast, J., 12 Dec 2018.

Research output: Contribution to conferencePosterResearchpeer-review

2020

A novel framework for a rational, fully-automatised calibration routine for DEM models of cohesive powders

Orefice, L. & Khinast, J. G., 1 Feb 2020, In : Powder Technology. 361, p. 687-703

Research output: Contribution to journalArticleResearchpeer-review

2019

Real-time measurement of coating film thickness

Wolfgang, M., Wahl, P., Sacher, S., Gartshein, E. & Khinas, J. G., 1 Mar 2019, In : Pharmaceutical technology. 43, 3, p. 36-47 12 p.

Research output: Contribution to journalComment/debateResearchpeer-review

Measuring bulk density variations in a moving powder bed via terahertz in-line sensing

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Khinast, J. G., Zeitler, J. A. & Markl, D., 15 Feb 2019, In : Powder Technology. 344, p. 152-160

Research output: Contribution to journalArticleResearchpeer-review

Measurement of granule layer thickness in a spouted bed coating process via optical coherence tomography

Pietsch, S., Peter, A., Wahl, P., Khinast, J. & Heinrich, S., Nov 2019, In : Powder Technology. 356, p. 139-147

Research output: Contribution to journalArticleResearchpeer-review

2018

COMBINATIONAL APPROACH FOR ADVANCED UNDERSTANDING OF A LOW-DOSE CAPSULE FILLING PROCESS FOR INHALATION APPLICATION

Faulhammer, E., Stranzinger, S., Calzolari, V., Biserni, S., Loidolt, P., Paudel, A. & Khinast, J., Apr 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 31, 2, p. A7-A7

Research output: Contribution to journalAbstractResearchpeer-review

Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors

Rehrl, J., Kartunnen, A-P., Nicolaï, N., Hörmann, T., Horn, M., Korhonnen, O., Nopens, I., de Beer, T. & Khinast, J., 30 May 2018, In : International Journal of Pharmaceutics. 543, 1-2, p. 60-72

Research output: Contribution to journalArticleResearchpeer-review

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing

Khinast, J., Leane, M., Pitt, K., Reynolds, G. K., Dawson, N., Ziegler, I., Szepes, A., Crean, A. M., Agnol, R. D., Broegmann, B., Charlton, S., Davies, C., Gamble, J., Gamlen, M., Hsiao, W. K., Khimyak, Y., Kleinebudde, P., Moreton, C., Oswald, M., Page, S. & 5 othersPaudel, A., Sahoo, R., Sheehan, S., Stamato, H. & Stone, E., 2018, In : Pharmaceutical development and technology. p. 964-977 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Continuous Manufacturing of Pharmaceuticals: Chapter 10 - Continuous Melt Extrusion and Direct Pelletization

Laske, S., Hörmann, T., Witschnigg, A., Koscher, G., Wahl, P., Hsiao, W. K. & Khinast, J., 2017, 1st ed. NJ, USA: Wiley & Sons. 337 p. (Advances in Pharmaceutical Technology; vol. Continuous Manufacturing of Pharmaceuticals, no. 1)

Research output: Book/ReportBookResearchpeer-review

2019

Predicting capsule fill weight from in-situ powder density measurements using terahertz reflection technology

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Zeitler, J. A., Biserni, S., Calzolari, V., Khinast, J. G. & Markl, D., 1 Dec 2019, In : International Journal of Pharmaceutics: X. 1, 100004.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2016

Scale-Up of an HME Process Supported by 3D SPH and 1D Mechanistic Modelling

Matic, J., Eitzlmayr, A. & Khinast, J., 2 Mar 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Particle-Based Modelling of Free-Surface Flow and Distributive Mixing in Modular Co-Rotating Twin-Screw Extruders

Matic, J., Eitzlmayr, A., Kondor, I., Koscher, G. & Khinast, J., 21 Apr 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Comparing particle size distributions of an arbitrary shape

Scheibelhofer, O., Besenhard, M., Piller, M. & Khinast, J., 16 Feb 2016, In : Powder Technology. 294, p. 134-145

Research output: Contribution to journalArticleResearchpeer-review

2018

The Effect of Liquid Bridge Model Details on the Dynamics of Wet Fluidized Beds

Wu, M., Khinast, J. & Radl, S., Feb 2018, In : AIChE Journal. 64, p. 437-456 10.1002/aic.15947.

Research output: Contribution to journalArticleResearchpeer-review

2020

Filling of lactose-based formulations in a tamping-pin capsule filler

Faulhammer, E., Kruisz, J., Scheibelhofer, O., Rehrl, J., Witschnigg, A. & Khinast, J. G., May 2020, In : Drug Development and Industrial Pharmacy. 46, 5, p. 775-787

Research output: Contribution to journalArticleResearchpeer-review

2017
2019

Ensuring Tablet Quality via Model-based Control of a Continuous Direct Compaction Process

Kirchengast, M., Celikovic, S., Rehrl, J., Sacher, S., Kruisz, J., Khinast, J. & Horn, M., 15 Aug 2019, In : International Journal of Pharmaceutics. 2019, 567, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2020

LIF or dye: Comparison of different tracing methods for granular solids

Scheibelhofer, O., Kruisz, J., Rehrl, J., Faulhammer, E., Witschnigg, A. & Khinast, J., 2020, In : Powder Technology. 367, p. 20-31

Research output: Contribution to journalArticleResearchpeer-review

2016

Liquid Transport in Bi-disperse Particle Beds revealed by Direct Numerical Simulations

Wu, M., Khinast, J. & Radl, S., 14 Sep 2016, p. 1-2. 2 p.

Research output: Contribution to conferenceAbstractResearch

Open Access
File