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• 2020

  Distinct chromophore-protein environments enable asymmetric activation of a bacteriophytochrome activated diguanylate cyclase

  Buhrke, D., Gourinchas, G., Müller, M., Michael, N., Hildebrandt, P. & Winkler, A., 10 Jan 2020, In : The Journal of Biological Chemistry. 295, 2, p. 539-551 13 p.

  Research output: Contribution to journal › Article

  Open Access

  • Chromophores
  • Chemical activation
  • Light
  • Signal transduction
  • Proteins

• Phytochrome-Activated Diguanylyl Cyclases: The Functional Relevance of Asymmetry

  Böhm, C., Balasso, M., Todorovic, N., Gourinchas, G. & Winkler, A., 6 Feb 2020.

  Research output: Contribution to conference › Poster

  • Phytochrome
  • Chemical activation
  • Biliverdine
  • Guanosine Triphosphate
  • Lighting
• 2019

  A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro

  Strandback, E., Lienhart, W-D., Hromic-Jahjefendic, A., Bourgeois, B., Högler, A., Waltenstorfer, D., Winkler, A., Zangger, K., Madl, T., Gruber, K. & Macheroux, P., 30 Oct 2019, In : FEBS letters.

  Research output: Contribution to journal › Article

  Open Access

  • Molecular Chaperones
  • NAD
  • Oxidoreductases
  • Enzyme Stability
  • Flavin-Adenine Dinucleotide

• Bacteriophytochromes - from informative model systems of phytochrome function to powerful tools in cell biology

  Gourinchas, G., Etzl, S. & Winkler, A., 1 Aug 2019, In : Current Opinion in Structural Biology. 57, p. 72-83 12 p.

  Research output: Contribution to journal › Review article

  • Biliverdine
  • Phytochrome
  • Cell Biology
  • Optogenetics
  • Fluorescent Dyes

• Influence of the N-terminal segment and the PHY-tongue element on light-regulation in bacteriophytochromes

  Gourinchas, G., Vide, U. & Winkler, A., 22 Mar 2019, In : The Journal of Biological Chemistry. 294, 12, p. 4498-4510 13 p.

  Research output: Contribution to journal › Article

  • Tongue
  • Light
  • Optogenetics
  • Chromophores
  • Availability

• Molecular mechanisms of light regulation in LOV-diguanylate cyclases

  Vide, U., Färber, J., Etzl, S., Zenzmaier, E. & Winkler, A., 18 Sep 2019.

  Research output: Contribution to conference › Poster
• 2018

  Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor

  Gourinchas, G., Heintz, U. & Winkler, A., 5 Jun 2018, In : eLife. 7, e34815.

  Research output: Contribution to journal › Article

  Open Access

  • Phytochrome
  • Chemical activation
  • Light
  • Optogenetics
  • Signal transduction

• Asymmetric structural rearrangements involved in light activation of a dimeric red light photoreceptor.

  Gourinchas, G. & Winkler, A., 2018, (Accepted/In press).

  Research output: Contribution to conference › Poster

• Molecular Mechanisms of Bacterial Bioluminescence

  Brodl, E., Winkler, A. & Macheroux, P., 2018, In : Computational and Structural Biotechnology Journal. 16, p. 551 564 p.

  Research output: Contribution to journal › Review article

  Open Access

• Molecular mechanisms of red-light regulation in phytochrome linked adenylate/guanylate cyclases

  Etzl, S., Nelson, M. & Winkler, A., 7 Mar 2018.

  Research output: Contribution to conference › Poster

• Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein

  Augustin, P. A., Toplak, M., Fuchs, A. K., Gerstmann, E., Prassl, R. & Winkler, A., 4 Jan 2018, In : The Journal of Biological Chemistry. 293, 8, p. 2829-2840 21 p.

  Research output: Contribution to journal › Article

• Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic applications

  Etzl, S., Lindner, R., Nelson, M. D. & Winkler, A., 8 Jun 2018, In : The Journal of Biological Chemistry. 293, 23, p. 9078-9089 12 p.

  Research output: Contribution to journal › Article

  Open Access

  • Optogenetics
  • Guanylate Cyclase
  • Phytochrome
  • Adenylyl Cyclases
  • Light

• The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase

  Toplak, M., Wiedemann, G., Ulićević, J., Daniel, B., Hoernstein, S. N. W., Kothe, J., Niederhauser, J., Reski, R., Winkler, A. & Macheroux, P., May 2018, In : The FEBS journal. 285, 10, p. 1923-1943 21 p.

  Research output: Contribution to journal › Article

  • Biosynthesis
  • Alkaloids
  • Cellulose
  • Eschscholzia
  • Genes
• 2017

  Functional cross talk of sensor and effector modules in red light activated diguanylyl cyclases

  Gourinchas, G., Winkler, A. & Vide, U., 2017, (In preparation).

  Research output: Contribution to conference › Poster

• Long-range allosteric regulation of GTP turnover in red-light modulated diguanylyl cyclases

  Gourinchas, G. S., Etzl, S. & Winkler, A., 3 Feb 2017, (Accepted/In press).

  Research output: Contribution to conference › Poster

• Long-Range Allosteric Signaling in Red Light-Regulated Diguanylyl Cyclases

  Gourinchas, G. S., Etzl, S., Göbl, C., Vide, U., Madl, T. & Winkler, A., 3 Mar 2017, In : Science Advances. 3, 3, e1602498.

  Research output: Contribution to journal › Article

  Open Access

  • red light
  • sensors (equipment)
  • guanosine
  • cell communication
  • phytochrome

• Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase

  Lindner, R., Hartmann, E., Tarnawski, M., Winkler, A., Frey, D., Reinstein, J., Meinhart, A. & Schlichting, I., 5 May 2017, In : Journal of molecular biology. 429, 9, p. 1336-1351 16 p.

  Research output: Contribution to journal › Article

  • Adenylyl Cyclases
  • Light
  • Deuterium Exchange Measurement
  • Beggiatoa
  • Catalytic Domain

• Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

  Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

  Research output: Contribution to conference › Poster

• Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

  Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

  Research output: Contribution to conference › Poster

• Stabilization of a cancer associated variant of human NQO1 by the use of small-molecular chaperones

  Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Waltenstorfer, D., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

  Research output: Contribution to conference › Poster

• The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions: A treasure-trove of oxidative reactions

  Daniel, B., Konrad, B., Toplak, M., Lahham, M., Messenlehner, J., Winkler, A. & Macheroux, P., 15 Oct 2017, In : Archives of Biochemistry and Biophysics. 632, p. 88-103 16 p.

  Research output: Contribution to journal › Review article

  • Flavin-Adenine Dinucleotide
  • Eschscholzia
  • Enzymes
  • Flavin Mononucleotide
  • Riboflavin

• The origin of the berberine bridge enzyme-like protein family in plants

  Toplak, M., Wiedemann, G., Ulicevic, J., Daniel, B., Hoernstein, S., Kothe, J., Reski, R., Winkler, A. & Macheroux, P., Jul 2017.

  Research output: Contribution to conference › Poster
• 2015

  Applications of hydrogen deuterium exchange (HDX) for the characterization of conformational dynamics in light-activated photoreceptors

  Lindner, R., Heintz, U. & Winkler, A., 2015, In : Frontiers in Molecular Biosciences . 2, 33, p. 1-13

  Research output: Contribution to journal › Article

• Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

  Brieke, C., Kratzig, V., Haslinger, K., Winkler, A. & Cryle, M. J., 2015, In : Organic & biomolecular chemistry. 13, 7, p. 2012-2021

  Research output: Contribution to journal › Article

• Structural and biochemical properties of LuxF from Photobacterium leiognathi

  Bergner, T., Tabib, C., Winkler, A., Stipsits, S., Kayer, H., Lee, J., Mayhew, S., Malthouse, J., Müller, F., Gruber, K. & Macheroux, P., 2015, In : Biochimica et Biophysica Acta. 1854, 10, p. 1466-1475

  Research output: Contribution to journal › Article

• Structural Details of Light Activation of the LOV2-based Photoswitch PA-Rac1

  Winkler, A., Barends, T. R. M., Udvarhelyi, A., Lenherr-Frey, D., Lomb, L., Menzel, A. & Schlichting, I., 2015, In : ACS Chemical Biology. 10, p. 502-509

  Research output: Contribution to journal › Article
• 2013

  A ternary AppA-PpsR-DNA complex mediates light regulation of photosynthesis-related gene expression

  Winkler, A., Heintz, U., Lindner, R., Reinstein, J., Shoeman, R. L. & Schlichting, I., 2013, In : Nature structural & molecular biology. 20, p. 859-867

  Research output: Contribution to journal › Article
• 2012

  Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme

  Wallner, S., Winkler, A., Riedl, S., Dully, C., Horvath, S., Gruber, K. & Macheroux, P., 2012, In : Biochemistry. 51, p. 6139-6147

  Research output: Contribution to journal › Article

• Role of a conserved active site histidine in berberine bridge enzyme

  Wallner, S., Hromic, A., Steiner, B., Daniel, B., Winkler, A., Gruber, K. & Macheroux, P., 2012.

  Research output: Contribution to conference › Poster
• 2011

  Biocatalytic enantioselective oxidative C-C coupling by aerobic C-H activation of N-CH3 to yield novel berberine alkaloid derivatives

  Schrittwieser, J. H., Resch, V., Sattler, J., Lienhart, W-D., Durchschein, K., Winkler, A., Gruber, K., Macheroux, P. & Kroutil, W., 2011, In : Angewandte Chemie / International Edition . 50, p. 1068-1071

  Research output: Contribution to journal › Article

• Biokatalytische enantioselektive oxidative C-C-Kupplung durch C-H-Aktivierung mit molekularem Sauerstoff

  Schrittwieser, J. H., Resch, V., Sattler, J., Lienhart, W-D., Durchschein, K., Winkler, A., Gruber, K., Macheroux, P. & Kroutil, W., 2011, In : Angewandte Chemie. 123, 5, p. 1100-1103

  Research output: Contribution to journal › Article

• Chemoenzymatic synthesis of enantiopure benzylisoquinoline and berbine alkaloids

  Schrittwieser, J., Resch, V., Sattler, J., Lienhart, W-D., Winkler, A., Macheroux, P. & Kroutil, W., 28 Feb 2011.

  Research output: Contribution to conference › (Old data) Lecture or Presentation