Find Research Outputs

Search results

• 2012

  100% double site saturation by individual expression of 400 muteins in Pichia pastoris

  Geier, M., 2012.

  Research output: Contribution to conference › Poster

• MuteinDB: the mutein database linking substrates, products and enzymatic reactions directly with genetic variants of enzymes

  Braun, A., Halwachs, B., Geier, M., Weinhandl, K., Guggemos, M., Marienhagen, J., Ruff, A. J., Schwaneberg, U., Torres Pazmiño, D. E., Rabin, V., Thallinger, G. & Glieder, A., 2012, In : Database - The Journal of Biological Databases and Curation . p. bas028-bas028

  Research output: Contribution to journal › Article

• Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes--a comparative study

  Geier, M., Braun, A., Emmerstorfer, A., Pichler, H. & Glieder, A., 2012, In : Biotechnology Journal. 7, 11, p. 1346-1358 13 p.

  Research output: Contribution to journal › Article

  • Cytochrome P-450 CYP2D6
  • Enzymes
  • Pharmaceutical Preparations
  • Pichia
  • Biotransformation

• Steroid biotransformations in biphasic systems with Yarrowia lipolytica expressing human liver cytochrome P450 genes

  Braun, A., Geier, M., Buehler, B., Schmid, A., Mauersberger, S. & Glieder, A., 2012, In : Microbial cell factories . 11, p. 106

  Research output: Contribution to journal › Article
• 2013

  ACIB and CHEM21: Towards greener and more sustainable pharmaceutical manufacturing processes

  Geier, M., Killinger, M., Wiltschi, B., Gruber-Khadjawi, M., Lypetska, K., Strohmeier, G., Breinbauer, R., Turrini, N., Faber, K. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation

  Geier, M., Braun, A., Fladischer, P., Stepniak, P., Rudroff, F., Hametner, C., Mihovilovic, M. & Glieder, A., 2013, In : The FEBS journal. 280, 13, p. 3094-108

  Research output: Contribution to journal › Article

• Efficient expression and purification of human flavin-containing monooxygenases (hFMOs): first steps towards the elucidation of FMO3 crystal structure

  Fiorentini, F., Geier, M., Winkler, M., Binda, C. & Mattevi, A., 2013.

  Research output: Contribution to conference › Poster

• Exploiting recombinant Pichia pastoris for drug metabolite synthesis: Towards an efficient CYP3A4-based whole-cell catalyst

  Geier, M., Schmid, C. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• First functional expression of cytochrome P450 3A4 in Pichia pastoris

  Geier, M., Schmid, C. & Glieder, A., 2013, In : Chimica Oggi. 31, 3, p. 24-27

  Research output: Contribution to journal › Article

• Human Flavin Monooxygenases as a Tool for Drug Metabolite Synthesis

  Bachler, T., Hanlon, S. P., Kittelmann, M., Geier, M., Camattari, A., Glieder, A., Wirz, B., Lütz, S. & Winkler, M., 2013.

  Research output: Contribution to conference › Poster

• Integrative expression vectors for stable pathway construction in the yeast Schizosaccharomyces pombe

  Geier, M., Hatzl, A-M., Mellitzer, A. & Glieder, A., 2013.

  Research output: Contribution to conference › Poster

• Protein Engineering Using Eukaryotic Expression Systems

  Geier, M. & Glieder, A., 2013, Protein Engineering Handbook - Volume 3. Weinheim, Germany: Wiley-VCH , p. 47-72

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Screening for cytochrome P450 expression in Pichia pastoris whole cells by P450-carbon monoxide complex determination

  Gudiminchi, R. K., Geier, M., Glieder, A. & Camattari, A., Jan 2013, In : Biotechnology Journal. 8, 1, p. 146-152 7 p.

  Research output: Contribution to journal › Article

  • Pichia
  • Carbon Monoxide
  • Cytochrome P-450 Enzyme System
  • Yeasts
  • Cytochrome P-450 CYP2D6

• Towards drug metabolite production on the multi-miligram scale: Generation of an efficient aldehyde oxidase (AOX1) based biocatalyst

  Bachler, T., Rodrigues, D. F., Kittelmann, M., Geier, M., Abad, S., Hanlon, S. P., Camattari, A., Lütz, S., Wirz, B. & Winkler, M., 2013.

  Research output: Contribution to conference › Poster
• 2014

  Generating a Platform of Human Non-CYP Drug Metabolizing Enzymes for API Modification

  Geier, M., Bachler, T., Eggimann, F., Rodrigues, D., Hanlon, S., Wirz, B., Kittelmann, M., Lütz, S., Glieder, A. & Winkler, M., 2014.

  Research output: Contribution to conference › Poster

• Human flavin monooxygenase 2: Heterologous expression in E. coli and API modification

  Winkler, M., Geier, M., Bachler, T., Hanlon, S. P., Kittelmann, M., Glieder, A., Lütz, S. & Wirz, B., 2014, New Biotechnology. ., p. S82-S82

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Human flavin monooxygenase 2: Heterologous expression in E. coli and API modification

  Winkler, M., Geier, M., Bachler, T., Hanlon, S., Kittelmann, M., Glieder, A., Lütz, S. & Wirz, B., 2014.

  Research output: Contribution to conference › Poster

• New tools for pathway generation employing the concepts of synthetic biology

  Geier, M., Vogl, T., Sturmberger, L., Schmid, C., Wiltschi, B. & Glieder, A., 2014.

  Research output: Contribution to conference › Poster

• Pichia pastoris with improved NADH regeneration: A novel platform strain for whole-cell biocatalysis

  Geier, M., Brandner, C. & Glieder, A., 2014.

  Research output: Contribution to conference › Poster

• Preliminary characterization of hFMO5. A human Bayer-Villiger Monooxygenase?

  Fiorentini, F., Hall, M., Winkler, M., Geier, M., Binda, C., Faber, K. & Mattevi, A., 2014.

  Research output: Contribution to conference › Poster
• 2015

  Biotransformations for drug metabolite synthesis

  Winkler, M., Bachler, T., Geier, M., Hanlon, S. P., Eggimann, F. K., Rodrigues, D., Ferreira Antunes, M., Kittelmann, M., Glieder, A., Wirz, B. & Lütz, S., 2015.

  Research output: Contribution to conference › Poster

• Compact multi-enzyme pathways in P. pastoris

  Geier, M., Fauland, P. C., Vogl, T. & Glieder, A., 2015, In : Chemical Communications. 15, 51;9, p. 1643-1646

  Research output: Contribution to journal › Article

• Drug Metabolizing Enzymes: From Heterologous Expression to Drug Metabolite Synthesis

  Winkler, M., Bachler, T., Geier, M., Glieder, A., Hanlon, S. P., Eggimann, F. K., Rodrigues, D., Antunes, M., Kittelmann, M., Wirz, B. & Lütz, S., 2015.

  Research output: Contribution to conference › Poster

• Engineering Pichia pastoris for improved NADH regeneration: A novel chassis strain for whole-cell catalysis

  Geier, M., Brandner, C., Strohmeier, G. A., Hall, M., Hartner, F. S. & Glieder, A., 2015, In : Beilstein Journal of Organic Chemistry . 11, p. 1741-8 8 p.

  Research output: Contribution to journal › Article

  • Chassis
  • NAD
  • Catalysis
  • Methanol
  • formaldehyde transketolase

• Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis

  Geier, M., Bachler, T., Hanlon, S. P., Eggimann, F. K., Kittelmann, M., Weber, H., Lütz, S., Wirz, B. & Winkler, M., 2015, In : Microbial cell factories . 14, 82, p. 1-10

  Research output: Contribution to journal › Article
• 2020

  Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

  Wiltschi, B., Cernava, T., Dennig, A., Galindo, M., Geier, M., Gruber, S., Haberbauer, M., Heidinger, P., Acero, E. H., Kratzer, R., Luley-Goedl, C., Müller, C. A., Pitzer, J., Ribitsch, D., Sauer, M., Schmölzer, K., Schnitzhofer, W., Sensen, C. W., Soh, J., Steiner, K. & 3 others, Winkler, C. K., Winkler, M. & Wriessnegger, T., 23 Jan 2020, In : Biotechnology Advances. 40, 107520.

  Research output: Contribution to journal › Review article

  Open Access

  • Enzymes
  • Recovery
  • Biocontrol
  • Bioconversion
  • Biocatalysts