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Author

  • Andreas Winkler
2011

Biocatalytic enantioselective oxidative C-C coupling by aerobic C-H activation of N-CH3 to yield novel berberine alkaloid derivatives

Schrittwieser, J. H., Resch, V., Sattler, J., Lienhart, W-D., Durchschein, K., Winkler, A., Gruber, K., Macheroux, P. & Kroutil, W., 2011, In : Angewandte Chemie / International Edition . 50, p. 1068-1071

Research output: Contribution to journalArticle

Biokatalytische enantioselektive oxidative C-C-Kupplung durch C-H-Aktivierung mit molekularem Sauerstoff

Schrittwieser, J. H., Resch, V., Sattler, J., Lienhart, W-D., Durchschein, K., Winkler, A., Gruber, K., Macheroux, P. & Kroutil, W., 2011, In : Angewandte Chemie. 123, 5, p. 1100-1103

Research output: Contribution to journalArticle

Chemoenzymatic synthesis of enantiopure benzylisoquinoline and berbine alkaloids

Schrittwieser, J., Resch, V., Sattler, J., Lienhart, W-D., Winkler, A., Macheroux, P. & Kroutil, W., 28 Feb 2011.

Research output: Contribution to conference(Old data) Lecture or Presentation

2012

Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme

Wallner, S., Winkler, A., Riedl, S., Dully, C., Horvath, S., Gruber, K. & Macheroux, P., 2012, In : Biochemistry. 51, p. 6139-6147

Research output: Contribution to journalArticle

Role of a conserved active site histidine in berberine bridge enzyme

Wallner, S., Hromic, A., Steiner, B., Daniel, B., Winkler, A., Gruber, K. & Macheroux, P., 2012.

Research output: Contribution to conferencePoster

2013

A ternary AppA-PpsR-DNA complex mediates light regulation of photosynthesis-related gene expression

Winkler, A., Heintz, U., Lindner, R., Reinstein, J., Shoeman, R. L. & Schlichting, I., 2013, In : Nature structural & molecular biology. 20, p. 859-867

Research output: Contribution to journalArticle

2014

Characterization of Elements Involved in Allosteric Light Regulation of Phosphodiesterase Activity by Comparison of Different Functional BlrP1 States

Winkler, A., Udvarhelyi, A., Hartmann, E., Reinstein, J., Menzel, A., Shoeman, R. L. & Schlichting, I., 2014, In : Journal of molecular biology. 426, 4, p. 853-868

Research output: Contribution to journalArticle

Hexicon 2: Automated Processing of Hydrogen-Deuterium Exchange Mass Spectrometry Data with Improved Deuteration Distribution Estimation

Lindner, R., Lou, X., Reinstein, J., Shoeman, R. L., Hamprecht, F. A. & Winkler, A., 2014, In : Journal of the American Society for Mass Spectrometry. 25, 6, p. 1018-1028

Research output: Contribution to journalArticle

Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides

Heintz, U., Meinhart, A. & Winkler, A., 2014, In : Acta Crystallographica / D. 70, 3, p. 863-876

Research output: Contribution to journalArticle

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

Benjdia, A., Heil, K., Winkler, A., Carell, T. & Schlichting, I., 2014, In : Chemical Communications. 50, p. 14201-14204

Research output: Contribution to journalArticle

2016

Characterization of longe-range signal transduction in red-light activated diguanylyl cyclases

Gourinchas, G. S., Etzl, S. & Winkler, A., 27 Jun 2016.

Research output: Contribution to conferencePoster

Exploring molecular mechanisms of signal transduction in light-regulated cyclases

Etzl, S. & Winkler, A., 29 Sep 2016.

Research output: Contribution to conferencePoster

Exploring molecular mechanisms of signal transduction in light-regulated cyclases

Etzl, S. & Winkler, A., 7 Jul 2016.

Research output: Contribution to conferencePoster

Exploring molecular mechanisms of signal transduction in light-regulated cyclases

Etzl, S. & Winkler, A., 24 Jan 2016.

Research output: Contribution to conferencePoster

Exploring molecular mechanisms of signal transduction on light-regulated cyclases

Etzl, S. & Winkler, A., 13 Sep 2016.

Research output: Contribution to conferencePoster

LOVTRAP: an optogenetic system for photoinduced protein dissociation

Wang, H., Vilela, M., Winkler, A., Tarnawski, M., Schlichting, I., Yumerefendi, H., Kuhlman, B., Liu, R., Danuser, G. & Hahn, K. M., 2016, In : Nature methods. 13, p. 755-758

Research output: Contribution to journalArticle

2017

Functional cross talk of sensor and effector modules in red light activated diguanylyl cyclases

Gourinchas, G., Winkler, A. & Vide, U., 2017, (In preparation).

Research output: Contribution to conferencePoster

Long-range allosteric regulation of GTP turnover in red-light modulated diguanylyl cyclases

Gourinchas, G. S., Etzl, S. & Winkler, A., 3 Feb 2017, (Accepted/In press).

Research output: Contribution to conferencePoster

Long-Range Allosteric Signaling in Red Light-Regulated Diguanylyl Cyclases

Gourinchas, G. S., Etzl, S., Göbl, C., Vide, U., Madl, T. & Winkler, A., 3 Mar 2017, In : Science Advances. 3, 3, e1602498.

Research output: Contribution to journalArticle

Open Access

Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase

Lindner, R., Hartmann, E., Tarnawski, M., Winkler, A., Frey, D., Reinstein, J., Meinhart, A. & Schlichting, I., 5 May 2017, In : Journal of molecular biology. 429, 9, p. 1336-1351 16 p.

Research output: Contribution to journalArticle

Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePoster

Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePoster

Stabilization of a cancer associated variant of human NQO1 by the use of small-molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Waltenstorfer, D., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePoster

The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions: A treasure-trove of oxidative reactions

Daniel, B., Konrad, B., Toplak, M., Lahham, M., Messenlehner, J., Winkler, A. & Macheroux, P., 15 Oct 2017, In : Archives of Biochemistry and Biophysics. 632, p. 88-103 16 p.

Research output: Contribution to journalReview article

The origin of the berberine bridge enzyme-like protein family in plants

Toplak, M., Wiedemann, G., Ulicevic, J., Daniel, B., Hoernstein, S., Kothe, J., Reski, R., Winkler, A. & Macheroux, P., Jul 2017.

Research output: Contribution to conferencePoster

2018

Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor

Gourinchas, G., Heintz, U. & Winkler, A., 5 Jun 2018, In : eLife. 7, e34815.

Research output: Contribution to journalArticle

Open Access

Asymmetric structural rearrangements involved in light activation of a dimeric red light photoreceptor.

Gourinchas, G. & Winkler, A., 2018, (Accepted/In press).

Research output: Contribution to conferencePoster

Molecular Mechanisms of Bacterial Bioluminescence

Brodl, E., Winkler, A. & Macheroux, P., 2018, In : Computational and Structural Biotechnology Journal. 16, p. 551 564 p.

Research output: Contribution to journalReview article

Open Access

Molecular mechanisms of red-light regulation in phytochrome linked adenylate/guanylate cyclases

Etzl, S., Nelson, M. & Winkler, A., 7 Mar 2018.

Research output: Contribution to conferencePoster

Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein

Augustin, P. A., Toplak, M., Fuchs, A. K., Gerstmann, E., Prassl, R. & Winkler, A., 4 Jan 2018, In : The Journal of Biological Chemistry. 293, 8, p. 2829-2840 21 p.

Research output: Contribution to journalArticle

Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic applications

Etzl, S., Lindner, R., Nelson, M. D. & Winkler, A., 8 Jun 2018, In : The Journal of Biological Chemistry. 293, 23, p. 9078-9089 12 p.

Research output: Contribution to journalArticle

Open Access

The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase

Toplak, M., Wiedemann, G., Ulićević, J., Daniel, B., Hoernstein, S. N. W., Kothe, J., Niederhauser, J., Reski, R., Winkler, A. & Macheroux, P., May 2018, In : The FEBS journal. 285, 10, p. 1923-1943 21 p.

Research output: Contribution to journalArticle

2019

A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro

Strandback, E., Lienhart, W-D., Hromic-Jahjefendic, A., Bourgeois, B., Högler, A., Waltenstorfer, D., Winkler, A., Zangger, K., Madl, T., Gruber, K. & Macheroux, P., 30 Oct 2019, In : FEBS letters.

Research output: Contribution to journalArticle

Open Access

Bacteriophytochromes - from informative model systems of phytochrome function to powerful tools in cell biology

Gourinchas, G., Etzl, S. & Winkler, A., 1 Aug 2019, In : Current Opinion in Structural Biology. 57, p. 72-83 12 p.

Research output: Contribution to journalReview article

Influence of the N-terminal segment and the PHY-tongue element on light-regulation in bacteriophytochromes

Gourinchas, G., Vide, U. & Winkler, A., 22 Mar 2019, In : The Journal of Biological Chemistry. 294, 12, p. 4498-4510 13 p.

Research output: Contribution to journalArticle

Molecular mechanisms of light regulation in LOV-diguanylate cyclases

Vide, U., Färber, J., Etzl, S., Zenzmaier, E. & Winkler, A., 18 Sep 2019.

Research output: Contribution to conferencePoster

2020

Distinct chromophore-protein environments enable asymmetric activation of a bacteriophytochrome activated diguanylate cyclase

Buhrke, D., Gourinchas, G., Müller, M., Michael, N., Hildebrandt, P. & Winkler, A., 10 Jan 2020, In : The Journal of Biological Chemistry. 295, 2, p. 539-551 13 p.

Research output: Contribution to journalArticle

Open Access

Phytochrome-Activated Diguanylyl Cyclases: The Functional Relevance of Asymmetry

Böhm, C., Balasso, M., Todorovic, N., Gourinchas, G. & Winkler, A., 6 Feb 2020.

Research output: Contribution to conferencePoster