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  • Johannes Khinast
2020

A novel framework for a rational, fully-automatised calibration routine for DEM models of cohesive powders

Orefice, L. & Khinast, J. G., 1 Feb 2020, In : Powder Technology. 361, p. 687-703

Research output: Contribution to journalArticleResearchpeer-review

Capsule filling process‐induced tribo‐charging behaviour of HPMC and gelatin capsules with different external lubricants

Wutscher, T., Zellnitz, S., Kobler, M., Buttini, F., Andrade, L., Daza, V., Mercandelli, A., Biserni, S., Probst, S. E., Khinast, J. & Paudel, A., 1 Apr 2020, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 33, 2, p. A7-A7 17.

Research output: Contribution to journalAbstractResearchpeer-review

Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective

Hsiao, W-K., Hörmann, T. R., Toson, P., Paudel, A., Ghiotti, P., Stauffer, F., Bauer, F., Lakio, S., Behrend, O., Maurer, R., Holman, J. & Khinast, J., Jan 2020, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticleResearchpeer-review

Filling of lactose-based formulations in a tamping-pin capsule filler

Faulhammer, E., Kruisz, J., Scheibelhofer, O., Rehrl, J., Witschnigg, A. & Khinast, J. G., May 2020, In : Drug Development and Industrial Pharmacy. 46, 5, p. 775-787

Research output: Contribution to journalArticleResearchpeer-review

LBM for two-phase (bio-)reactors

Eibl, P., Rustige, S., Witz, C. & Khinast, J., 30 May 2020, (Accepted/In press) Advances in Chemical Engineering. 67 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

LIF or dye: Comparison of different tracing methods for granular solids

Scheibelhofer, O., Kruisz, J., Rehrl, J., Faulhammer, E., Witschnigg, A. & Khinast, J., 2020, In : Powder Technology.

Research output: Contribution to journalArticleResearchpeer-review

Model predictive control for continuous pharmaceutical feeding blending units

Celikovic, S., Kirchengast, M., Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 2020, In : Chemical Engineering Research and Design / A. 2020, 154, p. 101-114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Powder flow and mixing in different tablet press feed frames

Siegmann, E., Forgber, T., Toson, P., Martinetz, M. C., Kureck, H., Brinz, T., Manz, S., Grass, T. & Khinast, J., 1 Jan 2020, (Accepted/In press) In : Advanced powder technology.

Research output: Contribution to journalArticleResearchpeer-review

Runtime Maximization of Continuous Precipitation in an Ultrasonic Process Chamber

Zettl, M., Kreimer, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. & Krumme, M., 17 Apr 2020, In : Organic Process Research & Devlopment. 24, 4, p. 508-519

Research output: Contribution to journalArticleResearchpeer-review

Towards a novel continuous HME-Tableting line: Process development and control concept

Sacher, S., Celikovic, S., Rehrl, J., Poms, J., Kirchengast, M., Kruisz, J., Sipek, M., Salar-Behzadi, S., Berger, H., Stark, G., Horn, M. & Khinast, J. G., 15 Jan 2020, In : European Journal of Pharmaceutical Sciences. 142

Research output: Contribution to journalArticleResearchpeer-review

2019

A novel in silico scale-up approach for hot melt extrusion processes

Matic, J., Witschnigg, A., Zagler, M., Eder, S. & Khinast, J., 31 Aug 2019, In : Chemical Engineering Science. 204, p. 257-269

Research output: Contribution to journalArticleResearchpeer-review

At-line validation of optical coherence tomography as in-line/at-line coating thickness measurement method

Wolfgang, M., Peter, A., Wahl, P., Markl, D., Zeitler, J. A. & Khinast, J. G., 15 Dec 2019, In : International Journal of Pharmaceutics. 572

Research output: Contribution to journalArticleResearchpeer-review

Computational Fluid Dynamics-Discrete Element Method Modeling of an Industrial-Scale Wurster Coater

Boehling, P., Khinast, J. G., Jajcevic, D., Davies, C., Carmody, A., Doshi, P., Ende, M. T. A. & Sarkar, A., Jan 2019, In : Journal of Pharmaceutical Sciences . 108, 1, p. 538-550

Research output: Contribution to journalArticleResearchpeer-review

Deriving control parameter settings from process models to control capsule fillers integrated into continuous manufacturing

Wagner, B., Cheong, S. F., Brinz, T. & Khinast, J., 2 Sep 2019, In : Drug Development and Industrial Pharmacy. 45, 9, p. 1523-1536

Research output: Contribution to journalArticleResearchpeer-review

Drying of supported catalysts for high metal concentrations: A reduced parameter model

Noorithaya, A. V., Bishop, C., Sarkar, P., Khinast, J. G. & Glasser, B. J., 12 Oct 2019, In : Chemical Engineering Science. 206, p. 361-374 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Ensuring Tablet Quality via Model-based Control of a Continuous Direct Compaction Process

Kirchengast, M., Celikovic, S., Rehrl, J., Sacher, S., Kruisz, J., Khinast, J. & Horn, M., 15 Aug 2019, In : International Journal of Pharmaceutics. 2019, 567, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

Amidon, G. E., Anderson, B. D., Balthasar, J. P., Bergstrom, C. A. S., Huang, S-M., Kasting, G., Kesisoglou, F., Khinast, J. G., Mager, D. E., Roberts, C. J. & Yu, L., Jan 2019, In : Journal of Pharmaceutical Sciences . 108, 1, p. 2-7

Research output: Contribution to journalArticleResearchpeer-review

Heat transfer of dry granular materials in a bladed mixer: Effect of thermal properties and agitation rate

Hartmanshenn, C., Khinast, J. G., Papageorgiou, C. D., Mitchell, C., Quon, J. & Glasser, B. J., 27 Nov 2019, In : AIChE Journal.

Research output: Contribution to journalArticleResearchpeer-review

IMPACT OF RELATIVE HUMIDITY AND POWDER FILLING LEVEL ON THE ELECTROSTATIC CHARGING BEHAVIOUR OF DIFFERENT CAPSULE TYPES

Wutscher, T., Zellnitz, S., Kobler, M., Buttini, F., Andrade, L., Daza, V., Mercandelli, A., Biserni, S., Ecenarro Probst, S., Khinast, J. & Paudel, A., 1 Apr 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 32, 2, p. A9-A10

Research output: Contribution to journalAbstractResearchpeer-review

Open Access

Industrial scale simulations of tablet coating using gpu based dem: A validation study

Kureck, H. G., Govender, N., Siegmann, E., Böhling, P., Radeke, C. & Khinast, J., 20 Jul 2019, In : Chemical Engineering Science. p. 462-480 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Measurement of granule layer thickness in a spouted bed coating process via optical coherence tomography

Pietsch, S., Peter, A., Wahl, P., Khinast, J. & Heinrich, S., Nov 2019, In : Powder Technology. 356, p. 139-147

Research output: Contribution to journalArticleResearchpeer-review

Measuring bulk density variations in a moving powder bed via terahertz in-line sensing

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Khinast, J. G., Zeitler, J. A. & Markl, D., 15 Feb 2019, In : Powder Technology. 344, p. 152-160

Research output: Contribution to journalArticleResearchpeer-review

Model-based approach to the design of pharmaceutical roller-compaction processes

Toson, P., Lopes, D. G., Paus, R., Kumar, A., Geens, J., Stibale, S., Quodbach, J., Kleinebudde, P., Hsiao, W-K. & Khinast, J., Dec 2019, In : International Journal of Pharmaceutics: X. 1, 100005.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Particle-level residence time data in a twin-screw feeder

Toson, P. & Khinast, J. G., Dec 2019, In : Data in Brief . 27, 104672

Research output: Contribution to journalArticleResearchpeer-review

Particle-Level Residence Time Data in a Twin-Screw Feeder

Toson, P. & Khinast, J., 22 Oct 2019

Research output: Non-print formData set/DatabaseResearch

Open Access

Performance Characterization of Static Mixers in Precipitating Environments

Kreimer, M., Zettl, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. G. & Krumme, M., Jul 2019, In : Organic Process Research & Devlopment. 23, 7, p. 1308-1320

Research output: Contribution to journalArticleResearchpeer-review

Predicting capsule fill weight from in-situ powder density measurements using terahertz reflection technology

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Zeitler, J. A., Biserni, S., Calzolari, V., Khinast, J. G. & Markl, D., 1 Dec 2019, In : International Journal of Pharmaceutics: X. 1, 100004.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Prediction of the anisotropic mechanical properties of compacted powders

Loidolt, P., Ulz, M. H. & Khinast, J., 2019, In : Powder Technology. 345, p. 589-600 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Real-time measurement of coating film thickness

Wolfgang, M., Wahl, P., Sacher, S., Gartshein, E. & Khinas, J. G., 1 Mar 2019, In : Pharmaceutical technology. 43, 3, p. 36-47 12 p.

Research output: Contribution to journalComment/debateResearchpeer-review

Sensitivity of a continuous hot-melt extrusion and strand pelletization line to control actions and composition variation

Hörmann, T. R., Rehrl, J., Scheibelhofer, O., Schaden, L. M., Funke, A., Makert, C. & Khinast, J. G., 20 Jul 2019, In : International Journal of Pharmaceutics. 566, p. 239-253 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Shedding light on coatings: Real-time monitoring of coating quality at industrial scale

Sacher, S., Wahl, P., Weissensteiner, M., Wolfgang, M., Pokhilchuk, Y., Looser, B., Thies, J., Raffa, A. & Khinast, J. G., 20 Jul 2019, In : International Journal of Pharmaceutics. 566, p. 57-66

Research output: Contribution to journalArticleResearchpeer-review

Study of the capsule-filling dosator process via calibrated DEM simulations

Madlmeir, S., Loidolt, P. & Khinast, J. G., 15 Aug 2019, In : International Journal of Pharmaceutics. 567

Research output: Contribution to journalArticleResearchpeer-review

The need for new control strategies for particulate matter in parenterals

Poms, J., Sacher, S., Nixdorf, M., Dekner, M., Wallner-Mang, S., Janssen, I., Khinast, J. G. & Schennach, R., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 739-750 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate

Zellnitz, S., Pinto, J., Brunsteiner, M., Schröttner, H., Khinast, J. & Paudel, A., 2019, In : Pharmaceutical research. 36, 6, p. 80 11 p., 36:80.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the motion of hard-shell capsules in dry powder inhalers

Benque, B. & Khinast, J., 2019, In : International Journal of Pharmaceutics. 567

Research output: Contribution to journalArticleResearchpeer-review

UNDERSTANDING THE MOTION OF ROTATING HARD SHELL CAPSULES IN DRY POWDER INHALERS

Benque, B. & Khinast, J., 1 Apr 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 32, 2, p. A20-A20

Research output: Contribution to journalAbstractResearchpeer-review

Using online content uniformity measurements for rapid automated process development exemplified via an X-ray system

Wagner, B., Brinz, T. & Khinast, J., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 775-787

Research output: Contribution to journalArticleResearchpeer-review

2017

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In : Chemie - Ingenieur - Technik. 89, 8

Research output: Contribution to journalArticleResearchpeer-review

Analysis of Flow and Mixing in Screw Elements of Corotating Twin-Screw Extruders via SPH

Eitzlmayr, A., Matic, J. & Khinast, J., Jun 2017, In : AIChE Journal. 63, 6, p. 2451-2463

Research output: Contribution to journalArticleResearchpeer-review

An investigation of the hydrodynamic similarity of single-spout fluidized beds using CFD-DEM simulations

Ebrahimi, M., Siegmann, E., Prieling, D., Glasser, B. J. & Khinast, J. G., Oct 2017, In : Advanced powder technology. 28, 10, p. 2465-2481

Research output: Contribution to journalArticleResearchpeer-review

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of video analysis and simulations of a drum coating process

Boehling, P., Toschkoff, G., Dreu, R., Just, S., Kleinebudde, P., Funke, A., Rehbaum, H. & Khinast, J. G., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 72-81 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Continuous Manufacturing of Pharmaceuticals: Chapter 10 - Continuous Melt Extrusion and Direct Pelletization

Laske, S., Hörmann, T., Witschnigg, A., Koscher, G., Wahl, P., Hsiao, W. K. & Khinast, J., 2017, 1st ed. NJ, USA: Wiley & Sons. 337 p. (Advances in Pharmaceutical Technology; vol. Continuous Manufacturing of Pharmaceuticals, no. 1)

Research output: Book/ReportBookResearchpeer-review

Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging

Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In : International Journal of Pharmaceutics. 518, 1-2, p. 130-137

Research output: Contribution to journalArticleResearchpeer-review

Crystal Engineering in Continuous Plug-Flow Crystallizers

Neugebauer, P., Besenhard, M., Khinast, J. & Scheibelhofer, O., 10 Oct 2017, In : Crystal Growth and Design.

Research output: Contribution to journalArticleResearchpeer-review

DEM study of granular transport in partially filled horizontal screw conveyors

Orefice, L. & Khinast, J. G., Jan 2017, In : Powder Technology. 305, p. 347-356

Research output: Contribution to journalArticleResearchpeer-review

Drug–Excipient Interactions in the Solid State: The Role of Different Stress Factors

Gressl, C., Brunsteiner, M., Davis, A., Landis, M., Pencheva, K., Scrivens, G., Sluggett, G. W., Wood, G. P. F., Gruber-Wölfler, H., Khinast, J. & Paudel, A., 2 Nov 2017, In : Molecular pharmaceutics. 14, 12, p. 4560-4571 11 p.

Research output: Contribution to journalArticleResearchpeer-review