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  • Johannes Khinast
2020

A novel framework for a rational, fully-automatised calibration routine for DEM models of cohesive powders

Orefice, L. & Khinast, J. G., 1 Feb 2020, In : Powder Technology. 361, p. 687-703

Research output: Contribution to journalArticleResearchpeer-review

Capsule filling process‐induced tribo‐charging behaviour of HPMC and gelatin capsules with different external lubricants

Wutscher, T., Zellnitz, S., Kobler, M., Buttini, F., Andrade, L., Daza, V., Mercandelli, A., Biserni, S., Probst, S. E., Khinast, J. & Paudel, A., 1 Apr 2020, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 33, 2, p. A7-A7 17.

Research output: Contribution to journalAbstractResearchpeer-review

Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective

Hsiao, W-K., Hörmann, T. R., Toson, P., Paudel, A., Ghiotti, P., Stauffer, F., Bauer, F., Lakio, S., Behrend, O., Maurer, R., Holman, J. & Khinast, J., Jan 2020, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticleResearchpeer-review

Filling of lactose-based formulations in a tamping-pin capsule filler

Faulhammer, E., Kruisz, J., Scheibelhofer, O., Rehrl, J., Witschnigg, A. & Khinast, J. G., May 2020, In : Drug Development and Industrial Pharmacy. 46, 5, p. 775-787

Research output: Contribution to journalArticleResearchpeer-review

LBM for two-phase (bio-)reactors

Eibl, P., Rustige, S., Witz, C. & Khinast, J., 30 May 2020, (Accepted/In press) Advances in Chemical Engineering. 67 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

LIF or dye: Comparison of different tracing methods for granular solids

Scheibelhofer, O., Kruisz, J., Rehrl, J., Faulhammer, E., Witschnigg, A. & Khinast, J., 2020, In : Powder Technology.

Research output: Contribution to journalArticleResearchpeer-review

Model predictive control for continuous pharmaceutical feeding blending units

Celikovic, S., Kirchengast, M., Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 2020, In : Chemical Engineering Research and Design / A. 2020, 154, p. 101-114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Powder flow and mixing in different tablet press feed frames

Siegmann, E., Forgber, T., Toson, P., Martinetz, M. C., Kureck, H., Brinz, T., Manz, S., Grass, T. & Khinast, J., 1 Jan 2020, (Accepted/In press) In : Advanced powder technology.

Research output: Contribution to journalArticleResearchpeer-review

Runtime Maximization of Continuous Precipitation in an Ultrasonic Process Chamber

Zettl, M., Kreimer, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. & Krumme, M., 17 Apr 2020, In : Organic Process Research & Devlopment. 24, 4, p. 508-519

Research output: Contribution to journalArticleResearchpeer-review

Towards a novel continuous HME-Tableting line: Process development and control concept

Sacher, S., Celikovic, S., Rehrl, J., Poms, J., Kirchengast, M., Kruisz, J., Sipek, M., Salar-Behzadi, S., Berger, H., Stark, G., Horn, M. & Khinast, J. G., 15 Jan 2020, In : European Journal of Pharmaceutical Sciences. 142

Research output: Contribution to journalArticleResearchpeer-review

2018

3D printing of oral drugs: a new reality or hype?

Hsiao, W. K., Lorber, B., Reitsamer, H. & Khinast, J., 2 Jan 2018, In : Expert opinion on drug delivery. 15, 1, p. 1-4 4 p.

Research output: Contribution to journalEditorialResearchpeer-review

A combined DEM & FEM approach for modelling roll compaction process

Mazor, A., Orefice, L., Michrafy, A., de Ryck, A. & Khinast, J. G., Sep 2018, In : Powder Technology. 337, p. 3-16 14 p.

Research output: Contribution to journalArticleResearchpeer-review

A system and a method for constant micro dosing and feeding of powder material

Fathollahi, S., Khinast, J., Klein, T., Besenhard, M. & Slama, E., 11 Apr 2018

Research output: PatentResearch

Automation of a dosing-disc capsule filler from the perspective of reliability and safety

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 4 Mar 2018, In : Drug Development and Industrial Pharmacy. 44, 3, p. 502-510 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the coating and tablet core roughness by means of 3D optical coherence tomography

Khinast, J., Markl, D., Wahl, P., Pichler, H. & Sacher, S., 2018, In : International Journal of Pharmaceutics. p. 459-466

Research output: Contribution to journalArticleResearchpeer-review

COMBINATIONAL APPROACH FOR ADVANCED UNDERSTANDING OF A LOW-DOSE CAPSULE FILLING PROCESS FOR INHALATION APPLICATION

Faulhammer, E., Stranzinger, S., Calzolari, V., Biserni, S., Loidolt, P., Paudel, A. & Khinast, J., Apr 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 31, 2, p. A7-A7

Research output: Contribution to journalAbstractResearchpeer-review

Continuous Drying of Pharmaceutical Powders Using a Twin-Screw Extruder

Kreimer, M., Aigner, I., Lepek, D. & Khinast, J., 20 Jul 2018, In : Organic Process Research & Devlopment. 22, 7, p. 813-823 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors

Rehrl, J., Kartunnen, A-P., Nicolaï, N., Hörmann, T., Horn, M., Korhonnen, O., Nopens, I., de Beer, T. & Khinast, J., 30 May 2018, In : International Journal of Pharmaceutics. 543, 1-2, p. 60-72

Research output: Contribution to journalArticleResearchpeer-review

Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer

Neugebauer, P., Besenhard, M., Peter, A., Gruber-Wölfler, H. & Khinast, J., 15 Jun 2018, In : Crystal Growth and Design. 18, 8, p. 4403-4415

Research output: Contribution to journalArticleResearchpeer-review

Detailed modeling and process design of an advanced continuous powder mixer

Toson, P., Siegmann, E., Trogrlic, M., Kureck, H., Khinast, J., Jajcevic, D., Doshi, P., Blackwood, D., Bonnassieux, A., Daugherity, P. D. & am Ende, M. T., 1 Dec 2018, In : International Journal of Pharmaceutics. 552, 1-2, p. 288-300 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of particle shape in grinding mills using a GPU based DEM code

Khinast, J., Govender, N., Rajamani, R. K., Wilke, D. N., Wu, C-Y. & Glasser, B. J., 2018, In : Minerals engineering. p. 71-84

Research output: Contribution to journalArticleResearchpeer-review

Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme

Khinast, J., Schaden, L-M., Wimmer-Teubenbacher, M., Poms, J., Laggner, P., Lohner, K., Sacher, S. & Salar-Behzadi, S., 2018, In : Pharmaceutical research.

Research output: Contribution to journalArticleResearchpeer-review

Flow of granular materials in a bladed mixer: Effect of particle properties and process parameters on impeller torque and power consumption

Boonkanokwong, V., Frank, R. P., Valliappan, P., Remy, B., Khinast, J. G. & Glasser, B. J., 1 Nov 2018, In : Advanced powder technology. 29, 11, p. 2733-2752 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Formulation performance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization

Hörmann, T., Jäger, N., Funke, A., Mürb, R-K., Khinast, J. G. & Paudel, A., 20 Dec 2018, In : International Journal of Pharmaceutics. 553, 1-2, p. 408-421 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Gluing Pills Technology: A novel route to multilayer tablet manufacturing

Demiri, V., Stranzinger, S., Rinner, P., Piller, M., Sacher, S., Lingitz, J., Khinast, J. & Salar-Behzadi, S., 5 Sep 2018, In : International Journal of Pharmaceutics. 548, 1, p. 672-681 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Hopper flow of irregularly shaped particles (non-convex polyhedra): GPU-based DEM simulation and experimental validation

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Pizette, P. & Xu, W., 2018, In : Chemical Engineering Science. p. 34-51

Research output: Contribution to journalArticleResearchpeer-review

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Large-scale GPU based DEM modeling of mixing using irregularly shaped particles

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Rajamani, R. K. & Glasser, B. J., 2018, In : Advanced powder technology. p. 2476-2490

Research output: Contribution to journalArticleResearchpeer-review

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing

Khinast, J., Leane, M., Pitt, K., Reynolds, G. K., Dawson, N., Ziegler, I., Szepes, A., Crean, A. M., Agnol, R. D., Broegmann, B., Charlton, S., Davies, C., Gamble, J., Gamlen, M., Hsiao, W. K., Khimyak, Y., Kleinebudde, P., Moreton, C., Oswald, M., Page, S. & 5 othersPaudel, A., Sahoo, R., Sheehan, S., Stamato, H. & Stone, E., 2018, In : Pharmaceutical development and technology. p. 964-977 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Material tracking in a continuous direct capsule-filling process via residence time distribution measurements

Kruisz, J., Rehrl, J., Faulhammer, E., Witschnigg, A. & Khinast, J., 2018, In : International Journal of Pharmaceutics. 550, 1-2, p. 347-358

Research output: Contribution to journalArticleResearchpeer-review

Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets

Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In : Powder Technology. 325, p. 247-260

Research output: Contribution to journalArticleResearchpeer-review

MODEL INFORMED DEVELOPMENT OF DRY POWDER INHALER (DPI) FORMULATIONS AND PROCESSES

Paudel, A., Zellnitz, S., Arora, S., Benque, B., Brunsteiner, M., Faulhammer, E., Loidolt, P. & Khinast, J. G., Apr 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 31, 2, p. A9-A9

Research output: Contribution to journalAbstractResearchpeer-review

Modeling yield properties of compacted powder using a multi-particle finite element model with cohesive contacts

Loidolt, P., Ulz, M. H. & Khinast, J., 15 Jun 2018, In : Powder Technology. 2018, 336

Research output: Contribution to journalArticleResearchpeer-review

Numerical investigation of a coarse-grain discrete element method in solid mixing in a spouted bed

Takabatake, K., Mori, Y., Khinast, J. G. & Sakai, M., 15 Aug 2018, In : Chemical Engineering Journal. 346, p. 416-426 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Rapid automated process development of a continuous capsule-filling process

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 30 Jul 2018, In : International Journal of Pharmaceutics. 546, 1-2, p. 154-165 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line

Martinetz, M., Kartunnen, A-P., Sacher, S., Wahl, P., Ketolainen, J., Khinast, J. & Korhonnen, O., 5 Jun 2018.

Research output: Contribution to conferencePaperResearchpeer-review

Open Access

Spatially Resolved Spectral Powder Analysis: Experiments and Modeling

Khinast, J., Scheibelhofer, O., Wahl, P., Larchevêque, B. & Chauchard, F., 2018, In : Applied Spectroscopy. p. 521-534

Research output: Contribution to journalArticleResearchpeer-review

Study of a low-dose capsule filling process by dynamic and static tests for advanced process understanding

Paudel, A., Stranzinger, S., Faulhammer, E., Scheibelhofer, O., Calzolari, V., Biserni, S. & Khinast, J., 5 Apr 2018, In : International Journal of Pharmaceutics. 540, 1-2, p. 22-30 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The Effect of Liquid Bridge Model Details on the Dynamics of Wet Fluidized Beds

Wu, M., Khinast, J. & Radl, S., Feb 2018, In : AIChE Journal. 64, p. 437-456 10.1002/aic.15947.

Research output: Contribution to journalArticleResearchpeer-review

The effect of saliva on the fate of nanoparticles

Teubl, B. J., Stojkovic, B., Docter, D., Pritz, E., Leitinger, G., Poberaj, I., Prassl, R., Stauber, R. H., Fröhlich, E., Khinast, J. G. & Roblegg, E., 1 Mar 2018, In : Clinical Oral Investigations. 22, 2, p. 929-940 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the motion of hard shell capsules in dry powder inhalers

Benque, B. & Khinast, J., 5 Nov 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Understanding the Motion of Hard-shell capsules in Dry Powder Inhalers

Benque, B. & Khinast, J., 12 Dec 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Using Perusall to Enhance Student Learning of Particle Technology at Graz University of Technology

Lepek, D., Radl, S. & Khinast, J., 24 Apr 2018.

Research output: Contribution to conferencePosterResearchpeer-review

2017

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In : Chemie - Ingenieur - Technik. 89, 8

Research output: Contribution to journalArticleResearchpeer-review

Analysis of Flow and Mixing in Screw Elements of Corotating Twin-Screw Extruders via SPH

Eitzlmayr, A., Matic, J. & Khinast, J., Jun 2017, In : AIChE Journal. 63, 6, p. 2451-2463

Research output: Contribution to journalArticleResearchpeer-review

An investigation of the hydrodynamic similarity of single-spout fluidized beds using CFD-DEM simulations

Ebrahimi, M., Siegmann, E., Prieling, D., Glasser, B. J. & Khinast, J. G., Oct 2017, In : Advanced powder technology. 28, 10, p. 2465-2481

Research output: Contribution to journalArticleResearchpeer-review

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of video analysis and simulations of a drum coating process

Boehling, P., Toschkoff, G., Dreu, R., Just, S., Kleinebudde, P., Funke, A., Rehbaum, H. & Khinast, J. G., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 72-81 10 p.

Research output: Contribution to journalArticleResearchpeer-review