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  • Johannes Khinast
2018

Hopper flow of irregularly shaped particles (non-convex polyhedra): GPU-based DEM simulation and experimental validation

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Pizette, P. & Xu, W., 2018, In : Chemical Engineering Science. p. 34-51

Research output: Contribution to journalArticleResearchpeer-review

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Large-scale GPU based DEM modeling of mixing using irregularly shaped particles

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Rajamani, R. K. & Glasser, B. J., 2018, In : Advanced powder technology. p. 2476-2490

Research output: Contribution to journalArticleResearchpeer-review

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing

Khinast, J., Leane, M., Pitt, K., Reynolds, G. K., Dawson, N., Ziegler, I., Szepes, A., Crean, A. M., Agnol, R. D., Broegmann, B., Charlton, S., Davies, C., Gamble, J., Gamlen, M., Hsiao, W. K., Khimyak, Y., Kleinebudde, P., Moreton, C., Oswald, M., Page, S. & 5 othersPaudel, A., Sahoo, R., Sheehan, S., Stamato, H. & Stone, E., 2018, In : Pharmaceutical development and technology. p. 964-977 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Material tracking in a continuous direct capsule-filling process via residence time distribution measurements

Kruisz, J., Rehrl, J., Faulhammer, E., Witschnigg, A. & Khinast, J., 2018, In : International Journal of Pharmaceutics. 550, 1-2, p. 347-358

Research output: Contribution to journalArticleResearchpeer-review

Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets

Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In : Powder Technology. 325, p. 247-260

Research output: Contribution to journalArticleResearchpeer-review

MODEL INFORMED DEVELOPMENT OF DRY POWDER INHALER (DPI) FORMULATIONS AND PROCESSES

Paudel, A., Zellnitz, S., Arora, S., Benque, B., Brunsteiner, M., Faulhammer, E., Loidolt, P. & Khinast, J. G., Apr 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 31, 2, p. A9-A9

Research output: Contribution to journalAbstractResearchpeer-review

Modeling yield properties of compacted powder using a multi-particle finite element model with cohesive contacts

Loidolt, P., Ulz, M. H. & Khinast, J., 15 Jun 2018, In : Powder Technology. 2018, 336

Research output: Contribution to journalArticleResearchpeer-review

Numerical investigation of a coarse-grain discrete element method in solid mixing in a spouted bed

Takabatake, K., Mori, Y., Khinast, J. G. & Sakai, M., 15 Aug 2018, In : Chemical Engineering Journal. 346, p. 416-426 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Rapid automated process development of a continuous capsule-filling process

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 30 Jul 2018, In : International Journal of Pharmaceutics. 546, 1-2, p. 154-165 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line

Martinetz, M., Kartunnen, A-P., Sacher, S., Wahl, P., Ketolainen, J., Khinast, J. & Korhonnen, O., 5 Jun 2018.

Research output: Contribution to conferencePaperResearchpeer-review

Open Access

Spatially Resolved Spectral Powder Analysis: Experiments and Modeling

Khinast, J., Scheibelhofer, O., Wahl, P., Larchevêque, B. & Chauchard, F., 2018, In : Applied Spectroscopy. p. 521-534

Research output: Contribution to journalArticleResearchpeer-review

Study of a low-dose capsule filling process by dynamic and static tests for advanced process understanding

Paudel, A., Stranzinger, S., Faulhammer, E., Scheibelhofer, O., Calzolari, V., Biserni, S. & Khinast, J., 5 Apr 2018, In : International Journal of Pharmaceutics. 540, 1-2, p. 22-30 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The Effect of Liquid Bridge Model Details on the Dynamics of Wet Fluidized Beds

Wu, M., Khinast, J. & Radl, S., Feb 2018, In : AIChE Journal. 64, p. 437-456 10.1002/aic.15947.

Research output: Contribution to journalArticleResearchpeer-review

The effect of saliva on the fate of nanoparticles

Teubl, B. J., Stojkovic, B., Docter, D., Pritz, E., Leitinger, G., Poberaj, I., Prassl, R., Stauber, R. H., Fröhlich, E., Khinast, J. G. & Roblegg, E., 1 Mar 2018, In : Clinical Oral Investigations. 22, 2, p. 929-940 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the motion of hard shell capsules in dry powder inhalers

Benque, B. & Khinast, J., 5 Nov 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Understanding the Motion of Hard-shell capsules in Dry Powder Inhalers

Benque, B. & Khinast, J., 12 Dec 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Using Perusall to Enhance Student Learning of Particle Technology at Graz University of Technology

Lepek, D., Radl, S. & Khinast, J., 24 Apr 2018.

Research output: Contribution to conferencePosterResearchpeer-review

2017

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In : Chemie - Ingenieur - Technik. 89, 8

Research output: Contribution to journalArticleResearchpeer-review

Analysis of Flow and Mixing in Screw Elements of Corotating Twin-Screw Extruders via SPH

Eitzlmayr, A., Matic, J. & Khinast, J., Jun 2017, In : AIChE Journal. 63, 6, p. 2451-2463

Research output: Contribution to journalArticleResearchpeer-review

An investigation of the hydrodynamic similarity of single-spout fluidized beds using CFD-DEM simulations

Ebrahimi, M., Siegmann, E., Prieling, D., Glasser, B. J. & Khinast, J. G., Oct 2017, In : Advanced powder technology. 28, 10, p. 2465-2481

Research output: Contribution to journalArticleResearchpeer-review

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of video analysis and simulations of a drum coating process

Boehling, P., Toschkoff, G., Dreu, R., Just, S., Kleinebudde, P., Funke, A., Rehbaum, H. & Khinast, J. G., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 72-81 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Continuous Manufacturing of Pharmaceuticals: Chapter 10 - Continuous Melt Extrusion and Direct Pelletization

Laske, S., Hörmann, T., Witschnigg, A., Koscher, G., Wahl, P., Hsiao, W. K. & Khinast, J., 2017, 1st ed. NJ, USA: Wiley & Sons. 337 p. (Advances in Pharmaceutical Technology; vol. Continuous Manufacturing of Pharmaceuticals, no. 1)

Research output: Book/ReportBookResearchpeer-review

Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging

Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In : International Journal of Pharmaceutics. 518, 1-2, p. 130-137

Research output: Contribution to journalArticleResearchpeer-review

Crystal Engineering in Continuous Plug-Flow Crystallizers

Neugebauer, P., Besenhard, M., Khinast, J. & Scheibelhofer, O., 10 Oct 2017, In : Crystal Growth and Design.

Research output: Contribution to journalArticleResearchpeer-review

DEM study of granular transport in partially filled horizontal screw conveyors

Orefice, L. & Khinast, J. G., Jan 2017, In : Powder Technology. 305, p. 347-356

Research output: Contribution to journalArticleResearchpeer-review

Drug–Excipient Interactions in the Solid State: The Role of Different Stress Factors

Gressl, C., Brunsteiner, M., Davis, A., Landis, M., Pencheva, K., Scrivens, G., Sluggett, G. W., Wood, G. P. F., Gruber-Wölfler, H., Khinast, J. & Paudel, A., 2 Nov 2017, In : Molecular pharmaceutics. 14, 12, p. 4560-4571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Efficient Discrete Element Method Simulation Strategy for Analyzing Large-Scale Agitated Powder Mixers

Siegmann, E., Jajcevic, D., Radeke, C., Strube, D., Friedrich, K. & Khinast, J. G., 1 Aug 2017, In : Chemie - Ingenieur - Technik. 89, 8, p. 995-1005 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates

Eder, S., Beretta, M., Witschnigg, A., Koutsamanis, I., Eggenreich, K., Khinast, J. G., Koscher, G., Paudel, A., Nickisch, K., Friedrich, M., Froehlich, E. & Roblegg, E., 1 Nov 2017, In : AAPS PharmSciTech . 18, 8, p. 2971-2976 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Impulse-based dynamics for studying quasi-static granular flows: Application to hopper emptying of non-spherical particles

Toson, P. & Khinast, J. G., 15 May 2017, In : Powder Technology. 313, p. 353-360 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Influence of Process Route on the Mechanical Properties of Polymer Based Intravaginal Drug Delivery Systems

Eggenreich, K., Schrank, S., Koscher, G., Nickisch, K., Roblegg, E. & Khinast, J., 2017, In : AIP Conference Proceedings. 1914

Research output: Contribution to journalArticleResearchpeer-review

Liquid Transport Rates during Binary Collisions of Unequally-sized Particles

Wu, M., Khinast, J. & Radl, S., 2017, In : Powder Technology. 309, p. 95-109 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mechanistic modeling of a capsule filling process

Loidolt, P., MadImeir, S. & Khinast, J. G., 30 Oct 2017, In : International Journal of Pharmaceutics. 532, 1, p. 47-54

Research output: Contribution to journalArticleResearchpeer-review

Mechansitic modeling of a capsule filling process

Loidolt, P., Madlmeir, S. & Khinast, J., 30 Oct 2017, In : International Journal of Pharmaceutics.

Research output: Contribution to journalArticleResearchpeer-review

Micro-feeding and dosing of powders via a small-scale powder pump

Besenhard, M., Fathollahi, S., Siegmann, E., Slama, E., Faulhammer, E. & Khinast, J., 2017, In : International Journal of Pharmaceutics. 519, 1-2, p. 314-322

Research output: Contribution to journalArticleResearchpeer-review

NUMERICAL STUDY ON THE EFFECT OF PARTICLE SHAPE ON MIXERS

Govender, N., Wilke, D. N., Rajamani, R. K., Pizette, P., Khinast, J. & Glasser, B. J., 2017

Research output: Other contributionResearch

Suzuki-Miyaura coupling reactions using novel metal oxide supported ionic palladium catalysts

Lichtenegger, G. J., Maier, M., Hackl, M., Khinast, J. G., Goessler, W., Griesser, T., Kumar, V. S. P., Gruber-Woelfler, H. & Deshpande, P. A., Jan 2017, In : Journal of molecular catalysis / A. 426, p. 39-51

Research output: Contribution to journalArticleResearchpeer-review

The effect of material attributes and process parameters on the powder bed uniformity during a low-dose dosator capsule filling process

Stranzinger, S., Faulhammer, E., Calzolari, V., Biserni, S., Dreu, R., Šibanc, R., Paudel, A. & Khinast, J., 10 Jan 2017, In : International Journal of Pharmaceutics. 516, p. 9-20 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Why Hot Melts Do Not Stick to Cold Surfaces

Treffer, D. F. & Khinast, J. G., Oct 2017, In : Polymer Engineering and Science. 57, 10, p. 1083-1089

Research output: Contribution to journalArticleResearchpeer-review

2016

A Kernel Interpolation Based Fast Multipole Method for Elastodynamic Problems

Traub, T., Brenn, G. (ed.), Holzapfel, G. (ed.), von der Linden, W. (ed.), Schanz, M. (ed.) & Khinast, J. (ed.), 2016, Verlag der Technischen Universität Graz. (Monographic Series TU Graz, Computation in Engineering and Science (CES))

Research output: Book/ReportBookResearchpeer-review

A Model to Predict Liquid Bridge Formation between Wet Particles Based on Direct Numerical Simulations

Wu, M., Radl, S. & Khinast, J., 16 Feb 2016, In : AIChE Journal. 62, p. 1877-1897 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Application of Model-Predictive Control to a Feeding Blending Unit

Rehrl, J., Kruisz, J., Sacher, S., Horn, M. & Khinast, J., 14 Nov 2016.

Research output: Contribution to conferencePosterResearchpeer-review

Ce0.495Sn0.495Pd0.01O2 as highly stable and low-leaching catalyst in continuous Suzuki-Miyaura cross-coupling reactions

Lichtenegger, G. J., Khinast, J. & Gruber-Wölfler, H., 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Comparing particle size distributions of an arbitrary shape

Scheibelhofer, O., Besenhard, M., Piller, M. & Khinast, J., 16 Feb 2016, In : Powder Technology. 294, p. 134-145

Research output: Contribution to journalArticleResearchpeer-review

Continuous feeding of low-dose APIs via periodic micro dosing

Faulhammer, E., Khinast, J. & Fathollahi, S., 17 May 2016, In : International Journal of Pharmaceutics.

Research output: Contribution to journalArticleResearchpeer-review