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Publication Year

  • 2019
  • 2018
  • 2017

Author

  • Johannes Khinast

IMPACT OF RELATIVE HUMIDITY AND POWDER FILLING LEVEL ON THE ELECTROSTATIC CHARGING BEHAVIOUR OF DIFFERENT CAPSULE TYPES

Wutscher, T., Zellnitz, S., Kobler, M., Buttini, F., Andrade, L., Daza, V., Mercandelli, A., Biserni, S., Ecenarro Probst, S., Khinast, J. & Paudel, A., 1 Apr 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 32, 2, p. A9-A10

Research output: Contribution to journalAbstract

Article

A combined DEM & FEM approach for modelling roll compaction process

Mazor, A., Orefice, L., Michrafy, A., de Ryck, A. & Khinast, J. G., Sep 2018, In : Powder Technology. 337, p. 3-16 14 p.

Research output: Contribution to journalArticle

Analysis of Flow and Mixing in Screw Elements of Corotating Twin-Screw Extruders via SPH

Eitzlmayr, A., Matic, J. & Khinast, J., Jun 2017, In : AIChE Journal. 63, 6, p. 2451-2463

Research output: Contribution to journalArticle

An investigation of the hydrodynamic similarity of single-spout fluidized beds using CFD-DEM simulations

Ebrahimi, M., Siegmann, E., Prieling, D., Glasser, B. J. & Khinast, J. G., Oct 2017, In : Advanced powder technology. 28, 10, p. 2465-2481

Research output: Contribution to journalArticle

A novel in silico scale-up approach for hot melt extrusion processes

Matic, J., Witschnigg, A., Zagler, M., Eder, S. & Khinast, J., 31 Aug 2019, In : Chemical Engineering Science. 204, p. 257-269

Research output: Contribution to journalArticle

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticle

Automation of a dosing-disc capsule filler from the perspective of reliability and safety

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 4 Mar 2018, In : Drug Development and Industrial Pharmacy. 44, 3, p. 502-510 9 p.

Research output: Contribution to journalArticle

Characterization of the coating and tablet core roughness by means of 3D optical coherence tomography

Khinast, J., Markl, D., Wahl, P., Pichler, H. & Sacher, S., 2018, In : International Journal of Pharmaceutics. p. 459-466

Research output: Contribution to journalArticle

Comparison of video analysis and simulations of a drum coating process

Boehling, P., Toschkoff, G., Dreu, R., Just, S., Kleinebudde, P., Funke, A., Rehbaum, H. & Khinast, J. G., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 72-81 10 p.

Research output: Contribution to journalArticle

Computational Fluid Dynamics-Discrete Element Method Modeling of an Industrial-Scale Wurster Coater

Boehling, P., Khinast, J. G., Jajcevic, D., Davies, C., Carmody, A., Doshi, P., Ende, M. T. A. & Sarkar, A., Jan 2019, In : Journal of Pharmaceutical Sciences . 108, 1, p. 538-550

Research output: Contribution to journalArticle

Continuous Drying of Pharmaceutical Powders Using a Twin-Screw Extruder

Kreimer, M., Aigner, I., Lepek, D. & Khinast, J., 20 Jul 2018, In : Organic Process Research & Devlopment. 22, 7, p. 813-823 11 p.

Research output: Contribution to journalArticle

Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging

Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In : International Journal of Pharmaceutics. 518, 1-2, p. 130-137

Research output: Contribution to journalArticle

Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors

Rehrl, J., Kartunnen, A-P., Nicolaï, N., Hörmann, T., Horn, M., Korhonnen, O., Nopens, I., de Beer, T. & Khinast, J., 30 May 2018, In : International Journal of Pharmaceutics. 543, 1-2, p. 60-72

Research output: Contribution to journalArticle

Crystal Engineering in Continuous Plug-Flow Crystallizers

Neugebauer, P., Besenhard, M., Khinast, J. & Scheibelhofer, O., 10 Oct 2017, In : Crystal Growth and Design.

Research output: Contribution to journalArticle

Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer

Neugebauer, P., Besenhard, M., Peter, A., Gruber-Wölfler, H. & Khinast, J., 15 Jun 2018, In : Crystal Growth and Design. 18, 8, p. 4403-4415

Research output: Contribution to journalArticle

DEM study of granular transport in partially filled horizontal screw conveyors

Orefice, L. & Khinast, J. G., Jan 2017, In : Powder Technology. 305, p. 347-356

Research output: Contribution to journalArticle

Deriving control parameter settings from process models to control capsule fillers integrated into continuous manufacturing

Wagner, B., Cheong, S. F., Brinz, T. & Khinast, J., 2 Sep 2019, In : Drug Development and Industrial Pharmacy. 45, 9, p. 1523-1536

Research output: Contribution to journalArticle

Detailed modeling and process design of an advanced continuous powder mixer

Toson, P., Siegmann, E., Trogrlic, M., Kureck, H., Khinast, J., Jajcevic, D., Doshi, P., Blackwood, D., Bonnassieux, A., Daugherity, P. D. & am Ende, M. T., 1 Dec 2018, In : International Journal of Pharmaceutics. 552, 1-2, p. 288-300 13 p.

Research output: Contribution to journalArticle

Drug–Excipient Interactions in the Solid State: The Role of Different Stress Factors

Gressl, C., Brunsteiner, M., Davis, A., Landis, M., Pencheva, K., Scrivens, G., Sluggett, G. W., Wood, G. P. F., Gruber-Wölfler, H., Khinast, J. & Paudel, A., 2 Nov 2017, In : Molecular pharmaceutics. 14, 12, p. 4560-4571 11 p.

Research output: Contribution to journalArticle

Drying of supported catalysts for high metal concentrations: A reduced parameter model

Noorithaya, A. V., Bishop, C., Sarkar, P., Khinast, J. G. & Glasser, B. J., 12 Oct 2019, In : Chemical Engineering Science. 206, p. 361-374 14 p.

Research output: Contribution to journalArticle

Effect of particle shape in grinding mills using a GPU based DEM code

Khinast, J., Govender, N., Rajamani, R. K., Wilke, D. N., Wu, C-Y. & Glasser, B. J., 2018, In : Minerals engineering. p. 71-84

Research output: Contribution to journalArticle

Efficient Discrete Element Method Simulation Strategy for Analyzing Large-Scale Agitated Powder Mixers

Siegmann, E., Jajcevic, D., Radeke, C., Strube, D., Friedrich, K. & Khinast, J. G., 1 Aug 2017, In : Chemie - Ingenieur - Technik. 89, 8, p. 995-1005 11 p.

Research output: Contribution to journalArticle

Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates

Eder, S., Beretta, M., Witschnigg, A., Koutsamanis, I., Eggenreich, K., Khinast, J. G., Koscher, G., Paudel, A., Nickisch, K., Friedrich, M., Froehlich, E. & Roblegg, E., 1 Nov 2017, In : AAPS PharmSciTech . 18, 8, p. 2971-2976 6 p.

Research output: Contribution to journalArticle

Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

Amidon, G. E., Anderson, B. D., Balthasar, J. P., Bergstrom, C. A. S., Huang, S-M., Kasting, G., Kesisoglou, F., Khinast, J. G., Mager, D. E., Roberts, C. J. & Yu, L., Jan 2019, In : Journal of Pharmaceutical Sciences . 108, 1, p. 2-7

Research output: Contribution to journalArticle

Flow of granular materials in a bladed mixer: Effect of particle properties and process parameters on impeller torque and power consumption

Boonkanokwong, V., Frank, R. P., Valliappan, P., Remy, B., Khinast, J. G. & Glasser, B. J., 1 Nov 2018, In : Advanced powder technology. 29, 11, p. 2733-2752 20 p.

Research output: Contribution to journalArticle

Heat transfer of dry granular materials in a bladed mixer: Effect of thermal properties and agitation rate

Hartmanshenn, C., Khinast, J. G., Papageorgiou, C. D., Mitchell, C., Quon, J. & Glasser, B. J., 27 Nov 2019, In : AIChE Journal.

Research output: Contribution to journalArticle

Hopper flow of irregularly shaped particles (non-convex polyhedra): GPU-based DEM simulation and experimental validation

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Pizette, P. & Xu, W., 2018, In : Chemical Engineering Science. p. 34-51

Research output: Contribution to journalArticle

Open Access

Industrial scale simulations of tablet coating using gpu based dem: A validation study

Kureck, H. G., Govender, N., Siegmann, E., Böhling, P., Radeke, C. & Khinast, J., 20 Jul 2019, In : Chemical Engineering Science. p. 462-480 19 p.

Research output: Contribution to journalArticle

Influence of Process Route on the Mechanical Properties of Polymer Based Intravaginal Drug Delivery Systems

Eggenreich, K., Schrank, S., Koscher, G., Nickisch, K., Roblegg, E. & Khinast, J., 2017, In : AIP Conference Proceedings. 1914

Research output: Contribution to journalArticle

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticle

Large-scale GPU based DEM modeling of mixing using irregularly shaped particles

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Rajamani, R. K. & Glasser, B. J., 2018, In : Advanced powder technology. p. 2476-2490

Research output: Contribution to journalArticle

Liquid Transport Rates during Binary Collisions of Unequally-sized Particles

Wu, M., Khinast, J. & Radl, S., 2017, In : Powder Technology. 309, p. 95-109 14 p.

Research output: Contribution to journalArticle

Open Access
File

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing

Khinast, J., Leane, M., Pitt, K., Reynolds, G. K., Dawson, N., Ziegler, I., Szepes, A., Crean, A. M., Agnol, R. D., Broegmann, B., Charlton, S., Davies, C., Gamble, J., Gamlen, M., Hsiao, W. K., Khimyak, Y., Kleinebudde, P., Moreton, C., Oswald, M., Page, S. & 5 others, Paudel, A., Sahoo, R., Sheehan, S., Stamato, H. & Stone, E., 2018, In : Pharmaceutical development and technology. p. 964-977 13 p.

Research output: Contribution to journalArticle

Measurement of granule layer thickness in a spouted bed coating process via optical coherence tomography

Pietsch, S., Peter, A., Wahl, P., Khinast, J. & Heinrich, S., Nov 2019, In : Powder Technology. 356, p. 139-147

Research output: Contribution to journalArticle

Measuring bulk density variations in a moving powder bed via terahertz in-line sensing

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Khinast, J. G., Zeitler, J. A. & Markl, D., 15 Feb 2019, In : Powder Technology. 344, p. 152-160

Research output: Contribution to journalArticle