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2015

Bioinformatics approaches to single-blastomere transcriptomics

Taher, L., Pfeiffer, M. J. & Fuellen, G., Feb 2015, In : Molecular Human Reproduction. 21, 2, p. 115-25 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Blastomeres
Computational Biology
Blastocyst
Gene Expression
Microfluidics

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness

Furusawa, T., Rochman, M., Taher, L., Dimitriadis, E. K., Nagashima, K., Anderson, S. & Bustin, M., 22 Jan 2015, In : Nature Communications. 6, p. 6138

Research output: Contribution to journalArticleResearchpeer-review

HMGN Proteins
chromatin
Heterochromatin
Nuclear Lamina
Chromatin

Comparative computational analysis of pluripotency in human and mouse stem cells

Ernst, M., Abu Dawud, R., Kurtz, A., Schotta, G., Taher, L. & Fuellen, G., 21 Jan 2015, In : Scientific reports. 5, p. 7927

Research output: Contribution to journalArticleResearchpeer-review

Stem Cells
Molecular Sequence Annotation
Acetylation
Histones
DNA Damage

Differences in embryo quality are associated with differences in oocyte composition: a proteomic study in inbred mice

Pfeiffer, M. J., Taher, L., Drexler, H., Suzuki, Y., Makałowski, W., Schwarzer, C., Wang, B., Fuellen, G. & Boiani, M., Feb 2015, In : Proteomics. 15, 4, p. 675-87 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteomics
Oocytes
Embryonic Structures
Inbred Strains Mice
Chemical analysis

Identification and computational analysis of gene regulatory elements

Taher, L., Narlikar, L. & Ovcharenko, I., 5 Jan 2015, In : Cold Spring Harbor Protocols. 2015, 1, p. pdb.top083642

Research output: Contribution to journalReview articleResearchpeer-review

Regulator Genes
Genome
Technology
Untranslated RNA
Human Genome

TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability

Bahnassawy, L., Perumal, T. M., Gonzalez-Cano, L., Hillje, A-L., Taher, L., Makalowski, W., Suzuki, Y., Fuellen, G., del Sol, A. & Schwamborn, J. C., 26 Aug 2015, In : Scientific reports. 5, p. 13456

Research output: Contribution to journalArticleResearchpeer-review

Induced Pluripotent Stem Cells
Knockout Mice
Fibroblasts
Regenerative Medicine
Neural Stem Cells
2016

Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms

Freiesleben, S., Hecker, M., Zettl, U. K., Fuellen, G. & Taher, L., 3 Oct 2016, In : Scientific reports. 6, p. 34512

Research output: Contribution to journalArticleResearchpeer-review

MicroRNAs
Transcriptome
Multiple Sclerosis
Gene Expression
Hematologic Diseases

Revealing complex function, process and pathway interactions with high-throughput expression and biological annotation data

Singh, N. K., Ernst, M., Liebscher, V., Fuellen, G. & Taher, L., 20 Oct 2016, In : Molecular BioSystems. 12, 10, p. 3196-208 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Biological Phenomena
Gene Expression
Gene Regulatory Networks
Liver
Cell Differentiation

Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate

Silberberg, S. N., Taher, L., Lindtner, S., Sandberg, M., Nord, A. S., Vogt, D., Mckinsey, G. L., Hoch, R., Pattabiraman, K., Zhang, D., Ferran, J. L., Rajkovic, A., Golonzhka, O., Kim, C., Zeng, H., Puelles, L., Visel, A. & Rubenstein, J. L. R., 5 Oct 2016, In : Neuron. 92, 1, p. 59-74 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Prosencephalon
Amygdala
Basal Ganglia
Transgenic Mice
Transcription Factors
2018

A Dispensable Chromosome Is Required for Virulence in the Hemibiotrophic Plant Pathogen Colletotrichum higginsianum

Plaumann, P-L., Schmidpeter, J., Dahl, M., Taher, L. & Koch, C., 2018, In : Frontiers in Microbiology . 9, p. 1005

Research output: Contribution to journalArticleResearchpeer-review

Colletotrichum
Virulence
Chromosomes, Human, Pair 11
Hyphae
Chromosomes

Comparative High-Resolution Transcriptome Sequencing of Lymphoma Cell Lines and de novo Lymphomas Reveals Cell-Line-Specific Pathway Dysregulation

Taher, L., Beck, J., Liu, W., Roolf, C., Soller, J. T., Rütgen, B. C., Hammer, S. E., Chodisetti, M., Sender, S., Sterenczak, K. A., Fuellen, G., Junghanss, C., Brenig, B., Nolte, I., Schütz, E. & Murua Escobar, H., 19 Apr 2018, In : Scientific reports. 8, 1, p. 6279

Research output: Contribution to journalArticleResearchpeer-review

Transcriptome
Lymphoma
Cell Line
Lymphocytes
Canidae

Genomic analysis of transcriptional networks directing progression of cell states during MGE development

Sandberg, M., Taher, L., Hu, J., Black, B. L., Nord, A. S. & Rubenstein, J. L. R., 14 Sep 2018, In : Neural networks. 13, 1, p. 21

Research output: Contribution to journalArticleResearchpeer-review

Median Eminence
Transcription factors
Gene Regulatory Networks
Cells
Neurons

Identification of Prognostic Biomarkers by Combined mRNA and miRNA Expression Microarray Analysis in Pancreatic Cancer

Liu, B., Yang, H., Taher, L., Denz, A., Grützmann, R., Pilarsky, C. & Weber, G. F., Jun 2018, In : Translational Oncology. 11, 3, p. 700-714 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Microarray Analysis
MicroRNAs
Pancreatic Neoplasms
Biomarkers
Messenger RNA

Pairs of Adjacent Conserved Noncoding Elements Separated by Conserved Genomic Distances Act as Cis-Regulatory Units

Li, L., Barth, N. K. H., Hirth, E. & Taher, L., 1 Sep 2018, In : Genome Biology and Evolution. 10, 9, p. 2535-2550 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Inborn Genetic Diseases
Medical Genetics
Human Genome
Epigenomics
Genome
2019

An integrated genome-wide multi-omics analysis of gene expression dynamics in the preimplantation mouse embryo

Israel, S., Ernst, M., Psathaki, O. E., Drexler, H. C. A., Casser, E., Suzuki, Y., Makalowski, W., Boiani, M., Fuellen, G. & Taher, L., 16 Sep 2019, In : Scientific reports. 9, 1, p. 13356

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Blastocyst
Genome
Gene Expression
Morula
Ribosomes

Cancer Is Associated with Alterations in the Three-Dimensional Organization of the Genome

Li, L., Barth, N. K. H., Pilarsky, C. & Taher, L., 27 Nov 2019, In : Cancers. 11, 12

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Genome
Neoplasms
Human Genome
Mutation
Precision Medicine

CRISPR/Cas9-Mediated Knock-Out of KrasG12D Mutated Pancreatic Cancer Cell Lines

Lentsch, E., Li, L., Pfeffer, S., Ekici, A. B., Taher, L., Pilarsky, C. & Grützmann, R., 14 Nov 2019, In : International Journal of Molecular Sciences . 20, 22, 11 p., 5706.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
CRISPR-Associated Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Pancreatic Neoplasms
cultured cells
cancer

Evolutionary conserved networks of human height identify multiple Mendelian causes of short stature

Hauer, N. N., Popp, B., Taher, L., Vogl, C., Dhandapany, P. S., Büttner, C., Uebe, S., Sticht, H., Ferrazzi, F., Ekici, A. B., De Luca, A., Klinger, P., Kraus, C., Zweier, C., Wiesener, A., Jamra, R. A., Kunstmann, E., Rauch, A., Wieczorek, D., Jung, A-M. & 5 othersRohrer, T. R., Zenker, M., Doerr, H-G., Reis, A. & Thiel, C. T., Jul 2019, In : European Journal of Human Genetics . 27, 7, p. 1061-1071 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Genes
Growth
Exome
Chondrocytes
Population

Suitability of ultrasound-guided fine-needle aspiration biopsy for transcriptome sequencing of the canine prostate

Thiemeyer, H., Taher, L., Schille, J. T., Harder, L., Hungerbuehler, S. O., Mischke, R., Hewicker-Trautwein, M., Kiełbowicz, Z., Brenig, B., Schütz, E., Beck, J., Murua Escobar, H. & Nolte, I., 1 Dec 2019, In : Scientific reports. 9, 1, 13216.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Fine Needle Biopsy
Transcriptome
Canidae
Prostate
RNA