GW-Synthesis of Mesalazine - Continuous synthesis of Mesalazine via Kolbe-Schmitt reaction in a twin-screw extruder

Project: Research project

Project Details


In a first stage, methods for the chemical analyses of the starting material 4-aminophenol and the product Mesalazine will be developed and possible process parameters for the synthesis of Mesalazine via the Kolbe-Schmitt synthesis will be evaluated as well as the stability and feed-ability of the starting compounds. Therefore, it is planned to carry out different experiments in batch mode. The experiments will be carried out in close interaction with RCPE in order to guarantee an easy transfer of the lab synthesis to the twin-screw extruder process.
Effective start/end date1/10/2031/12/20