Project Details
Description
Pd-catalyzed cross-coupling reactions are the most straightforward and general method for carbon-carbon bond formation. The only exception to the claim of universality is the coupling of secondary sp3-hybridized electrophiles. In this proposal an innovative method concerning this problem is outlined. By varying the substructure of established BUCHWALD biarylphosphine ligands, the resulting electron-rich catalysts might be suitable for the oxidative addition of sterically hindered secondary sp3-electrophiles. For proof of concept two natural products will be synthesized with the newly developed methodology integrated.
Status | Finished |
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Effective start/end date | 1/09/19 → 31/08/20 |
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