The stereospecific formation of CC bonds is at the basis of the synthesis of chiral compounds utilized in a wide variety of applications from flavors to drugs. Optimization of the reaction conditions is, therefore, rather important. Although several catalytically active complexes have been crystallized and their geometry was determined by X-ray analysis, it is likely that these complexes adopt distinctly different geometries in solution during the course of a homogenous catalytic reaction. We have been investigating Cu(II)-complex catalyzed reactions step by step. Our recent results indicate that the solvent and the counterions participate at the first coordination sphere around the Cu(II) cation in a subtle way.
|Effective start/end date||1/11/07 → 1/11/10|