This Integrated Project will undertake a research programme that has as its major goal the understanding and exploitation of brain mechanisms for the enhancement of presence and interaction in mixed and virtual reality. The project is highly interdisciplinary, combining neuroscience, computer science, psychiatry, psychology, psychophysics, mechanical engineering, philosophy and drama. By presence we mean the propensity of humans to respond to fake stimuli as if they were real, something observed daily in every virtual reality laboratory. Understanding the neural basis of this 'presence response' its enhancement and its application is the fundamental object of study within the IP from many different points of view, and including visual, haptic and auditory modalities. The most interesting, challenging and useful mixed environments are social. The types of interaction we plan in mixed reality are those supporting interactions between real people and other remote real people, real people and virtual people, and between virtual people and virtual people. The aim is to make people's responses real even if the perception of the reality is based on virtual stimuli. The project will carry out fundamental research adopting a neuroscience methodology and theoretical standpoint combined with research in the delivery of presence through multisensory modelling and rendering, and wide area tracking and display systems. A substantial part of the project is concerned with interaction through brain-computer interfaces. The whole will be brought together through a number of applications, in particular a persistent virtual community that represents the project itself, methods for projecting sensations of ownership to virtual representations of self, and the exploitation of neurofeedback for the enhancement of creativity through mixed reality environments.