Endomyocardial biopsy (EMB) is an important tool for the diagnosis of myocarditis and infiltrative cardiac diseases. However, in clinical routine biopsies are obtained under fluoroscopic X-ray guidance, an imaging method with poor soft-tissue contrast that cannot visualize myocardial lesions. Thus, despite taking multiple biopsies, the diagnostic value remains limited due to considerable sampling errors of non-affected areas providing a diagnostic readout in only 25.5% in heart failure of unknown origin. In contrast to X-ray, cardiac magnetic resonance (MR) imaging provides excellent soft-tissue contrast. In particular, late gadolinium enhancement (LGE) is a proven diagnostic approach to directly visualize necrotic or fibrotic myocardium. Moreover, cardiac MR allows free orientation of the imaging plane in 3D and avoids ionizing radiation completely. Hence, the goal of this project is to develop a procedure for targeted EMB under real-time MRI guidance.
|Effective start/end date||1/04/22 → 31/03/25|
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