Development of the "Plug&Play" reactor for the continuous synthesis of active pharmaceutical ingredients

    Project: Research area

    Description

    The so-called Plug & Play Reactor is a novel reaction device with exchangeable reaction segments as well as modules for heating/cooling and mixing. The performance of the reactor is demonstrated with two model processes: the production of acetylsalicylic acid with a fixed-bed of commercial ion-exchange particles, and a Suzuki-Miyaura cross-coupling with a solid Pd-catalyst developed by us. The reaction progress was monitored by inline UV/Vis spectroscopy and compared with offline HPLC. The novel set-up leads to quantitative yields and selectivity as well as to an improved practicability of the processes. Thus, the Plug & Play reactor is an attractive alternative to existing batch processes.
    StatusFinished
    Effective start/end date2/01/1331/01/16