The so-called Plug & Play Reactor is a novel reaction device with exchangeable reaction segments as well as modules for heating/cooling and mixing. The performance of the reactor is demonstrated with two model processes: the production of acetylsalicylic acid with a fixed-bed of commercial ion-exchange particles, and a Suzuki-Miyaura cross-coupling with a solid Pd-catalyst developed by us. The reaction progress was monitored by inline UV/Vis spectroscopy and compared with offline HPLC. The novel set-up leads to quantitative yields and selectivity as well as to an improved practicability of the processes. Thus, the Plug & Play reactor is an attractive alternative to existing batch processes.
|Effective start/end date||2/01/13 → 31/01/16|