Cellulose drugs - Cellulose-based carrier matrices for conrolled drug delivery

The aim of this project is to develop and evaluate a method for applying drugs on paper carrier materials in laboratory as well as in industrial manufacturing processes. Active Pharmaceutical Ingredients (API) and additives are printed on paper using the drop-on-demand printing technology. The printed paper may then be inserted into a gelatine capsule for peroral applications or directly administered orally after additional modifications. The capabilities of various paper grades are evaluated with respect to the utilization as a pharmaceutical carrier material, considering the intended registration as a pharma-excipient. In addition, models are developed to describe the main phenomena during the printing process and to simulate application, impact, penetration and drying of fluids with porous materials.