A2 AG-Biotechnology

Research output

Research output per year 2002 2003 2006 2008 2008

• 10 Article
• 7 Poster
• 2 (Old data) Lecture or Presentation
• 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2008

  Candida tenuis Xylose reductase (AKR2B5) utilizes different catalytic mechanisms for NADH-dependent carbonyl group reduction in aldehyde and quinone substrates

  Pival, S., Klimacek, M., Kratzer, R. & Nidetzky, B., 2008.

  Research output: Contribution to conference › Poster

• Characterization of recombinant Aspergillus fumigatus mannitol-1-phosphate 5-dehydrogenase and its application for the stereoselective synthesis of protio and deuterio forms of D-mannitol 1-phosphate

  Krahulec, S., Armao, G. C., Weber, H., Klimacek, M. & Nidetzky, B., 2008, In: Carbohydrate Research. 343, p. 1414-1423

  Research output: Contribution to journal › Article › peer-review

• Novel Chemo-Enzymatic Mimic of Hydrogen Peroxide-Forming NAD(P)H Oxidase for Efficient Regeneration of NAD+ and NADP+

  Pival, S., Klimacek, M. & Nidetzky, B., 2008, In: Advanced Synthesis & Catalysis. 350, 14-15, p. 2305-2312

  Research output: Contribution to journal › Article › peer-review

• Structure-guided engineering of the coenzyme specificity of Pseudomonas fluorescens mannitol 2-dehydrogenase to enable efficient utilization of NAD(H) and NADP(H)

  Bubner, P., Klimacek, M. & Nidetzky, B., 2008, In: FEBS Letters. 582, 2, p. 233-237

  Research output: Contribution to journal › Article › peer-review

• Tyr-51 is the proton donor–acceptor for NAD(H)-dependent interconversion of xylose and xylitol by Candida tenuis xylose reductase (AKR2B5)

  Pival, S., Klimacek, M., Kratzer, R. & Nidetzky, B., 2008, In: FEBS Letters. 29, p. 4095-4099

  Research output: Contribution to journal › Article › peer-review
• 2007

  Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu-154->Cys forms of yeast xylitol dehydrogenase

  Klimacek, M., Hellmer, H. & Nidetzky, B., 2007, In: Biochemical Journal. 3, p. 421-429

  Research output: Contribution to journal › Article › peer-review

• Role of Phe-114 in substrate specificity of Candida tenuis xylose reductase (AKR2B5)

  Klimacek, M., Kratzer, R., Szekely, M. & Nidetzky, B., 2007, In: Biocatalysis and Biotransformation. 25, 2-4, p. 194-201

  Research output: Contribution to journal › Article › peer-review
• 2006

  Electrostatic stabilization in alcohol dehydrogenase mechanisms: the oxyanion hole of D-mannitol 2-dehydrogenase from Pseudomonas fluorescens is a novel structural motif that facilitates the catalytic step of hydride transfer

  Klimacek, M. & Nidetzky, B., 2006.

  Research output: Contribution to conference › Poster

• Mechanism and specificity of Candida tenuis xylose reductase (AKR2B5).

  Nidetzky, B., Kratzer, R., Klimacek, M., Petschacher, B., Pival, S. & Wilson, D. K., 11 Jul 2006.

  Research output: Contribution to conference › (Old data) Lecture or Presentation

• Optimization of an innovative hollow-fiber process to produce lactose-reduced skim milk.

  Neuhaus, W., Novalin, S., Klimacek, M., Splechtna, B., Petzelbauer, I., Szivak, A. & Kulbe, K. D., 2006, In: Applied Biochemistry and Biotechnology / A. p. 1-14

  Research output: Contribution to journal › Article › peer-review
• 2004

  Structural and functional characterization of recombinant fungal trehalose phosphorylase from Schizophyllum commune

  Gödl, C., Griessler, R., Schwarz, A., Klimacek, M. & Nidetzky, B., 2004.

  Research output: Contribution to conference › Poster

• Structural and functional characterization of recombinant fungal trehalose phosphorylase from Schizophyllum commune

  Gödl, C., Griessler, R., Schwarz, A., Klimacek, M. & Nidetzky, B., 2004.

  Research output: Contribution to conference › Poster
• 2003

  Glyco-Biotechnology. Oxidoreductases.

  Kratzer, R., Petschacher, B., Gabler, E., Klimacek, M., Steiner, W. & Nidetzky, B., 25 Jun 2003.

  Research output: Contribution to conference › (Old data) Lecture or Presentation

• On the role of Bronsted catalysis in Pseudomonas fluorescens mannitol 2-dehydrogenase.

  Klimacek, M., Kavanagh, K. L., Wilson, D. K. & Nidetzky, B., 2003, In: Biochemical Journal. 375, p. 141-149

  Research output: Contribution to journal › Article › peer-review

• Structure-function relationships and reaction mechanism of microbial NAD(P)-dependent oxidoreductases belonging to three different protein superfamilies: aldo-keto reductases, medium- and long-chain dehydrogenases/reductases

  Klimacek, M., 2003

  Research output: Thesis › Doctoral Thesis

• The reaction mechanism of D-mannitol 2-dehydrogenase from Pseudomonas fluorescens (PsM2DH) reveals convergent evolution of two alcohol dehydrogenase superfamilies.

  Klimacek, M., Kavanagh, K. L., Wilson, D. K. & Nidetzky, B., 2003.

  Research output: Contribution to conference › Poster

• The structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases.

  Kavanagh, K. L., Klimacek, M., Nidetzky, B. & Wilson, D. K., 2003, In: Biochemical Journal. 373, p. 319-326

  Research output: Contribution to journal › Article › peer-review

• The xylose reductase (AKR2B5) structure: homology and divergence from other aldo-keto reductases and opportunities for protein engineering.

  Wilson, D., Kavanagh, K., Klimacek, M. & Nidetzky, B., 2003, In: Chemico-Biological Interactions. 143-144, p. 515-521

  Research output: Contribution to journal › Article › peer-review
• 2002

  Structure-function relationships for xylose reductase from the yeast Candida tenuis.

  Klimacek, M., Kavanagh, K. L., Wilson, D. K. & Nidetzky, B., 2002.

  Research output: Contribution to conference › Poster

• The family of long-chain mannitol dehydrogenases brought into focus.

  Klimacek, M., Kavanagh, K. L., Wilson, D. K. & Nidetzky, B., 2002.

  Research output: Contribution to conference › Poster