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Tanja Wrodnigg

Assoc.Prof. Dipl.-Ing. Dr.techn.

1988 …2020
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Research Output 1996 2019

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2019

Carbohydrates@MOFs

Astria, E., Thonhofer, M., Ricco, R., Liang, W., Angela, C., Tarzia, A., Alt, K., Hagemeyer, C., Rattenberger, J., Schröttner, H., Wrodnigg, T. M., Amenitsch, H., Huang, D., Doonan, C. & Falcaro, P., 1 Jun 2019, In : Materials Horizons. 6, 5, p. 969-977 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Synthesis of modified 1,5‑imino‑d‑xylitols as ligands for lysosomal β‑glucocerebrosidase

Zoidl, M., Wolfsgruber, A., Schalli, M., Nasseri, S. A., Weber, P., Stütz, A., Withers, S. G. & Wrodnigg, T. M., 2019, In : Monatshefte für Chemie = Chemical monthly. 150, 5, p. 831-842 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucosylceramidase
Substitution reactions
Glucosidases
Ligands
Xylitol
2018

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Weber, P., Nasseri, S. A., Pabst, B., Torvisco Gomez, A., Müller, P., Paschke, E., Tschernutter, M., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Stütz, A., 2018, In : Molecules . 23, 3, 11 p., 708.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Imidazole Based Magnesium Salt as Conductive Salt for Rechargeable Magnesium-Ion Batteries

Zoidl, M., God, C., Fischer, R., Lenardt, C., Schmuck, M. & Wrodnigg, T., 2016, In : Journal of the Electrochemical Society. 10, p. A2461-A2463

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of AB4-Type Carbohydrate Scaffolds as Branching Units in the Glycosciences

Gloe, T., Mueller, A., Ciuk, A., Wrodnigg, T. & Lindhorst, T., 2016, In : Carbohydrate Research. 245, 1-9, p. 1-9

Research output: Contribution to journalArticleResearchpeer-review

The Amadori Rearrangement for Carbohydrate Conjugation: Scope and Limitations

Hojnik, C., Mueller, A., Gloe, T., Lindhorst, T. & Wrodnigg, T., 2016, In : European journal of organic chemistry. 25, p. 4328-4337

Research output: Contribution to journalArticleResearchpeer-review

The Staudinger/aza-Wittig/Grignard Reaction as Key Step for the Concise Synthesis of 1-C-Alkyl-Iminoalditol Glycomimetics

Zoidl, M., Santana, A. G., Torvisco Gomez, A., Siriwardena, A., Withers, S. G. & Wrodnigg, T., 2016, In : Carbohydrate Research. 429, p. 62-70

Research output: Contribution to journalArticleResearchpeer-review

2015

Are D-manno-configured Amadori products ligands of the bacterial lectin FimH?

Gloe, T-E., Stamer, I., Hojnik, C., Wrodnigg, T. & Lindhorst, T. K., 2015, In : Beilstein Journal of Organic Chemistry . p. 1096-1104

Research output: Contribution to journalArticleResearchpeer-review

2014

Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy

Zoidl, M., Müller, B., Torvisco Gomez, A., Tysoe, C., Benazza, M., Siriwardena, A., Withers, S. & Wrodnigg, T., 2014, In : Bioorganic & Medicinal Chemistry Letters. 24, p. 2777-2780

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2013

YARROWIA LIPOLYTICA DEHYDROGENASE/ REDUCTASE: AN ENZYME TOLERANT FOR LIPOPHILIC COMPOUNDS AND CARBOHYDRATE SUBSTRATES

Napora, K., Wrodnigg, T., Kosmus, P., Thonhofer, M., Robins, K. & Winkler, M., 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, p. 3393-3395

Research output: Contribution to journalArticleResearchpeer-review

2012

Fluorous Iminoalditols act as Effective Pharmacological Chaperones against Gene Products from GLB1 Alleles causing GM1-Gangliosidosis and Morquio B Disease

Fantur, K., Wrodnigg, T., Stütz, A., Pabst, B. M. & Paschke, E., 2012, In : Journal of inherited metabolic disease. 35, 3, p. 495-503

Research output: Contribution to journalArticleResearchpeer-review

Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Davies, G., Thompson, A., Gloster, T., Williams, R., Hakki, Z., Wennekes, T., Songsrirote, K., Wrodnigg, T., Spreitz, J., Stütz, A., Thomas-Oates, J. & Williams, S., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, p. 781-786

Research output: Contribution to journalArticleResearchpeer-review

The Amadori Rearrangement as Glycoconjugation Method: Synthesis of Non-natural C-Glycosyl Type Glycoconjugates

Gallas, K., Pototschnig, G., Adanitsch, F., Stütz, A. & Wrodnigg, T., 2012, In : Beilstein Journal of Organic Chemistry . p. 1619-1629

Research output: Contribution to journalArticleResearchpeer-review

The Two Faces of Iminoalditols: Powerful Inhibitors Trigger Glycosidase Activation

Wrodnigg, T. & Stütz, A., 2012, In : Current enzyme inhibition. 8, p. 47-99

Research output: Contribution to journalArticleResearchpeer-review

Two Faces of Iminoalditols: Powerful Inhibitors Trigger Glycosidase Activation

Wrodnigg, T. & Stütz, A., 2012, In : Current enzyme inhibition. 8, 1, p. 47-99

Research output: Contribution to journalArticleResearch

2011

1-Deoxy-D-galactonojirimycins with Dansyl Capped N-Substituents as -Galactosidase Inhibitors and Potential Probes for GM1 Gangliosidosis Affected Cell Lines

Fröhlich, R., Furneaux, R., Mahuran, D. J., Saf, R., Stütz, A., Tropak, M. B., Wicki, J., Withers, S. G. & Wrodnigg, T., 2011, In : Carbohydrate Research. 346, 12, p. 1592-1598

Research output: Contribution to journalArticleResearchpeer-review

A Fluorescent Probe for GM1 Gangliosidosis Related -Gal: N-(Dansylamino)hexylaminocarbonyl- pentyl-1,5-dideoxy-1,5-imino-D-galactitol

Fröhlich, R., Fantur, K., Furneaux, R., Paschke, E., Stütz, A., Wicki, J., Withers, S. G. & Wrodnigg, T., 2011, In : Bioorganic & Medicinal Chemistry Letters. 15, 22, p. 6872-6875

Research output: Contribution to journalArticleResearchpeer-review

Iminosugars and glycoside hydrolases: Historic context, current aspects, emerging trends

Stütz, A. & Wrodnigg, T., 2011, In : Advances in Carbohydrate Chemistry and Biochemistry. 66, p. 187-298

Research output: Contribution to journalArticleResearchpeer-review

2010

1-Deoxynojirimycins with Dansyl Capped N-Substituents as Probes for Morbus Gaucher Affected Cell Lines

Fröhlich, R., Furneaux, R., Mahuran, D., Rigat, B., Stütz, A., Tropak, M., Wicki, J., Withers, S. & Wrodnigg, T., 2010, In : Carbohydrate Research. 345, 10, p. 1371-1376

Research output: Contribution to journalArticleResearchpeer-review

Biotin-Iminoalditol Conjugates: Molecular Probes for Glycosylhydrolases

Pototschnig, G., Morales De Csáky, C., Montenegro Burke, J., Schitter, G., Stütz, A., Tarling, C., Withers, S. & Wrodnigg, T., 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 14, p. 4077-4079

Research output: Contribution to journalArticleResearchpeer-review

DLHex-DGJ, a Novel Derivative of 1-Deoxygalactonojirimycin with Pharmalogical Chaperone Activity in Human GM1-Gangliosidosis Fibroplasts

Fantur, K., Hofer, D., Schitter, G., Steiner, A., Pabst, B., Wrodnigg, T., Stütz, A. & Paschke, E., 2010, In : Molecular genetics and metabolism. 100, 3, p. 262-268

Research output: Contribution to journalArticleResearchpeer-review

Fluorescent-tagged sp2-iminosugars with potential b-glucosidase inhibitory activity

Aguilar-Moncayo, M., García-Moreno, I., Stütz, A., García Fernández, J., Wrodnigg, T. & Ortiz Mellet, C., 2010, In : Bioorganic & Medicinal Chemistry. 18, p. 7439-7445

Research output: Contribution to journalArticleResearchpeer-review

Fluorous Iminoalditols: A New Family of N-Modified Glycosidase Inhibitors

Schitter, G., Steiner, A., Pototschnig, G., Scheucher, E., Thonhofer, M., Tarling, C., Withers, S., Fantur, K., Paschke, E., Mahuran, D., Rigat, B., Tropak, M., Illaszewicz-Trattner, C., Saf, R., Stütz, A. & Wrodnigg, T., 2010, In : ChemBioChem. 11, 14, p. 2026-2033

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of Lipophilic 1-Deoxygalactonojirimycin Derivatives as Galactosidase Inhibitors

Schitter, G., Scheucher, E., Steiner, A., Stütz, A., Thonhofer, M., Tarling, C., Withers, S., Wicki, J., Fantur, K., Paschke, E., Mahuran, D., Rigat, B., Tropak, M. & Wrodnigg, T., 2010, In : Beilstein Journal of Organic Chemistry . 6, 21, 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

2-Acetamino-1,2-dideoxynojirimycin-lysine hybrids as hexosaminidase inhibitors

Steiner, A., Schitter, G., Stütz, A., Wrodnigg, T., Tarling, C., Withers, S., Mahuran, D. & Tropak, M., 2009, In : Tetrahedron / Asymmetry. 20, p. 832-835

Research output: Contribution to journalArticleResearchpeer-review

Update on carbohydrate-containing antibacterial agents

Schitter, G. & Wrodnigg, T., 2009, In : Expert opinion on drug discovery. 4, 3, p. 315-356

Research output: Contribution to journalArticleResearchpeer-review

2008

1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors

Steiner, A., Schitter, G., Stütz, A., Wrodnigg, T., Tarling, C., Withers, S., Fantur, K. & Mahuran, D., 2008, In : Bioorganic & Medicinal Chemistry. 16, 24, p. 1779-1925

Research output: Contribution to journalArticleResearchpeer-review

Glycosidase Profiling with Immobilised Glycosidase Inhibiting Iminoalditols – A Proof-of-Concept Study

Steiner, A., Stütz, A., Wrodnigg, T. M., Tarling, C. A., Withers, S. G., Hermetter, A. & Schmidinger, H., 2008, In : Bioorganic & Medicinal Chemistry Letters. 18, 6, p. 1922-1925

Research output: Contribution to journalArticleResearchpeer-review

Natural and Synthetic Iminosugars as Carbohydrate Processing Enzyme Inhibitors for Cancer Therapy

Wrodnigg, T. M., Steiner, A. & Überbacher, B., 2008, In : Anti-cancer Agents in Medicinal Chemistry. 8, 1, p. 77-85

Research output: Contribution to journalArticleResearchpeer-review

The Amadori Rearrangement as Key Reaction for the Synthesis of Neoglycoconjugates

Wrodnigg, T., Kartusch, C. & Illaszewicz-Trattner, C., 2008, In : Carbohydrate Research. 343, 12, p. 2057-2066

Research output: Contribution to journalArticleResearchpeer-review

2007

Iminoalditol-amino acid hybrids: synthesis and evaluation as glycosidase inhibitors

Steiner, A., Stütz, A., Tarling, C., Withers, S. & Wrodnigg, T., 2007, In : Carbohydrate Research. 342, 12-13, p. 1850-1858

Research output: Contribution to journalArticleResearchpeer-review

The Structural Basis of Glycosidase Inhibition by Five-Membered Iminocyclitols: The Clan A Glycoside Hydrolase Endoglycoceramidase as a Model System

Caines, M., Hancock, S., Tarling, C., Wrodnigg, T. M., Stick, R., Stütz, A., Vasella, A., Withers, S. & Strynadka, N., 2007, In : Angewandte Chemie / International Edition . 46, 27, p. 4474-4476

Research output: Contribution to journalArticleResearchpeer-review

2006

Fine Tuning of b-Glucosidase Inhibitory Activity in the 2,5-Dideoxy-2,5-imino-D-mannitol (DMDP) System

Wrodnigg, T. M., Stütz, A., Withers, S. G. & Tarling, C. A., 2006, In : Carbohydrate Research. 341, p. 1717-1722

Research output: Contribution to journalArticleResearchpeer-review

Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols

Greimel, P., Häusler, H., Lundt, I., Rupitz, K., Stütz, A., Tarling, C., Withers, S. G. & Wrodnigg, T. M., 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, 8, p. 2067-2070

Research output: Contribution to journalArticleResearchpeer-review

Fluorescent glycosidase inhibiting 1,5-iminoalditols

Greimel, P., Häusler, H., Lundt, I., Rupitz, K., Stütz, A., Tarling, C., Withers, S. G. & Wrodnigg, T. M., 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, p. 2067-2070

Research output: Contribution to journalArticleResearchpeer-review

Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics

Lundt, I., Steiner, A., Stütz, A., Tarling, C. A., Ully, S., Withers, S. G. & Wrodnigg, T. M., 2006, In : Bioorganic & Medicinal Chemistry. 14, p. 1737-1742

Research output: Contribution to journalArticleResearchpeer-review

L-Idoseptanosides: substrates of D-glucosidases

Tauss, A., Rupitz, K., Steiner, A., Stütz, A., Tarling, C. A., Withers, S. G. & Wrodnigg, T. M., 2006, In : Tetrahedron / Asymmetry. 17, p. 234-239

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of N-Protected Galactosamine Building Blocks from D-Tagatose via the Heyns Rearrangement

Wrodnigg, T. M., Lubdt, I. & Stütz, A., 2006, In : Journal of carbohydrate chemistry. 25, 1, p. 33-41

Research output: Contribution to journalArticleResearchpeer-review

2005

Non-natural aldofuranosides as substrates of a beta-glucosidase

Tauss, A., Greimel, P., Rupitz, K., Steiner, A., Stütz, A., Withers, S. G. & Wrodnigg, T. M., 2005, In : Tetrahedron / Asymmetry. 16, p. 159-165

Research output: Contribution to journalArticleResearchpeer-review

2004

Bioactive Carbohydrates and Recently Discovered Bioactive Analogues as Chemotherapeutics

Wrodnigg, T. M. & Sprenger, F., 2004, In : Mini-reviews in medicinal chemistry. 4, p. 437-449

Research output: Contribution to journalArticleResearchpeer-review

In situ Extension as an Approach for Identifying Novel a-Amylase Inhibitors

Numoa, S., Damagar, I., Li, C., Wrodnigg, T. M., Begum, A., Overall, C. M., Brayer, G. D. & Withers, S. G., 2004, In : The Journal of Biological Chemistry. 279, p. 48282-48291

Research output: Contribution to journalArticleResearchpeer-review

Probing the aglycon binding site of β–glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors

Wrodnigg, T. M., Diness, F., Gruber, C., Häusler, H., Lundt, I., Rupitz, K., Steiner, A., Stütz, A., Tarling, C. A., Withers, S. G. & Wölfler, H., 2004, In : Bioorganic & Medicinal Chemistry. 12, 13, p. 3485-3495

Research output: Contribution to journalArticleResearchpeer-review

Iminosugars and relatives as antiviral and potential antiinfective agents

Greimel, P., Spreitz, J., Stütz, A. & Wrodnigg, T. M., 2003, In : Current topics in medicinal chemistry. 3, 5, p. 513-523

Research output: Contribution to journalArticleResearchpeer-review

2002

A Simple Access to the D-Mannosidase Inhibitor 1-Deoxynojirimycin

Spreitz, J., Stütz, A. & Wrodnigg, T. M., 2002, In : Carbohydrate Research. 337, p. 183-186

Research output: Contribution to journalArticleResearchpeer-review

From Liana to a Glycotechnology Tool, 25 Years of 2,5-Imino-2,5-dideoxy-imino-D-mannitol (DMDP)

Wrodnigg, T. M., 2002, In : Monatshefte für Chemie = Chemical monthly. 133, p. 393-426

Research output: Contribution to journalArticleResearchpeer-review

2001

Enzymatic O-galactosylation of selected free and partially protected ketohexoses

Eder, B., Lundt, I., Stütz, A. & Wrodnigg, T. M., 2001, In : Journal of carbohydrate chemistry. 20, p. 647-657

Research output: Contribution to journalArticleResearchpeer-review

Novel lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors

Wrodnigg, T. M., Withers, S. G. & Stütz, A., 2001, In : Bioorganic & Medicinal Chemistry Letters. 11, p. 1063-1064

Research output: Contribution to journalArticleResearchpeer-review