Stephan Sacher

Dipl.-Ing.

20012020
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Research Output 2001 2020

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Article
2020

Model predictive control for continuous pharmaceutical feeding blending units

Celikovic, S., Kirchengast, M., Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 2020, In : Chemical Engineering Research and Design / A. 2020, 154, p. 101-114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Towards a novel continuous HME-Tableting line: Process development and control concept

Sacher, S., Celikovic, S., Rehrl, J., Poms, J., Kirchengast, M., Kruisz, J., Sipek, M., Salar-Behzadi, S., Berger, H., Stark, G., Horn, M. & Khinast, J. G., 15 Jan 2020, In : European Journal of Pharmaceutical Sciences. 142

Research output: Contribution to journalArticleResearchpeer-review

2019

Ensuring Tablet Quality via Model-based Control of a Continuous Direct Compaction Process

Kirchengast, M., Celikovic, S., Rehrl, J., Sacher, S., Kruisz, J., Khinast, J. & Horn, M., 15 Aug 2019, In : International Journal of Pharmaceutics. 2019, 567, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Particle Size
Linear Models
Pharmaceutical Preparations
Temperature

Shedding light on coatings: Real-time monitoring of coating quality at industrial scale

Sacher, S., Wahl, P., Weissensteiner, M., Wolfgang, M., Pokhilchuk, Y., Looser, B., Thies, J., Raffa, A. & Khinast, J. G., 20 Jul 2019, In : International Journal of Pharmaceutics. 566, p. 57-66

Research output: Contribution to journalArticleResearchpeer-review

The need for new control strategies for particulate matter in parenterals

Poms, J., Sacher, S., Nixdorf, M., Dekner, M., Wallner-Mang, S., Janssen, I., Khinast, J. G. & Schennach, R., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 739-750 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Particulate Matter
Process Assessment (Health Care)
Risk Management
Patient Safety
Guidelines
2018

Characterization of the coating and tablet core roughness by means of 3D optical coherence tomography

Khinast, J., Markl, D., Wahl, P., Pichler, H. & Sacher, S., 2018, In : International Journal of Pharmaceutics. p. 459-466

Research output: Contribution to journalArticleResearchpeer-review

Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme

Khinast, J., Schaden, L-M., Wimmer-Teubenbacher, M., Poms, J., Laggner, P., Lohner, K., Sacher, S. & Salar-Behzadi, S., 2018, In : Pharmaceutical research.

Research output: Contribution to journalArticleResearchpeer-review

Gluing Pills Technology: A novel route to multilayer tablet manufacturing

Demiri, V., Stranzinger, S., Rinner, P., Piller, M., Sacher, S., Lingitz, J., Khinast, J. & Salar-Behzadi, S., 5 Sep 2018, In : International Journal of Pharmaceutics. 548, 1, p. 672-681 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tablets
Technology
Povidone
Precision Medicine
Translational Medical Research

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Residence time distribution
Extrusion
Drug products
Color
Surface-Active Agents

Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets

Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In : Powder Technology. 325, p. 247-260

Research output: Contribution to journalArticleResearchpeer-review

2017

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In : Chemie - Ingenieur - Technik. 89, 8

Research output: Contribution to journalArticleResearchpeer-review

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Technology
Pharmaceutical Preparations
Pressure
Temperature
Research

Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging

Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In : International Journal of Pharmaceutics. 518, 1-2, p. 130-137

Research output: Contribution to journalArticleResearchpeer-review

2016

Monitoring of a Hot Melt Coating Process via a Novel Multipoint Near-Infrared Spectrometer

Hohl, R., Scheibelhofer, O., Stocker, E., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Lochmann, D., Sacher, S. & Zimmer, A., 2 Mar 2016, In : AAPS PharmSciTech .

Research output: Contribution to journalArticleResearchpeer-review

Optimized continuous pharmaceutical manufacturing via model-predictive control

Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 16 Jun 2016, In : International Journal of Pharmaceutics. 510, p. 100-115

Research output: Contribution to journalArticleResearchpeer-review

2015

Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography

Markl, D., Zettl, M., Hannesschläger, G., Sacher, S., Leitner, M., Buchsbaum, A. & Khinast, J., 2015, In : Chemical Engineering Science. 125, p. 200-208

Research output: Contribution to journalArticleResearchpeer-review

Designed Blending for Near Infrared Calibration

Scheibelhofer, O., Grabner, B., Bondi, R. W. J., Igne, B., Sacher, S. & Khinast, J., 2015, In : Journal of Pharmaceutical Sciences . 7, 104, p. 2312-2322

Research output: Contribution to journalArticleResearchpeer-review

2014

Automatic correction for window fouling of near infrared probes in fluidised systems

Scheibelhofer, O., Hohl, R., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Sacher, S., Menezes, J. C. & Khinast, J., 2014, In : Journal of near infrared spectroscopy. 22, 3, p. 229-238

Research output: Contribution to journalArticleResearchpeer-review

In-line quality control of moving objects by means of spectral-domain OCT

Markl, D., Hannesschläger, G., Buchsbaum, A., Sacher, S., Khinast, J. & Leitner, M., 2014, In : Optics and lasers in engineering. 59, p. 1-10

Research output: Contribution to journalArticleResearchpeer-review

Near infrared light spectroscopy: Applicability and new developments

Scheibelhofer, O., Sacher, S. & Khinast, J., 2014, In : European pharmaceutical review. 19, 1, p. 51-55

Research output: Contribution to journalArticleResearch

Optical coherence tomography: An Alternative Methodology to Monitor Pharmaceutical Coating Processes

Markl, D., Sacher, S. & Khinast, J., 2014, In : GIT laboratory journal Europe. 7, p. 17-22

Research output: Contribution to journalArticleResearch

Optical coherence tomography as a novel tool for in-line monitoring of a pharmaceutical film-coating process

Markl, D., Hannesschläger, G., Sacher, S., Leitner, M. & Khinast, J., 2014, In : European Journal of Pharmaceutical Sciences. 55, p. 58-67

Research output: Contribution to journalArticleResearchpeer-review

PAT for Tableting: Inline Monitoring of API and Excipients via NIR Spectroscopy

Wahl, P., Fruhmann, G., Sacher, S., Straka, G., Sebastian, S. & Khinast, J., 2014, In : European journal of pharmaceutics and biopharmaceutics. 87;2, p. 271-278

Research output: Contribution to journalArticleResearchpeer-review

Use of mechanistic simulations as a quantitative risk-ranking tool within the quality by design framework

Stocker, E., Toschkoff, G., Sacher, S. & Khinast, J., 2014, In : International Journal of Pharmaceutics. 475, 1-2, p. 245–255

Research output: Contribution to journalArticleResearchpeer-review

2005

Investigation of different crystal habits without chemical additives in a three-phase reactor

Sacher, S. & Krammer, G., 2005, In : Chemical Engineering Science. 60, 22, p. 6307-6312

Research output: Contribution to journalArticleResearchpeer-review

Untersuchung von Kristallisationsprozessen in einem Ultraschall-Levitator

Sacher, S. & Krammer, G., 2005, In : Chemie - Ingenieur - Technik. 77, 3, p. 290-294

Research output: Contribution to journalArticleResearchpeer-review