Stephan Sacher

Dipl.-Ing.

20012020

Research output per year

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Research Output

2020

Model predictive control for continuous pharmaceutical feeding blending units

Celikovic, S., Kirchengast, M., Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 2020, In : Chemical Engineering Research and Design / A. 2020, 154, p. 101-114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Towards a novel continuous HME-Tableting line: Process development and control concept

Sacher, S., Celikovic, S., Rehrl, J., Poms, J., Kirchengast, M., Kruisz, J., Sipek, M., Salar-Behzadi, S., Berger, H., Stark, G., Horn, M. & Khinast, J. G., 15 Jan 2020, In : European Journal of Pharmaceutical Sciences. 142

Research output: Contribution to journalArticleResearchpeer-review

2019

Ensuring Tablet Quality via Model-based Control of a Continuous Direct Compaction Process

Kirchengast, M., Celikovic, S., Rehrl, J., Sacher, S., Kruisz, J., Khinast, J. & Horn, M., 15 Aug 2019, In : International Journal of Pharmaceutics. 2019, 567, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Real-time measurement of coating film thickness

Wolfgang, M., Wahl, P., Sacher, S., Gartshein, E. & Khinas, J. G., 1 Mar 2019, In : Pharmaceutical technology. 43, 3, p. 36-47 12 p.

Research output: Contribution to journalComment/debateResearchpeer-review

Shedding light on coatings: Real-time monitoring of coating quality at industrial scale

Sacher, S., Wahl, P., Weissensteiner, M., Wolfgang, M., Pokhilchuk, Y., Looser, B., Thies, J., Raffa, A. & Khinast, J. G., 20 Jul 2019, In : International Journal of Pharmaceutics. 566, p. 57-66

Research output: Contribution to journalArticleResearchpeer-review

The need for new control strategies for particulate matter in parenterals

Poms, J., Sacher, S., Nixdorf, M., Dekner, M., Wallner-Mang, S., Janssen, I., Khinast, J. G. & Schennach, R., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 739-750 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Characterization of the coating and tablet core roughness by means of 3D optical coherence tomography

Khinast, J., Markl, D., Wahl, P., Pichler, H. & Sacher, S., 2018, In : International Journal of Pharmaceutics. p. 459-466

Research output: Contribution to journalArticleResearchpeer-review

Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme

Khinast, J., Schaden, L-M., Wimmer-Teubenbacher, M., Poms, J., Laggner, P., Lohner, K., Sacher, S. & Salar-Behzadi, S., 2018, In : Pharmaceutical research.

Research output: Contribution to journalArticleResearchpeer-review

Gluing Pills Technology: A novel route to multilayer tablet manufacturing

Demiri, V., Stranzinger, S., Rinner, P., Piller, M., Sacher, S., Lingitz, J., Khinast, J. & Salar-Behzadi, S., 5 Sep 2018, In : International Journal of Pharmaceutics. 548, 1, p. 672-681 10 p.

Research output: Contribution to journalArticleResearchpeer-review

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets

Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In : Powder Technology. 325, p. 247-260

Research output: Contribution to journalArticleResearchpeer-review

RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line

Martinetz, M., Kartunnen, A-P., Sacher, S., Wahl, P., Ketolainen, J., Khinast, J. & Korhonnen, O., 5 Jun 2018.

Research output: Contribution to conferencePaperResearchpeer-review

Open Access
2017

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In : Chemie - Ingenieur - Technik. 89, 8

Research output: Contribution to journalArticleResearchpeer-review

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging

Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In : International Journal of Pharmaceutics. 518, 1-2, p. 130-137

Research output: Contribution to journalArticleResearchpeer-review

2016

Application of Model-Predictive Control to a Feeding Blending Unit

Rehrl, J., Kruisz, J., Sacher, S., Horn, M. & Khinast, J., 14 Nov 2016.

Research output: Contribution to conferencePosterResearchpeer-review

Development of a Model-Based Control Concept for a Direct Compaction Process

Kruisz, J., Rehrl, J., Martinetz, M., Sacher, S., Horn, M. & Khinast, J., 2016.

Research output: Contribution to conferencePosterResearch

In-situ observation of the transformation of amorphous calcium phosphate to crystalline hydroxyapatite

Stammeier, J. A., Hippler, D., Mavromatis, V., Sacher, S. & Dietzel, M., 2016, Geophysical Research Abstracts: EGU General Assembly 2016 Abstracts. European Geosciences Union, Vol. 18. p. 17043-17043 EGU2016-17043

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Monitoring of a Hot Melt Coating Process via a Novel Multipoint Near-Infrared Spectrometer

Hohl, R., Scheibelhofer, O., Stocker, E., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Lochmann, D., Sacher, S. & Zimmer, A., 2 Mar 2016, In : AAPS PharmSciTech .

Research output: Contribution to journalArticleResearchpeer-review

NIR-Hyperspectral Imaging and Raman Chemical Mapping of Multilayer-Tablets

Poms, J., Scheibelhofer, O., Sacher, S. & Khinast, J., 30 Mar 2016.

Research output: Contribution to conferencePosterResearchpeer-review

Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process

Wolfgang, M., Wahl, P., Zettl, M., Sacher, S., Khinast, J. G., Bastian, R. & Fränkel, T., 17 Nov 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Optimized continuous pharmaceutical manufacturing via model-predictive control

Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 16 Jun 2016, In : International Journal of Pharmaceutics. 510, p. 100-115

Research output: Contribution to journalArticleResearchpeer-review

Real-Time Monitoring and Ejection of out-of-Spec Tablets Via NIR Chemical Imaging

Wolfgang, M., Wahl, P., Hauseder, G., Sacher, S., Kerschhaggl, M. & Khinast, J., 14 Nov 2016.

Research output: Contribution to conferencePosterResearchpeer-review

Speed change experiments in a rotary tablet press

Martinetz, M., Aigner, I., Rehrl, J., Sacher, S. & Khinast, J., 3 Oct 2016.

Research output: Contribution to conferencePosterResearchpeer-review

2015

Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography

Markl, D., Zettl, M., Hannesschläger, G., Sacher, S., Leitner, M., Buchsbaum, A. & Khinast, J., 2015, In : Chemical Engineering Science. 125, p. 200-208

Research output: Contribution to journalArticleResearchpeer-review

Designed Blending for Near Infrared Calibration

Scheibelhofer, O., Grabner, B., Bondi, R. W. J., Igne, B., Sacher, S. & Khinast, J., 2015, In : Journal of Pharmaceutical Sciences . 7, 104, p. 2312-2322

Research output: Contribution to journalArticleResearchpeer-review

Flowsheet Modelling as a Tool for Plant-wide Control Strategy Development for Continuous Processes

Kruisz, J., Rehrl, J., Gruber, A. F., Sacher, S. & Khinast, J., 18 May 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

In-line Monitoring of Segregation Effects in a Pharmaceutical Tableting Process

Sacher, S., Wahl, P., Scheibelhofer, O., Hohl, R. & Khinast, J., 25 Jan 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Monitoring of a Hot Melt Coating Process

Scheibelhofer, O., Hohl, R., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Lochmann, D., Sacher, S. & Khinast, J., 2015.

Research output: Contribution to conferencePosterResearch

Total Surveillance! Inline Monitoring of Tablets via NIR Chemical Imaging

Wahl, P., Scheibelhofer, O., Sacher, S. & Khinast, J., 25 Jan 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

2014

100% Monitoring of Manufactured Tablets with NIR Chemical Imaging

Wahl, P., Scheibelhofer, O., Sacher, S., Kerschhaggl, P. & Khinast, J., 2014.

Research output: Contribution to conferencePosterResearch

Always the same? Location of Segregation Via Spectroscopy

Hohl, R., Scheibelhofer, O., Wahl, P., Sacher, S. & Khinast, J., 16 Nov 2014.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Automatic correction for window fouling of near infrared probes in fluidised systems

Scheibelhofer, O., Hohl, R., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Sacher, S., Menezes, J. C. & Khinast, J., 2014, In : Journal of near infrared spectroscopy. 22, 3, p. 229-238

Research output: Contribution to journalArticleResearchpeer-review

Device and method for monitoring a property of a coating of a solid dosage form during a coating process forming the coating of the solid dosage form

Markl, D., Hannesschläger, G., Leitner, M., Sacher, S., Koller, D. & Khinast, J., 30 Oct 2014, Patent No. US 2014/0322429 A1

Research output: PatentResearch

In-line quality control of moving objects by means of spectral-domain OCT

Markl, D., Hannesschläger, G., Buchsbaum, A., Sacher, S., Khinast, J. & Leitner, M., 2014, In : Optics and lasers in engineering. 59, p. 1-10

Research output: Contribution to journalArticleResearchpeer-review

Near infrared light spectroscopy: Applicability and new developments

Scheibelhofer, O., Sacher, S. & Khinast, J., 2014, In : European pharmaceutical review. 19, 1, p. 51-55

Research output: Contribution to journalArticleResearch

Optical coherence tomography: An Alternative Methodology to Monitor Pharmaceutical Coating Processes

Markl, D., Sacher, S. & Khinast, J., 2014, In : GIT laboratory journal Europe. 7, p. 17-22

Research output: Contribution to journalArticleResearch

Optical coherence tomography as a novel tool for in-line monitoring of a pharmaceutical film-coating process

Markl, D., Hannesschläger, G., Sacher, S., Leitner, M. & Khinast, J., 2014, In : European Journal of Pharmaceutical Sciences. 55, p. 58-67

Research output: Contribution to journalArticleResearchpeer-review

Optical coherence tomography data processing for in-line monitoring of a pharmaceutical film-coating process

Markl, D., Hannesschläger, G., Sacher, S., Buchsbaum, A. & Khinast, J., 2014, Proceedings of the 10th Minisymposium Verfahrenstechnik. ., p. 142-145

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Optical Coherence Tomography for In-line Quality Control of Pharmaceutical Film-Coated Tablets

Markl, D., Hannesschläger, G., Sacher, S., Leitner, M. & Khinast, J., 21 Jan 2014.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

PAT for Tableting: Inline Monitoring of API and Excipients via NIR Spectroscopy

Wahl, P., Fruhmann, G., Sacher, S., Straka, G., Sebastian, S. & Khinast, J., 2014, In : European journal of pharmaceutics and biopharmaceutics. 87;2, p. 271-278

Research output: Contribution to journalArticleResearchpeer-review

Real-time data processing for in-line monitoring of a pharmaceutical coating process by optical coherence tomography

Markl, D., Ziegler, J., Hannesschläger, G., Sacher, S., Buchsbaum, A., Leitner, M. & Khinast, J., 2014, Biophotonics: Photonic Solutions for Better Health Care IV. ., Vol. 9129. p. 1-12 (Proceeding of SPIE).

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Use of mechanistic simulations as a quantitative risk-ranking tool within the quality by design framework

Stocker, E., Toschkoff, G., Sacher, S. & Khinast, J., 2014, In : International Journal of Pharmaceutics. 475, 1-2, p. 245–255

Research output: Contribution to journalArticleResearchpeer-review

2013

A multipoint measurement spectrometer for monitoring pharmaceutical processes

Scheibelhofer, O., Sacher, S., Menezes, J. C., Kerschhaggl, P. & Khinast, J., 2013.

Research output: Contribution to conferencePosterResearch

A multipoint measurement spectrometer for monitoring pharmaceutical processes

Scheibelhofer, O., Sacher, S., Menezes, J. C., Kerschhaggl, P. & Khinast, J., 2013, NIR 2013 Proceedings. ., p. 393-396

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Collecting, condensing, comprehending and culling spectral data: A pharmaceutical process monitored with SIMCA online

Scheibelhofer, O., Hohl, R., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Lochmann, D., Sacher, S. & Khinast, J., 24 Sep 2013.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Optical coherence tomography for non-destructive analysis of coatings in pharmaceutical tablets

Markl, D., Hannesschläger, G., Sacher, S., Khinast, J. & Leitner, M., 2013, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials. Ferraro, P. (ed.). ., Vol. 8792. p. 879202-879202 (SPIE Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review