Sandy Schmidt

Dipl.-Biochem. Dr.rer.nat.

20152019
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Research Output 2015 2019

Article

A Fed-Batch Synthetic Strategy for a Three-Step Enzymatic Synthesis of Poly-ϵ-caprolactone

Scherkus, C., Schmidt, S., Bornscheuer, U. T., Gröger, H., Kara, S. & Liese, A., 2016, In : ChemCatChem. 8, 22

Research output: Contribution to journalArticleResearchpeer-review

Alcohol Dehydrogenases Catalyze the Reduction of Thioesters

Younes, S. H. H., Ni, Y., Schmidt, S., Kroutil, W. & Hollmann, F., 21 Apr 2017, In : ChemCatChem. 9, 8, p. 1389-1392 4 p.

Research output: Contribution to journalArticleResearchpeer-review

dehydrogenases
Alcohol Dehydrogenase
Carboxylic Acids
Ketones
Carboxylic acids

An alternative approach towards poly-epsilon-caprolactone through a chemoenzymatic synthesis: combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates

Wedde, S., Rommelmann, P., Scherkus, C., Schmidt, S., Bornscheuer, U. T., Liese, A. & Gröger, H., 2017, In : Green chemistry. 19, 5

Research output: Contribution to journalArticleResearchpeer-review

An enzyme cascade synthesis of ε-caprolactone and its oligomers

Schmidt, S., Scherkus, C., Muschiol, J., Menyes, U., Winkler, T., Hummel, W., Gröger, H., Liese, A., Herz, H. G. & Bornscheuer, U. T., 23 Feb 2015, In : Angewandte Chemie / International Edition . 54, 9, p. 2784-2787 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclohexanols
Mixed Function Oxygenases
Oligomers
Enzymes
Peracetic Acid

Biocatalytic Access to Chiral Polyesters by an Artificial Enzyme Cascade Synthesis

Schmidt, S., Büchsenschütz, H. C., Scherkus, C., Liese, A., Gröger, H. & Bornscheuer, U. T., 1 Dec 2015, In : ChemCatChem. 7, 23, p. 3951-3955 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyesters
Alcohol Dehydrogenase
polyesters
enzymes
cascades

Biocatalytic oxidation reactions - a Chemist's perspective

Dong, J., Fernández-Fueyo, E., Hollmann, F., Paul, C., Pasic, M., Schmidt, S., Wang, Y., Younes, S. & Zhang, W., Jul 2018, In : Angewandte Chemie / International Edition . 57, 30, p. 9238-9261

Research output: Contribution to journalArticleResearchpeer-review

Oxidation
Oxidoreductases
Enzymes
Halogenation
Redox reactions

Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization

Zhang, W., Fernández-Fueyo, E., Hollmann, F., Leemans Martin, L., Pesic, M., Wardenga, R., Höhne, M. & Schmidt, S., 10 Jan 2019, In : European journal of organic chemistry. 2019, 1, p. 80-84 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Durch Trennen verbinden

Schmidt, S., Gröger, H. & Kourist, R., Oct 2017, In : Nachrichten aus der Chemie. 65, 10, p. 985-988 4 p.

Research output: Contribution to journalArticleResearch

Eine Enzymkaskade zur Synthese von ε-Caprolacton und dessen Oligomeren

Schmidt, S., Scherkus, C., Muschiol, J., Menyes, U., Winkler, T., Hummel, W., Gröger, H., Liese, A., Herz, H. G. & Bornscheuer, U. T., 2015, In : Angewandte Chemie. 127, 9, p. 2825-2828 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering the Amine Transaminase from Vibrio fluvialis towards Branched-Chain Substrates

Genz, M., Melse, O., Schmidt, S., Vickers, C., Dörr, M., Van Den Bergh, T., Joosten, H-J. & Bornscheuer, U. T., 20 Oct 2016, In : ChemCatChem. 8, 20, p. 3199-3202 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Transaminases
Amines
amines
engineering
Substrates

Enzymatic Oxyfunctionalization Driven by Photosynthetic Water-Splitting in the Cyanobacterium Synechocystis sp. PCC 6803

Böhmer, S., Köninger, K., Gomez-Baraibar, A., Bojarra, S., Mügge, C., Schmidt, S., Nowaczyk, M. & Kourist, R., Aug 2017, In : Catalysts. 7, 8, 8 p., 240.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
water splitting
regeneration
Fueling
Oxygenation
Niacinamide

Fully automatized high-throughput enzyme library screening using a robotic platform

Dörr, M., Fibinger, M. P. C., Last, D., Schmidt, S., Santos-Aberturas, J., Böttcher, D., Hummel, A., Vickers, C., Voss, M. & Bornscheuer, U. T., Jul 2016, In : Biotechnology and Bioengineering. 113, 7, p. 1421-32 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Robotics
Screening
Enzymes
Throughput
amidase

Hydrogen-driven cofactor regeneration for stereoselective whole-cell C=C bond reduction in Cupriavidus necator

Assil Companioni, L., Schmidt, S., Heidinger, P., Schwab, H. & Kourist, R., 19 Mar 2019, In : ChemSusChem. 12, 11, p. 2361-2365 5 p.

Research output: Contribution to journalArticleResearchpeer-review

biotransformation
Hydrogen
regeneration
hydrogen
Hydrogenase

Kinetic insights into ϵ-caprolactone synthesis: Improvement of an enzymatic cascade reaction

Scherkus, C., Schmidt, S., Bornscheuer, U. T., Gröger, H., Kara, S. & Liese, A., 1 Jun 2017, In : Biotechnology and Bioengineering. 114, 6, p. 1215-1221 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Emitter coupled logic circuits
Cyclohexanols
Lipase
Kinetics
Lipases

Overcoming the incompatibility challenge in chemo-enzymatic and multi-catalytic cascade reactions.

Schmidt, S., Castiglione, K. & Kourist, R., 6 Sep 2017, In : Chemistry - a European Journal.

Research output: Contribution to journalArticleResearchpeer-review

Photobiocatalytic alcohol oxidation using LED light sources

Rauch, M., Schmidt, S., Arends, I. W. C. E., Oppelt, K., Kara, S. & Hollmann, F., 2017, In : Green chemistry. 19, 2

Research output: Contribution to journalArticleResearchpeer-review

Process Development through Solvent Engineering in the Biocatalytic Synthesis of the Heterocyclic Bulk Chemical ε-Caprolactone

Reimer, A., Wedde, S., Staudt, S., Schmidt, S., Höffer, D., Hummel, W., Kragl, U., Bornscheuer, U. T. & Gröger, H., 2017, In : Journal of heterocyclic chemistry. 54, 1, p. 391-396 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Switch in Cofactor Specificity of a Baeyer-Villiger Monooxygenase

Beier, A., Bordewick, S., Genz, M., Schmidt, S., Van Den Bergh, T., Peters, C., Joosten, H-J. & Bornscheuer, U. T., 14 Dec 2016, In : ChemBioChem. 17, 24, p. 2312-2315 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Mixed Function Oxygenases
NAD
NADP
Switches
Bearings (structural)

Switching the Regioselectivity of a Cyclohexanone Monooxygenase toward (+)-trans-Dihydrocarvone by Rational Protein Design

Balke, K., Schmidt, S., Genz, M. & Bornscheuer, U. T., 15 Jan 2016, In : ACS Chemical Biology. 11, 1, p. 38-43 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Regioselectivity
Lactones
Switches
Arthrobacter
Proteins

The effect of disulfide bond introduction and related Cys/Ser mutations on the stability of a cyclohexanone monooxygenase

Schmidt, S., Genz, M., Balke, K. & Bornscheuer, U. T., 20 Nov 2015, In : Journal of Biotechnology. 214, p. 199-211 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mixed Function Oxygenases
Disulfides
Mutation
Enzymes
Acinetobacter

The Extreme Structural Plasticity in the CYP153 Subfamily of P450s Directs Development of Designer Hydroxylases

Fiorentini, F., Hatzl, A-M., Schmidt, S., Savino, S., Glieder, A. & Mattevi, A., 2018, In : Biochemistry. 57, 48, p. 6701-6714

Research output: Contribution to journalArticleResearchpeer-review

Mixed Function Oxygenases
Plasticity
Hydroxylation
lauric acid
Substrates

Towards environmentally acceptable synthesis of chiral alpha-hydroxy ketones via oxidase-lyase cascades

Schmidt, S., Pedroso de Almeida, T., Rother, D. & Hollmann, F., 2017, In : Green chemistry. 19, 5

Research output: Contribution to journalArticleResearchpeer-review

Using Deep Eutectic Solvents to Overcome Limited Substrate Solubility in the Enzymatic Decarboxylation of Bio-Based Phenolic Acids

Schweiger, A. K., Ríos-Lombardía, N., Winkler, C. K., Schmidt, S., Morís, F., González-Sabín, J. & Kourist, R., 8 Aug 2019, In : ACS Sustainable Chemistry & Engineering. 7, 19, p. 16364-16370

Research output: Contribution to journalArticleResearchpeer-review

decarboxylation
Eutectics
solubility
Solubility
substrate
Chapter

Library growth and protein expression: Optimal and reproducible microtiter plate expression of recombinant enzymes in E. coli using MTP Shakers

Schmidt, S., Dörr, M. & Bornscheuer, U. T., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1685. p. 145-156 12 p. (Methods in Molecular Biology; vol. 1685).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Libraries
Escherichia coli
Enzymes
Growth
Proteins
Poster

A light-driven enzyme cascade reaction for the synthesis of lactones

Büchsenschütz, H. C., Schultes, F., Schmidt, S. & Kourist, R., 9 Apr 2018.

Research output: Contribution to conferencePosterResearch

A light-driven enzyme cascade reaction for the synthesis of lactones.

Büchsenschütz, H. C., Schultes, F., Schmidt, S. & Kourist, R., 26 Aug 2018.

Research output: Contribution to conferencePosterResearch

A ‘COMBINATORIAL EXPLOSION’ OF PRODUCTS THROUGH PHOTO-CHEMO-ENZYMATIC CASCADES

Schmidt, S., Zhang, W., Leemans Martin, L., Fernandez Fueyo, E., Pesic, M., Wardenga, R., Kroutil, W. & Hollmann, F., 9 Jul 2017.

Research output: Contribution to conferencePosterResearch

Expanding the potential of phenolic acid decarboxylase from Bacillus subtilis by use of non-conventional solvents

Schweiger, A. K., Ríos-Lombardía, N., Winkler, C. K., Schmidt, S., Morís, F., Kroutil, W., González-Sabín, J. & Kourist, R., Jul 2019.

Research output: Contribution to conferencePosterResearch

Exploring the Substrate Scope of a Phenolic Acid Decarboxylase Variant

Schweiger, A. K., Gómez Baraibar, Á., Winkler, C. K., Kroutil, W., Schmidt, S. & Kourist, R., Jul 2017.

Research output: Contribution to conferencePosterResearch

Exploring the Substrate Scope of a Phenolic Acid Decarboxylase Variant

Schweiger, A. K., Gómez Baraibar, Á., Winkler, C. K., Kroutil, W., Schmidt, S. & Kourist, R., Sep 2017.

Research output: Contribution to conferencePosterResearch

Photobiocatalytic Nicotinamide REcycling

Winkler, C. K., Schmidt, S., Büchsenschütz, H. C., Vidimce-Risteski, V., Kourist, R. & Kroutil, W., 15 Nov 2017.

Research output: Contribution to conferencePosterResearch

Photosynthesis-driven Asymmetric reduction of c=c double bonds

Schmidt, S., Winkler, C. K., Büchsenschütz, H. C., Vidimce-Risteski, V., Kroutil, W. & Kourist, R., 15 Nov 2017.

Research output: Contribution to conferencePosterResearch

SETUP AND CHARACTERIZATION OF A CASCADE TRANSFORMING ARYL ALCOHOLS INTO Β-NITRO-ARYL ALCOHOLS

Pedroso de Almeida, T., Younes, S. H. H., Fernandez Fueyo, E., Schmidt, S., Arends, I. W. C. E., Riul Jr., A. & Hollmann, F., 9 Jul 2017.

Research output: Contribution to conferencePosterResearch

Small molecule Aldehydes from Carboxylic acid bioreduction

Horvat, M., Fiume, G., Stolterfoht, H., Schwendenwein, D., Schmidt, S. & Winkler, M., 14 Nov 2017.

Research output: Contribution to conferencePosterResearch

Small molecule Aldehydes from Carboxylic acid bioreduction

Horvat, M., Fiume, G., Stolterfoht, H., Schwendenwein, D., Schmidt, S. & Winkler, M., 9 Feb 2018.

Research output: Contribution to conferencePosterResearch

Review article

Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions

Schmidt, S., Castiglione, K. & Kourist, R., 6 Feb 2018, In : Chemistry - a European Journal. 24, 8, p. 1755-1768 14 p.

Research output: Contribution to journalReview articleResearchpeer-review

Enzyme immobilization
Purification
Catalysts
Enzymes

Photo-Biocatalysis: Biotransformations in the Presence of Light

Schmermund, L., Jurkaš, V., Özgen, F. F., Barone, G. D., Büchsenschütz, H. C., Winkler, C. K., Schmidt, S., Kourist, R. & Kroutil, W., 2019, In : ACS Catalysis. 9, 5, p. 4115-4144 30 p.

Research output: Contribution to journalReview articleResearchpeer-review

Chemical reactions
Enzymes
Biotransformation
Biocatalysis
Biocatalysts