Sandy Schmidt &ndash; Research Outputs

Article

A Fed-Batch Synthetic Strategy for a Three-Step Enzymatic Synthesis of Poly-ϵ-caprolactone

Scherkus, C., Schmidt, S., Bornscheuer, U. T., Gröger, H., Kara, S. & Liese, A., 2016, In : ChemCatChem. 8, 22

Research output: Contribution to journal › Article › Research › peer-review

Alcohol Dehydrogenases Catalyze the Reduction of Thioesters

Younes, S. H. H., Ni, Y., Schmidt, S., Kroutil, W. & Hollmann, F., 21 Apr 2017, In : ChemCatChem. 9, 8, p. 1389-1392 4 p.

Research output: Contribution to journal › Article › Research › peer-review

dehydrogenases

Alcohol Dehydrogenase

Carboxylic Acids

Ketones

Carboxylic acids

An alternative approach towards poly-epsilon-caprolactone through a chemoenzymatic synthesis: combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates

Wedde, S., Rommelmann, P., Scherkus, C., Schmidt, S., Bornscheuer, U. T., Liese, A. & Gröger, H., 2017, In : Green chemistry. 19, 5

Research output: Contribution to journal › Article › Research › peer-review

An enzyme cascade synthesis of ε-caprolactone and its oligomers

Schmidt, S., Scherkus, C., Muschiol, J., Menyes, U., Winkler, T., Hummel, W., Gröger, H., Liese, A., Herz, H. G. & Bornscheuer, U. T., 23 Feb 2015, In : Angewandte Chemie / International Edition . 54, 9, p. 2784-2787 4 p.

Research output: Contribution to journal › Article › Research › peer-review

Cyclohexanols

Mixed Function Oxygenases

Oligomers

Enzymes

Peracetic Acid

Biocatalytic Access to Chiral Polyesters by an Artificial Enzyme Cascade Synthesis

Schmidt, S., Büchsenschütz, H. C., Scherkus, C., Liese, A., Gröger, H. & Bornscheuer, U. T., 1 Dec 2015, In : ChemCatChem. 7, 23, p. 3951-3955 5 p.

Research output: Contribution to journal › Article › Research › peer-review

Polyesters

Alcohol Dehydrogenase

polyesters

enzymes

cascades

Biocatalytic oxidation reactions - a Chemist's perspective

Dong, J., Fernández-Fueyo, E., Hollmann, F., Paul, C., Pasic, M., Schmidt, S., Wang, Y., Younes, S. & Zhang, W., Jul 2018, In : Angewandte Chemie / International Edition . 57, 30, p. 9238-9261

Research output: Contribution to journal › Article › Research › peer-review

Oxidation

Oxidoreductases

Enzymes

Halogenation

Redox reactions

Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization

Zhang, W., Fernández-Fueyo, E., Hollmann, F., Leemans Martin, L., Pesic, M., Wardenga, R., Höhne, M. & Schmidt, S., 10 Jan 2019, In : European journal of organic chemistry. 2019, 1, p. 80-84 5 p.

Research output: Contribution to journal › Article › Research › peer-review

Durch Trennen verbinden

Schmidt, S., Gröger, H. & Kourist, R., Oct 2017, In : Nachrichten aus der Chemie. 65, 10, p. 985-988 4 p.

Research output: Contribution to journal › Article › Research

Eine Enzymkaskade zur Synthese von ε-Caprolacton und dessen Oligomeren

Schmidt, S., Scherkus, C., Muschiol, J., Menyes, U., Winkler, T., Hummel, W., Gröger, H., Liese, A., Herz, H. G. & Bornscheuer, U. T., 2015, In : Angewandte Chemie. 127, 9, p. 2825-2828 4 p.

Research output: Contribution to journal › Article › Research › peer-review

Engineering the Amine Transaminase from Vibrio fluvialis towards Branched-Chain Substrates

Genz, M., Melse, O., Schmidt, S., Vickers, C., Dörr, M., Van Den Bergh, T., Joosten, H-J. & Bornscheuer, U. T., 20 Oct 2016, In : ChemCatChem. 8, 20, p. 3199-3202 4 p.

Research output: Contribution to journal › Article › Research › peer-review

Transaminases

Amines

amines

engineering

Substrates

Enzymatic Oxyfunctionalization Driven by Photosynthetic Water-Splitting in the Cyanobacterium Synechocystis sp. PCC 6803

Böhmer, S., Köninger, K., Gomez-Baraibar, A., Bojarra, S., Mügge, C., Schmidt, S., Nowaczyk, M. & Kourist, R., Aug 2017, In : Catalysts. 7, 8, 8 p., 240.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

water splitting

regeneration

Fueling

Oxygenation

Niacinamide

Fully automatized high-throughput enzyme library screening using a robotic platform

Dörr, M., Fibinger, M. P. C., Last, D., Schmidt, S., Santos-Aberturas, J., Böttcher, D., Hummel, A., Vickers, C., Voss, M. & Bornscheuer, U. T., Jul 2016, In : Biotechnology and Bioengineering. 113, 7, p. 1421-32 12 p.

Research output: Contribution to journal › Article › Research › peer-review

Robotics

Screening

Enzymes

Throughput

amidase

Hydrogen-driven cofactor regeneration for stereoselective whole-cell C=C bond reduction in Cupriavidus necator

Assil Companioni, L., Schmidt, S., Heidinger, P., Schwab, H. & Kourist, R., 19 Mar 2019, In : ChemSusChem. 12, 11, p. 2361-2365 5 p.

Research output: Contribution to journal › Article › Research › peer-review

biotransformation

Hydrogen

regeneration

hydrogen

Hydrogenase

Kinetic insights into ϵ-caprolactone synthesis: Improvement of an enzymatic cascade reaction

Scherkus, C., Schmidt, S., Bornscheuer, U. T., Gröger, H., Kara, S. & Liese, A., 1 Jun 2017, In : Biotechnology and Bioengineering. 114, 6, p. 1215-1221 7 p.

Research output: Contribution to journal › Article › Research › peer-review

Emitter coupled logic circuits

Cyclohexanols

Lipase

Kinetics

Lipases

Overcoming the incompatibility challenge in chemo-enzymatic and multi-catalytic cascade reactions.

Schmidt, S., Castiglione, K. & Kourist, R., 6 Sep 2017, In : Chemistry - a European Journal.

Research output: Contribution to journal › Article › Research › peer-review

Photobiocatalytic alcohol oxidation using LED light sources

Rauch, M., Schmidt, S., Arends, I. W. C. E., Oppelt, K., Kara, S. & Hollmann, F., 2017, In : Green chemistry. 19, 2

Research output: Contribution to journal › Article › Research › peer-review

Process Development through Solvent Engineering in the Biocatalytic Synthesis of the Heterocyclic Bulk Chemical ε-Caprolactone

Reimer, A., Wedde, S., Staudt, S., Schmidt, S., Höffer, D., Hummel, W., Kragl, U., Bornscheuer, U. T. & Gröger, H., 2017, In : Journal of heterocyclic chemistry. 54, 1, p. 391-396 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Switch in Cofactor Specificity of a Baeyer-Villiger Monooxygenase

Beier, A., Bordewick, S., Genz, M., Schmidt, S., Van Den Bergh, T., Peters, C., Joosten, H-J. & Bornscheuer, U. T., 14 Dec 2016, In : ChemBioChem. 17, 24, p. 2312-2315 4 p.

Research output: Contribution to journal › Article › Research › peer-review

Mixed Function Oxygenases

NAD

NADP

Switches

Bearings (structural)

Switching the Regioselectivity of a Cyclohexanone Monooxygenase toward (+)-trans-Dihydrocarvone by Rational Protein Design

Balke, K., Schmidt, S., Genz, M. & Bornscheuer, U. T., 15 Jan 2016, In : ACS Chemical Biology. 11, 1, p. 38-43 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Regioselectivity

Lactones

Switches

Arthrobacter

Proteins

The effect of disulfide bond introduction and related Cys/Ser mutations on the stability of a cyclohexanone monooxygenase

Schmidt, S., Genz, M., Balke, K. & Bornscheuer, U. T., 20 Nov 2015, In : Journal of Biotechnology. 214, p. 199-211 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Mixed Function Oxygenases

Disulfides

Mutation

Enzymes

Acinetobacter

The Extreme Structural Plasticity in the CYP153 Subfamily of P450s Directs Development of Designer Hydroxylases

Fiorentini, F., Hatzl, A-M., Schmidt, S., Savino, S., Glieder, A. & Mattevi, A., 2018, In : Biochemistry. 57, 48, p. 6701-6714

Research output: Contribution to journal › Article › Research › peer-review

Mixed Function Oxygenases

Plasticity

Hydroxylation

lauric acid

Substrates

Towards environmentally acceptable synthesis of chiral alpha-hydroxy ketones via oxidase-lyase cascades

Schmidt, S., Pedroso de Almeida, T., Rother, D. & Hollmann, F., 2017, In : Green chemistry. 19, 5

Research output: Contribution to journal › Article › Research › peer-review

Using Deep Eutectic Solvents to Overcome Limited Substrate Solubility in the Enzymatic Decarboxylation of Bio-Based Phenolic Acids

Schweiger, A. K., Ríos-Lombardía, N., Winkler, C. K., Schmidt, S., Morís, F., González-Sabín, J. & Kourist, R., 8 Aug 2019, In : ACS Sustainable Chemistry & Engineering. 7, 19, p. 16364-16370

Research output: Contribution to journal › Article › Research › peer-review

decarboxylation

Eutectics

solubility

Solubility

substrate

Chapter

Library growth and protein expression: Optimal and reproducible microtiter plate expression of recombinant enzymes in E. coli using MTP Shakers

Schmidt, S., Dörr, M. & Bornscheuer, U. T., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1685. p. 145-156 12 p. (Methods in Molecular Biology; vol. 1685).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Libraries

Escherichia coli

Enzymes

Growth

Proteins

Poster

Review article

Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions

Schmidt, S., Castiglione, K. & Kourist, R., 6 Feb 2018, In : Chemistry - a European Journal. 24, 8, p. 1755-1768 14 p.

Research output: Contribution to journal › Review article › Research › peer-review

Enzyme immobilization

Purification

Catalysts

Enzymes

Photo-Biocatalysis: Biotransformations in the Presence of Light

Schmermund, L., Jurkaš, V., Özgen, F. F., Barone, G. D., Büchsenschütz, H. C., Winkler, C. K., Schmidt, S., Kourist, R. & Kroutil, W., 2019, In : ACS Catalysis. 9, 5, p. 4115-4144 30 p.

Research output: Contribution to journal › Review article › Research › peer-review

Chemical reactions

Enzymes

Biotransformation

Biocatalysis

Biocatalysts