Sandy Schmidt

Dipl.-Biochem. Dr.rer.nat.

20152019
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Research Output 2015 2019

A Fed-Batch Synthetic Strategy for a Three-Step Enzymatic Synthesis of Poly-ϵ-caprolactone

Scherkus, C., Schmidt, S., Bornscheuer, U. T., Gröger, H., Kara, S. & Liese, A., 2016, In : ChemCatChem. 8, 22

Research output: Contribution to journalArticleResearchpeer-review

Alcohol Dehydrogenases Catalyze the Reduction of Thioesters

Younes, S. H. H., Ni, Y., Schmidt, S., Kroutil, W. & Hollmann, F., 21 Apr 2017, In : ChemCatChem. 9, 8, p. 1389-1392 4 p.

Research output: Contribution to journalArticleResearchpeer-review

dehydrogenases
Alcohol Dehydrogenase
Carboxylic Acids
Ketones
Carboxylic acids

A light-driven enzyme cascade reaction for the synthesis of lactones

Büchsenschütz, H. C., Schultes, F., Schmidt, S. & Kourist, R., 9 Apr 2018.

Research output: Contribution to conferencePosterResearch

A light-driven enzyme cascade reaction for the synthesis of lactones.

Büchsenschütz, H. C., Schultes, F., Schmidt, S. & Kourist, R., 26 Aug 2018.

Research output: Contribution to conferencePosterResearch

An alternative approach towards poly-epsilon-caprolactone through a chemoenzymatic synthesis: combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates

Wedde, S., Rommelmann, P., Scherkus, C., Schmidt, S., Bornscheuer, U. T., Liese, A. & Gröger, H., 2017, In : Green chemistry. 19, 5

Research output: Contribution to journalArticleResearchpeer-review

An enzyme cascade synthesis of ε-caprolactone and its oligomers

Schmidt, S., Scherkus, C., Muschiol, J., Menyes, U., Winkler, T., Hummel, W., Gröger, H., Liese, A., Herz, H. G. & Bornscheuer, U. T., 23 Feb 2015, In : Angewandte Chemie / International Edition . 54, 9, p. 2784-2787 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclohexanols
Mixed Function Oxygenases
Oligomers
Enzymes
Peracetic Acid

A ‘COMBINATORIAL EXPLOSION’ OF PRODUCTS THROUGH PHOTO-CHEMO-ENZYMATIC CASCADES

Schmidt, S., Zhang, W., Leemans Martin, L., Fernandez Fueyo, E., Pesic, M., Wardenga, R., Kroutil, W. & Hollmann, F., 9 Jul 2017.

Research output: Contribution to conferencePosterResearch

Biocatalytic Access to Chiral Polyesters by an Artificial Enzyme Cascade Synthesis

Schmidt, S., Büchsenschütz, H. C., Scherkus, C., Liese, A., Gröger, H. & Bornscheuer, U. T., 1 Dec 2015, In : ChemCatChem. 7, 23, p. 3951-3955 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyesters
Alcohol Dehydrogenase
polyesters
enzymes
cascades

Biocatalytic oxidation reactions - a Chemist's perspective

Dong, J., Fernández-Fueyo, E., Hollmann, F., Paul, C., Pasic, M., Schmidt, S., Wang, Y., Younes, S. & Zhang, W., Jul 2018, In : Angewandte Chemie / International Edition . 57, 30, p. 9238-9261

Research output: Contribution to journalArticleResearchpeer-review

Oxidation
Oxidoreductases
Enzymes
Halogenation
Redox reactions

Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization

Zhang, W., Fernández-Fueyo, E., Hollmann, F., Leemans Martin, L., Pesic, M., Wardenga, R., Höhne, M. & Schmidt, S., 10 Jan 2019, In : European journal of organic chemistry. 2019, 1, p. 80-84 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Durch Trennen verbinden

Schmidt, S., Gröger, H. & Kourist, R., Oct 2017, In : Nachrichten aus der Chemie. 65, 10, p. 985-988 4 p.

Research output: Contribution to journalArticleResearch

Eine Enzymkaskade zur Synthese von ε-Caprolacton und dessen Oligomeren

Schmidt, S., Scherkus, C., Muschiol, J., Menyes, U., Winkler, T., Hummel, W., Gröger, H., Liese, A., Herz, H. G. & Bornscheuer, U. T., 2015, In : Angewandte Chemie. 127, 9, p. 2825-2828 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering the Amine Transaminase from Vibrio fluvialis towards Branched-Chain Substrates

Genz, M., Melse, O., Schmidt, S., Vickers, C., Dörr, M., Van Den Bergh, T., Joosten, H-J. & Bornscheuer, U. T., 20 Oct 2016, In : ChemCatChem. 8, 20, p. 3199-3202 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Transaminases
Amines
amines
engineering
Substrates

Enzymatic Oxyfunctionalization Driven by Photosynthetic Water-Splitting in the Cyanobacterium Synechocystis sp. PCC 6803

Böhmer, S., Köninger, K., Gomez-Baraibar, A., Bojarra, S., Mügge, C., Schmidt, S., Nowaczyk, M. & Kourist, R., Aug 2017, In : Catalysts. 7, 8, 8 p., 240.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
water splitting
regeneration
Fueling
Oxygenation
Niacinamide

Expanding the potential of phenolic acid decarboxylase from Bacillus subtilis by use of non-conventional solvents

Schweiger, A. K., Ríos-Lombardía, N., Winkler, C. K., Schmidt, S., Morís, F., Kroutil, W., González-Sabín, J. & Kourist, R., Jul 2019.

Research output: Contribution to conferencePosterResearch

Exploring the Substrate Scope of a Phenolic Acid Decarboxylase Variant

Schweiger, A. K., Gómez Baraibar, Á., Winkler, C. K., Kroutil, W., Schmidt, S. & Kourist, R., Jul 2017.

Research output: Contribution to conferencePosterResearch

Exploring the Substrate Scope of a Phenolic Acid Decarboxylase Variant

Schweiger, A. K., Gómez Baraibar, Á., Winkler, C. K., Kroutil, W., Schmidt, S. & Kourist, R., Sep 2017.

Research output: Contribution to conferencePosterResearch

Fully automatized high-throughput enzyme library screening using a robotic platform

Dörr, M., Fibinger, M. P. C., Last, D., Schmidt, S., Santos-Aberturas, J., Böttcher, D., Hummel, A., Vickers, C., Voss, M. & Bornscheuer, U. T., Jul 2016, In : Biotechnology and Bioengineering. 113, 7, p. 1421-32 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Robotics
Screening
Enzymes
Throughput
amidase

Hydrogen-driven cofactor regeneration for stereoselective whole-cell C=C bond reduction in Cupriavidus necator

Assil Companioni, L., Schmidt, S., Heidinger, P., Schwab, H. & Kourist, R., 19 Mar 2019, In : ChemSusChem. 12, 11, p. 2361-2365 5 p.

Research output: Contribution to journalArticleResearchpeer-review

biotransformation
Hydrogen
regeneration
hydrogen
Hydrogenase

Kinetic insights into ϵ-caprolactone synthesis: Improvement of an enzymatic cascade reaction

Scherkus, C., Schmidt, S., Bornscheuer, U. T., Gröger, H., Kara, S. & Liese, A., 1 Jun 2017, In : Biotechnology and Bioengineering. 114, 6, p. 1215-1221 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Emitter coupled logic circuits
Cyclohexanols
Lipase
Kinetics
Lipases

Library growth and protein expression: Optimal and reproducible microtiter plate expression of recombinant enzymes in E. coli using MTP Shakers

Schmidt, S., Dörr, M. & Bornscheuer, U. T., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1685. p. 145-156 12 p. (Methods in Molecular Biology; vol. 1685).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Libraries
Escherichia coli
Enzymes
Growth
Proteins

Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions

Schmidt, S., Castiglione, K. & Kourist, R., 6 Feb 2018, In : Chemistry - a European Journal. 24, 8, p. 1755-1768 14 p.

Research output: Contribution to journalReview articleResearchpeer-review

Enzyme immobilization
Purification
Catalysts
Enzymes

Overcoming the incompatibility challenge in chemo-enzymatic and multi-catalytic cascade reactions.

Schmidt, S., Castiglione, K. & Kourist, R., 6 Sep 2017, In : Chemistry - a European Journal.

Research output: Contribution to journalArticleResearchpeer-review

Photo-Biocatalysis: Biotransformations in the Presence of Light

Schmermund, L., Jurkaš, V., Özgen, F. F., Barone, G. D., Büchsenschütz, H. C., Winkler, C. K., Schmidt, S., Kourist, R. & Kroutil, W., 2019, In : ACS Catalysis. 9, 5, p. 4115-4144 30 p.

Research output: Contribution to journalReview articleResearchpeer-review

Chemical reactions
Enzymes
Biotransformation
Biocatalysis
Biocatalysts

Photobiocatalytic alcohol oxidation using LED light sources

Rauch, M., Schmidt, S., Arends, I. W. C. E., Oppelt, K., Kara, S. & Hollmann, F., 2017, In : Green chemistry. 19, 2

Research output: Contribution to journalArticleResearchpeer-review

Photobiocatalytic Nicotinamide REcycling

Winkler, C. K., Schmidt, S., Büchsenschütz, H. C., Vidimce-Risteski, V., Kourist, R. & Kroutil, W., 15 Nov 2017.

Research output: Contribution to conferencePosterResearch

Photosynthesis-driven Asymmetric reduction of c=c double bonds

Schmidt, S., Winkler, C. K., Büchsenschütz, H. C., Vidimce-Risteski, V., Kroutil, W. & Kourist, R., 15 Nov 2017.

Research output: Contribution to conferencePosterResearch

Process Development through Solvent Engineering in the Biocatalytic Synthesis of the Heterocyclic Bulk Chemical ε-Caprolactone

Reimer, A., Wedde, S., Staudt, S., Schmidt, S., Höffer, D., Hummel, W., Kragl, U., Bornscheuer, U. T. & Gröger, H., 2017, In : Journal of heterocyclic chemistry. 54, 1, p. 391-396 6 p.

Research output: Contribution to journalArticleResearchpeer-review

SETUP AND CHARACTERIZATION OF A CASCADE TRANSFORMING ARYL ALCOHOLS INTO Β-NITRO-ARYL ALCOHOLS

Pedroso de Almeida, T., Younes, S. H. H., Fernandez Fueyo, E., Schmidt, S., Arends, I. W. C. E., Riul Jr., A. & Hollmann, F., 9 Jul 2017.

Research output: Contribution to conferencePosterResearch

Small molecule Aldehydes from Carboxylic acid bioreduction

Horvat, M., Fiume, G., Stolterfoht, H., Schwendenwein, D., Schmidt, S. & Winkler, M., 9 Feb 2018.

Research output: Contribution to conferencePosterResearch

Small molecule Aldehydes from Carboxylic acid bioreduction

Horvat, M., Fiume, G., Stolterfoht, H., Schwendenwein, D., Schmidt, S. & Winkler, M., 14 Nov 2017.

Research output: Contribution to conferencePosterResearch

Switch in Cofactor Specificity of a Baeyer-Villiger Monooxygenase

Beier, A., Bordewick, S., Genz, M., Schmidt, S., Van Den Bergh, T., Peters, C., Joosten, H-J. & Bornscheuer, U. T., 14 Dec 2016, In : ChemBioChem. 17, 24, p. 2312-2315 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Mixed Function Oxygenases
NAD
NADP
Switches
Bearings (structural)

Switching the Regioselectivity of a Cyclohexanone Monooxygenase toward (+)-trans-Dihydrocarvone by Rational Protein Design

Balke, K., Schmidt, S., Genz, M. & Bornscheuer, U. T., 15 Jan 2016, In : ACS Chemical Biology. 11, 1, p. 38-43 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Regioselectivity
Lactones
Switches
Arthrobacter
Proteins

The effect of disulfide bond introduction and related Cys/Ser mutations on the stability of a cyclohexanone monooxygenase

Schmidt, S., Genz, M., Balke, K. & Bornscheuer, U. T., 20 Nov 2015, In : Journal of Biotechnology. 214, p. 199-211 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mixed Function Oxygenases
Disulfides
Mutation
Enzymes
Acinetobacter

The Extreme Structural Plasticity in the CYP153 Subfamily of P450s Directs Development of Designer Hydroxylases

Fiorentini, F., Hatzl, A-M., Schmidt, S., Savino, S., Glieder, A. & Mattevi, A., 2018, In : Biochemistry. 57, 48, p. 6701-6714

Research output: Contribution to journalArticleResearchpeer-review

Mixed Function Oxygenases
Plasticity
Hydroxylation
lauric acid
Substrates

Towards environmentally acceptable synthesis of chiral alpha-hydroxy ketones via oxidase-lyase cascades

Schmidt, S., Pedroso de Almeida, T., Rother, D. & Hollmann, F., 2017, In : Green chemistry. 19, 5

Research output: Contribution to journalArticleResearchpeer-review

Using Deep Eutectic Solvents to Overcome Limited Substrate Solubility in the Enzymatic Decarboxylation of Bio-Based Phenolic Acids

Schweiger, A. K., Ríos-Lombardía, N., Winkler, C. K., Schmidt, S., Morís, F., González-Sabín, J. & Kourist, R., 8 Aug 2019, In : ACS Sustainable Chemistry & Engineering. 7, 19, p. 16364-16370

Research output: Contribution to journalArticleResearchpeer-review

decarboxylation
Eutectics
solubility
Solubility
substrate