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Research Output 1995 2019

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2019

Festphasen- und Flowsynthese (Trendbericht, Organische Chemie 2018)

Breinbauer, R., 2019, In : Nachrichten aus der Chemie. 67, 3, p. 53-54

Research output: Contribution to journalArticleResearch

Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities

Unterhauser, K., Pöltl, L., Schneditz, G., Kienesberger, S., Glabonjat, R. A., Kitsera, M., Pletz, J., Josa-Prado, F., Dornisch, E., Lembacher-Fadum, C., Roier, S., Gorkiewicz, G., Lucena, D., Barasoain, I., Kroutil, W., Wiedner, M., Loizou, J. I., Breinbauer, R., Díaz, J. F., Schild, S. & 2 othersHögenauer, C. & Zechner, E. L., 26 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3774-3783 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Klebsiella oxytoca
Enterotoxins
Microtubules
Pseudomembranous Enterocolitis
Colitis

Selective Formation of 4,4′-Biphenols by Anodic Dehydrogenative Cross- and Homo-Coupling Reaction

Dahms, B., Kohlpaintner, P. J., Wiebe, A., Breinbauer, R., Schollmeyer, D. & Waldvogel, S. R., 21 Feb 2019, In : Chemistry - A European Journal. 25, 11, p. 2713-2716 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Phenols
Electricity
Chemical activation
Economics
Catalysts

Synthesis of 2-Pyrrolidinones by Palladium-Catalyzed [3+2] Cycloaddition of Isocyanates

Kljajic, M., Schlatzer, T. & Breinbauer, R., 2019, In : Synlett. 30, 5, p. 581-585 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Isocyanates
Cycloaddition
Palladium
Alkenes
Allylation
2018

Aliphatic hydroxylation and epoxidation of capsaicin by Cytochrome P450 CYP505X

Migglautsch, A. K., Willim, M., Schweda, B., Glieder, A., Breinbauer, R. & Winkler, M., 31 Aug 2018, In : Tetrahedron. 74, p. 6199-6204

Research output: Contribution to journalArticleResearchpeer-review

Application of Threonine Aldolases for the Asymmetric Synthesis of α-Quaternary α-Amino Acids

Blesl, J., Trobe, M., Anderl, F., Breinbauer, R., Strohmeier, G. A. & Fesko, K., 21 Aug 2018, In : ChemCatChem. 10, 16, p. 3453-3458 6 p.

Research output: Contribution to journalArticleResearchpeer-review

aldolase
Glycine Hydroxymethyltransferase
amino acids
Amino acids
pseudomonas

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie / International Edition . 57, p. 7240 –7244

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Asymmetrische reduktive Carbocyclisierung durch modifizierte En‐Reduktasen

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie. 130, p. 7360-7364

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase

Parajuli, N., Takahara, S., Matsumura, N., Kim, T. T., Ferdaoussi, M., Migglautsch, A. K., Zechner, R., Breinbauer, R., Kershaw, E. E. & Dyck, J. R. B., 1 Oct 2018, In : American Journal of Physiology / Heart and Circulatory Physiology. 315, 4, p. H879-H884

Research output: Contribution to journalArticleResearchpeer-review

Lipase
Adipocytes
Heart Failure
Treatment Failure
atglistatin

Festphasen- und Flowsynthese (Trendbericht, Organische Chemie 2017)

Breinbauer, R., 2018, In : Nachrichten aus der Chemie. 66, p. 256-257

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention

Guttenberger, N., Schlatzer, T., Leypold, M., Tassoti, S. & Breinbauer, R., 2018, In : Monatshefte für Chemie = Chemical monthly. 149, p. 847-856 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition

Aschauer, P., Zimmermann, R., Breinbauer, R., Pavkov-Keller, T. & Oberer, M., 2018, In : Scientific reports. 8, 1, 8948.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2017

Additive-Free Pd-Catalyzed α-Allylation of Imine-Containing Heterocycles

Kljajic, M., Puschnig, J. G., Weber, H. & Breinbauer, R., 2017, In : Organic letters. 19, p. 126-129

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Biosynthese des enterotoxischen Pyrrolobenzodiazepin-Naturstoffs Tilivallin

Dornisch, E., Pletz, J., Glabonjat, R. A., Martin, F., Lembacher-Fadum, C., Neger, M., Högenauer, C., Francesconi, K. A., Kroutil, W., Zangger, K., Breinbauer, R. & Zechner, E. L., 2017, In : Angewandte Chemie. 129, p. 14948–14952

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline

Dornisch, E., Pletz, J., Glabonjat, R. A., Martin, F., Lembacher-Fadum, C., Neger, M., Högenauer, C., Francesconi, K. A., Kroutil, W., Zangger, K., Breinbauer, R. & Zechner, E. L., 2017, In : Angewandte Chemie / International Edition . 56, p. 14753–14757

Research output: Contribution to journalArticleResearchpeer-review

Open Access

C-H and C-C bond insertion reactions of diazo compounds into aldehydes

Guttenberger, N. & Breinbauer, R., 2017, In : Tetrahedron. 73, p. 6815-6829

Research output: Contribution to journalArticleResearchpeer-review

Festphasen- und Flowsynthese (Trendbericht Organische Chemie 2016)

Breinbauer, R., 2017, In : Nachrichten aus der Chemie. 65, p. 274-275

Research output: Contribution to journalArticleResearchpeer-review

Mechanisms and Specificity of Phenazine Biosynthesis Protein PhzF

Diederich, C., Leypold, M., Culka, M., Weber, H., Breinbauer, R., Ullmann, G. M. & Blankenfeldt, W., 1 Dec 2017, In : Scientific reports. 7, 1, 6272.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Molecular mechanics
Quantum theory
Biosynthesis
Hydrogen
Protons

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Schweiger, M., Romauch, M., Schreiber, R., Grabner, G., Hütter, S., Kotzbeck, P., Benedikt, P., Eichmann, T. O., Yamada, S., Knittelfelder, O., Diwoky, C., Doler, C. J., Mayer, N., De Cocco, W., Breinbauer, R., Zimmermann, R. & Zechner, R., 2017, In : Nature Communications . 8, 14 p., 14859.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products

Guttenberger, N., Blankenfeldt, W. & Breinbauer, R., 2017, In : Bioorganic & medicinal chemistry. 25, p. 6149-6166

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Sequential and iterative Pd-catalyzed cross-coupling reactions in organic synthesis

Dobrounig, P. S., Trobe, M. & Breinbauer, R., 2017, In : Monatshefte für Chemie = Chemical monthly. 148, 1, p. 3-35

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases

Brodl, E., Ivkovic, J., Tabib, C., Breinbauer, R. & Macheroux, P., 13 Jan 2017, In : Bioorganic & medicinal chemistry. 25, 4, p. 1487-1495

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Bacterial Luciferases
Aldehydes
Bioluminescence
Light emission
Substrates
2016

A General and Direct Reductive Amination of Aldehydes and Ketones with Electron-Deficient Anilines

Pletz, J., Berg, B. & Breinbauer, R., 2016, In : Synthesis. 48, p. 1301-1307

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Aus zwei mach eins: die Biosynthese der Phenazine

Diederich, C., Leypold, M., Breinbauer, R. & Blankenfeldt, W., 2016, In : Biospektrum. 22, p. 137-139

Research output: Contribution to journalArticleResearch

Characterization of the monolignol oxidoreductase AtBBE-like protein 15 L182V for biocatalytic applications

Pils, S., Schnabl, K., Wallner, S., Kljajic, M., Kupresanin, N., Breinbauer, R., Schrittwieser, J., Fuchs, M., Kroutil, W., Daniel, B. & Macheroux, P., 2016, In : Journal of molecular catalysis / B. 133, Suppl.1, p. S6-S14

Research output: Contribution to journalArticleResearchpeer-review

Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism

Doler, C. J., Schweiger, M., Zimmermann, R. & Breinbauer, R., 2016, In : ChemBioChem. 17, p. 358 – 377

Research output: Contribution to journalArticleResearchpeer-review

Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p

Aschauer, P., Rengachari, S., Lichtenegger, J., Schittmayer, M., Das, K. M., Mayer, N., Breinbauer, R., Birner-Grünberger, R., Gruber, C. C., Zimmermann, R., Gruber, K. & Oberer, M., 2016, In : Biochimica et biophysica acta. 1861, p. 462 470 p.

Research output: Contribution to journalArticleResearchpeer-review

Enzymatic hydrolysis of poly(ethylene furanoate)

Pellis, A., Haernvall, K., Pichler, C. M., Ghazaryan, G., Breinbauer, R. & Gübitz, G., 2016, In : Journal of Biotechnology. 235, p. 47-53

Research output: Contribution to journalArticleResearchpeer-review

Festphasen- und Flowsynthese (Trendbericht, Organische Chemie 2015)

Breinbauer, R., 2016, In : Nachrichten aus der Chemie. 64, p. 262-263

Research output: Contribution to journalArticleResearch

Improved and Scalable Synthesis of Building Blocks for the Modular Synthesis of Teraryl-based alpha-Helix Mimetics

Trobe, M. & Breinbauer, R., 2016, In : Monatshefte für Chemie = Chemical monthly. 147, p. 509-521

Research output: Contribution to journalArticleResearchpeer-review

Target identification of covalently binding drugs by activity-based protein profiling (ABPP)

Pichler, C. M., Krysiak, J. M. & Breinbauer, R., 2016, In : Bioorganic & medicinal chemistry. 24, p. 3291-3303

Research output: Contribution to journalArticleResearchpeer-review

Target identification of small molecule drugs and chemical probes

Breinbauer, R., 2016, In : Bioorganic & medicinal chemistry. 24, p. 3231-3231

Research output: Contribution to journalArticleResearchpeer-review

Tracking protein S-fatty acylation with proteomics

Birner-Gruenberger, R. & Breinbauer, R., 2016, In : ChemBioChem. 17, p. 1488-1490

Research output: Contribution to journalArticleResearchpeer-review

2015

Adiose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of the hepatic stellate cells

Taschler, U., Schreiber, R., Chitraju, C., Grabner, G. F., Romauch, M., Wolinski, H., Haemmerle, G., Breinbauer, R., Zechner, R., Lass, A. & Zimmermann, R., 2015, In : Biochimica et biophysica acta. 1851, p. 937-945

Research output: Contribution to journalArticleResearchpeer-review

A robust and simple protocol for the synthesis of arylfluorophosphonates

Leypold, M., Wallace, P. W., Kljajic, M., Schittmayer, M., Pletz, J., Illaszewicz-Trattner, C., Gübitz, G., Birner-Grünberger, R. & Breinbauer, R., 2015, In : Tetrahedron letters. 56, p. 5619-5622

Research output: Contribution to journalArticleResearchpeer-review

Biocatalyzed approach for the surface functionalization of poly(L-lactic acid) films using hydrolytic enzymes

Pellis, A., Herrero Acero, E., Weber, H., Obersriebnig, M., Breinbauer, R., Srebotnik, E. & Gübitz, G., 2015, In : Biotechnology journal. 10, p. 1739-1749

Research output: Contribution to journalArticleResearchpeer-review

Diversity-Oriented Synthesis of a Library of Star-Shaped 2H-Imidazolines

Yu, X., Guttenberger, N., Fuchs, E., Peters, M., Weber, H. & Breinbauer, R., 2015, In : ACS Combinatorial Science. 17, p. 682-690

Research output: Contribution to journalArticleResearchpeer-review

Expanding the threonine aldolase toolbox for the asymmetric synthesis of tertiary α-amino acids

Lypetska (Fesko), K., Strohmeier, G. & Breinbauer, R., 2015, In : Applied Microbiology and Biotechnology. 99, p. 9651-9661

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Fatty acid-binding proteins interact with comparative gene identification-58 linking lipolysis with lipid ligand shuttling

Hofer, P., Boeszoermenyi, A., Jaeger, D., Feiler, U., Arthanari, H., Mayer, N., Zehender, F., Rechberger, G., Oberer, M., Zimmermann, R., Lass, A., Haemmerle, G., Breinbauer, R., Zechner, R. & Preiss-Landl, K., 2015, In : The Journal of Biological Chemistry. 290, p. 18438-18453

Research output: Contribution to journalArticleResearchpeer-review

Festphasen- und Flowsynthese (Trendberichte Organische Chemie 2014)

Breinbauer, R., 2015, In : Nachrichten aus der Chemie. 63, p. 273-273

Research output: Contribution to journalArticleResearchpeer-review

Structure-activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL)

Mayer, N., Schweiger, M., Melcher, M-C., Fledelius, C., Zechner, R., Zimmermann, R. & Breinbauer, R., 2015, In : Bioorganic & medicinal chemistry. 23, p. 2904-2916

Research output: Contribution to journalArticleResearchpeer-review

Weighing the Proteasome for Covalent Modifications

Birner-Gruenberger, R. & Breinbauer, R., 2015, In : Chemistry & biology. 22, p. 315-316

Research output: Contribution to journalArticleResearchpeer-review

α/β Hydrolase Domain-Containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

Pribasnig, M. A., Mrak, I., Grabner, G. F., Taschler, U., Knittelfelder, O., Scherz, B., Eichmann, T. O., Heier, C., Grumet, L., Kowaliuk, J., Romauch, M., Holler, S., Anderl, F., Wolinski, H., Lass, A., Breinbauer, R., Marsche, G., Brown, J. M. & Zimmermann, R., 2015, In : The Journal of Biological Chemistry. 290, p. 29869-29881

Research output: Contribution to journalArticleResearchpeer-review

2014

Biosynthese der Phenazine

Diederich, C., Leypold, M., Breinbauer, R. & Blankenfeldt, W., 2014, In : Nachrichten aus der Chemie. 62, p. 975-980

Research output: Contribution to journalArticleResearchpeer-review

Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis

Schneditz, G., Rentner, J., Roier, S., Pletz, J., Herzog, K. A. T., Brücker, R., Tröger, H., Schild, S., Weber, H., Breinbauer, R., Gorkiewicz, G., Högenauer, C. & Zechner, E. L., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, p. 13181-13186

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Exploring the new threonine aldolases with broad donor specificity

Lypetska, K., Strohmeier, G. & Breinbauer, R., 2014, In : New biotechnology. 31, p. S87-S87

Research output: Contribution to journalArticleResearchpeer-review

Festphasensynthese (Trendberichte Organische Chemie 2013)

Breinbauer, R., 2014, In : Nachrichten aus der Chemie. 62, p. 273-274

Research output: Contribution to journalArticleResearchpeer-review

More than just a halogenase: modification of fatty acyl moieties by a trifunctional metal enzyme

Pratter, S. M., Ivkovic, J., Birner-Gruenberger, R., Breinbauer, R., Zangger, K. & Straganz, G. D., 2014, In : ChemBioChem. 15, 4, p. 567-574

Research output: Contribution to journalArticleResearchpeer-review

Recent advances and applications of reductive desulfurization in organic synthesis

Rentner, J., Kljajic, M., Offner, L. & Breinbauer, R., 2014, In : Tetrahedron. 70, p. 8983-9027

Research output: Contribution to journalArticleResearchpeer-review