1995 …2021
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Research Output 1995 2019

2019

Capsaicin Metabolite Synthesis by Fungal Cytochrome P450

Willim, M., Bachler, T., Schweda, B., Migglautsch, A. K., Glieder, A., Breinbauer, R. & Winkler, M., 14 Feb 2019.

Research output: Contribution to conferencePosterResearch

Festphasen- und Flowsynthese (Trendbericht, Organische Chemie 2018)

Breinbauer, R., 2019, In : Nachrichten aus der Chemie. 67, 3, p. 53-54

Research output: Contribution to journalArticleResearch

Iodonium-based Probes for the Activity-based Protein Profiling of Oxidoreductases

Kljajic, M., Darnhofer, B., Schittmayer, M., Kollau, A., Mayer, B., Birner-Grünberger, R. & Breinbauer, R., 28 Mar 2019.

Research output: Contribution to conferencePosterResearchpeer-review

Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities

Unterhauser, K., Pöltl, L., Schneditz, G., Kienesberger, S., Glabonjat, R. A., Kitsera, M., Pletz, J., Josa-Prado, F., Dornisch, E., Lembacher-Fadum, C., Roier, S., Gorkiewicz, G., Lucena, D., Barasoain, I., Kroutil, W., Wiedner, M., Loizou, J. I., Breinbauer, R., Díaz, J. F., Schild, S. & 2 othersHögenauer, C. & Zechner, E. L., 26 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3774-3783 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Klebsiella oxytoca
Enterotoxins
Microtubules
Pseudomembranous Enterocolitis
Colitis

Selective Formation of 4,4′-Biphenols by Anodic Dehydrogenative Cross- and Homo-Coupling Reaction

Dahms, B., Kohlpaintner, P. J., Wiebe, A., Breinbauer, R., Schollmeyer, D. & Waldvogel, S. R., 21 Feb 2019, In : Chemistry - A European Journal. 25, 11, p. 2713-2716 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Phenols
Electricity
Chemical activation
Economics
Catalysts

Synthesis of 2-Pyrrolidinones by Palladium-Catalyzed [3+2] Cycloaddition of Isocyanates

Kljajic, M., Schlatzer, T. & Breinbauer, R., 2019, In : Synlett. 30, 5, p. 581-585 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Isocyanates
Cycloaddition
Palladium
Alkenes
Allylation
2018

Aliphatic hydroxylation and epoxidation of capsaicin by Cytochrome P450 CYP505X

Migglautsch, A. K., Willim, M., Schweda, B., Glieder, A., Breinbauer, R. & Winkler, M., 31 Aug 2018, In : Tetrahedron. 74, p. 6199-6204

Research output: Contribution to journalArticleResearchpeer-review

Application of Threonine Aldolases for the Asymmetric Synthesis of α-Quaternary α-Amino Acids

Blesl, J., Trobe, M., Anderl, F., Breinbauer, R., Strohmeier, G. A. & Fesko, K., 21 Aug 2018, In : ChemCatChem. 10, 16, p. 3453-3458 6 p.

Research output: Contribution to journalArticleResearchpeer-review

aldolase
Glycine Hydroxymethyltransferase
amino acids
Amino acids
pseudomonas

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie / International Edition . 57, p. 7240 –7244

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Asymmetrische reduktive Carbocyclisierung durch modifizierte En‐Reduktasen

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie. 130, p. 7360-7364

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase

Parajuli, N., Takahara, S., Matsumura, N., Kim, T. T., Ferdaoussi, M., Migglautsch, A. K., Zechner, R., Breinbauer, R., Kershaw, E. E. & Dyck, J. R. B., 1 Oct 2018, In : American Journal of Physiology / Heart and Circulatory Physiology. 315, 4, p. H879-H884

Research output: Contribution to journalArticleResearchpeer-review

Lipase
Adipocytes
Heart Failure
Treatment Failure
atglistatin

Development of Small-Molecule Inhibitors of Adipose Triglyceride Lipase (ATGL)

Migglautsch, A. K., Doler, C. J., Schweiger, M., Mayer, N., Fuchs, E., Grabner, G., Romauch, M., Zechner, R., Zimmermann, R. & Breinbauer, R., 6 Sep 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Festphasen- und Flowsynthese (Trendbericht, Organische Chemie 2017)

Breinbauer, R., 2018, In : Nachrichten aus der Chemie. 66, p. 256-257

Research output: Contribution to journalArticleResearchpeer-review

Palladium-Mediated Allylation of Cysteine for Site-Selective Bioconjugation

Schlatzer, T., Kriegesmann, J., Becker, C. F. W. & Breinbauer, R., 18 Sep 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Palladium-Mediated Allylation of Cysteine for Site-Selective Bioconjugation

Schlatzer, T., Kriegesmann, J., Becker, C. F. W. & Breinbauer, R., 13 Dec 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Palladium-Mediated Allylation of Cysteine for Site-Selective Bioconjugation of Peptides and Proteins

Schlatzer, T., Kriegesmann, J., Schröder, H., Trobe, M., Becker, C. F. W. & Breinbauer, R., 29 Aug 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Pd-Mediated Allylation of Cysteine for Site-Selective Bioconjugation of Peptides and Proteins

Schlatzer, T., Kriegesmann, J., Schröder, H., Trobe, M., Lembacher-Fadum, C., Becker, C. F. W. & Breinbauer, R., 10 Sep 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Synthesis and Biological Characterization of Teraryl-based alpha-Helix-Mimetics

Blesl, J., Vareka, M., Trobe, M. & Breinbauer, R., 26 Jun 2018.

Research output: Contribution to conferencePosterResearch

Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention

Guttenberger, N., Schlatzer, T., Leypold, M., Tassoti, S. & Breinbauer, R., 2018, In : Monatshefte für Chemie = Chemical monthly. 149, p. 847-856 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition

Aschauer, P., Zimmermann, R., Breinbauer, R., Pavkov-Keller, T. & Oberer, M., 2018, In : Scientific reports. 8, 1, 8948.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Total Syntheses of Tilivalline and Tilimycin, Cytotoxic Secondary Metabolites of Klebsiella Oxytoca

Lembacher-Fadum, C., Dornisch, E., Pletz, J., Glabonjat, R. A., Martin, F., Neger, M., Högenauer, C., Francesconi, K. A., Kroutil, W., Zangger, K., Zechner, E. L. & Breinbauer, R., 27 Aug 2018.

Research output: Contribution to conferencePosterResearchpeer-review

2017

Additive-Free Pd-Catalyzed α-Allylation of Imine-Containing Heterocycles

Kljajic, M., Puschnig, J. G., Weber, H. & Breinbauer, R., 2017, In : Organic letters. 19, p. 126-129

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A General and Direct Reductive Amination of Aldehydes and Ketones with Electron-Deficient Anilines

Berg, B., Pletz, J. & Breinbauer, R., 3 Sep 2017.

Research output: Contribution to conferencePosterResearch

Biosynthese des enterotoxischen Pyrrolobenzodiazepin-Naturstoffs Tilivallin

Dornisch, E., Pletz, J., Glabonjat, R. A., Martin, F., Lembacher-Fadum, C., Neger, M., Högenauer, C., Francesconi, K. A., Kroutil, W., Zangger, K., Breinbauer, R. & Zechner, E. L., 2017, In : Angewandte Chemie. 129, p. 14948–14952

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline

Dornisch, E., Pletz, J., Glabonjat, R. A., Martin, F., Lembacher-Fadum, C., Neger, M., Högenauer, C., Francesconi, K. A., Kroutil, W., Zangger, K., Breinbauer, R. & Zechner, E. L., 2017, In : Angewandte Chemie / International Edition . 56, p. 14753–14757

Research output: Contribution to journalArticleResearchpeer-review

Open Access

C-H and C-C bond insertion reactions of diazo compounds into aldehydes

Guttenberger, N. & Breinbauer, R., 2017, In : Tetrahedron. 73, p. 6815-6829

Research output: Contribution to journalArticleResearchpeer-review

Chemoenzymatic Synthesis of α-Quaternary Stereogenic α-Amino Acids

Blesl, J., Strohmeier, G., Fesko, K. & Breinbauer, R., 30 Aug 2017.

Research output: Contribution to conferencePosterResearch

Chemoenzymatic Synthesis of α-Quaternary Stereogenic α-Amino Acids

Blesl, J., Strohmeier, G., Fesko, K. & Breinbauer, R., 25 Sep 2017.

Research output: Contribution to conferencePosterResearch

Comparative Activity-Based Flavin-Dependent Oxidase Profiling

Krysiak, J. M. & Breinbauer, R., 2017, Methods in Molecular Biology: Activity-Based Proteomics. Springer, Vol. 1491. p. 87-99

Research output: Chapter in Book/Report/Conference proceedingChapterResearch

Development of small-molecule inhibitors of Adipose Triglyceride Lipase (ATGL)

Migglautsch, A. K., Doler, C. J., Schweiger, M., Mayer, N., Fuchs, E., Grabner, G., Romauch, M., Zechner, R., Zimmermann, R. & Breinbauer, R., 25 Sep 2017.

Research output: Contribution to conferencePosterResearch

Festphasen- und Flowsynthese (Trendbericht Organische Chemie 2016)

Breinbauer, R., 2017, In : Nachrichten aus der Chemie. 65, p. 274-275

Research output: Contribution to journalArticleResearchpeer-review

Investigation of an Unexpected Cyclization During a Horner-Wadsworth-Emmons Reaction

Lembacher-Fadum, C., Ivkovic, J., Pletz, J., Ratzenböck, K., Maringer, M., Weber, H., Fischer, R. & Breinbauer, R., 5 Sep 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Kinetic studies of inhibition of hDPP3 by hydroxyethylene transition state peptidomimetics

Jha, S., Ivkovic, J., Kumar, P., Taschler, U., Zimmermann, R., Gruber, K., Breinbauer, R. & Macheroux, P., 3 Feb 2017.

Research output: Contribution to conferencePosterResearch

Mechanisms and Specificity of Phenazine Biosynthesis Protein PhzF

Diederich, C., Leypold, M., Culka, M., Weber, H., Breinbauer, R., Ullmann, G. M. & Blankenfeldt, W., 1 Dec 2017, In : Scientific reports. 7, 1, 6272.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Molecular mechanics
Quantum theory
Biosynthesis
Hydrogen
Protons

New Palladium Catalyzed Approach towards 5-membered Nitrogen-containing Heterocycles

Kljajic, M. & Breinbauer, R., 22 Jul 2017.

Research output: Contribution to conferencePosterResearch

New “old yellow enzyme”: a reductive C-C bond formation using engineered enoate reductase

Heckenbichler, K., Schweiger, A. K., Gruber, K., Macheroux, P. & Breinbauer, R., 9 Jul 2017.

Research output: Contribution to conferencePosterResearch

Peptidomimetic transition state inhibitors as chemical probes to explore in-vivo role of dipeptidyl peptidase 3

Jha, S., Ivkovic, J., Kumar, P., Taschler, U., Zimmermann, R., Gruber, K., Breinbauer, R. & Macheroux, P., Jul 2017.

Research output: Contribution to conferencePosterResearch

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Schweiger, M., Romauch, M., Schreiber, R., Grabner, G., Hütter, S., Kotzbeck, P., Benedikt, P., Eichmann, T. O., Yamada, S., Knittelfelder, O., Diwoky, C., Doler, C. J., Mayer, N., De Cocco, W., Breinbauer, R., Zimmermann, R. & Zechner, R., 2017, In : Nature Communications . 8, 14 p., 14859.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Pharmacological Inhibition of Adipose Triglyceride Lipase corrects High-Fat Diet-Induced Insulin Resistance and Hepatosteatosis in mice

Breinbauer, R., Doler, C. J., Schweiger, M., Migglautsch, A. K., Mayer, N., Grabner, G., Zechner, R. & Zimmermann, R., 13 Sep 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Pharmacological inhibition of ATGL (Adipose Triglyceride Lipase) corrects high-fat diet-induced hepatosteatosis in mice

Schweiger, M., Mayer, N., Romauch, M., Grabner, G., Doler, C. J., Migglautsch, A. K., Hütter, S., Kotzbeck, P., Eichmann, T. O., Yamada, S., Knittelfelder, O., Diwoky, C., Lass, A., Zechner, R., Zimmermann, R. & Breinbauer, R., 27 Jun 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Post-Translational Pd-Catalyzed S-Prenylation of Peptides and Proteins

Schlatzer, T., Schröder, H., Trobe, M., Lembacher-Fadum, C., Becker, C. & Breinbauer, R., 28 Sep 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products

Guttenberger, N., Blankenfeldt, W. & Breinbauer, R., 2017, In : Bioorganic & medicinal chemistry. 25, p. 6149-6166

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePosterResearch

Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePosterResearch

Sequential and iterative Pd-catalyzed cross-coupling reactions in organic synthesis

Dobrounig, P. S., Trobe, M. & Breinbauer, R., 2017, In : Monatshefte für Chemie = Chemical monthly. 148, 1, p. 3-35

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Stabilization of a cancer associated variant of human NQO1 by the use of small-molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Waltenstorfer, D., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePosterResearch

Substrate specificity of CYP505X from Aspergillus fumigatus

Bachler, T., Alkofer, A., Gralewska, P., Weninger, A., Glieder, A., Breinbauer, R. & Winkler, M., 11 Jul 2017.

Research output: Contribution to conferencePosterResearch

Synthesis of an Amphiphilic Oligoaryl-based ApoA1 Mimetic

Dobrounig, P. S. & Breinbauer, R., 29 Jul 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases

Brodl, E., Ivkovic, J., Tabib, C., Breinbauer, R. & Macheroux, P., 13 Jan 2017, In : Bioorganic & medicinal chemistry. 25, 4, p. 1487-1495

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Bacterial Luciferases
Aldehydes
Bioluminescence
Light emission
Substrates
2016

A General and Direct Reductive Amination of Aldehydes and Ketones with Electron-Deficient Anilines

Pletz, J., Berg, B. & Breinbauer, R., 28 Jun 2016.

Research output: Contribution to conferencePosterResearch