Peter Macheroux

Univ.-Prof. Dr.rer.nat.

1982 …2020
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Research Output 1982 2018

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2018

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie / International Edition . 57, p. 7240 –7244

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Asymmetrische reduktive Carbocyclisierung durch modifizierte En‐Reduktasen

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie. 130, p. 7360-7364

Research output: Contribution to journalArticleResearchpeer-review

Open Access

In Situ Measurement and Correlation of Cell Density and Light Emission of Bioluminescent Bacteria

Brodl, E., Niederhauser, J. & Macheroux, P., 26 Jun 2018, In : Journal of visualized experiments . 136, e57881, 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Novel concurrent redox cascades of (R)- and (S)-carvones enables access to carvo-lactones with distinct regio- and enantioselectivity

Iqbal, N., Stewart, J. D., Macheroux, P., Rudroff, F. & Mihovilovic, M. D., 27 Dec 2018, In : Tetrahedron. 74, 52, p. 7389-7394 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Regioselectivity
Stereoisomerism
Enantioselectivity
Lactones
Mixed Function Oxygenases

Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family

Lahham, M., Pavkov-Keller, T., Fuchs, M., Niederhauser, J., Chalhoub, G., Daniel, B., Kroutil, W., Gruber, K. & Macheroux, P., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 44, p. 17021-17032 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Dihydroxyphenylalanine
Cyclization
Amines
Oxidoreductases
Stereoisomerism

The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase

Toplak, M., Wiedemann, G., Ulićević, J., Daniel, B., Hoernstein, S. N. W., Kothe, J., Niederhauser, J., Reski, R., Winkler, A. & Macheroux, P., May 2018, In : The FEBS journal. 285, 10, p. 1923-1943 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Biosynthesis
Alkaloids
Cellulose
Eschscholzia
Genes
2017

Biosensor for the characterisation of hMAO B inhibitors and the quantification of selegiline

Aigner, M., Preissegger, P., Kalcher, K., Mehmeti, E., Macheroux, P., Edmondson, D. & Ortner, A., 4 Jul 2017, In : Talanta. 174 (2017), p. 696-702

Research output: Contribution to journalArticleResearchpeer-review

Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H: quinone oxidoreductase 1 (NQO1)

Lienhart, W. D., Strandback, E., Gudipati, V., Koch, K., Binter, A., Uhl, M. K., Rantasa, D. M., Bourgeois, B., Madl, T., Zangger, K., Gruber, K. & Macheroux, P., 1 Apr 2017, In : FEBS Journal. 284, 8, p. 1233-1245 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mental Competency
Enzyme activity
Enzymes
Chemical activation
Cells

Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides theraiotaomicron

Sabljic, I., Meštrović Radan, N., Vukelić, B., Macheroux, P., Gruber, K., Luić, M. & Abramic, M., 2 Nov 2017, In : PLoS ONE.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Evidence for the generation of myristylated FMN by bacterial luciferase

Tabib, C., Brodl, E. & Macheroux, P., 19 Apr 2017, In : Molecular microbiology. 104, 6, p. 1027–1036

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability

Tongsook, C., Niederhauser, J., Kronegger, E., Straganz, G. D. & Macheroux, P., 1 Jan 2017, In : Biochimica et Biophysica Acta / Molecular Basis of Disease. 1863, 1, p. 188-199 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Histamine N-Methyltransferase
Protein Stability
Leucine
Intellectual Disability
Histamine

Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H: quinone oxidoreductase

Koch, K., Hromic, A., Sorokina, M., Strandback, E., Reisinger, M., Gruber, K. & Macheroux, P., 1 Aug 2017, In : Biochimica et Biophysica Acta / Proteins and Proteomics. 1865, 8, p. 1046-1056 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Flavin Mononucleotide
NAD
Yeast
Saccharomyces cerevisiae
Oxidoreductases

Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases

Brodl, E., Ivkovic, J., Tabib, C., Breinbauer, R. & Macheroux, P., 13 Jan 2017, In : Bioorganic & Medicinal Chemistry. 25, 4, p. 1487-1495

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Bacterial Luciferases
Aldehydes
Bioluminescence
Light emission
Substrates
2016

Characterization of the monolignol oxidoreductase AtBBE-like protein 15 L182V for biocatalytic applications

Pils, S., Schnabl, K., Wallner, S., Kljajic, M., Kupresanin, N., Breinbauer, R., Schrittwieser, J., Fuchs, M., Kroutil, W., Daniel, B. & Macheroux, P., 2016, In : Journal of molecular catalysis / B. 133, Suppl.1, p. S6-S14

Research output: Contribution to journalArticleResearchpeer-review

Determination of Total Monoamines in Rat Brain via Nanotubes Based Human Monoamine Oxidase B Biosensor

Macheroux, P., Lienhart, W-D., Wallner, S., Aigner, M., Ortner, A., Kalcher, K. & Edmondson, D., 1 Aug 2016, In : Electroanalysis. p. 367-373

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural and kinetic studies on RosA, the enzyme catalyzing the methylation of 8-demethyl-8-amino-D-riboflavin to the antibiotic roseoflavin

Tongsook, C., Uhl, M. K., Jankowitsch, F., Mack, M., Gruber, K. & Macheroux, P., 2016, In : The FEBS journal. 283, 8, p. 1531-1549

Research output: Contribution to journalArticleResearchpeer-review

Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant

Augustin, P., Hromic, A., Pavkov-Keller, T., Gruber, K. & Macheroux, P., 1 Oct 2016, In : The FEBS journal. p. 3587-3603 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Dimethylglycine Dehydrogenase
Enzymes
Databases
Flavin-Adenine Dinucleotide
Pichia

Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae

Daniel, B., Wallner, S., Steiner, B., Oberdorfer, G., Kumar, P., van der Graaff, E., Roitsch, T., Sensen, C. W., Gruber, K. & Macheroux, P., 2016, In : PLoS ONE. 11, 6, p. e0156892

Research output: Contribution to journalArticleResearchpeer-review

Brassicaceae
berberine
Histidine
active sites
Catalytic Domain

Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition

Kumar, P., Reithofer, V., Reisinger, M., Pavkov-Keller, T., Wallner, S., Macheroux, P. & Gruber, K., 2016, In : Scientific reports. 6, 23787.

Research output: Contribution to journalArticleResearchpeer-review

2015

Amperometric biosensor for total monoamines using a glassy carbon paste electrode modified with human monoamine oxidase B and manganese dioxide particles

Aigner, M., Telsnig, D., Kalcher, K., Teubl, C., Macheroux, P., Wallner, S., Edmondson, D. & Ortner, A., 2015, In : Microchimica acta. 182, p. 925-931

Research output: Contribution to journalArticleResearchpeer-review

Anthranoyl-CoA monooxygenase/reductase from Azoarcus evansii possesses both FMN and FAD in two distinct and independent active sites

Bergner, T., Pavkov-Keller, T., Kreuzer, K., Kowaliuk, J., Plank, M., Runggatscher, K., Turrini, N. G., Zucol, B., Wallner, S., Faber, K., Gruber, K. & Macheroux, P., 2015, In : Biochimica et Biophysica Acta. 1854, 8, p. 890-896

Research output: Contribution to journalArticleResearchpeer-review

Enantioselective oxidative aerobic dealkylation of N-ethylbenzylisoquinolines employing the berberine bridge enzyme

Gandomkar, S., Fischereder, E-M., Schrittwieser, J., Wallner, S., Habibi, Z., Macheroux, P. & Kroutil, W., 2015, In : Angewandte Chemie / International Edition . 54, p. 15051-15054

Research output: Contribution to journalArticleResearchpeer-review

Enantioselektive oxidative aerobe Desalkylierung von N-Ethylbenzyl-isochinolinen mithilfe des Berberin-Brücken-Enzyms

Gandomkar, S., Fischereder, E-M., Schrittwieser, J. H., Wallner, S., Habibi, Z., Macheroux, P. & Kroutil, W., 2015, In : Angewandte Chemie. 127, p. 15265-15268

Research output: Contribution to journalArticleResearchpeer-review

Mutations in the histamine N-methyltransferase gene, HNMT, are associated with non-syndromic autosomal recessive intellectual disability

Heidari, A., Tongsook, C., Najafipour, R., Musante, L., Vasli, N., Garshasbi, M., Hu, H., Mittal, K., McNaughton, A., Sritharan, K., Hudson, M., Stehr, H., Talebi, S., Moradi, M., Darvish, H., Rafiq, M. A., Mozhdehipanah, H., Windpassinger, C., Gillessen-Kaesbach, G., Tzschach, A. & 11 othersAhmed, I., Mikhailov, A., Stavropoulos, J., Carter, M., Keshavarz, S., Ayub, M., Najmabadi, H., Liu, X., Ropers, H. H., Macheroux, P. & Vincent, J., 2015, In : Human molecular genetics. 24, 20, p. 5697-5710

Research output: Contribution to journalArticleResearchpeer-review

Oxidation of monolignols by members of the berberine bridge enzyme family suggests a role in plant cell wall metabolism

Daniel, B., Pavkov-Keller, T., Steiner, B., Dodic, A., Gutmann, A., Nidetzky, B., Sensen, C. W., van der Graaff, E., Wallner, S., Gruber, K. & Macheroux, P., 2015, In : The Journal of Biological Chemistry. 290, 30, p. 18770-18781

Research output: Contribution to journalArticleResearchpeer-review

Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction

Zafred, D., Steiner, B., Teufelberger, A. R., Hromic, A., Karplus, A. P., Schofield, C. J., Wallner, S. & Macheroux, P., 2015, In : The FEBS journal. 282, p. 3060-3074

Research output: Contribution to journalArticleResearchpeer-review

Structural and biochemical properties of LuxF from Photobacterium leiognathi

Bergner, T., Tabib, C., Winkler, A., Stipsits, S., Kayer, H., Lee, J., Mayhew, S., Malthouse, J., Müller, F., Gruber, K. & Macheroux, P., 2015, In : Biochimica et Biophysica Acta. 1854, 10, p. 1466-1475

Research output: Contribution to journalArticleResearchpeer-review

Structure-based mechanism of oleate hydratase from Elizabethkingia meningoseptica

Engleder, M., Pavkov-Keller, T., Emmerstorfer, A., Altijana, H., Schrempf, S., Steinkellner, G., Wriessnegger, T., Leitner, E., Strohmeier, G., Kaluzna, I., Daniel, M., Martin, S., Wallner, S., Macheroux, P., Gruber, K. & Pichler, H., 2015, In : ChemBioChem. 16, p. 1730-1734

Research output: Contribution to journalArticleResearchpeer-review

2014

Collapse of the native structure by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase (NQO1)

Lienhart, W-D., Gudipati, V., Uhl, M. K., Binter, A., Pulido, S., Saf, R., Zangger, K., Gruber, K. & Macheroux, P., 2014, In : The FEBS journal. 281, p. 4691-4704

Research output: Contribution to journalArticleResearchpeer-review

Deracemisierung durch simultane bio-oxidative Racematspaltung und Stereoinversion

Schrittwieser, J. H., Groenendaal, B., Resch, V., Ghislieri, D., Wallner, S., Fischereder, E-M., Fuchs, E., Grischek, B., Sattler, J. H., Macheroux, P., Turner, N. J. & Kroutil, W., 2014, In : Angewandte Chemie. 126, 14, p. 3805-3809

Research output: Contribution to journalArticleResearchpeer-review

Determination of free and bound riboflavin in cow's milk using a novel flavin-binding protein

Koop, J., Monschein, S., Macheroux, E. P., Knaus, T. & Macheroux, P., 2014, In : Food chemistry. 146, p. 94-97

Research output: Contribution to journalArticleResearchpeer-review

Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability

Bernkopf, M., Webersinke, G., Tongsook, C., Koyani, C. N., Arshad, M., Ayaz, M., Müller, D., Enzinger, C., Aslam, M., Naeem, F., Schmidt, K., Gruber, K., Speicher, M. R., Malle, E., Macheroux, P., Ayub, M., Vincent, J. B., Windpassinger, C. & Duba, H-C., 2014, In : Human molecular genetics. 23, 15, p. 4015-4023

Research output: Contribution to journalArticleResearchpeer-review

Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations

Steinkellner, G., Gruber, C. C., Pavkov-Keller, T., Binter, A., Steiner, K., Winkler, C., Lyskowski, A., Schwamberger, O., Oberer, M., Schwab, H., Faber, K., Macheroux, P. & Gruber, K., 2014, In : Nature Communications . 5, 4150, p. 1-9

Research output: Contribution to journalArticleResearchpeer-review

Simultaneous bio-oxidative kinetic resolution and stereoinversion

Schrittwieser, J. H., Groenendaal, B., Resch, V., Ghislieri, D., Wallner, S., Fischereder, E-M., Fuchs, E., Grischek, B., Sattler, J. H., Macheroux, P., Turner, N. J. & Kroutil, W., 2014, In : Angewandte Chemie / International Edition . 53, p. 3731-3734

Research output: Contribution to journalArticleResearchpeer-review

Structure and stability of an unusual zinc-binding protein from Bacteroides thetaiotaomicron

Knaus, T., Uhl, M. K., Monschein, S., Moratti, S., Gruber, K. & Macheroux, P., 2014, In : Biochimica et Biophysica Acta. 1844, p. 2298-2305

Research output: Contribution to journalArticleResearchpeer-review

The flavoproteome of the yeast Saccharomyces cerevisiae

Gudipati, V., Koch, K., Lienhart, W-D. & Macheroux, P., 2014, In : Biochimica et Biophysica Acta. 1844, 3, p. 535-544

Research output: Contribution to journalArticleResearchpeer-review

2013

Asymmetric amination of tetralone and chromanone derivatives employing omega-transaminases

Pressnitz, D., Fuchs, C. S., Sattler, J. H., Knaus, T., Macheroux, P., Mutti, F. G. & Kroutil, W., 2013, In : ACS Catalysis. 3, p. 555-559

Research output: Contribution to journalArticleResearchpeer-review

One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases

Schober, M., Toesch, M., Knaus, T., Strohmeier, G., van Loo, B., Fuchs, M., Hollfelder, F., Macheroux, P. & Faber, K., 2013, In : Angewandte Chemie / International Edition . 52, 11, p. 3277-3279

Research output: Contribution to journalArticleResearchpeer-review

One-pot deracemization of sec-alcohols: enantioconvergent enzymatic hydrolysis of alkyl sulfates using stereo complementary sulfatases

Schober, M., Knaus, T., Toesch, M., Strohmeier, G., van Loo, B., Fuchs, M., Hollfelder, F., Macheroux, P. & Faber, K., 2013, In : Angewandte Chemie. 125, 11, p. 3359-3361

Research output: Contribution to journalArticleResearchpeer-review

The flavoenzyme azobenzene reductase AzoR from Escherichia coli binds roseoflavin mononucleotide (RoFMN) with high affinity and is less active in its RoFMN form

Langer, S., Nakanishi, S., Mathes, T., Knaus, T., Binter, A., Macheroux, P., Mase, T., Miyakawa, T., Tanokura, M. & Mack, M., 2013, In : Biochemistry. 52, p. 4288-4295

Research output: Contribution to journalArticleResearchpeer-review

The human flavoproteome

Lienhart, W-D., Gudipati, V. & Macheroux, P., 2013, In : Archives of Biochemistry and Biophysics. 535, p. 150-162

Research output: Contribution to journalArticleResearchpeer-review

The shikimate pathway in apicomplexan parasites: Implications for drug development

Derrer, B., Macheroux, P. & Kappes, B., 2013, In : Frontiers in bioscience / Landmark edition. 18, 3, p. 944-969

Research output: Contribution to journalArticleResearchpeer-review

The structure of glycerol trinitrate reductase NerA from Agrobacterium radiobacter reveals the molecular reason for nitro- and ene-reductase activity in OYE homologues

Oberdorfer, G., Binter, A., Wallner, S., Durchschein, K., Hall, M., Faber, K., Macheroux, P. & Gruber, K., 2013, In : ChemBioChem. 14, p. 836-845

Research output: Contribution to journalArticleResearchpeer-review

2012

Activity-Based Probes for Studying the Activity of Flavin-Dependent Oxidases and for the Protein Target Profiling of Monoamine Oxidase Inhibitors

Krysiak, J. M., Kreuzer, J., Macheroux, P., Hermetter, A., Sieber, S. A. & Breinbauer, R., 2012, In : Angewandte Chemie / International Edition . 51, p. 7035-7040

Research output: Contribution to journalArticleResearchpeer-review

Aktivitätsbasierte Sondenmoleküle zur Untersuchung der Aktivität Flavin-abhängiger Oxidasen und zum Zielprotein-Profiling von Monoaminooxidase-Inhibitoren

Krysiak, J. M., Kreuzer, J., Macheroux, P., Hermetter, A., Sieber, S. A. & Breinbauer, R., 2012, In : Angewandte Chemie. 124, p. 7142-7147

Research output: Contribution to journalArticleResearchpeer-review

Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme

Wallner, S., Winkler, A., Riedl, S., Dully, C., Horvath, S., Gruber, K. & Macheroux, P., 2012, In : Biochemistry. 51, p. 6139-6147

Research output: Contribution to journalArticleResearchpeer-review

Entropy driven binding of opioid peptides induces a large domain motion in human DPP III

Bezerra, G. A., Dobrovetsky, E., Viertlmayer, R., Dong, A., Binter, A., Abramic, M., Macheroux, P., Dhe-Paganon, S. & Gruber, K., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, p. 6525-6530

Research output: Contribution to journalArticleResearchpeer-review

Inverting the regioselectivity of berberine bridge enzyme employing customized fluorine-containing substrates

Resch, V., Lechner, H., Schrittwieser, J. H., Wallner, S., Gruber, K., Macheroux, P. & Kroutil, W., 2012, In : Chemistry - A European Journal. 18, 41, p. 13173-13179

Research output: Contribution to journalArticleResearchpeer-review

Nicotinamide-dependent ene reductases as alternative biocatalysts for the reduction of activated alkenes

Durchschein, K., Wallner, S., Macheroux, P., Schwab, W., Winkler, T., Kreis, W. & Faber, K., 2012, In : European journal of organic chemistry. p. 4963-4968

Research output: Contribution to journalArticleResearchpeer-review

Reverse structural genomics: An unusual flavin binding site in a putative protease from Bacteroides thetaiotaomicron

Knaus, T., Eger, E., Koop, J., Stipsits, S., Kinsland, C. L., Ealick, S. E. & Macheroux, P., 2012, In : The Journal of Biological Chemistry. 287, p. 27490-27498

Research output: Contribution to journalArticleResearchpeer-review