Peter Macheroux

Univ.-Prof. Dr.rer.nat.

1982 …2023
If you made any changes in Pure these will be visible here soon.

Research Output 1982 2018

2018

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie / International Edition . 57, p. 7240 –7244

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Asymmetrische reduktive Carbocyclisierung durch modifizierte En‐Reduktasen

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie. 130, p. 7360-7364

Research output: Contribution to journalArticleResearchpeer-review

Open Access

In Situ Measurement and Correlation of Cell Density and Light Emission of Bioluminescent Bacteria

Brodl, E., Niederhauser, J. & Macheroux, P., 26 Jun 2018, In : Journal of visualized experiments . 136, e57881, 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

LuxF and its various roles in bacterial bioluminescence

Brodl, E., Horn, C., Niederhauser, J. & Macheroux, P., 2018.

Research output: Contribution to conferencePosterResearch

Molecular Mechanisms of Bacterial Bioluminescence

Brodl, E., Winkler, A. & Macheroux, P., 2018, In : Computational and Structural Biotechnology Journal. 16, p. 551 564 p.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access

Novel concurrent redox cascades of (R)- and (S)-carvones enables access to carvo-lactones with distinct regio- and enantioselectivity

Iqbal, N., Stewart, J. D., Macheroux, P., Rudroff, F. & Mihovilovic, M. D., 27 Dec 2018, In : Tetrahedron. 74, 52, p. 7389-7394 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Regioselectivity
Stereoisomerism
Enantioselectivity
Lactones
Mixed Function Oxygenases

Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family

Lahham, M., Pavkov-Keller, T., Fuchs, M., Niederhauser, J., Chalhoub, G., Daniel, B., Kroutil, W., Gruber, K. & Macheroux, P., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 44, p. 17021-17032 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Dihydroxyphenylalanine
Cyclization
Amines
Oxidoreductases
Stereoisomerism

The monolignol oxidoreductase AtBBE-like protein 15: Characterization, rational engineering and biocatalytic applications.

Daniel, B., Messenlehner, J., Schrittwieser, J. H., Pils, S., Kroutil, W. & Macheroux, P., 28 Aug 2018.

Research output: Contribution to conferencePosterResearchpeer-review

The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase

Toplak, M., Wiedemann, G., Ulićević, J., Daniel, B., Hoernstein, S. N. W., Kothe, J., Niederhauser, J., Reski, R., Winkler, A. & Macheroux, P., May 2018, In : The FEBS journal. 285, 10, p. 1923-1943 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Biosynthesis
Alkaloids
Cellulose
Eschscholzia
Genes
2017

Application of hydratases for flavor and fragrance synthesis

Engleder, M., Pavkov-Keller, T., Emmerstorfer, A., Hromic, A., Schrempf, S., Steinkellner, G., Wriessnegger, T., Leitner, E., Strohmeier, G., Kaluzna, I., Daniel, M., Schürmann, M., Wallner, S., Macheroux, P., Pichler, H. & Gruber, K., 14 Nov 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Application of hydratases for flavour and fragrance synthesis

Engleder, M., Pavkov-Keller, T., Emmerstorfer, A., Altijana, H., Schrempf, S., Steinkellner, G., Wriessnegger, T., Leitner, E., Strohmeier, G., Kaluzna, I., Mink, D., Schürmann, M., Wallner, S., Macheroux, P., Gruber, K. & Pichler, H., 20 Sep 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Bacterial bioluminescence: the in vitro formation of myrFMN

Brodl, E., Tabib, C. & Macheroux, P., 3 Feb 2017.

Research output: Contribution to conferencePosterResearch

Biosensor for the characterisation of hMAO B inhibitors and the quantification of selegiline

Aigner, M., Preissegger, P., Kalcher, K., Mehmeti, E., Macheroux, P., Edmondson, D. & Ortner, A., 4 Jul 2017, In : Talanta. 174 (2017), p. 696-702

Research output: Contribution to journalArticleResearchpeer-review

Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H: quinone oxidoreductase 1 (NQO1)

Lienhart, W. D., Strandback, E., Gudipati, V., Koch, K., Binter, A., Uhl, M. K., Rantasa, D. M., Bourgeois, B., Madl, T., Zangger, K., Gruber, K. & Macheroux, P., 1 Apr 2017, In : FEBS Journal. 284, 8, p. 1233-1245 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mental Competency
Enzyme activity
Enzymes
Chemical activation
Cells

Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides theraiotaomicron

Sabljic, I., Meštrović Radan, N., Vukelić, B., Macheroux, P., Gruber, K., Luić, M. & Abramic, M., 2 Nov 2017, In : PLoS ONE.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Evidence for the generation of myristylated FMN by bacterial luciferase

Tabib, C., Brodl, E. & Macheroux, P., 19 Apr 2017, In : Molecular microbiology. 104, 6, p. 1027–1036

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Genomic integration of luxF into the Vibrio harveyi lux operon

Brodl, E., Schild, S. & Macheroux, P., 2017.

Research output: Contribution to conferencePosterResearch

Kinetic studies of inhibition of hDPP3 by hydroxyethylene transition state peptidomimetics

Jha, S., Ivkovic, J., Kumar, P., Taschler, U., Zimmermann, R., Gruber, K., Breinbauer, R. & Macheroux, P., 3 Feb 2017.

Research output: Contribution to conferencePosterResearch

Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability

Tongsook, C., Niederhauser, J., Kronegger, E., Straganz, G. D. & Macheroux, P., 1 Jan 2017, In : Biochimica et Biophysica Acta / Molecular Basis of Disease. 1863, 1, p. 188-199 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Histamine N-Methyltransferase
Protein Stability
Leucine
Intellectual Disability
Histamine

New “old yellow enzyme”: a reductive C-C bond formation using engineered enoate reductase

Heckenbichler, K., Schweiger, A. K., Gruber, K., Macheroux, P. & Breinbauer, R., 9 Jul 2017.

Research output: Contribution to conferencePosterResearch

Peptidomimetic transition state inhibitors as chemical probes to explore in-vivo role of dipeptidyl peptidase 3

Jha, S., Ivkovic, J., Kumar, P., Taschler, U., Zimmermann, R., Gruber, K., Breinbauer, R. & Macheroux, P., Jul 2017.

Research output: Contribution to conferencePosterResearch

Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePosterResearch

Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePosterResearch

Stabilization of a cancer associated variant of human NQO1 by the use of small-molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Waltenstorfer, D., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePosterResearch

Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H: quinone oxidoreductase

Koch, K., Hromic, A., Sorokina, M., Strandback, E., Reisinger, M., Gruber, K. & Macheroux, P., 1 Aug 2017, In : Biochimica et Biophysica Acta / Proteins and Proteomics. 1865, 8, p. 1046-1056 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Flavin Mononucleotide
NAD
Yeast
Saccharomyces cerevisiae
Oxidoreductases

Structure-based reaction mechanism of oleate hydratase from Elizabethkingia meningoseptica

Engleder, M., Pavkov-Keller, T., Emmerstorfer-Augustin, A., Hromic, A., Schrempf, S., Steinkellner, G., Wriessnegger, T., Leitner, E., Strohmeier, G., Kaluzna, I., Daniel, M., Martin, S., Wallner, S., Macheroux, P., Gruber, K. & Pichler, H., 23 Apr 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Hydro-Lyases
Oleic Acid
Hydration
Flavin-Adenine Dinucleotide
Carbon

Studying the role of the only berberine bridge enzyme-like protein in Physcomitrella patens

Toplak, M., Ulicevic, J., Daniel, B., Wallner, S. & Macheroux, P., 3 Feb 2017.

Research output: Contribution to conferencePosterResearch

Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases

Brodl, E., Ivkovic, J., Tabib, C., Breinbauer, R. & Macheroux, P., 13 Jan 2017, In : Bioorganic & Medicinal Chemistry. 25, 4, p. 1487-1495

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Bacterial Luciferases
Aldehydes
Bioluminescence
Light emission
Substrates

The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions: A treasure-trove of oxidative reactions

Daniel, B., Konrad, B., Toplak, M., Lahham, M., Messenlehner, J., Winkler, A. & Macheroux, P., 15 Oct 2017, In : Archives of Biochemistry and Biophysics. 632, p. 88-103 16 p.

Research output: Contribution to journalReview articleResearchpeer-review

Flavin-Adenine Dinucleotide
Eschscholzia
Enzymes
Flavin Mononucleotide
Riboflavin

The origin of the berberine bridge enzyme-like protein family in plants

Toplak, M., Wiedemann, G., Ulicevic, J., Daniel, B., Hoernstein, S., Kothe, J., Reski, R., Winkler, A. & Macheroux, P., Jul 2017.

Research output: Contribution to conferencePosterResearch

2016

Bacterial bioluminescence: the mystery of myristylated flavins

Macheroux, P., 15 Apr 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Berberine bridge enzyme-like proteins: a multi-gene family from vascular plants

Daniel, B., Steiner, B., Pavkov-Keller, T., Gruber, K., van der Graaff, E., Roitsch, T., Wallner, S. & Macheroux, P., 14 Jun 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Berberine bridge enzyme-like proteins: From characterization to application

Daniel, B., Pils, S., Steiner, B., Wallner, S., Pavkov-Keller, T., Gruber, K., Schrittwieser, J., Fuchs, M., Kroutil, W. & Macheroux, P., 12 Sep 2016.

Research output: Contribution to conferencePosterResearch

Characterization and therapeutic exploitation of human dipeptidyl peptidase III (hDPPIII): an enzyme with multifaceted functionality

Jha, S., Taschler, U., Ivkovic, J., Breinbauer, R., Gruber, K., Zimmermann, R. & Macheroux, P., Sep 2016.

Research output: Contribution to conferencePosterResearch

Characterization of the monolignol oxidoreductase AtBBE-like protein 15 L182V for biocatalytic applications

Pils, S., Schnabl, K., Wallner, S., Kljajic, M., Kupresanin, N., Breinbauer, R., Schrittwieser, J., Fuchs, M., Kroutil, W., Daniel, B. & Macheroux, P., 2016, In : Journal of molecular catalysis / B. 133, Suppl.1, p. S6-S14

Research output: Contribution to journalArticleResearchpeer-review

Determination of Total Monoamines in Rat Brain via Nanotubes Based Human Monoamine Oxidase B Biosensor

Macheroux, P., Lienhart, W-D., Wallner, S., Aigner, M., Ortner, A., Kalcher, K. & Edmondson, D., 1 Aug 2016, In : Electroanalysis. p. 367-373

Research output: Contribution to journalArticleResearchpeer-review

Open Access

EasC and EasE – what is their role in chanoclavine I formation?

Toplak, M., Wallner, S. & Macheroux, P., Feb 2016.

Research output: Contribution to conferencePosterResearch

Function of monolignol oxidoreductases from the berberine bridge enzyme-like protein family in Arabidopsis thaliana

Steiner, B., Daniel, B., Jammer, A., Wallner, S., Gruber, K., Pavkov, T., van der Graaff, E., Müller, M., Roitsch, T. & Macheroux, P., 2016.

Research output: Contribution to conferencePosterResearch

Investigation of the Reasons for the Destabilization of a Natural Variant of NAD(P)H:quinone oxidoreductase 1

Strandback, E. S., Lienhart, W-D., Gudipati, V. & Macheroux, P., 5 Feb 2016.

Research output: Contribution to conferencePosterResearch

In vitro bioluminescence: an enzyme cascade producing myrFMN

Brodl, E., Tabib, C. & Macheroux, P., 28 Aug 2016.

Research output: Contribution to conferencePosterResearch

Monolignol oxidoreductases from the berberine bridge enzyme-like protein family

Steiner, B., Daniel, B., Wallner, S., Gruber, K., Pavkov, T., van der Graaff, E., Roitsch, T. & Macheroux, P., 2016.

Research output: Contribution to conferencePosterResearch

New insights in bacterial bioluminescence: in vitro myrFMN production

Brodl, E., Tabib, C. & Macheroux, P., 7 Jul 2016.

Research output: Contribution to conferencePosterResearch

New “old yellow enzyme”: Reductive C-C bond formation using an engineered enoate reductase

Heckenbichler, K., Schweiger, A. K., Binter, A., Macheroux, P., Gruber, K. & Breinbauer, R., 2016.

Research output: Contribution to conferencePosterResearch

Novel insights into structural destabilization of a cancer associated variant of human NQO1

Strandback, E. S., Lienhart, W-D., Hromic, A., Pletz, J., Köberl, C., Gudipati, V., Gruber, K., Breinbauer, R. & Macheroux, P., 2016.

Research output: Contribution to conferencePosterResearch

On the way to rescue the stability and activity of a cancer associated variant of human NQO1

Strandback, E. S., Lienhart, W-D., Köberl, C., Hromic, A., Pletz, J., Gudipati, V., Zangger, K., Gruber, K., Breinbauer, R. & Macheroux, P., 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

PpBBE-studying the origine of BBE-like enzymes in plants

Toplak, M., Ulicevic, J., Daniel, B., Wallner, S. & Macheroux, P., 30 Sep 2016.

Research output: Contribution to conferencePosterResearch

PpBBE – the ancestor of berberine bridge enzyme-like enzymes in plants?

Toplak, M., Daniel, B., Wallner, S., Wiedemann, G., Reski, R. & Macheroux, P., Jul 2016.

Research output: Contribution to conferencePosterResearch

Role of enzymes involved in Bacterial Bioluminescence

Brodl, E., Tabib, C., Ivkovic, J., Breinbauer, R. & Macheroux, P., 7 Jan 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Structural and kinetic studies on RosA, the enzyme catalyzing the methylation of 8-demethyl-8-amino-D-riboflavin to the antibiotic roseoflavin

Tongsook, C., Uhl, M. K., Jankowitsch, F., Mack, M., Gruber, K. & Macheroux, P., 2016, In : The FEBS journal. 283, 8, p. 1531-1549

Research output: Contribution to journalArticleResearchpeer-review