19992020

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2020

Co-factor demand and regeneration in the enzymatic one-step reduction of carboxylates to aldehydes in cell-free systems

Strohmeier, G., Schwarz, A., Andexer, J. N. & Winkler, M., 10 Jan 2020, In : Journal of Biotechnology. 307, p. 202-207 14 p.

Research output: Contribution to journalArticle

Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

Wiltschi, B., Cernava, T., Dennig, A., Galindo, M., Geier, M., Gruber, S., Haberbauer, M., Heidinger, P., Acero, E. H., Kratzer, R., Luley-Goedl, C., Müller, C. A., Pitzer, J., Ribitsch, D., Sauer, M., Schmölzer, K., Schnitzhofer, W., Sensen, C. W., Soh, J., Steiner, K. & 3 others, Winkler, C. K., Winkler, M. & Wriessnegger, T., 22 Jan 2020, In : Biotechnology Advances. p. 107520

Research output: Contribution to journalArticle

Functional Expression and Characterization of a Panel of Cobalt and Iron-Dependent Nitrile Hydratases

Grill, B., Glänzer, M., Schwab, H., Kerstin, S., Pienaar, D., Brady, D., Donsbach, K. & Winkler, M., 29 May 2020, In : Molecules . 25, 11, 11 p., 2521.

Research output: Contribution to journalArticle

Open Access

High-throughput in-field bioprospecting for cyanogenic plants and hydroxynitrile lyases

Tomescu, M-S., Davids, D., DuPlessis, M., Darnhofer, B., Birner-Gruenberger, R., Archer, R., Schwendenwein, D., Thallinger, G., Winkler, M. & Rumbold, K., 2020, In : Biocatalysis and Biotransformation. 38, 3, p. 234-240

Research output: Contribution to journalArticle

In vivo reduction of medium- to long-chain fatty acids by carboxylic acid reductase (CAR) enzymes: limitations and solutions

Horvat, M. & Winkler, M., 7 Jul 2020, (Accepted/In press) In : ChemCatChem. 16 p.

Research output: Contribution to journalArticle

Open Access

Pyrazines: Synthesis and Industrial Application of these Valuable Flavor and Fragrance Compounds

Mortzfeld, F. B., Hashem, C., Vranková, K., Winkler, M. & Rudroff, F., 17 Jul 2020, In : Biotechnology Journal. 2020, 15

Research output: Contribution to journalArticle

Open Access
Open Access
2019

A functionally-distinct carboxylic acid reductase (PcCAR4) unearthed from a repertoire of type IV CARs in the white-rot fungus Pycnoporus cinnabarinus

Ling, J. G., Mansor, M. H., Murad, M. A., Khalid, R. M., Quay, D. H-X., Winkler, M. & Bakar, F. D. A., 2019, In : Journal of Biotechnology. 2020, 307, p. 55-62

Research output: Contribution to journalArticle

Characterization of Type IV Carboxylate Reductases (CARs) for Whole Cell-Mediated Preparation of 3-Hydroxytyrosol

Horvat, M., Fritsche, S., Kourist, R. & Winkler, M., 19 Mar 2019, In : ChemCatChem. p. 4171-4181

Research output: Contribution to journalArticle

Open Access

Discovery of carboxylic acid reductase (CAR) from Thermothelomyces thermophilus and its evaluation for vanillin synthesis

Horvat, M., Fiume, G., Fritsche, S. & Winkler, M., 12 Aug 2019, In : Journal of Biotechnology. 304, p. 44-51

Research output: Contribution to journalArticle

Enzymatic One-Step Reduction of Carboxylates to Aldehydes with Cell-Free Regeneration of ATP and NADPH

Strohmeier, G., Eiteljörg, I., Schwarz, A. & Winkler, M., 26 Apr 2019, In : Chemistry - a European Journal. 25, 24, p. 6119-6123 5 p.

Research output: Contribution to journalArticle

Open Access

Exploring the Biocatalytic Potential of a Self‐Sufficient Cytochrome P450 from Thermothelomyces thermophila

Fürst, M. J. L. J., Kerschbaumer, B., Rinnofner, C., Migglautsch, A. K., Winkler, M. & Fraaije, M. W., 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2487-2496

Research output: Contribution to journalArticle

Open Access

Random Mutagenesis-Driven Improvement of Carboxylate Reductase Activity Using an Amino Benzamidoxime-Mediated High-Throughput Assay

Schwendenwein, D., Ressmann, A. K., Dörr, M., Höhne, M., Mihovilovic, M. D., Bornscheuer, U. T., Rudroff, F. & Winkler, M., 6 Jun 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2544-2549 6 p.

Research output: Contribution to journalArticle

Substrate-Independent High-Throughput Assay for the Quantification of Aldehydes

Ressmann, A. K., Schwendenwein, D., Leonhartsberger, S., Mihovilovic, M. D., Bornscheuer, U. T., Winkler, M. & Rudroff, F., 6 Jul 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2538-2543 6 p.

Research output: Contribution to journalArticle

2018

Aliphatic hydroxylation and epoxidation of capsaicin by Cytochrome P450 CYP505X

Migglautsch, A. K., Willim, M., Schweda, B., Glieder, A., Breinbauer, R. & Winkler, M., 31 Aug 2018, In : Tetrahedron. 74, p. 6199-6204

Research output: Contribution to journalArticle

Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090

Liu, Y., Gong, R., Liu, X., Zhang, P., Zhang, Q., Cai, Y-S., Deng, Z., Winkler, M., Wu, J. & Chen, W., 2018, In : Microbial cell factories . 17, 10 p., 131.

Research output: Contribution to journalArticle

Open Access

Identification of key residues for enzymatic carboxylate reduction

Stolterfoht, H., Steinkellner, G., Schwendenwein, D., Pavkov-Keller, T., Gruber, K. & Winkler, M., 12 Feb 2018, In : Frontiers in Microbiology . 9, 250.

Research output: Contribution to journalArticle

Production of Hydroxynitrile Lyase from Davallia tyermannii (DtHNL) in Komagataella phaffii and Its Immobilization as a CLEA to Generate a Robust Biocatalyst

Lanfranchi, E., Grill, B., Raghoebar, Z., Van Pelt, S., Sheldon, R. A., Steiner, K., Glieder, A. & Winkler, M., 2018, In : ChemBioChem. 19, 4, p. 312-316 10.1002/cbic.201700419.

Research output: Contribution to journalArticle

2017

Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily

Lanfranchi, E., Pavkov-Keller, T., Koehler, E-M., Diepold, M., Steiner, K., Darnhofer, B., Hartler, J., Van Den Bergh, T., Joosten, H-J., Gruber-Khadjawi, M., Thallinger, G. G., Birner-Gruenberger, R., Gruber, K., Winkler, M. & Glieder, A., 10 May 2017, In : Scientific Reports. 7, 46738.

Research output: Contribution to journalArticle

Open Access

Erratum: Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily

Lanfranchi, E., Pavkov-Keller, T., Koehler, E-M., Diepold, M., Steiner, K., Darnhofer, B., Hartler, J., Bergh, T. V. D., Joosten, H-J., Gruber-Khadjawi, M., Thallinger, G. G., Birner-Gruenberger, R., Gruber, K., Winkler, M. & Glieder, A., 26 May 2017, In : Scientific Reports. 7, 46834.

Research output: Contribution to journalArticle

Open Access

IN VIVO SYNTHESIS OF POLYHYDROXYLATED COMPOUNDS FROM A ‘HIDDEN RESERVOIR’ OF TOXIC ALDEHYDE SPECIES

Bayer, T., Wiesinger, T., Milker, S., Winkler, M., Mihovilovic, M. D. & Rudroff, F., 2017, In : ChemCatChem. 9, p. 2919-2923

Research output: Contribution to journalArticle

2016

Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans

Fiorentini, F., Geier, M., Binda, C., Winkler, M., Faber, K., Hall, M. & Matteiv, A., 2016, In : ACS Chemical Biology. p. 1039 1048 p.

Research output: Contribution to journalArticle

Human xanthine oxidase recombinant in E. coli: A whole cell catalyst for preparative drug metabolite synthesis

Ferreira Antunes, M., Eggimann, F. K., Kittelmann, M., Lütz, S., Hanlon, S. P., Wirz, B., Bachler, T. & Winkler, M., 2016, In : Journal of Biotechnology. 235, p. 3-10

Research output: Contribution to journalArticle

Pichia pastoris mutants as host strains for efficient secretion of recombinant Branched Chain Aminotransferase (BCAT)

Weinhandl, K., Ballach, M., Winkler, M., Mudassar, A., Glieder, A., Birner-Gruenberger, R., Fotheringham, I. & Escalettes, F., 2016, In : Journal of Biotechnology. 235, p. 84-91 8 p.

Research output: Contribution to journalArticle

TRAMETES VERSICOLOR CARBOXYLATE REDUCTASE UNCOVERED

Winkler, M. & Winkler, C. K., Mar 2016, In : Monatshefte für Chemie = Chemical monthly. 147, 3, p. 575-578

Research output: Contribution to journalArticle

2015

Bioprospecting for Hydroxynitrile Lyases by Blue Native PAGE Coupled HCN Detection

Lanfranchi, E., Köhler, E-M., Darnhofer, B., Steiner, K., Birner-Grünberger, R., Glieder, A. & Winkler, M., 2015, In : Current biotechnology. 4, 2, p. 111-117

Research output: Contribution to journalArticle

Drug Metabolite Synthesis with Human Enzymes

Winkler, M., 2015, In : International pharmaceutical industry. 7, 3, p. 32-36

Research output: Contribution to journalArticle

FLUORINATED AMINO ACIDS – A RARITY IN NATURE YET A PROSPECT FOR PROTEIN ENGINEERING

Odar, C., Winkler, M. & Wiltschi, B., 2015, In : Biotechnology Journal. 10, 3, p. 427-446

Research output: Contribution to journalArticle

Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis

Geier, M., Bachler, T., Hanlon, S. P., Eggimann, F. K., Kittelmann, M., Weber, H., Lütz, S., Wirz, B. & Winkler, M., 2015, In : Microbial cell factories . 14, 82, p. 1-10

Research output: Contribution to journalArticle

The Nitrile forming Enzyme 7-Cyano-7-deazaguanine Synthase from Geobacillus kaustophilus: A reverse Nitrilase?

Winkler, M., Dokulil, K., Weber, H., Pavkov-Keller, T. & Wilding, B., 2015, In : ChemBioChem. 16, p. 2373-2378

Research output: Contribution to journalArticle

2014

BIOCATALYTIC REDUCTION OF CARBOXYLIC ACIDS

Napora, K., Strohmeier, G. & Winkler, M., 2014, In : Biotechnology Journal. 9, p. 822-843

Research output: Contribution to journalArticle

Carbon source dependent promoters in yeasts

Weinhandl, K., Winkler, M., Glieder, A. & Camattari, A., 2014, In : Microbial cell factories . 13, p. 5-21

Research output: Contribution to journalArticle

PRODUCTION OF RECOMBINANT HUMAN ALDEHYDE OXIDASE IN E. COLI AND OPTIMIZATION OF ITS APPLICATION FOR PREPARATIVE SYNTHESIS OF OXIDIZED DRUG METABOLITES

Rodrigues, D., Kittelmann, M., Eggimann, F., Bachler, T., Abad, S., Camattari, A., Glieder, A., Winkler, M. & Lütz, S., 2014, In : ChemCatChem. 6, 4, p. 1028-1042

Research output: Contribution to journalArticle

Whole cell carboxylate reduction for the synthesis of 3-hydroxytyrosol

Napora, K., Robins, K., Osorio-Lozada, A. & Winkler, M., 2014, In : ChemCatChem. 6, 4, p. 1089-1095

Research output: Contribution to journalArticle

2013

Enantiocomplementary Yarrowia lipolytica Oxidoreductases: Alcohol Dehydrogenase 2 and Short Chain Dehydrogenase/Reductase

Napora, K., Strohmeier, G., Sonavane, M. N., Avi, M., Robins, K. & Winkler, M., 2013, In : Biomolecules. 3, p. 449-460

Research output: Contribution to journalArticle

RECENT DEVELOPMENTS IN HYDROXYNITRILE LYASES FOR INDUSTRIAL BIOTECHNOLOGY

Lanfranchi, E., Steiner, K., Glieder, A., Hajnal, I., Sheldon, R. A., van Pelt, S. & Winkler, M., 2013, In : Recent patents on biotechnology. 7, 3, p. 197-206

Research output: Contribution to journalArticle

Targeting the Substrate Binding Site of E. coli Nitrile Reductase QueF by Modeling, Substrate and Enzyme Engineering

Wilding, B., Winkler, M., Petschacher, B., Kratzer, R., Egger, S., Steinkellner, G., Lyskowski, A. F., Nidetzky, B., Gruber, K. & Klempier, N., 2013, In : Chemistry - a European Journal. 19, 22, p. 7007-7012

Research output: Contribution to journalArticle

2012

Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale

Hanlon, S. P., Camattari, A., Abad, S., Glieder, A., Wirz, B., Kittelmann, M., Lütz, S. & Winkler, M., 2012, In : Chemical Communications. 48, 48, p. 6001-6003 3 p.

Research output: Contribution to journalArticle

2011

HIGH LEVEL EXPRESSION OF RHODOTORULA GRACILIS D-AMINO ACID OXIDASE IN PICHIA PASTORIS

Abad, S., Nahalka, J., Winkler, M., Bergler, G., Speight, R., Glieder, A. & Nidetzky, B., 2011, In : Biotechnology Letters. 33, 3, p. 557-563

Research output: Contribution to journalArticle

Old Yellow Enzyme catalyzed dehydrogenation of saturated ketones

Schittmayer, M., Glieder, A., Uhl, M. K., Winkler, A., Zach, S., Schrittwieser, J., Kroutil, W., Macheroux, P., Gruber, K., Kambourakis, S., Rozzell, J. D. & Winkler, M., 2011, In : Advanced Synthesis & Catalysis. 252, 2-3, p. 268-274

Research output: Contribution to journalArticle

2010

Directed evolution of Alcaligenes faecalis nitrilase

Schreiner, U., Hecher, B., Obrowsky, S., Waich, K., Klempier, N., Steinkellner, G., Gruber, K., Rozzell, J. D., Glieder, A. & Winkler, M., 2010, In : Enzyme and microbial technology. 47, p. 140-146

Research output: Contribution to journalArticle

IMPROVED FITNESS OF ARABIDOPSIS THALIANA NITRILASE 2

Schreiner, U., Steinkellner, G., Glieder, A., Rozzell, J. D. & Winkler, M., 2010, In : ChemCatChem. 2, 3, p. 263-267

Research output: Contribution to journalArticle

Monooxygenases as biocatalysts: classification, mechanistic aspects and biotechnological applications

Torres Pazmiño, D. E., Winkler, M., Glieder, A. & Fraaije, M. W., 2010, In : Journal of Biotechnology. 146, p. 9-24

Research output: Contribution to journalArticle