19992020

Research output per year

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Research Output

2020

Co-factor demand and regeneration in the enzymatic one-step reduction of carboxylates to aldehydes in cell-free systems

Strohmeier, G., Schwarz, A., Andexer, J. N. & Winkler, M., 10 Jan 2020, In : Journal of Biotechnology. 307, p. 202-207 14 p.

Research output: Contribution to journalArticle

Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

Wiltschi, B., Cernava, T., Dennig, A., Galindo, M., Geier, M., Gruber, S., Haberbauer, M., Heidinger, P., Acero, E. H., Kratzer, R., Luley-Goedl, C., Müller, C. A., Pitzer, J., Ribitsch, D., Sauer, M., Schmölzer, K., Schnitzhofer, W., Sensen, C. W., Soh, J., Steiner, K. & 3 others, Winkler, C. K., Winkler, M. & Wriessnegger, T., 22 Jan 2020, In : Biotechnology Advances. p. 107520

Research output: Contribution to journalArticle

Functional Expression and Characterization of a Panel of Cobalt and Iron-Dependent Nitrile Hydratases

Grill, B., Glänzer, M., Schwab, H., Kerstin, S., Pienaar, D., Brady, D., Donsbach, K. & Winkler, M., 29 May 2020, In : Molecules . 25, 11, 11 p., 2521.

Research output: Contribution to journalArticle

Open Access

High-throughput in-field bioprospecting for cyanogenic plants and hydroxynitrile lyases

Tomescu, M-S., Davids, D., DuPlessis, M., Darnhofer, B., Birner-Gruenberger, R., Archer, R., Schwendenwein, D., Thallinger, G., Winkler, M. & Rumbold, K., 2020, In : Biocatalysis and Biotransformation. 38, 3, p. 234-240

Research output: Contribution to journalArticle

In vivo reduction of medium- to long-chain fatty acids by carboxylic acid reductase (CAR) enzymes: limitations and solutions

Horvat, M. & Winkler, M., 7 Jul 2020, (Accepted/In press) In : ChemCatChem. 16 p.

Research output: Contribution to journalArticle

Open Access

Pyrazines: Synthesis and Industrial Application of these Valuable Flavor and Fragrance Compounds

Mortzfeld, F. B., Hashem, C., Vranková, K., Winkler, M. & Rudroff, F., 17 Jul 2020, In : Biotechnology Journal. 2020, 15

Research output: Contribution to journalArticle

Open Access
Open Access
2019

3-Hydroxytyrosol: A whole cell mediated Bioreduction using a type IV Carboxylate Reductase

Horvat, M. & Winkler, M., 9 Jul 2019.

Research output: Contribution to conferencePoster

A cell-free in vitro reduction of carboxylate to aldehyde

Schwarz, A., Strohmeier, G., Eiteljörg, I., Kohrt, J., Howard, R. & Winkler, M., Nov 2019.

Research output: Contribution to conferencePoster

A functionally-distinct carboxylic acid reductase (PcCAR4) unearthed from a repertoire of type IV CARs in the white-rot fungus Pycnoporus cinnabarinus

Ling, J. G., Mansor, M. H., Murad, M. A., Khalid, R. M., Quay, D. H-X., Winkler, M. & Bakar, F. D. A., 2019, In : Journal of Biotechnology. 2020, 307, p. 55-62

Research output: Contribution to journalArticle

A Multi-Enzyme System for the In vitro Reduction of Carboxylic Acids to Aldehydes

Strohmeier, G., Schwarz, A., Eiteljörg, I., Kohrt, J., Howard, R. & Winkler, M., Jul 2019.

Research output: Contribution to conferencePoster

Capsaicin Metabolite Synthesis by Fungal Cytochrome P450

Willim, M., Bachler, T., Schweda, B., Migglautsch, A. K., Glieder, A., Breinbauer, R. & Winkler, M., 14 Feb 2019.

Research output: Contribution to conferencePoster

Carboxylic acid reductases in the white-rot fungus Pycnoporus cinnnabarinus

Ling, J. G., Mansor, M. H., Murad, M. A., Khalid, R. M., Quay, D. H-X., Eiteljörg, I., Stolterfoht, H., Winkler, M. & Bakar, F. D. A., Nov 2019.

Research output: Contribution to conferencePoster

Characterization of carboxylate reductases (CARs) for the reduction of aromatic carboxylic acids with integrated in vitro cofactor recycling

Weber, D., Patsch, D., Winkler, M., Turner, N. J. & Rother, D., Nov 2019.

Research output: Contribution to conferencePoster

Characterization of Type IV Carboxylate Reductases (CARs) for Whole Cell-Mediated Preparation of 3-Hydroxytyrosol

Horvat, M., Fritsche, S., Kourist, R. & Winkler, M., 19 Mar 2019, In : ChemCatChem. p. 4171-4181

Research output: Contribution to journalArticle

Chimeric Carboxylate Reductases

Stolterfoht, H., Gradischnig, D. & Winkler, M., Nov 2019.

Research output: Contribution to conferencePoster

Comparison of two new and a known Type IV fungal Carboxylate reductase

Horvat, M., Fritsche, S. & Winkler, M., Nov 2019.

Research output: Contribution to conferencePoster

Cytochrome P450 mediated hydroxylation of ibuprofen using Pichia pastoris as biocatalyst

Rinnofner, C., Kerschbaumer, B., Weber, H., Glieder, A. & Winkler, M., Nov 2019.

Research output: Contribution to conferencePoster

Cytochrome P450 mediated hydroxylation of ibuprofen using Pichia pastoris as biocatalyst

Rinnofner, C., Kerschbaumer, B., Weber, H., Glieder, A. & Winkler, M., Apr 2019.

Research output: Contribution to conferencePoster

Open Access

Discovery of carboxylic acid reductase (CAR) from Thermothelomyces thermophilus and its evaluation for vanillin synthesis

Horvat, M., Fiume, G., Fritsche, S. & Winkler, M., 12 Aug 2019, In : Journal of Biotechnology. 304, p. 44-51

Research output: Contribution to journalArticle

Enzymatic One-Step Reduction of Carboxylates to Aldehydes with Cell-Free Regeneration of ATP and NADPH

Strohmeier, G., Eiteljörg, I., Schwarz, A. & Winkler, M., 26 Apr 2019, In : Chemistry - a European Journal. 25, 24, p. 6119-6123 5 p.

Research output: Contribution to journalArticle

Open Access

Enzyme-catalyzed synthesis of amides from nitriles

Glänzer, M., Grill, B., Schwab, H., Pogorevcnik, U., Reicher, K., Donsbach, K., Pienaar, D. & Winkler, M., Sep 2019.

Research output: Contribution to conferencePoster

Exploring the Biocatalytic Potential of a Self‐Sufficient Cytochrome P450 from Thermothelomyces thermophila

Fürst, M. J. L. J., Kerschbaumer, B., Rinnofner, C., Migglautsch, A. K., Winkler, M. & Fraaije, M. W., 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2487-2496

Research output: Contribution to journalArticle

Open Access

Form follows function: Structure of the carboxylate reductase from Neurospora crassa (NcCAR)

Daniel, B., Pavkov-Keller, T., Leithold, M., Stolterfoht, H., Winkler, M. & Gruber, K., Nov 2019.

Research output: Contribution to conferencePoster

Human drug metabolite synthesis catalysed by recombinant P450 enzymes

Glieder, A., Weninger, A., Schmid, C., Rinnofner, C., Winkler, M., Müller, M., Schürmann, M., Woodley, J., Valero, F., Garcia-Ortega, X., Fürst, M. J. L. J. & Fraaije, M. W., Jun 2019.

Research output: Contribution to conferenceAbstract

Nitrile hydratasees for synthesis of amides from nitriles

Grill, B., Schwab, H., Pogorevcnik, U., Glänzer, M., Reicher, K., Donsbach, K. & Winkler, M., Nov 2019.

Research output: Contribution to conferencePoster

Optimizing the heterologous expression of the carboxylic acid reductase from Nocardia otitidiscavium for the reduction of aromatic acids

Weber, D., Patsch, D., Winkler, M., Turner, N. & Rother, D., 9 Jul 2019.

Research output: Contribution to conferencePoster

Random Mutagenesis-Driven Improvement of Carboxylate Reductase Activity Using an Amino Benzamidoxime-Mediated High-Throughput Assay

Schwendenwein, D., Ressmann, A. K., Dörr, M., Höhne, M., Mihovilovic, M. D., Bornscheuer, U. T., Rudroff, F. & Winkler, M., 6 Jun 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2544-2549 6 p.

Research output: Contribution to journalArticle

Random mutagenesis of carboxylate reductase enabled by a substrate independent HT-assay

Rudroff, F., Winkler, M., Schwendenwein, D., Ressmann, A. K., Mihovilovic, M. D., Bornscheuer, U. T. & Dörr, M., Jul 2019.

Research output: Contribution to conferencePoster

Structure elucidation of the carboxylate reductase from Neurospora crassa (NcCAR)

Daniel, B., Pavkov-Keller, T., Leithold, M., Gruber, K., Stolterfoht, H. & Winkler, M., 9 Jul 2019.

Research output: Contribution to conferencePoster

Substrate-Independent High-Throughput Assay for the Quantification of Aldehydes

Ressmann, A. K., Schwendenwein, D., Leonhartsberger, S., Mihovilovic, M. D., Bornscheuer, U. T., Winkler, M. & Rudroff, F., 6 Jul 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2538-2543 6 p.

Research output: Contribution to journalArticle

Towards a new panel of nitrile hydratases

Grill, B., Schwab, H., Glänzer, M., Steinkellner, G., Strohmeier, G., Pogorevcnik, U., Reicher, K., Gruber, K., Donsbach, K. & Winkler, M., 26 Jun 2019.

Research output: Contribution to conferencePoster

2018

Aliphatic hydroxylation and epoxidation of capsaicin by Cytochrome P450 CYP505X

Migglautsch, A. K., Willim, M., Schweda, B., Glieder, A., Breinbauer, R. & Winkler, M., 31 Aug 2018, In : Tetrahedron. 74, p. 6199-6204

Research output: Contribution to journalArticle

A novel assay for the detection of carboxylic acid reductase (CAR) activity in whole cells

Schwendenwein, D., Ressmann, A. K., Mihovilovic, M. D., Bornscheuer, U. T., Dörr, M., Rudroff, F. & Winkler, M., 27 Aug 2018.

Research output: Contribution to conferencePoster

Carboxylic acid reductase enzymes (CARs)

Winkler, M., 2018, In : Current opinion in chemical biology. 43, p. 23-29

Research output: Contribution to journalReview article

Combinatorial optimization strategies to increase Human P450 catalytic Activity in whole cell

Weninger, A., Alkofer, A., Schmid, C., Bitter, J., Volpini de Maestri, A., Pranjic, M., Winkler, M. & Glieder, A., Sep 2018.

Research output: Contribution to conferencePoster

Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090

Liu, Y., Gong, R., Liu, X., Zhang, P., Zhang, Q., Cai, Y-S., Deng, Z., Winkler, M., Wu, J. & Chen, W., 2018, In : Microbial cell factories . 17, 10 p., 131.

Research output: Contribution to journalArticle

Open Access

Fatty Alcohols: enzymatically from Free fatty Acids

Horvat, M., Zabielska, J., Kourist, R. & Winkler, M., 3 Jul 2018.

Research output: Contribution to conferencePoster

Fragrance synthesis via a chemo- & multi enzyme cascade

Rudroff, F., Winkler, M., Entner, M., Schwendenwein, D., Ressmann, A. K. & Mihovilovic, M. D., Jul 2018.

Research output: Contribution to conferencePoster

Humane Enzyme für die Organische Synthese

Winkler, M., Geier, M., Hanlon, S. P., Nidetzky, B. & Glieder, A., 2018, In : Angewandte Chemie. 130, p. 13592-13610

Research output: Contribution to journalReview article

Human Enzymes for Organic Synthesis

Winkler, M., Geier, M., Hanlon, S. P., Nidetzky, B. & Glieder, A., 2018, In : Angewandte Chemie / International Edition . 57, 41, p. 13406-13423 18 p.

Research output: Contribution to journalReview article

Hybrid CARs (carboxylate reductases)

Stolterfoht, H., Gradischnig, D. & Winkler, M., 10 Oct 2018.

Research output: Contribution to conferencePoster

Identification of key residues for enzymatic carboxylate reduction

Stolterfoht, H., Steinkellner, G., Schwendenwein, D., Pavkov-Keller, T., Gruber, K. & Winkler, M., 12 Feb 2018, In : Frontiers in Microbiology . 9, 250.

Research output: Contribution to journalArticle

Production of Hydroxynitrile Lyase from Davallia tyermannii (DtHNL) in Komagataella phaffii and Its Immobilization as a CLEA to Generate a Robust Biocatalyst

Lanfranchi, E., Grill, B., Raghoebar, Z., Van Pelt, S., Sheldon, R. A., Steiner, K., Glieder, A. & Winkler, M., 2018, In : ChemBioChem. 19, 4, p. 312-316 10.1002/cbic.201700419.

Research output: Contribution to journalArticle

Screening for new plant hydroxynitrile lyases

Winkler, M., Schwendenwein, D., Archer, R. & Rumbold, K., 2 Jul 2018.

Research output: Contribution to conferencePoster