Johannes Khinast

Univ.-Prof. Dipl.-Ing. Dr.techn.

1991 …2022
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Research Output 1991 2019

2019

Ensuring Tablet Quality via Model-based Control of a Continuous Direct Compaction Process

Kirchengast, M., Celikovic, S., Rehrl, J., Sacher, S., Kruisz, J., Khinast, J. & Horn, M., 15 Aug 2019, In : International Journal of Pharmaceutics. 2019, 567, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Prediction of the anisotropic mechanical properties of compacted powders

Loidolt, P., Ulz, M. H. & Khinast, J., 2019, In : Powder Technology. 345, p. 589-600 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Powders
Compaction
Mechanical properties
Anisotropy
Boundary conditions

The need for new control strategies for particulate matter in parenterals

Poms, J., Sacher, S., Nixdorf, M., Dekner, M., Wallner-Mang, S., Janssen, I., Khinast, J. G. & Schennach, R., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 739-750 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Particulate Matter
Process Assessment (Health Care)
Risk Management
Patient Safety
Guidelines

Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate

Zellnitz, S., Pinto, J., Brunsteiner, M., Schröttner, H., Khinast, J. & Paudel, A., 2019, In : Pharmaceutical research. 36, 6, p. 80 11 p., 36:80.

Research output: Contribution to journalArticleResearchpeer-review

2018

3D printing of oral drugs: a new reality or hype?

Hsiao, W. K., Lorber, B., Reitsamer, H. & Khinast, J., 2 Jan 2018, In : Expert opinion on drug delivery. 15, 1, p. 1-4 4 p.

Research output: Contribution to journalEditorialResearchpeer-review

A combined DEM & FEM approach for modelling roll compaction process

Mazor, A., Orefice, L., Michrafy, A., de Ryck, A. & Khinast, J. G., Sep 2018, In : Powder Technology. 337, p. 3-16 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Rolls (machine components)
Finite difference method
Compaction
Powders
Finite element method

A system and a method for constant micro dosing and feeding of powder material

Fathollahi, S., Khinast, J., Klein, T., Besenhard, M. & Slama, E., 11 Apr 2018

Research output: PatentResearch

Automation of a dosing-disc capsule filler from the perspective of reliability and safety

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 4 Mar 2018, In : Drug development and industrial pharmacy. 44, 3, p. 502-510 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Automation
Capsules
Fillers
Powders
Safety

Characterization of the coating and tablet core roughness by means of 3D optical coherence tomography

Khinast, J., Markl, D., Wahl, P., Pichler, H. & Sacher, S., 2018, In : International Journal of Pharmaceutics. p. 459-466

Research output: Contribution to journalArticleResearchpeer-review

Continuous Drying of Pharmaceutical Powders Using a Twin-Screw Extruder

Kreimer, M., Aigner, I., Lepek, D. & Khinast, J., 20 Jul 2018, In : Organic Process Research and Development. 22, 7, p. 813-823 11 p.

Research output: Contribution to journalArticleResearchpeer-review

screws
Extruders
Powders
drying
Drying

Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors

Rehrl, J., Kartunnen, A-P., Nicolaï, N., Hörmann, T., Horn, M., Korhonnen, O., Nopens, I., de Beer, T. & Khinast, J., 30 May 2018, In : International Journal of Pharmaceutics. 543, 1-2, p. 60-72

Research output: Contribution to journalArticleResearchpeer-review

Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer

Neugebauer, P., Besenhard, M., Peter, A., Gruber-Wölfler, H. & Khinast, J., 15 Jun 2018, In : Crystal Growth and Design. 18, 8, p. 4403-4415

Research output: Contribution to journalArticleResearchpeer-review

Detailed modeling and process design of an advanced continuous powder mixer

Toson, P., Siegmann, E., Trogrlic, M., Kureck, H., Khinast, J., Jajcevic, D., Doshi, P., Blackwood, D., Bonnassieux, A., Daugherity, P. D. & am Ende, M. T., 1 Dec 2018, In : International Journal of Pharmaceutics. 552, 1-2, p. 288-300 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Powders
Equipment Design
Equipment and Supplies
Technology

Effect of particle shape in grinding mills using a GPU based DEM code

Khinast, J., Govender, N., Rajamani, R. K., Wilke, D. N., Wu, C-Y. & Glasser, B. J., 2018, In : Minerals engineering. p. 71-84

Research output: Contribution to journalArticleResearchpeer-review

Flow of granular materials in a bladed mixer: Effect of particle properties and process parameters on impeller torque and power consumption

Boonkanokwong, V., Frank, R. P., Valliappan, P., Remy, B., Khinast, J. G. & Glasser, B. J., 1 Nov 2018, In : Advanced powder technology. 29, 11, p. 2733-2752 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Granular materials
Particles (particulate matter)
Electric power utilization
Torque
Glass

Formulation performance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization

Hörmann, T., Jäger, N., Funke, A., Mürb, R-K., Khinast, J. G. & Paudel, A., 20 Dec 2018, In : International Journal of Pharmaceutics. 553, 1-2, p. 408-421 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Nimodipine
Polymers
Vacuum
Temperature
Fourier Transform Infrared Spectroscopy

Gluing Pills Technology: A novel route to multilayer tablet manufacturing

Demiri, V., Stranzinger, S., Rinner, P., Piller, M., Sacher, S., Lingitz, J., Khinast, J. & Salar-Behzadi, S., 5 Sep 2018, In : International Journal of Pharmaceutics. 548, 1, p. 672-681 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tablets
Technology
Povidone
Precision Medicine
Translational Medical Research

Hopper flow of irregularly shaped particles (non-convex polyhedra): GPU-based DEM simulation and experimental validation

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Pizette, P. & Xu, W., 2018, In : Chemical Engineering Science. p. 34-51

Research output: Contribution to journalArticleResearchpeer-review

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Residence time distribution
Extrusion
Drug products
Color
Surface-Active Agents

Large-scale GPU based DEM modeling of mixing using irregularly shaped particles

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Rajamani, R. K. & Glasser, B. J., 2018, In : Advanced powder technology. p. 2476-2490

Research output: Contribution to journalArticleResearchpeer-review

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing

Khinast, J., Leane, M., Pitt, K., Reynolds, G. K., Dawson, N., Ziegler, I., Szepes, A., Crean, A. M., Agnol, R. D., Broegmann, B., Charlton, S., Davies, C., Gamble, J., Gamlen, M., Hsiao, W. K., Khimyak, Y., Kleinebudde, P., Moreton, C., Oswald, M., Page, S. & 5 othersPaudel, A., Sahoo, R., Sheehan, S., Stamato, H. & Stone, E., 2018, In : Pharmaceutical development and technology. p. 964-977 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Industry
Particle Size
Pharmaceutical Preparations
Proxy
Drug Compounding

Material tracking in a continuous direct capsule-filling process via residence time distribution measurements

Kruisz, J., Rehrl, J., Faulhammer, E., Witschnigg, A. & Khinast, J., 2018, In : International Journal of Pharmaceutics. 550, 1-2, p. 347-358

Research output: Contribution to journalArticleResearchpeer-review

Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets

Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In : Powder Technology. 325, p. 247-260

Research output: Contribution to journalArticleResearchpeer-review

Modeling yield properties of compacted powder using a multi-particle finite element model with cohesive contacts

Loidolt, P., Ulz, M. H. & Khinast, J., 15 Jun 2018, In : Powder Technology. 2018, 336

Research output: Contribution to journalArticleResearchpeer-review

Numerical investigation of a coarse-grain discrete element method in solid mixing in a spouted bed

Takabatake, K., Mori, Y., Khinast, J. G. & Sakai, M., 15 Aug 2018, In : Chemical Engineering Journal. 346, p. 416-426 11 p.

Research output: Contribution to journalArticleResearchpeer-review

discrete element method
Finite difference method
pressure drop
Conveying
Velocity distribution

Rapid automated process development of a continuous capsule-filling process

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 30 Jul 2018, In : International Journal of Pharmaceutics. 546, 1-2, p. 154-165 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Capsules
Weights and Measures
Dosage Forms
Statistical Models
Immersion
Open Access
Molecular Dynamics Simulation
Solubility
Excipients
Polymers
Pharmaceutical Preparations

RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line

Martinetz, M., Kartunnen, A-P., Sacher, S., Wahl, P., Ketolainen, J., Khinast, J. & Korhonnen, O., 5 Jun 2018.

Research output: Contribution to conferencePaperResearchpeer-review

Open Access

Spatially Resolved Spectral Powder Analysis: Experiments and Modeling

Khinast, J., Scheibelhofer, O., Wahl, P., Larchevêque, B. & Chauchard, F., 2018, In : Applied Spectroscopy. p. 521-534

Research output: Contribution to journalArticleResearchpeer-review

Study of a low-dose capsule filling process by dynamic and static tests for advanced process understanding

Paudel, A., Stranzinger, S., Faulhammer, E., Scheibelhofer, O., Calzolari, V., Biserni, S. & Khinast, J., 5 Apr 2018, In : International Journal of Pharmaceutics. 540, 1-2, p. 22-30 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Powders
Capsules
Weights and Measures
Vibration
Lactose

The Effect of Liquid Bridge Model Details on the Dynamics of Wet Fluidized Beds

Wu, M., Khinast, J. & Radl, S., Feb 2018, In : AIChE Journal. 64, p. 437-456 10.1002/aic.15947.

Research output: Contribution to journalArticleResearchpeer-review

Surface Tension
Fluidized beds
Rupture
Liquids
Surface tension

The effect of saliva on the fate of nanoparticles

Teubl, B. J., Stojkovic, B., Docter, D., Pritz, E., Leitinger, G., Poberaj, I., Prassl, R., Stauber, R. H., Fröhlich, E., Khinast, J. G. & Roblegg, E., 1 Mar 2018, In : Clinical Oral Investigations. 22, 2, p. 929-940 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Saliva
Nanoparticles
Viscosity
Mouth Diseases
Optical Tweezers

Using Perusall to Enhance Student Learning of Particle Technology at Graz University of Technology

Lepek, D., Radl, S. & Khinast, J., 24 Apr 2018.

Research output: Contribution to conferencePosterResearchpeer-review

learning
student
poster
Austria
textbook
2017

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In : Chemie-Ingenieur-Technik. 89, 8

Research output: Contribution to journalArticleResearchpeer-review

Analysis of Flow and Mixing in Screw Elements of Corotating Twin-Screw Extruders via SPH

Eitzlmayr, A., Matic, J. & Khinast, J., Jun 2017, In : AIChE Journal. 63, 6, p. 2451-2463

Research output: Contribution to journalArticleResearchpeer-review

Extruders
Hydrodynamics
Conveying
Pressure
Geometry

An investigation of the hydrodynamic similarity of single-spout fluidized beds using CFD-DEM simulations

Ebrahimi, M., Siegmann, E., Prieling, D., Glasser, B. J. & Khinast, J. G., Oct 2017, In : Advanced powder technology. 28, 10, p. 2465-2481

Research output: Contribution to journalArticleResearchpeer-review

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Technology
Pharmaceutical Preparations
Pressure
Temperature
Research

Comparison of video analysis and simulations of a drum coating process

Boehling, P., Toschkoff, G., Dreu, R., Just, S., Kleinebudde, P., Funke, A., Rehbaum, H. & Khinast, J. G., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 72-81 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tablets
Drug Industry
Mechanics

Continuous Manufacturing of Pharmaceuticals: Chapter 10 - Continuous Melt Extrusion and Direct Pelletization

Laske, S., Hörmann, T., Witschnigg, A., Koscher, G., Wahl, P., Hsiao, W. K. & Khinast, J., 2017, 1st ed. NJ, USA: Wiley & Sons. 337 p. (Advances in Pharmaceutical Technology; vol. Continuous Manufacturing of Pharmaceuticals, no. 1)

Research output: Book/ReportBookResearchpeer-review

Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging

Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In : International Journal of Pharmaceutics. 518, 1-2, p. 130-137

Research output: Contribution to journalArticleResearchpeer-review

Crystal Engineering in Continuous Plug-Flow Crystallizers

Neugebauer, P., Besenhard, M., Khinast, J. & Scheibelhofer, O., 10 Oct 2017, In : Crystal Growth and Design.

Research output: Contribution to journalArticleResearchpeer-review

DEM study of granular transport in partially filled horizontal screw conveyors

Orefice, L. & Khinast, J. G., Jan 2017, In : Powder Technology. 305, p. 347-356

Research output: Contribution to journalArticleResearchpeer-review

Drug–Excipient Interactions in the Solid State: The Role of Different Stress Factors

Gressl, C., Brunsteiner, M., Davis, A., Landis, M., Pencheva, K., Scrivens, G., Sluggett, G. W., Wood, G. P. F., Gruber-Wölfler, H., Khinast, J. & Paudel, A., 2 Nov 2017, In : Molecular pharmaceutics. 14, 12, p. 4560-4571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Citric Acid
Humidity
Pharmaceutical Preparations
Drug Stability
Codeine

Efficient Discrete Element Method Simulation Strategy for Analyzing Large-Scale Agitated Powder Mixers

Siegmann, E., Jajcevic, D., Radeke, C., Strube, D., Friedrich, K. & Khinast, J. G., 1 Aug 2017, In : Chemie-Ingenieur-Technik. 89, 8, p. 995-1005 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Finite difference method
Product development
Powders
Drug products
Pharmaceutical Preparations

Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates

Eder, S., Beretta, M., Witschnigg, A., Koutsamanis, I., Eggenreich, K., Khinast, J. G., Koscher, G., Paudel, A., Nickisch, K., Friedrich, M., Froehlich, E. & Roblegg, E., 1 Nov 2017, In : AAPS PharmSciTech . 18, 8, p. 2971-2976 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Vacuum
extrusion
drugs
manufacturing
Skin

Impulse-based dynamics for studying quasi-static granular flows: Application to hopper emptying of non-spherical particles

Toson, P. & Khinast, J. G., 15 May 2017, In : Powder Technology. 313, p. 353-360 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hoppers
Finite difference method
Virtual reality
Aspect ratio
Robotics

Influence of Process Route on the Mechanical Properties of Polymer Based Intravaginal Drug Delivery Systems

Eggenreich, K., Schrank, S., Koscher, G., Nickisch, K., Roblegg, E. & Khinast, J., 2017, In : AIP Conference Proceedings. 1914

Research output: Contribution to journalArticleResearchpeer-review