Heidrun Gruber-Wölfler

Assoc.Prof. Dipl.-Ing. Dr.techn.

20032023

Research output per year

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Research Output

2020

A chemo-enzymatic tandem reaction in a mixture of deep eutectic solvent and water in continuous flow

Grabner, B., Schweiger, A. K., Gavric, K., Kourist, R. & Gruber-Wölfler, H., 2020, In : Reaction Chemistry & Engineering. 5, 2, p. 263-269

Research output: Contribution to journalArticleResearchpeer-review

Open Access

DERA in Flow: Synthesis of a Statin Side Chain Precursor in Continuous Flow Employing Deoxyribose-5-Phosphate Aldolase Immobilized in Alginate-Luffa Matrix

Grabner, B., Pokhilchuk, Y. & Gruber-Wölfler, H., 2020, In : Catalysts. 10, 1

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2019

Combined Enzymatic Decarboxylation and Pd-catalyzed Heck Coupling in Continuous Flow

Grabner, B., Schweiger, A. K., Gavric, K., Kourist, R. & Gruber-Wölfler, H., Sep 2019.

Research output: Contribution to conferencePosterResearchpeer-review

Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow

Hiebler, K., Dertnig, C. A., Soritz, S., Maier, M. C., Hörmann, T., Grabner, B. & Gruber-Wölfler, H., 3 Dec 2019, In : Journal of Flow Chemistry. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

From One-pot to One-flow: A chemo-enzymatic tandem reaction in continuous flow

Grabner, B., Schweiger, A. K., Gavric, K., Kourist, R. & Gruber-Wölfler, H., Sep 2019.

Research output: Contribution to conferencePosterResearch

Multistep synthesis of a valsartan precursor in continuous flow

Hiebler, K., Soritz, S., Gavric, K., Birrer, S., Maier, M. C., Grabner, B. & Gruber-Woelfler, H., 1 Jan 2019, In : Journal of Flow Chemistry. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Multistep synthesis of the active pharmaceutical ingredients valsartan and sacubitril in continuous flow

Hiebler, K. & Gruber-Wölfler, H., 25 Sep 2019.

Research output: Contribution to conferencePosterResearchpeer-review

2018

Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles

Betke, T., Maier, M. C., Gruber-Wölfler, H. & Gröger, H., 30 Nov 2018, In : Nature Communications . 9, p. 5112 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Continuous Aldol-Condensation by immobilized E.coli Cells

Grabner, B., Pokhilchuk, Y. & Gruber-Wölfler, H., Sep 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Continuous-Flow In-Line Solvent-Swap Crystallization of Vitamin D3

Escriba-Gelonch, M., Hessel, V., Maier, M. C., Neira, M. F. & Gruber-Wölfler, H., 2018, In : Organic process research & development. 22, 2, p. 178-189

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer

Neugebauer, P., Besenhard, M., Peter, A., Gruber-Wölfler, H. & Khinast, J., 15 Jun 2018, In : Crystal Growth and Design. 18, 8, p. 4403-4415

Research output: Contribution to journalArticleResearchpeer-review

Development and application of Pd-stabilized Pickering emulsions for catalytic cascade reactions in continuous flow

Hiebler, K., Gruber-Wölfler, H., Gonzales-Groom, R. & Binks, B. P., 2018.

Research output: Contribution to conferenceAbstractResearchpeer-review

Development of customized 3D printed stainless steel reactors with inline oxygen sensors for aerobic oxidation of Grignard reagents in continuous flow

Maier, M. C., Lebl, R., Sulzer, P., Lechner, J., Mayr, T., Zadravec, M., Slama, E., Pfanner, S., Schmoelzer, C., Poechlauer, P., Kappe, C. O. & Gruber-Wölfler, H., 2018, In : Reaction Chemistry & Engineering.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Development of Pd catalyzed Pickering Emulsions for Catalytic Cascade Reactions in Continuous Flow

Hiebler, K., Gruber-Wölfler, H., Binks, B. P. & Gonzales-Groom, R., 2018.

Research output: Contribution to conferenceAbstractResearchpeer-review

Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry

Hiebler, K., Lichtenegger, G. J., Maier, M. C., Park, E. S., Gonzales-Groom, R., Binks, B. P. & Gruber-Wölfler, H., 18 Mar 2018, In : Beilstein Journal of Organic Chemistry . 14, p. 648 - 658

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Room-temperature solid phase ionic liquid (RTSPIL) coated omega-transaminase: Development and application in orgranic solvents

Grabner, B., Nazario, Gundersen, M. T., Lois, S., Fantini, S., Bartsch, S., Woodley, J. M. & Gruber-Wölfler, H., Jun 2018, In : Molecular Catalysis. 452, p. 11-19

Research output: Contribution to journalArticleResearchpeer-review

2017

Catalytic cascade reactions for syntheses of sartans in continuous flow

Hiebler, K. & Gruber-Wölfler, H., 2017, (Accepted/In press).

Research output: Contribution to conferencePosterResearch

Continuous Synthesis meets Purification: Handling Particles in Continuous Flow

Gruber-Wölfler, H., 14 Nov 2017.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

DERA-catalyzed Statin Side-Chain Precursor Synthesis: Optimization using Design of Experiments

Grabner, B. & Gruber-Wölfler, H., Jul 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Design and 3D printing of a stainless steel reactor for continuous difluoromethylations using fluoroform

Gutmann, B., Köckinger, M., Glotz, G., Ciaglia, T., Slama, E., Zadravec, M., Pfanner, S., Maier, M. C., Gruber-Wölfler, H. & Kappe, O., 20 Nov 2017.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Drug–Excipient Interactions in the Solid State: The Role of Different Stress Factors

Gressl, C., Brunsteiner, M., Davis, A., Landis, M., Pencheva, K., Scrivens, G., Sluggett, G. W., Wood, G. P. F., Gruber-Wölfler, H., Khinast, J. & Paudel, A., 2 Nov 2017, In : Molecular pharmaceutics. 14, 12, p. 4560-4571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Acetonitrile-Based Crystallization Conditions on the Crystal Quality of Vitamin D3

Gruber-Woelfler, H., Escribà-Gelonch, M., Noël, T., Maier, M. C. & Hessel, V., 1 Nov 2017, In : Chemical Engineering & Technology. 40, 11, p. 2016-2024 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Heck Reaction using Pd-substituted Se-Sn-Oxides

Filzwieser, M., Grabner, B. & Gruber-Wölfler, H., Sep 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Optimized process conditions for Deoxyribose-phosphate aldolase in chemical synthesis

Grabner, B. & Gruber-Wölfler, H., Sep 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Pd-substituted mixed Ce-Sn-Oxides for Heck Reaction

Grabner, B., Filzwieser, M. & Gruber-Wölfler, H., Oct 2017.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Reaction Calorimetry in Microreactor Environments—Measuring Heat of Reaction by Isothermal Heat Flux Calorimetry

Glotz, G., Podmore, P., Knoechel, D. J., Gruber-Wölfler, H. & Kappe, C. O., 20 Apr 2017, In : Organic process research & development.

Research output: Contribution to journalArticleResearchpeer-review

Suzuki-Miyaura coupling reactions using novel metal oxide supported ionic palladium catalysts

Lichtenegger, G. J., Maier, M., Hackl, M., Khinast, J. G., Goessler, W., Griesser, T., Kumar, V. S. P., Gruber-Woelfler, H. & Deshpande, P. A., Jan 2017, In : Journal of molecular catalysis / A. 426, p. 39-51

Research output: Contribution to journalArticleResearchpeer-review

2016

Ce0.495Sn0.495Pd0.01O2 as highly stable and low-leaching catalyst in continuous Suzuki-Miyaura cross-coupling reactions

Lichtenegger, G. J., Khinast, J. & Gruber-Wölfler, H., 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Development of an Integrated Continuous Crystallization Process of Vitamin D3

Escriba-Gelonch, M., Hessel, V., Noel, T. & Gruber-Wölfler, H., 14 Sep 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Development of an Integrated Continuous Crystallization Process of Vitamin D3

Escriba-Gelonch, M., Hessel, V., Noel, T. & Gruber-Wölfler, H., Sep 2016, Chemie Ingenieur Technik: Special Issue: ProcessNet-Jahrestagung und 32. DECHEMA-Jahrestagung der Biotechnologen 2016 . 9 ed. Vol. 88.

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearch

Ionic Liquid Coated Transaminase for Biocatalysis in Organic Solvents

Grabner, B., Gundersen, M. T., Lois, S., Fantini, S., Gruber-Wölfler, H. & Woodley, J. M., 2016, (In preparation).

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Mit ionischen Flüssigkeiten überzogene Transaminase für Biokatalyse in organischen Lösungsmitteln

Grabner, B., Gundersen, M. T., Lois, S., Fantini, S., Gruber-Wölfler, H. & Woodley, J. M., Sep 2016, Chemie Ingenieur Technik: Special Issue: ProcessNet-Jahrestagung 2016 und 32. DECHEMA-Jahrestagung der Biotechnolgie 2016. 9 ed. Wiley-VCH , Vol. 88. p. 1244

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearch

Mit ionischen Flüssigkeiten überzogene Transaminase für Biokatalyse in organischen Lösungsmitteln

Grabner, B., Gundersen, M. T., Lois, S., Fantini, S., Bartsch, S., Gruber-Wölfler, H. & Woodley, J. M., Sep 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Particle Loaded Monolithic Materials for Separations via Planar Electrochromatography

Gruber-Wölfler, H., Braunbruck, M-G., Laskowski, R., Feenstra, P., Khinast, J. & Bart, H-J., 2016, In : Journal of planar chromatography - modern TLC. 29, 1

Research output: Contribution to journalArticleResearchpeer-review

Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure

Planchette, C., Pichler, H., Wimmer-Teubenbacher, M., Gruber, M., Gruber-Wölfler, H., Mohr, S., Tetyczka, C., Hsiao, W. K., Paudel, A., Roblegg, E. & Khinast, J., 2016, In : International Journal of Pharmaceutics. p. 518-527

Research output: Contribution to journalArticleResearchpeer-review

Suzuki-Miyaura coupling reactions using novel metal oxide supportedionic palladium catalysts

Lichtenegger, G. J., Maier, M. C., Hackl, M., Khinast, J., Gössler, W., Griesser, T., Phani Kumard, V. S., Gruber-Wölfler, H. & Deshpande, P. A., 1 Nov 2016, In : Journal of molecular catalysis / A. 426, p. 39-51

Research output: Contribution to journalArticleResearchpeer-review

The Plug & Play Reactor: A Highly Flexible Device for Heterogeneous Reactions in Continuous Flow

Lichtenegger, G. J., Turšič, V., Kitzler, H., Obermaier, K., Khinast, J. & Gruber-Wölfler, H., 27 Jul 2016, In : Chemie - Ingenieur - Technik. 88, 10

Research output: Contribution to journalArticleResearchpeer-review

2015

Chemically Treatment of Glass Surfaces to Reduce Alkali Ion Diffusion into Aqueous Solutions

Gruber-Wölfler, H., Schweiger, S. & Neubauer, C., 21 Sep 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Effective reaction rate in a fixed bed reactor

Gruber-Woelfler, H., Pichler, R. & Radl, S., 1 Jan 2015, Catalysis and Reaction Engineering Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting. American Institute of Chemical Engineers, p. 53-62 10 p. (Catalysis and Reaction Engineering Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Effect of Particle Swelling on the Effective Reaction Rate in a Fixed Bed Reactor

Gruber-Wölfler, H., Pichler, R. & Radl, S., 8 Nov 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Heterogeneous Catalysis in Continuous Flow: Plug and Play

Lichtenegger, G. J., Kitzler, H., Obermaier, K., Khinast, J. & Gruber-Wölfler, H., 11 Nov 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Implementation of a UV/Vis System for the Inline Analytics of Heterogeneous Reactions in Continuous Flow Mode

Gruber-Wölfler, H., Turšič, V. & Lichtenegger, G. J., 14 Sep 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

IPPE-TU Graz: green engineering inside and beyond the borders of process technology

Gruber-Wölfler, H., Schnitzer, H., Narodoslawsky, M. & Khinast, J., 2015, In : Green processing and synthesis. 4, 1, p. 51-54

Research output: Contribution to journalArticleResearchpeer-review

Novel palladium substituted cerium-tin-oxides as highly active catalysts for continuous Suzuki-Miyaura reactions

Lichtenegger, G. J., Deshpande, P., Gruber-Wölfler, H. & Khinast, J., 2015.

Research output: Contribution to conferencePosterResearch

Open Access
File

Palladium Substituted Mixed Cerium-Tin-Oxides as Heterogeneous Catalysts for Continuous Suzuki Cross-Coupling Reactions

Lichtenegger, G. J., Deshpande, P. A., Gruber-Wölfler, H. & Khinast, J., 22 Sep 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Retention-time prediction for polycyclic aromatic compounds in reversed-phase capillary electro-chromatography.

Feenstra, P., Gruber-Wölfler, H., Brunsteiner, M. & Khinast, J., 2015, In : Journal of molecular modeling. 21, p. 124-133

Research output: Contribution to journalArticleResearchpeer-review

Strategies to develop leaching-free heterogeneous catalysts

Lichtenegger, G. J. & Gruber-Wölfler, H., 2015, In : Chimica Oggi. 33, 4, p. 12-19

Research output: Contribution to journalArticleResearch

The Plug & Play Reactor: A Highly Flexible Device for Heterogeneous Reactions in Continuous Flow Mode

Gruber-Wölfler, H., Lichtenegger, G. J., Kitzler, H., Obermaier, K. & Khinast, J., 16 Jun 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

2014

Coating of glass substrates to prevent alkali ion diffusion into pharmaceutical solutions

Schweiger, S., Neubauer, C., Fraser, S., Klein, T., Schennach, R., Reichmann, A. & Gruber-Wölfler, H., 2014, In : Surface & coatings technology. 258, p. 1249-1255

Research output: Contribution to journalArticleResearchpeer-review