Gustav Oberdorfer

Mag.rer.nat. Dr.rer.nat.

20072024
If you made any changes in Pure these will be visible here soon.

Research Output 2007 2018

Filter
Article
2018

De novo design of a non-local β-sheet protein with high stability and accuracy

Marcos, E., Chidyausiku, T. M., McShan, A. C., Evangelidis, T., Nerli, S., Carter, L., Nivón, L. G., Davis, A., Oberdorfer, G., Tripsianes, K., Sgourakis, N. G. & Baker, D., 1 Nov 2018, In : Nature Structural and Molecular Biology. 25, 11, p. 1028-1034 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteins
Hydrogen Bonding
Magnetic Resonance Spectroscopy

De novo design of self-assembling helical protein filaments

Shen, H., Fallas, J. A., Lynch, E., Sheffler, W., Parry, B., Jannetty, N., Decarreau, J., Wagenbach, M., Vicente, J. J., Chen, J., Wang, L., Dowling, Q., Oberdorfer, G., Stewart, L., Wordeman, L., De Yoreo, J., Jacobs-Wagner, C., Kollman, J. & Baker, D., 9 Nov 2018, In : Science. 362, 6415, p. 705-709 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteins
Cryoelectron Microscopy
In Vitro Techniques
2017

Principles for designing proteins with cavities formed by curved b sheets

Marcos, E., Basanta, B., Chidyausiku, T. M., Tang, Y., Oberdorfer, G., Liu, G., Swapna, G. V. T., Guan, R., Silva, D. A., Dou, J., Pereira, J. H., Xiao, R., Sankaran, B., Zwart, P. H., Montelione, G. T. & Baker, D., 13 Jan 2017, In : Science. 355, 6321, 6321.

Research output: Contribution to journalArticleResearchpeer-review

Ligands
Catalytic Domain
Proteins
Protein Folding
Carrier Proteins
2016

Computational design of a homotrimeric metalloprotein with a trisbipyridyl core

Mills, J. H., Sheffler, W., Ener, M. E., Almhjell, P. J., Oberdorfer, G., Pereira, J. H., Parmeggiani, F., Sankaran, B., Zwart, P. H. & Baker, D., 27 Dec 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 52, p. 15012-15017 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Metalloproteins
Metals
Proteins
Alanine
Amino Acids

De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity

Boyken, S. E., Chen, Z., Groves, B., Langan, R. A., Oberdorfer, G., Ford, A., Gilmore, J. M., Xu, C., DiMaio, F., Pereira, J. H., Sankaran, B., Seelig, G., Zwart, P. H. & Baker, D., 6 May 2016, In : Science. 352, 6286, p. 680-687 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Hydrogen
Proteins
Synthetic Biology
X Ray Crystallography
DNA

Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae

Daniel, B., Wallner, S., Steiner, B., Oberdorfer, G., Kumar, P., van der Graaff, E., Roitsch, T., Sensen, C. W., Gruber, K. & Macheroux, P., 2016, In : PLoS ONE. 11, 6, p. e0156892

Research output: Contribution to journalArticleResearchpeer-review

Brassicaceae
berberine
Histidine
active sites
Catalytic Domain
2015

The crystal structure of D-threonine aldolase from alcaligenes xylosoxidans provides insight into a metal ion assisted PLPDependent mechanism

Uhl, M. K., Oberdorfer, G., Steinkellner, G., Riegler-Berket, L., Mink, D., Van Assema, F., Schürmann, M. & Gruber, K., 17 Apr 2015, In : PLoS ONE. 10, 4, e0124056.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Achromobacter xylosoxidans
glycine hydroxymethyltransferase
Alcaligenes
crystal structure
metal ions
2014

High thermodynamic stability of parametrically designed helical bundles

Huang, P. S., Oberdorfer, G., Xu, C., Pei, X. Y., Nannenga, B. L., Rogers, J. M., DiMaio, F., Gonen, T., Luisi, B. & Baker, D., 24 Oct 2014, In : Science. 346, 6208, p. 481-485 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Thermodynamics
Proteins
2013

Engineering V-type nerve agents detoxifying enzymes using computationally focused libraries

Cherny, I., Greisen, P., Ashani, Y., Khare, S. D., Oberdorfer, G., Leader, H., Baker, D. & Tawfik, D. S., 15 Nov 2013, In : ACS Chemical Biology. 8, 11, p. 2394-2403 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Phosphoric Triester Hydrolases
Poisons
Choline
Libraries
Detoxification

Fusion of binding-domains to Thermobifida cellulosilytica cutinase to tune sorption characteristics and enhancing PET hydrolysis

Ribitsch, D., Antonio, O. Y., Zitzenbacher, S., Wu, J., Nowitsch, S., Steinkellner, G., Greimel, K. J., Aleš, D., Oberdorfer, G., Gruber, C., Gruber, K., Schwab, H., Karin, S-K., Herrero Acero, E. & Gübitz, G., 2013, In : Biomacromolecules. 14, 6, p. 1769–1776

Research output: Contribution to journalArticleResearchpeer-review

2012

Stereocontrol strategies in the asymmetric bioreduction of alkenes

Oberdorfer, G., Gruber, K., Faber, K. & Hall, M., 23 Jul 2012, In : Synlett. 23, 13, p. 1857-1864 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Alkenes
Substrates
Oxidoreductases
Stereoselectivity
Enantiomers

Structural and functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin biosynthesis

Oberdorfer, G., Binter, A., Ginj, C., Macheroux, P. & Gruber, K., 2012, In : The Journal of Biological Chemistry. 287, p. 31427-31436

Research output: Contribution to journalArticleResearchpeer-review

Biosynthesis
Transferases
Nucleosides
Genes
Chitin Synthase

Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: Reaction intermediates revealed by crystallography and mass spectrometry

Lang, B. S., Gorren, A. C. F., Oberdorfer, G., Wenzl, M. V., Furdui, C. M., Poole, L. B., Mayer, B. & Gruber, K., 2 Nov 2012, In : Journal of Biological Chemistry. 287, 45, p. 38124-38134 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Reaction intermediates
Aldehyde Dehydrogenase
Crystallography
Nitroglycerin
Mass spectrometry
2011

Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis

Binter, A., Oberdorfer, G., Hofzumahaus, S., Nerstheimer, S., Altenbacher, G., Gruber, K. & MacHeroux, P., 1 Nov 2011, In : FEBS Journal. 278, 21, p. 4122-4135 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Biosynthesis
Streptomyces
Transaminases
Chitin Synthase
Deamination

Improved molecular replacement by density- and energy-guided protein structure optimization

Dimaio, F., Terwilliger, T. C., Read, R. J., Wlodawer, A., Oberdorfer, G., Wagner, U., Valkov, E., Alon, A., Fass, D., Axelrod, H. L., Das, D., Vorobiev, S. M., Iwaï, H., Pokkuluri, P. R. & Baker, D., 26 May 2011, In : Nature. 473, 7348, p. 540-543 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteins
X-Ray Diffraction
Datasets

Stereopreferences of old yellow enzymes: Structure correlations and sequence patterns in enoate reductases

Oberdorfer, G., Steinkellner, G., Stueckler, C., Faber, K. & Gruber, K., 17 Oct 2011, In : ChemCatChem. 3, 10, p. 1562-1566 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Epoxide-hydrolase-initiated hydrolysis/rearrangement cascade of a methylene-interrupted bis-epoxide yields chiral THF moieties without involvement of a "Cyclase"

Ueberbacher, B. T., Oberdorfer, G., Gruber, K. & Faber, K., 6 Jul 2009, In : ChemBioChem. 10, 10, p. 1697-1704 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Epoxide Hydrolases
Cyclization
Epoxy Compounds
Hydrolysis
Enzymes
2008

Asymmetric bioreduction of C=C bonds using enoate reductases OPR1, OPR3 and YqjM: enzyme-based stereocontrol

Hall, M., Stueckler, C., Ehammer, H., Pointner, E. M., Oberdorfer, G., Gruber, K., Hauer, B., Stuermer, R., Kroutil, W., Macheroux, P. & Faber, K., 2008, In : Advanced Synthesis & Catalysis. 350, 3, p. 411-418

Research output: Contribution to journalArticleResearchpeer-review

Alkenes
Olefins
Oxidoreductases
Maleimides
Enzymes

Stereocomplementary asymmetric reduction of bulky-bulky ketones by biocatalytic hydrogen transfer

Lavandera, I., Oberdorfer, G., Gross, J., De Wildeman, S. & Kroutil, W., 1 May 2008, In : European journal of organic chemistry. 15, p. 2539-2543 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Ketones
ketones
Hydrogen
ethyl alcohol
Ethanol
2007

An algorithm for the deconvolution of mass spectrosopic patterns in isotope labeling studies. Evaluation for the hydrogen-deuterium exchange reaction in ketones

Gruber, C. C., Oberdorfer, G., Voss, C. V., Kremsner, J. M., Kappe, C. O. & Kroutil, W., 20 Jul 2007, In : Journal of Organic Chemistry. 72, 15, p. 5778-5783 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Deuterium
Deconvolution
Ketones
Isotopes
Labeling