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Arnold Stütz

Ao.Univ.-Prof. Dipl.-Ing. Dr.techn.

1981 …2020
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Research Output 1981 2019

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Article
2019

Synthesis of modified 1,5‑imino‑d‑xylitols as ligands for lysosomal β‑glucocerebrosidase

Zoidl, M., Wolfsgruber, A., Schalli, M., Nasseri, S. A., Weber, P., Stütz, A., Withers, S. G. & Wrodnigg, T. M., 2019, In : Monatshefte für Chemie = Chemical monthly. 150, 5, p. 831-842 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucosylceramidase
Xylitol
Substitution reactions
Ligands
beta-Glucosidase
2018

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Weber, P., Nasseri, S. A., Pabst, B., Torvisco Gomez, A., Müller, P., Paschke, E., Tschernutter, M., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Stütz, A., 2018, In : Molecules . 23, 3, 11 p., 708.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2017

A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.

Lebl, R., Thonhofer, M., Tysoe, C., Pabst, B. M., Schalli, M., Weber, P., Paschke, E., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2017, In : Carbohydrate research. p. 31-40

Research output: Contribution to journalArticleResearchpeer-review

A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols.

Schalli, M., Weber, P., Tysoe, C., Pabst, B. M., Thonhofer, M., Paschke, E., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2017, In : Bioorganic & Medicinal Chemistry Letters. p. 3431-3435

Research output: Contribution to journalArticleResearchpeer-review

C-5a-substituted validamine type glycosidase inhibitors.

Schalli, M., Wolfsgruber, A., Gonzalez Santana, A., Tysoe, C., Fischer, R., Stütz, A., Thonhofer, M. & Withers, S. G., 2017, In : Carbohydrate research. 440-441, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant.

Schalli, M., Tysoe, C., Fischer, R., Pabst, B. M., Thonhofer, M., Paschke, E., Rappitsch, T., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2017, In : Carbohydrate research. 443-444, p. 15-22 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful beta-galactosidase inhibitors and low concentartion activators of GM1-gangliosidosis related human lysosomal beta-galactosidase

Thonhofer, M., Weber, P., Gonzalez Santana, A., Fischer, R., Pabst, B., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, p. 1438-1442

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.

Thonhofer, M., Weber, P., Santana, A. G., Fischer, R., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 5, p. 1438-1442 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.

Thonhofer, M., Weber, P., Gonzalez Santana, A., Tysoe, C., Fischer, R., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2016, In : Carbohydrate research. 429, p. 71-80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Fluorous Iminoalditols act as Effective Pharmacological Chaperones against Gene Products from GLB1 Alleles causing GM1-Gangliosidosis and Morquio B Disease

Fantur, K., Wrodnigg, T., Stütz, A., Pabst, B. M. & Paschke, E., 2012, In : Journal of inherited metabolic disease. 35, 3, p. 495-503

Research output: Contribution to journalArticleResearchpeer-review

Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Davies, G., Thompson, A., Gloster, T., Williams, R., Hakki, Z., Wennekes, T., Songsrirote, K., Wrodnigg, T., Spreitz, J., Stütz, A., Thomas-Oates, J. & Williams, S., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, p. 781-786

Research output: Contribution to journalArticleResearchpeer-review

The Amadori Rearrangement as Glycoconjugation Method: Synthesis of Non-natural C-Glycosyl Type Glycoconjugates

Gallas, K., Pototschnig, G., Adanitsch, F., Stütz, A. & Wrodnigg, T., 2012, In : Beilstein Journal of Organic Chemistry . p. 1619-1629

Research output: Contribution to journalArticleResearchpeer-review

The Two Faces of Iminoalditols: Powerful Inhibitors Trigger Glycosidase Activation

Wrodnigg, T. & Stütz, A., 2012, In : Current enzyme inhibition. 8, p. 47-99

Research output: Contribution to journalArticleResearchpeer-review

Two Faces of Iminoalditols: Powerful Inhibitors Trigger Glycosidase Activation

Wrodnigg, T. & Stütz, A., 2012, In : Current enzyme inhibition. 8, 1, p. 47-99

Research output: Contribution to journalArticleResearch

2011

1-Deoxy-D-galactonojirimycins with Dansyl Capped N-Substituents as -Galactosidase Inhibitors and Potential Probes for GM1 Gangliosidosis Affected Cell Lines

Fröhlich, R., Furneaux, R., Mahuran, D. J., Saf, R., Stütz, A., Tropak, M. B., Wicki, J., Withers, S. G. & Wrodnigg, T., 2011, In : Carbohydrate research. 346, 12, p. 1592-1598

Research output: Contribution to journalArticleResearchpeer-review

A Fluorescent Probe for GM1 Gangliosidosis Related -Gal: N-(Dansylamino)hexylaminocarbonyl- pentyl-1,5-dideoxy-1,5-imino-D-galactitol

Fröhlich, R., Fantur, K., Furneaux, R., Paschke, E., Stütz, A., Wicki, J., Withers, S. G. & Wrodnigg, T., 2011, In : Bioorganic & Medicinal Chemistry Letters. 15, 22, p. 6872-6875

Research output: Contribution to journalArticleResearchpeer-review

Iminosugars and glycoside hydrolases: Historic context, current aspects, emerging trends

Stütz, A. & Wrodnigg, T., 2011, In : Advances in Carbohydrate Chemistry and Biochemistry. 66, p. 187-298

Research output: Contribution to journalArticleResearchpeer-review

2010

1-Deoxynojirimycins with Dansyl Capped N-Substituents as Probes for Morbus Gaucher Affected Cell Lines

Fröhlich, R., Furneaux, R., Mahuran, D., Rigat, B., Stütz, A., Tropak, M., Wicki, J., Withers, S. & Wrodnigg, T., 2010, In : Carbohydrate research. 345, 10, p. 1371-1376

Research output: Contribution to journalArticleResearchpeer-review

Biotin-Iminoalditol Conjugates: Molecular Probes for Glycosylhydrolases

Pototschnig, G., Morales De Csáky, C., Montenegro Burke, J., Schitter, G., Stütz, A., Tarling, C., Withers, S. & Wrodnigg, T., 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 14, p. 4077-4079

Research output: Contribution to journalArticleResearchpeer-review

DLHex-DGJ, a Novel Derivative of 1-Deoxygalactonojirimycin with Pharmalogical Chaperone Activity in Human GM1-Gangliosidosis Fibroplasts

Fantur, K., Hofer, D., Schitter, G., Steiner, A., Pabst, B., Wrodnigg, T., Stütz, A. & Paschke, E., 2010, In : Molecular genetics and metabolism. 100, 3, p. 262-268

Research output: Contribution to journalArticleResearchpeer-review

Fluorescent-tagged sp2-iminosugars with potential b-glucosidase inhibitory activity

Aguilar-Moncayo, M., García-Moreno, I., Stütz, A., García Fernández, J., Wrodnigg, T. & Ortiz Mellet, C., 2010, In : Bioorganic & Medicinal Chemistry. 18, p. 7439-7445

Research output: Contribution to journalArticleResearchpeer-review

Fluorous Iminoalditols: A New Family of N-Modified Glycosidase Inhibitors

Schitter, G., Steiner, A., Pototschnig, G., Scheucher, E., Thonhofer, M., Tarling, C., Withers, S., Fantur, K., Paschke, E., Mahuran, D., Rigat, B., Tropak, M., Illaszewicz-Trattner, C., Saf, R., Stütz, A. & Wrodnigg, T., 2010, In : ChemBioChem. 11, 14, p. 2026-2033

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of Lipophilic 1-Deoxygalactonojirimycin Derivatives as Galactosidase Inhibitors

Schitter, G., Scheucher, E., Steiner, A., Stütz, A., Thonhofer, M., Tarling, C., Withers, S., Wicki, J., Fantur, K., Paschke, E., Mahuran, D., Rigat, B., Tropak, M. & Wrodnigg, T., 2010, In : Beilstein Journal of Organic Chemistry . 6, 21, 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

2-Acetamino-1,2-dideoxynojirimycin-lysine hybrids as hexosaminidase inhibitors

Steiner, A., Schitter, G., Stütz, A., Wrodnigg, T., Tarling, C., Withers, S., Mahuran, D. & Tropak, M., 2009, In : Tetrahedron / Asymmetry. 20, p. 832-835

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of 1,5-dideoxy-1,5-iminoxylitol-amino acid hybrids as xylosidase inhibitors

Steiner, A., Stütz, A., Tarling, C., Withers, S. & Wrodnigg, T., 2009, In : Australian Journal of Chemistry. 62, p. 553-557

Research output: Contribution to journalArticleResearchpeer-review

2008

1-Deoxygalactonojirimycin-lysine hybrids as potent beta-galactosidase inhibitors

Steiner, A., Schitter, G., Stütz, A., Wrodnigg, T. M., Tarling, C., Withers, S. G., Fantur, K., Mahuran, D., Paschke, E. & Tropak, M., 2008, In : Bioorganic & Medicinal Chemistry. 16, p. 10216-10220

Research output: Contribution to journalArticleResearchpeer-review

Glycosidase Profiling with Immobilised Glycosidase Inhibiting Iminoalditols – A Proof-of-Concept Study

Steiner, A., Stütz, A., Wrodnigg, T. M., Tarling, C. A., Withers, S. G., Hermetter, A. & Schmidinger, H., 2008, In : Bioorganic & Medicinal Chemistry Letters. 18, 6, p. 1922-1925

Research output: Contribution to journalArticleResearchpeer-review

2007

1,5-Anhydro-D-fructose from D-fructose

Dekany, G., Lundt, I., Niedermair, F., Bichler, S., Spreitz, J., Sprenger, F. & Stütz, A., 2007, In : Carbohydrate research. 342, p. 1249-1253

Research output: Contribution to journalArticleResearchpeer-review

Iminoalditol-amino acid hybrids: synthesis and evaluation as glycosidase inhibitors

Steiner, A., Stütz, A., Tarling, C., Withers, S. & Wrodnigg, T., 2007, In : Carbohydrate research. 342, 12-13, p. 1850-1858

Research output: Contribution to journalArticleResearchpeer-review

2006

Fine Tuning of b-Glucosidase Inhibitory Activity in the 2,5-Dideoxy-2,5-imino-D-mannitol (DMDP) System

Wrodnigg, T. M., Stütz, A., Withers, S. G. & Tarling, C. A., 2006, In : Carbohydrate research. 341, p. 1717-1722

Research output: Contribution to journalArticleResearchpeer-review

Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols

Greimel, P., Häusler, H., Lundt, I., Rupitz, K., Stütz, A., Tarling, C., Withers, S. G. & Wrodnigg, T. M., 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, 8, p. 2067-2070

Research output: Contribution to journalArticleResearchpeer-review

Fluorescent glycosidase inhibiting 1,5-iminoalditols

Greimel, P., Häusler, H., Lundt, I., Rupitz, K., Stütz, A., Tarling, C., Withers, S. G. & Wrodnigg, T. M., 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, p. 2067-2070

Research output: Contribution to journalArticleResearchpeer-review

Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics

Lundt, I., Steiner, A., Stütz, A., Tarling, C. A., Ully, S., Withers, S. G. & Wrodnigg, T. M., 2006, In : Bioorganic & Medicinal Chemistry. 14, p. 1737-1742

Research output: Contribution to journalArticleResearchpeer-review

L-Idoseptanosides: substrates of D-glucosidases

Tauss, A., Rupitz, K., Steiner, A., Stütz, A., Tarling, C. A., Withers, S. G. & Wrodnigg, T. M., 2006, In : Tetrahedron / Asymmetry. 17, p. 234-239

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of 1,4-anhydro-D-fructose and 1,4-anhydro-D-tagatose

Dekany, G., Lundt, I., Steiner, A. & Stütz, A., 2006, In : Carbohydrate research. 341, p. 1737-1742

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of N-Protected Galactosamine Building Blocks from D-Tagatose via the Heyns Rearrangement

Wrodnigg, T. M., Lubdt, I. & Stütz, A., 2006, In : Journal of carbohydrate chemistry. 25, 1, p. 33-41

Research output: Contribution to journalArticleResearchpeer-review

2005

Non-natural aldofuranosides as substrates of a beta-glucosidase

Tauss, A., Greimel, P., Rupitz, K., Steiner, A., Stütz, A., Withers, S. G. & Wrodnigg, T. M., 2005, In : Tetrahedron / Asymmetry. 16, p. 159-165

Research output: Contribution to journalArticleResearchpeer-review

2004

Golgi endomannosidase inhibitor, alpha-D-glucopyranosyl-(1-3)-1-deoxynojirimycin: A five step synthesis from maltulose and examples of N-modified derivatives

Spreitz, J. & Stütz, A., 2004, In : Carbohydrate research. 339, p. 1823-1827

Research output: Contribution to journalArticleResearchpeer-review

Probing the aglycon binding site of β–glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors

Wrodnigg, T. M., Diness, F., Gruber, C., Häusler, H., Lundt, I., Rupitz, K., Steiner, A., Stütz, A., Tarling, C. A., Withers, S. G. & Wölfler, H., 2004, In : Bioorganic & Medicinal Chemistry. 12, 13, p. 3485-3495

Research output: Contribution to journalArticleResearchpeer-review

Simple syntheses of 4-O-glucosylated 1-deoxynojirimycins from maltose and cellobiose

Steiner, A. & Stütz, A., 2004, In : Carbohydrate research. 339, 15, p. 2615-2619

Research output: Contribution to journalArticleResearchpeer-review

Iminosugars and relatives as antiviral and potential antiinfective agents

Greimel, P., Spreitz, J., Stütz, A. & Wrodnigg, T. M., 2003, In : Current topics in medicinal chemistry. 3, 5, p. 513-523

Research output: Contribution to journalArticleResearchpeer-review

2002

A Simple Access to the D-Mannosidase Inhibitor 1-Deoxynojirimycin

Spreitz, J., Stütz, A. & Wrodnigg, T. M., 2002, In : Carbohydrate research. 337, p. 183-186

Research output: Contribution to journalArticleResearchpeer-review

A simple method for the preparation of 1-deoxynojirimycin from D-fructose

Spreitz, J. & Stütz, A., 2002, In : Carbohydrate research. 337, p. 183-186

Research output: Contribution to journalArticleResearchpeer-review

N-Alkylated Derivatives of 1,5-Dideoxy-1,5-iminoxylitol as beta-Xylosidase and beta-Glucosidase Inhibitors

Häusler, H., Rupitz, K., Stütz, A. & Withers, S. G., 2002, In : Monatshefte für Chemie = Chemical monthly. 133, p. 555-560

Research output: Contribution to journalArticleResearchpeer-review

2001

D-Xylose (D-glucose) isomerase and related enzymes in carbohydrate synthesis

Häusler, H. & Stütz, A., 2001, In : Topics in current chemistry. 215, p. 77-114

Research output: Contribution to journalArticleResearchpeer-review