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Arnold Stütz

Ao.Univ.-Prof. Dipl.-Ing. Dr.techn.

1981 …2020
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Research Output 1981 2019

2019

Synthesis of modified 1,5‑imino‑d‑xylitols as ligands for lysosomal β‑glucocerebrosidase

Zoidl, M., Wolfsgruber, A., Schalli, M., Nasseri, S. A., Weber, P., Stütz, A., Withers, S. G. & Wrodnigg, T. M., 2019, In : Monatshefte für Chemie = Chemical monthly. 150, 5, p. 831-842 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucosylceramidase
Substitution reactions
Glucosidases
Ligands
Xylitol
2018

Cyclopentanoid D-Galactosidase Inhibitors and potential Pharmacological Chaperones for GM1-Gangliosidosis

Weber, P., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W., Withers, S. G. & Wrodnigg, T. M., 2018.

Research output: Contribution to conferencePosterResearchpeer-review

CYCLOPENTANOID N-ACETYL-β-D-HEXOSAMINIDASE INHIBITORS

Weber, P., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W., Wolfsgruber, A. & Wrodnigg, T. M., 2018.

Research output: Contribution to conferencePosterResearchpeer-review

FURANOID CARBASUGARS AS GH 20 HEXOSAMINIDASE INHIBITORS AND POTENTIAL PHARMACOLOGICAL CHAPERONES

Wolfsgruber, A., Nasseri, S. A., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Torvisco Gomez, A., Müller, P., Tschernutter, M., Weber, P., Windischhofer, W., Withers, S. G. & Wrodnigg, T. M., 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Weber, P., Nasseri, S. A., Pabst, B., Torvisco Gomez, A., Müller, P., Paschke, E., Tschernutter, M., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Stütz, A., 2018, In : Molecules . 23, 3, 11 p., 708.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2017

A Morita-Baylis-Hillman Based de novo Synthesis of 5a-C-Pentyl-4-epi-Isofagomine - A Powerful Pharmacological Chaperone for GM1-Gangliosidosis

Lebl, R., Schalli, M., Tysoe, C., Pabst, B., Paschke, E., Stütz, A., Tschernutter, M., Weber, P., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Zoidl, M., 2017.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.

Lebl, R., Thonhofer, M., Tysoe, C., Pabst, B. M., Schalli, M., Weber, P., Paschke, E., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2017, In : Carbohydrate Research. p. 31-40

Research output: Contribution to journalArticleResearchpeer-review

A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols.

Schalli, M., Weber, P., Tysoe, C., Pabst, B. M., Thonhofer, M., Paschke, E., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2017, In : Bioorganic & Medicinal Chemistry Letters. p. 3431-3435

Research output: Contribution to journalArticleResearchpeer-review

C-5a-substituted validamine type glycosidase inhibitors.

Schalli, M., Wolfsgruber, A., Gonzalez Santana, A., Tysoe, C., Fischer, R., Stütz, A., Thonhofer, M. & Withers, S. G., 2017, In : Carbohydrate Research. 440-441, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Experimental Pharmacological Chaperones for Lysosomal Glycosidase Mutants

Schalli, M., Thonhofer, M., Lebl, R., Weber, P., Tysoe, C., Pabst, B., Paschke, E., Stütz, A., Tschernutter, M., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Zoidl, M., 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Furanoid Carbasugars as Hexosaminidase Inhibitors and Potential Pharmacological Chaperones

Weber, P., Lebl, R., Müller, S., Pabst, B., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Tysoe, C., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Zoidl, M., Jul 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Furanoid Carbasugars as Hexosaminidase Inhibitors and Potential Pharmacological Chaperones (D-galacto)

Weber, P., Lebl, R., Schalli, M., Schuh, L., Stütz, A., Withers, S. G., Wrodnigg, T. M. & Zoidl, M., 2017.

Research output: Contribution to conferencePosterResearchpeer-review

New Dansylated Derivates of 4-epi-Isofagomine

Thonhofer, M., Schalli, M., Tysoe, C., Pabst, B., Lebl, R., Paschke, E., Stütz, A., Tschernutter, M., Weber, P., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Zoidl, M., 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Novel Furanoid Carbasugars as Hexosaminidase Inhibitors and Potential Pharmalogical Chaparones for Tay Sachs, Sanfilippo B and Schindler/Kanzaki Diseases

Weber, P., Schalli, M., Lebl, R., Stütz, A., Wrodnigg, T. M. & Zoidl, M., 2017.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant.

Schalli, M., Tysoe, C., Fischer, R., Pabst, B. M., Thonhofer, M., Paschke, E., Rappitsch, T., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2017, In : Carbohydrate Research. 443-444, p. 15-22 8 p.

Research output: Contribution to journalArticleResearchpeer-review

N-Substituted 5-amino-1-hydroxymethyl-Cyclopentanetriols: A new Family of Promotors for GM1-Gangliosidosis Related Human Lysosomal β-Galactosidase Mutants

Schalli, M., Weber, P., Tysoe, C., Pabst, B., Lebl, R., Paschke, E., Stütz, A., Tschernutter, M., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Zoidl, M., 2017.

Research output: Contribution to conferencePosterResearchpeer-review

SYNTHESIS AND CHARACTERIZATION OF SUGAR-BASED TETRAACYLGERMANES

Schuh, L., Haas, M., Schalli, M., Weber, P., Stütz, A., Torvisco Gomez, A. & Stüger, H., 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Synthesis of 5a-C-Extended 4-epi-Isofagomine Derivatives from D-Glyceraldehyde – Powerful Pharmacological Chaperones for GM1-Gangliosidosis

Lebl, R., Thonhofer, M., Tysoe, C., Pabst, B., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Weber, P., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Zoidl, M., 2017.

Research output: Contribution to conferencePosterResearchpeer-review

Synthesis of C-Glycosyl Iminosugar Based Gycomimetics for Different Applications

Zoidl, M., Lebl, R., Gonzales-Santana, A., Schalli, M., Tysoe, C., Stütz, A., Weber, P., Withers, S. G. & Wrodnigg, T. M., 2017.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Synthesis of Iminoalditol Based Glycomimetics for Different Applications

Zoidl, M., Lebl, R., Schalli, M., Stütz, A., Thonhofer, M., Tysoe, C., Weber, P., Withers, S. G. & Wrodnigg, T. M., 2017.

Research output: Contribution to conferencePosterResearchpeer-review

2016

5-Fluoro derivatives of 4-epi-isofagomine as D-galactosidase inhibitors and potential pharmacological chaperones for GM1-gangliosidosis as well as Fabry's disease

Thonhofer, M., Gonzalez Santana, A., Fischer, R., Torvisco Gomez, A., Saf, R., Schalli, M., Stütz, A. & Withers, S. G., 2016, In : Carbohydrate Research. 420, p. 6-12

Research output: Contribution to journalArticleResearchpeer-review

Chemical synthesis of C-5a modified derivatives of the powerful β-glucosidase inhibitor isofagomine

Weber, P., Thonhofer, M., Hojnik, C., Lebl, R., Schalli, M., Stütz, A., Withers, S. G., Wrodnigg, T. M. & Zoidl, M., 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Synthesis and biological evaluation of C-5a extended derivatives of 4-epi-isofagomine

Thonhofer, M., Fischer, R., Gonzales-Santana, A., Hojnik, C., Lebl, R., Papst, B., Schalli, M., Stütz, A., Tschernutter, M., Weber, P., Windischhofer, W., Withers, S. G., Wrodnigg, T. & Zoidl, M., 11 Feb 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful beta-galactosidase inhibitors and low concentartion activators of GM1-gangliosidosis related human lysosomal beta-galactosidase

Thonhofer, M., Weber, P., Gonzalez Santana, A., Fischer, R., Pabst, B., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, p. 1438-1442

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.

Thonhofer, M., Weber, P., Santana, A. G., Fischer, R., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 5, p. 1438-1442 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.

Thonhofer, M., Weber, P., Gonzalez Santana, A., Tysoe, C., Fischer, R., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2016, In : Carbohydrate Research. 429, p. 71-80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of carbacyclic inhibitors for ß-galactosidases

Schalli, M., Fischer, R., Hojnik, C., Lebl, R., Thonhofer, M., Stütz, A., Weber, P., Wrodnigg, T. & Zoidl, M., 11 Feb 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

The Amadori rearrangement as conjugation method: scope and limitations

Hojnik, C., Gloe, T., Lebl, R., Lindhorst, T., Schalli, M., Stütz, A., Torvisco Gomez, A., Thonhofer, M., Weber, P., Wrodnigg, T. & Zoidl, M., 12 Feb 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

The Staudinger/aza-Wittig - Grignard reaction cascade: Stereochemical considerations and biological evaluation

Zoidl, M., Hojnik, C., Lebl, R., Schalli, M., Stütz, A., Thonhofer, M., Torvisco Gomez, A., Weber, P. & Wrodnigg, T., 12 Feb 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

The Staudinger/aza-Wittig nucleophile reaction cascade: Scope and limitations

Lebl, R., Hojnik, C., Schalli, M., Stütz, A., Thonhofer, M., Torvisco Gomez, A., Weber, P., Wrodnigg, T. & Zoidl, M., 12 Feb 2016.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

2015

A POWERFUL APPROACH TOWARDS C-GLYCOSYL TYPE IMINOALDITOL BUILDING BLOCKS FOR BIOLOGICAL APPLICATIONS

Zoidl, M., Gonzales-Santana, A., Hojnik, C., Schalli, M., Siriwardena, A., Stütz, A., Thonhofer, M., Torvisco Gomez, A., Wrodnigg, T. & Withers, S., 2015.

Research output: Contribution to conferencePosterResearch

Are D-manno-configured Amadori products ligands of bacterial lectin FimH?

Hojnik, C., Gloe, T-E., Hoff, O., Lindhorst, T. K., Schalli, M., Stütz, A., Thonhofer, M., Wrodnigg, T. & Zoidl, M., 12 Feb 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Exploration of the SAW-Grignard Reaction for the Synthesis of Iminoalditol Based Glycoprobes.

Zoidl, M., Hoff, O., Hojnik, C., Schalli, M., Siriwardena, A., Stütz, A., Thonhofer, M. & Wrodnigg, T., 12 Feb 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

GLYCOLIPID MIMETICS: FLUORINE CONTAINING ISOIMINOSUGARS AS CHEMICAL CHAPERONES FOR GM1 GANGLIOSIDOSIS AND FABRY´S DISEASE

Stütz, A., Fischer, R., Gonzalez Santana, A., Hojnik, C., Paschke, E., Schalli, M., Thonhofer, M., Torvisco Gomez, A., Withers, S. G., Wrodnigg, T. & Zoidl, M., 2015.

Research output: Contribution to conferencePosterResearch

GLYCOLIPID MIMETICS: LIPOPHILIC 4-EPI-ISOFAGOMINE DERIVATIVES AS CHEMICAL CHAPERONES FOR GM1-GANGLIOSIDOSIS AND MORQUIO B

Thonhofer, M., Fischer, R., Gonzalez-Santana, A., Hojnik, C., Paschke, E., Schalli, M., Stütz, A., Weber, P., Withers, S. G., Wrodnigg, T. & Zoidl, M., 2015.

Research output: Contribution to conferencePosterResearch

GLYCOLIPID MIMETICS: LIPOPHILIC CARBASUGARS AS INHIBITORS AND CHEMICAL CHAPERONES FOR GM1 GANGLIOSIDOSIS

Schalli, M., Fischer, R., Gonzalez Santana, A., Hojnik, C., Paschke, E., Stütz, A., Thonhofer, M., Withers, S. G., Wrodnigg, T. & Zoidl, M., 2015.

Research output: Contribution to conferencePosterResearch

New Synthesis of C5a-derivatives of 4-epi-isofagomine and analogues

Thonhofer, M., Stütz, A., Wrodnigg, T., Fischer, R., Hojnik, C., Zoidl, M., Weber, P. & Schalli, M., 12 Feb 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Synthesis of D-galacto-validamine derivatives

Schalli, M., Hojnik, C., Thonhofer, M., Stütz, A., Wrodnigg, T. & Zoidl, M., 12 Feb 2015.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

The Amadori Rearrangement: A Versatile Reaction for the Synthesis of Neoglycoconjugates

Hojnik, C., Gloe, T-E., Lindhorst, T. K., Schalli, M., Stütz, A., Thonhofer, M., Wrodnigg, T. & Zoidl, M., 2015.

Research output: Contribution to conferencePosterResearch

The Amadori Rearrangement as Key Step for the Synthesis of Biologically Relevant C-Glycosyl Type Neoglycoconjugates

Wrodnigg, T., Hojnik, C., Gloe, T., Lindhorst, T., Schalli, M., Stütz, A., Thonhofer, M. & Zoidl, M., 2015.

Research output: Contribution to conferencePosterResearch

2014

A Convenient One-Pot Synthesis for functionalised Iminosugar Scaffolds as Building Blocks for Glycoprobes

Zoidl, M., Schalli, M., Siriwardena, A., Stütz, A., Withers, S. & Wrodnigg, T., 2014.

Research output: Contribution to conferencePosterResearch

Open Access
File

A Multicomponent Approach towards functionalised Iminoalditols as Building Blocks for Glycoprobes

Zoidl, M., Müller, B., Hojnik, C., Schalli, M., Siriwardena, A., Stütz, A., Thonhofer, M., Withers, S. & Wrodnigg, T., 2014.

Research output: Contribution to conferencePosterResearch

Open Access
File

A new approach to fluorinated 4-epi-isofagomine derivatives and their D-galactosidase inhibitory properties

Thonhofer, M., Fischer, R., Gonzalez-Santana, A., Hojnik, C., Saf, R., Schalli, M., Stütz, A., Torvisco Gomez, A., Withers, S. G., Wrodnigg, T. & Zoidl, M., 5 Sep 2014.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Carbacyclic Amines as Active Site Ligands for Carbohydrate Processing Enzymes.

Schalli, M., Hojnik, C., Stütz, A., Thonhofer, M., Torvisco Gomez, A., Withers, S., Wrodnigg, T. & Zoidl, M., 2014.

Research output: Contribution to conferencePosterResearch

Diversity Oriented Synthesis of Iminoalditol Building Blocks for Glycoprobes

Zoidl, M., Gonzalez Santana, A., Hojnik, C., Saf, R., Schalli, M., Stütz, A., Thonhofer, M., Withers, S. & Wrodnigg, T., 5 Sep 2014.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch

Open Access
File

New 4-epi -Isofagomine Derivatives for Glycosidase Research

Thonhofer, M., Stütz, A., Schalli, M., Hojnik, C., Zoidl, M., Wrodnigg, T., Torvisco Gomez, A. & Withers, S. G., 2014.

Research output: Contribution to conferencePosterResearch

New Synthesis of 4-epi-Isofagomine and Fluoro Derivatives

Thonhofer, M., Schalli, M., Torvisco Gomez, A., Zoidl, M., Wrodnigg, T. & Stütz, A., 13 Feb 2014.

Research output: Contribution to conference(Old data) Lecture or PresentationResearch