Research Center Pharmaceutical Engineering (RCPE) (98888)

  • 8010

    Inffeldgasse 13 Graz

    Austria

Research Output 1991 2020

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2018

Ensuring parenteral biologics’ quality and safety

Stegemann, S., 1 Jul 2018, In : AAPS Newsmagazine. 7, p. 12-17 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Formulation performance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization

Hörmann, T., Jäger, N., Funke, A., Mürb, R-K., Khinast, J. G. & Paudel, A., 20 Dec 2018, In : International Journal of Pharmaceutics. 553, 1-2, p. 408-421 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Nimodipine
Polymers
Vacuum
Temperature
Fourier Transform Infrared Spectroscopy

Gluing Pills Technology: A novel route to multilayer tablet manufacturing

Demiri, V., Stranzinger, S., Rinner, P., Piller, M., Sacher, S., Lingitz, J., Khinast, J. & Salar-Behzadi, S., 5 Sep 2018, In : International Journal of Pharmaceutics. 548, 1, p. 672-681 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tablets
Technology
Povidone
Precision Medicine
Translational Medical Research

Hopper flow of irregularly shaped particles (non-convex polyhedra): GPU-based DEM simulation and experimental validation

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Pizette, P. & Xu, W., 2018, In : Chemical Engineering Science. p. 34-51

Research output: Contribution to journalArticleResearchpeer-review

Improving therapeutics to better care for older adults and the young: Report from an American College of Clinical Pharmacology workshop

Lau, S. W. J., Schlender, J. F., Abernethy, D. R., Burckart, G. J., Golden, A., Slattum, P. W., Stegemann, S. & Eissing, T., 31 Jan 2018, In : The journal of clinical pharmacology. 58, 3, p. 277-280 4 p.

Research output: Contribution to journalArticleResearchpeer-review

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Residence time distribution
Extrusion
Drug products
Color
Surface-Active Agents
adhesives
sulfates
drugs
aerodynamics
powders

Key acceptability attributes of orodispersible films

Scarpa, M., Paudel, A., Kloprogge, F., Hsiao, W. K., Bresciani, M., Gaisford, S. & Orlu, M., Apr 2018, In : European journal of pharmaceutics and biopharmaceutics. 125, p. 131-140 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Carboxymethylcellulose Sodium
Mouth
Polymers
Molecular Weight
Literature

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing

Khinast, J., Leane, M., Pitt, K., Reynolds, G. K., Dawson, N., Ziegler, I., Szepes, A., Crean, A. M., Agnol, R. D., Broegmann, B., Charlton, S., Davies, C., Gamble, J., Gamlen, M., Hsiao, W. K., Khimyak, Y., Kleinebudde, P., Moreton, C., Oswald, M., Page, S. & 5 othersPaudel, A., Sahoo, R., Sheehan, S., Stamato, H. & Stone, E., 2018, In : Pharmaceutical development and technology. p. 964-977 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Industry
Particle Size
Pharmaceutical Preparations
Proxy
Drug Compounding

Material tracking in a continuous direct capsule-filling process via residence time distribution measurements

Kruisz, J., Rehrl, J., Faulhammer, E., Witschnigg, A. & Khinast, J., 2018, In : International Journal of Pharmaceutics. 550, 1-2, p. 347-358

Research output: Contribution to journalArticleResearchpeer-review

Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets

Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In : Powder Technology. 325, p. 247-260

Research output: Contribution to journalArticleResearchpeer-review

Patient centric drug product design in modern drug delivery as an opportunity to increase safety and effectiveness

Stegemann, S., 1 Jun 2018, In : Expert opinion on drug delivery. 15, 6, p. 619-627 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Dry Powder Inhalers
Surface Properties
Capsules
Weights and Measures
Lactose

Pharmaceutical-grade oral films as substrates for printed medicine

Wimmer-Teubenbacher, M., Planchette, C., Pichler, H., Markl, D., Hsiao, W. K., Paudel, A. & Stegemann, S., 2018, In : International Journal of Pharmaceutics. 547, 1-2, p. 169-180 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Printing
Medicine
Pharmaceutical Preparations
Polymers
Polarization Microscopy

Polymer adhesion predictions for oral dosage forms to enhance drug administration safety. Part 2: In vitro approach using mechanical force methods

Drumond, N. & Stegemann, S., 5 Mar 2018, In : Colloids and Surfaces / B. 166, p. 17-23

Research output: Contribution to journalArticleResearchpeer-review

Particle interactions
Dosage Forms
safety
Polymers
drugs
Open Access
Molecular Dynamics Simulation
Solubility
Excipients
Polymers
Pharmaceutical Preparations

Spatially Resolved Spectral Powder Analysis: Experiments and Modeling

Khinast, J., Scheibelhofer, O., Wahl, P., Larchevêque, B. & Chauchard, F., 2018, In : Applied Spectroscopy. p. 521-534

Research output: Contribution to journalArticleResearchpeer-review

Study of a low-dose capsule filling process by dynamic and static tests for advanced process understanding

Paudel, A., Stranzinger, S., Faulhammer, E., Scheibelhofer, O., Calzolari, V., Biserni, S. & Khinast, J., 5 Apr 2018, In : International Journal of Pharmaceutics. 540, 1-2, p. 22-30 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Powders
Capsules
Weights and Measures
Vibration
Lactose

Voidage correction algorithm for unresolved Euler–Lagrange simulations

Askarishahi, M., Salehi, M. & Radl, S., 2018, In : Computational Particle Mechanics. p. 1-19

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Exchange rate
Coarsening
Drag
Suspensions
Drag Force
2017

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In : Chemie - Ingenieur - Technik. 89, 8

Research output: Contribution to journalArticleResearchpeer-review

Analysis of Flow and Mixing in Screw Elements of Corotating Twin-Screw Extruders via SPH

Eitzlmayr, A., Matic, J. & Khinast, J., Jun 2017, In : AIChE Journal. 63, 6, p. 2451-2463

Research output: Contribution to journalArticleResearchpeer-review

Extruders
Hydrodynamics
Conveying
Pressure
Geometry

Analytical Solution for Thermal Transport in Packed Beds with Volumetric Heat Source

Salehi, M., Askarishahi, M. & Radl, S., 20 Jan 2017, In : Chemical Engineering Journal. 316, p. 131-136

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Packed beds
heat source
Fluids
fluid
temperature profile

An investigation of the hydrodynamic similarity of single-spout fluidized beds using CFD-DEM simulations

Ebrahimi, M., Siegmann, E., Prieling, D., Glasser, B. J. & Khinast, J. G., Oct 2017, In : Advanced powder technology. 28, 10, p. 2465-2481

Research output: Contribution to journalArticleResearchpeer-review

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules

Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In : Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Technology
Pharmaceutical Preparations
Pressure
Temperature
Research

Comparison of video analysis and simulations of a drum coating process

Boehling, P., Toschkoff, G., Dreu, R., Just, S., Kleinebudde, P., Funke, A., Rehbaum, H. & Khinast, J. G., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 72-81 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tablets
Drug Industry
Mechanics

Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging

Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In : International Journal of Pharmaceutics. 518, 1-2, p. 130-137

Research output: Contribution to journalArticleResearchpeer-review

Crystal Engineering in Continuous Plug-Flow Crystallizers

Neugebauer, P., Besenhard, M., Khinast, J. & Scheibelhofer, O., 10 Oct 2017, In : Crystal Growth and Design.

Research output: Contribution to journalArticleResearchpeer-review

DEM study of granular transport in partially filled horizontal screw conveyors

Orefice, L. & Khinast, J. G., Jan 2017, In : Powder Technology. 305, p. 347-356

Research output: Contribution to journalArticleResearchpeer-review

Drug–Excipient Interactions in the Solid State: The Role of Different Stress Factors

Gressl, C., Brunsteiner, M., Davis, A., Landis, M., Pencheva, K., Scrivens, G., Sluggett, G. W., Wood, G. P. F., Gruber-Wölfler, H., Khinast, J. & Paudel, A., 2 Nov 2017, In : Molecular pharmaceutics. 14, 12, p. 4560-4571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Citric Acid
Humidity
Pharmaceutical Preparations
Drug Stability
Codeine

Effect of Acetonitrile-Based Crystallization Conditions on the Crystal Quality of Vitamin D3

Gruber-Woelfler, H., Escribà-Gelonch, M., Noël, T., Maier, M. C. & Hessel, V., 1 Nov 2017, In : Chemical Engineering & Technology. 40, 11, p. 2016-2024 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Vitamins
Crystallization
Acetonitrile
Cholecalciferol
Crystals

Efficient Discrete Element Method Simulation Strategy for Analyzing Large-Scale Agitated Powder Mixers

Siegmann, E., Jajcevic, D., Radeke, C., Strube, D., Friedrich, K. & Khinast, J. G., 1 Aug 2017, In : Chemie - Ingenieur - Technik. 89, 8, p. 995-1005 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Finite difference method
Product development
Powders
Drug products
Pharmaceutical Preparations

Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates

Eder, S., Beretta, M., Witschnigg, A., Koutsamanis, I., Eggenreich, K., Khinast, J. G., Koscher, G., Paudel, A., Nickisch, K., Friedrich, M., Froehlich, E. & Roblegg, E., 1 Nov 2017, In : AAPS PharmSciTech . 18, 8, p. 2971-2976 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Vacuum
extrusion
drugs
manufacturing
Skin

Full-Physics Simulations of Spray-Particle Interaction in a Bubbling Fluidized Bed

Askarishahi, M., Salehi, M. & Radl, S., 31 Jan 2017, In : AIChE Journal. 63, 7, p. 2569–2587

Research output: Contribution to journalArticleResearchpeer-review

File
Particle interactions
Physics
Fluidized beds
Evaporation
Hot Temperature

How does secondary processing affect the physicochemical properties of inhalable salbutamol sulphate particles? A temporal investigation

Pinto, J., Radivojev, S., Zellnitz, S., Roblegg, E. & Paudel, A., 7 Aug 2017, In : International Journal of Pharmaceutics. 528, 1-2, p. 416-428 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Albuterol
Sulfates
Chemical Phenomena
Pharmaceutical Preparations
Dry Powder Inhalers

Impulse-based dynamics for studying quasi-static granular flows: Application to hopper emptying of non-spherical particles

Toson, P. & Khinast, J. G., 15 May 2017, In : Powder Technology. 313, p. 353-360 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hoppers
Finite difference method
Virtual reality
Aspect ratio
Robotics

Influence of Process Route on the Mechanical Properties of Polymer Based Intravaginal Drug Delivery Systems

Eggenreich, K., Schrank, S., Koscher, G., Nickisch, K., Roblegg, E. & Khinast, J., 2017, In : AIP Conference Proceedings. 1914

Research output: Contribution to journalArticleResearchpeer-review

Liquid Transport Rates during Binary Collisions of Unequally-sized Particles

Wu, M., Khinast, J. & Radl, S., 2017, In : Powder Technology. 309, p. 95-109 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Liquids
Computer simulation

Micro-feeding and dosing of powders via a small-scale powder pump

Besenhard, M., Fathollahi, S., Siegmann, E., Slama, E., Faulhammer, E. & Khinast, J., 2017, In : International Journal of Pharmaceutics. 519, 1-2, p. 314-322

Research output: Contribution to journalArticleResearchpeer-review

Reaction Calorimetry in Microreactor Environments—Measuring Heat of Reaction by Isothermal Heat Flux Calorimetry

Glotz, G., Podmore, P., Knoechel, D. J., Gruber-Wölfler, H. & Kappe, C. O., 20 Apr 2017, In : Organic process research & development.

Research output: Contribution to journalArticleResearchpeer-review

Replacing conventional decontamination of hatching eggs with a natural defense strategy based on antimicrobial, volatile pyrazines

Kusstatscher, P., Cernava, T., Liebminger, S. & Berg, G., Oct 2017, In : Scientific reports. 7, 13253.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
pyrazines
decontamination
hatching
anti-infective agents
fumigation

Self-emulsification of Lipidic Drug Delivery System in Pure Water and in Concentrated Glycerol Solution

Planchette, C., Mercuri, A., Arcangeli, L., Kriechbaum, M. & Laggner, P., 2017, In : AAPS PharmSciTech . 18, 8, p. 3053-3063

Research output: Contribution to journalArticleResearchpeer-review

The effect of material attributes and process parameters on the powder bed uniformity during a low-dose dosator capsule filling process

Stranzinger, S., Faulhammer, E., Calzolari, V., Biserni, S., Dreu, R., Šibanc, R., Paudel, A. & Khinast, J., 10 Jan 2017, In : International Journal of Pharmaceutics. 516, p. 9-20 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Powders
Capsules
Weights and Measures
Excipients
Lactose
2016

A model for the non-isothermal drying of particle-laden pastes

Brenn, G., Steiner, H., Kondor, I., Planchette, C., Mercuri, A. & Scharrer, G., 2016, In : International journal of heat and mass transfer. 92, p. 558-571

Research output: Contribution to journalArticleResearchpeer-review

An in vitro–in vivo correlation study for nifedipine immediate release capsules administered with water, alcoholic and non-alcoholic beverages: Impact of in vitro dissolution media and hydrodynamics

Mercuri, A., Fares, R., Bresciani, M. & Nikoletta, F., 2016, In : International Journal of Pharmaceutics. 499, 1-2, p. 330-342

Research output: Contribution to journalArticleResearchpeer-review

Bending modulus of bidisperse rafts: Local and collective contributions

Petit, P., Biance, A-L., Lorenceau, E. & Planchette, C., 2016, In : Physical review / E. 93, p. 042802

Research output: Contribution to journalArticleResearchpeer-review