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2019

Sensitivity of a continuous hot-melt extrusion and strand pelletization line to control actions and composition variation

Hörmann, T. R., Rehrl, J., Scheibelhofer, O., Schaden, L. M., Funke, A., Makert, C. & Khinast, J. G., 20 Jul 2019, In : International Journal of Pharmaceutics. 566, p. 239-253 15 p.

Research output: Contribution to journalArticle

Shedding light on coatings: Real-time monitoring of coating quality at industrial scale

Sacher, S., Wahl, P., Weissensteiner, M., Wolfgang, M., Pokhilchuk, Y., Looser, B., Thies, J., Raffa, A. & Khinast, J. G., 20 Jul 2019, In : International Journal of Pharmaceutics. 566, p. 57-66

Research output: Contribution to journalArticle

The need for new control strategies for particulate matter in parenterals

Poms, J., Sacher, S., Nixdorf, M., Dekner, M., Wallner-Mang, S., Janssen, I., Khinast, J. G. & Schennach, R., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 739-750 12 p.

Research output: Contribution to journalArticle

Theory and practice of European co-operative education and training for the support of energy transition

Maier, S., Narodoslawsky, M., Borell-Damián, L., Arentsen, M., Kienberger, M., Bauer, W., Ortner, M., Foxhall, N., Oswald, G., Joval, J. M., Krozer, Y., Urbanz, T., Sakulin, C., Tihamer-Tibor, S. & Dobravec, V., 25 Jul 2019, In : Energy, Sustainability and Society . 9, 12 p., 29.

Research output: Contribution to journalArticle

Open Access

Towards rigorous multiscale flow models of nanoparticle reactivity in chemical looping applications

Andersson, S., Radl, S., Svenum, I-H., Shevlin, S. A., Guo, Z. X. & Amini, S., 10 Jun 2019, In : Catalysis Today.

Research output: Contribution to journalArticle

Open Access

Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate

Zellnitz, S., Pinto, J., Brunsteiner, M., Schröttner, H., Khinast, J. & Paudel, A., 2019, In : Pharmaceutical research. 36, 6, p. 80 11 p., 36:80.

Research output: Contribution to journalArticle

Two-Fluid-Model-Based Full Physics Simulations of Mixing in Noncohesive Wet Fluidized Beds

Askarishahi, M., Salehi, M. S. & Radl, S., 10 Jul 2019, In : Industrial and Engineering Chemistry Research. 58, 27, p. 12323-12346 24 p.

Research output: Contribution to journalArticle

Use of PBPK Modeling to Evaluate the Performance of Dissolv It, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products

Hassoun, M., Malmlöf, M., Scheibelhofer, O., Kumar, A., Bansal, S., Selg, E., Nowenwik, M., Gerde, P., Radivojev, S., Paudel, A., Arora, S. & Forbes, B., 4 Mar 2019, In : Molecular pharmaceutics. 16, 3, p. 1245-1254 10 p.

Research output: Contribution to journalArticle

Open Access

Using online content uniformity measurements for rapid automated process development exemplified via an X-ray system

Wagner, B., Brinz, T. & Khinast, J., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 775-787

Research output: Contribution to journalArticle

2018

A combined DEM & FEM approach for modelling roll compaction process

Mazor, A., Orefice, L., Michrafy, A., de Ryck, A. & Khinast, J. G., Sep 2018, In : Powder Technology. 337, p. 3-16 14 p.

Research output: Contribution to journalArticle

A multivariate process monitoring strategy and control concept for a small-scale fermenter in a PAT environment

Besenhard, M. O., Scheibelhofer, O., François, K., Joksch, M. & Kavsek, B., 1 Oct 2018, In : Journal of Intelligent Manufacturing. 29, 7, p. 1501-1514 14 p.

Research output: Contribution to journalArticle

Automation of a dosing-disc capsule filler from the perspective of reliability and safety

Wagner, B., Brinz, T., Otterbach, S. & Khinast, J., 4 Mar 2018, In : Drug Development and Industrial Pharmacy. 44, 3, p. 502-510 9 p.

Research output: Contribution to journalArticle

Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles

Betke, T., Maier, M. C., Gruber-Wölfler, H. & Gröger, H., 30 Nov 2018, In : Nature Communications . 9, p. 5112 9 p.

Research output: Contribution to journalArticle

Open Access

Characterization of the coating and tablet core roughness by means of 3D optical coherence tomography

Khinast, J., Markl, D., Wahl, P., Pichler, H. & Sacher, S., 2018, In : International Journal of Pharmaceutics. p. 459-466

Research output: Contribution to journalArticle

Continuous Drying of Pharmaceutical Powders Using a Twin-Screw Extruder

Kreimer, M., Aigner, I., Lepek, D. & Khinast, J., 20 Jul 2018, In : Organic Process Research & Devlopment. 22, 7, p. 813-823 11 p.

Research output: Contribution to journalArticle

Continuous-Flow In-Line Solvent-Swap Crystallization of Vitamin D3

Escriba-Gelonch, M., Hessel, V., Maier, M. C., Neira, M. F. & Gruber-Wölfler, H., 2018, In : Organic Process Research & Devlopment. 22, 2, p. 178-189

Research output: Contribution to journalArticle

Open Access

Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors

Rehrl, J., Kartunnen, A-P., Nicolaï, N., Hörmann, T., Horn, M., Korhonnen, O., Nopens, I., de Beer, T. & Khinast, J., 30 May 2018, In : International Journal of Pharmaceutics. 543, 1-2, p. 60-72

Research output: Contribution to journalArticle

Critical Evaluation of Organic Thin-Film Transistor Models

Krammer, M., Borchert, J. W., Petritz, A., Karner-Petritz, E., Schider, G., Stadlober, B., Klauk, H. & Zojer, K., 20 Dec 2018, In : arXiv.org e-Print archive.

Research output: Contribution to journalArticle

Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer

Neugebauer, P., Besenhard, M., Peter, A., Gruber-Wölfler, H. & Khinast, J., 15 Jun 2018, In : Crystal Growth and Design. 18, 8, p. 4403-4415

Research output: Contribution to journalArticle

Density fluctuations in amorphous pharmaceutical solids. Can SAXS help to predict stability?

Laggner, P. & Paudel, A., 2 May 2018, In : Colloids and Surfaces / B. 168, p. 76-82 6 p.

Research output: Contribution to journalArticle

Detailed modeling and process design of an advanced continuous powder mixer

Toson, P., Siegmann, E., Trogrlic, M., Kureck, H., Khinast, J., Jajcevic, D., Doshi, P., Blackwood, D., Bonnassieux, A., Daugherity, P. D. & am Ende, M. T., 1 Dec 2018, In : International Journal of Pharmaceutics. 552, 1-2, p. 288-300 13 p.

Research output: Contribution to journalArticle

Development and verification of anisotropic drag closures for filtered Two Fluid Models

Cloete, J. H., Cloete, S., Municchi, F., Radl, S. & Amini, S., Dec 2018, In : Chemical Engineering Science. 192, p. 930-954

Research output: Contribution to journalArticle

Development and verification of anisotropic solids stress closures for filtered Two Fluid Model

Cloete, J. H., Cloete, S., Radl, S. & Amini, S., 16 Jun 2018, In : Chemical Engineering Science. 192, p. 906-929

Research output: Contribution to journalArticle

Open Access

Effect of particle shape in grinding mills using a GPU based DEM code

Khinast, J., Govender, N., Rajamani, R. K., Wilke, D. N., Wu, C-Y. & Glasser, B. J., 2018, In : Minerals engineering. p. 71-84

Research output: Contribution to journalArticle

EMA : Die Expertise der Apotheker ist gefragt.

Translated title of the contribution: EMA: The expertise of pharmacists are rrequiredStegemann, S., 1 Jan 2018, In : Österreichische Apotheker-Zeitung. 72, 1, p. 60-62 3 p.

Research output: Contribution to journalArticle

Ensuring parenteral biologics’ quality and safety

Stegemann, S., 1 Jul 2018, In : AAPS Newsmagazine. 7, p. 12-17 5 p.

Research output: Contribution to journalArticle

Flow of granular materials in a bladed mixer: Effect of particle properties and process parameters on impeller torque and power consumption

Boonkanokwong, V., Frank, R. P., Valliappan, P., Remy, B., Khinast, J. G. & Glasser, B. J., 1 Nov 2018, In : Advanced powder technology. 29, 11, p. 2733-2752 20 p.

Research output: Contribution to journalArticle

Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry

Hiebler, K., Lichtenegger, G. J., Maier, M. C., Park, E. S., Gonzales-Groom, R., Binks, B. P. & Gruber-Wölfler, H., 18 Mar 2018, In : Beilstein Journal of Organic Chemistry . 14, p. 648 - 658

Research output: Contribution to journalArticle

Open Access

Hopper flow of irregularly shaped particles (non-convex polyhedra): GPU-based DEM simulation and experimental validation

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Pizette, P. & Xu, W., 2018, In : Chemical Engineering Science. p. 34-51

Research output: Contribution to journalArticle

Improving therapeutics to better care for older adults and the young: Report from an American College of Clinical Pharmacology workshop

Lau, S. W. J., Schlender, J. F., Abernethy, D. R., Burckart, G. J., Golden, A., Slattum, P. W., Stegemann, S. & Eissing, T., 31 Jan 2018, In : The journal of clinical pharmacology. 58, 3, p. 277-280 4 p.

Research output: Contribution to journalArticle

In-line measurement of residence time distribution in melt extrusion via video analysis

Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In : Polymer Engineering and Science. 58, 2, p. 170-179 10 p.

Research output: Contribution to journalArticle

Key acceptability attributes of orodispersible films

Scarpa, M., Paudel, A., Kloprogge, F., Hsiao, W. K., Bresciani, M., Gaisford, S. & Orlu, M., Apr 2018, In : European journal of pharmaceutics and biopharmaceutics. 125, p. 131-140 9 p.

Research output: Contribution to journalArticle

Large-scale GPU based DEM modeling of mixing using irregularly shaped particles

Khinast, J., Govender, N., Wilke, D. N., Wu, C-Y., Rajamani, R. K. & Glasser, B. J., 2018, In : Advanced powder technology. p. 2476-2490

Research output: Contribution to journalArticle

Manufacturing classification system in the real world: factors influencing manufacturing process choices for filed commercial oral solid dosage formulations, case studies from industry and considerations for continuous processing

Khinast, J., Leane, M., Pitt, K., Reynolds, G. K., Dawson, N., Ziegler, I., Szepes, A., Crean, A. M., Agnol, R. D., Broegmann, B., Charlton, S., Davies, C., Gamble, J., Gamlen, M., Hsiao, W. K., Khimyak, Y., Kleinebudde, P., Moreton, C., Oswald, M., Page, S. & 5 others, Paudel, A., Sahoo, R., Sheehan, S., Stamato, H. & Stone, E., 2018, In : Pharmaceutical development and technology. p. 964-977 13 p.

Research output: Contribution to journalArticle

Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets

Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In : Powder Technology. 325, p. 247-260

Research output: Contribution to journalArticle

Microstructure evolution in a 6082 aluminium alloy during thermomechanical treatment

Poletti, C., Bureau, R., Loidolt, P., Simon, P., Mitsche, S. & Spuller, M., 30 Jul 2018, In : Materials. 11, 8, 1319.

Research output: Contribution to journalArticle

Open Access
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Numerical investigation of a coarse-grain discrete element method in solid mixing in a spouted bed

Takabatake, K., Mori, Y., Khinast, J. G. & Sakai, M., 15 Aug 2018, In : Chemical Engineering Journal. 346, p. 416-426 11 p.

Research output: Contribution to journalArticle