Research Output

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Poster
2017

Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePoster

Stabilization of a cancer associated variant of human NQO1 by the use of small-molecular chaperones

Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Waltenstorfer, D., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

Research output: Contribution to conferencePoster

Structure-based reaction mechanism of oleate hydratase from Elizabethkingia meningoseptica

Engleder, M., Pavkov-Keller, T., Emmerstorfer-Augustin, A., Hromic, A., Schrempf, S., Steinkellner, G., Wriessnegger, T., Leitner, E., Strohmeier, G., Kaluzna, I., Daniel, M., Martin, S., Wallner, S., Macheroux, P., Gruber, K. & Pichler, H., 23 Apr 2017.

Research output: Contribution to conferencePoster

Substrate specificity of CYP505X from Aspergillus fumigatus

Bachler, T., Alkofer, A., Gralewska, P., Weninger, A., Glieder, A., Breinbauer, R. & Winkler, M., 11 Jul 2017.

Research output: Contribution to conferencePoster

Synthesis of 5a-C-Extended 4-epi-Isofagomine Derivatives from D-Glyceraldehyde – Powerful Pharmacological Chaperones for GM1-Gangliosidosis

Lebl, R., Thonhofer, M., Tysoe, C., Pabst, B., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Weber, P., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Zoidl, M., 2017.

Research output: Contribution to conferencePoster

Synthesis of an Amphiphilic Oligoaryl-based ApoA1 Mimetic

Dobrounig, P. S., 19 Apr 2017.

Research output: Contribution to conferencePoster

Synthesis of an Amphiphilic Oligoaryl-based ApoA1 Mimetic

Dobrounig, P. S. & Breinbauer, R., 29 Jul 2017.

Research output: Contribution to conferencePoster

Synthesis of Iminoalditol Based Glycomimetics for Different Applications

Zoidl, M., Lebl, R., Schalli, M., Stütz, A., Thonhofer, M., Tysoe, C., Weber, P., Withers, S. G. & Wrodnigg, T. M., 2017.

Research output: Contribution to conferencePoster

2016

A General and Direct Reductive Amination of Aldehydes and Ketones with Electron-Deficient Anilines

Pletz, J., Berg, B. & Breinbauer, R., 28 Jun 2016.

Research output: Contribution to conferencePoster

A Modular Synthesis of an Amphiphilic Oligoaryl-based ApoA1 Mimetic as a Potential Drug Carrier

Dobrounig, P. S. & Breinbauer, R., 28 Jun 2016.

Research output: Contribution to conferencePoster

An Additive-Free Approach for the Alpha-Allylation of Nitrogen Heterocycles

Kljajic, M. & Breinbauer, R., 30 Jun 2016.

Research output: Contribution to conferencePoster

Berberine bridge enzyme-like proteins: From characterization to application

Daniel, B., Pils, S., Steiner, B., Wallner, S., Pavkov-Keller, T., Gruber, K., Schrittwieser, J., Fuchs, M., Kroutil, W. & Macheroux, P., 12 Sep 2016.

Research output: Contribution to conferencePoster

Characterization and therapeutic exploitation of human dipeptidyl peptidase III (hDPPIII): an enzyme with multifaceted functionality

Jha, S., Taschler, U., Ivkovic, J., Breinbauer, R., Gruber, K., Zimmermann, R. & Macheroux, P., Sep 2016.

Research output: Contribution to conferencePoster

Chemo-, regio- and stereoselectivity of carboxylic acid reductases

Winkler, C. K., Plank, M., Winkler, M. & Faber, K., 30 Aug 2016.

Research output: Contribution to conferencePoster

Development of small-molecule inhibitors targeting adipose triglyceride lipase (ATGL)

Doler, C. J., Migglautsch, A., Mayer, N., Fuchs, E., Schweiger, M., Romauch, M., Grabner, G., Zechner, R., Zimmermann, R. & Breinbauer, R., 28 Jun 2016, p. 1-1. 1 p.

Research output: Contribution to conferencePoster

Expression of fungal cytochrome P450 variants in E. coli and their validation for API metabolite synthesis

Bachler, T., Eichmann, J. P-R., Weninger, A., Hammer, K., Tunjic, S., Glieder, A., Breinbauer, R. & Winkler, M., 12 Sep 2016.

Research output: Contribution to conferencePoster

Modular Synthesis of Teraryl-based alpha-Helix-Mimetics

Breinbauer, R., Trobe, M., Peters, M., Grimm, S. & Wölfl, B., 5 Sep 2016.

Research output: Contribution to conferencePoster

Modular Synthesis of Teraryl-based alpha-Helix-Mimetics for the Inhibition of Protein-Protein-Interactions

Trobe, M., Peters, M., Grimm, S., Wölfl, B. & Breinbauer, R., 1 Sep 2016.

Research output: Contribution to conferencePoster

New “old yellow enzyme”: Reductive C-C bond formation using an engineered enoate reductase

Heckenbichler, K., Schweiger, A. K., Binter, A., Macheroux, P., Gruber, K. & Breinbauer, R., 2016.

Research output: Contribution to conferencePoster

Novel insights into structural destabilization of a cancer associated variant of human NQO1

Strandback, E. S., Lienhart, W-D., Hromic, A., Pletz, J., Köberl, C., Gudipati, V., Gruber, K., Breinbauer, R. & Macheroux, P., 2016.

Research output: Contribution to conferencePoster

Structure-based reaction mechanism of oleate hydratase from Elizabethkingia meningoseptica

Engleder, M., Pavkov-Keller, T., Emmerstorfer-Augustin, A., Altijana, H., Schrempf, S., Steinkellner, G., Wriessnegger, T., Leitner, E., Strohmeier, G., Kaluzna, I., Daniel, M., Schurmann, M., Wallner, S., Macheroux, P., Gruber, K. & Pichler, H., 15 Nov 2016.

Research output: Contribution to conferencePoster

Targeting human dipeptidyl peptidase III (hDPPIII): a therapeutic potential for safer pain management

Jha, S., Ivkovic, J., Taschler, U., Kumar, P., Zimmermann, R., Gruber, K., Breinbauer, R. & Macheroux, P., Sep 2016.

Research output: Contribution to conferencePoster

Towards API Metabolite Synthesis by Fungal Cytochrome P450 variants

Bachler, T., Eichmann, J. P-R., Weninger, A., Glieder, A., Breinbauer, R. & Winkler, M., 16 Nov 2016.

Research output: Contribution to conferencePoster

Towards understanding the structural destabilization of a cancer associated variant of human NQO1

Strandback, E. S., Lienhart, W-D., Köberl, C., Hromic, A., Pletz, J., Gudipati, V., Gruber, K., Breinbauer, R. & Macheroux, P., 2016.

Research output: Contribution to conferencePoster

2015

A Base- and Additive-Free Approach of the Tsuji-Trost Reaction for the Synthesis of N-Heterocycles

Kljajic, M. & Breinbauer, R., 2015.

Research output: Contribution to conferencePoster

Open Access
File

A luciferous surprise: A new natural aldehyde substrate for bacterial bioluminescence

Tabib, C., Brodl, E., Bergner, T., Ivkovic, J., Wallner, S., Breinbauer, R. & Macheroux, P., 2015.

Research output: Contribution to conferencePoster

A modular synthesis of teraryl-based alpha-helix mimetics for inhibition of protein-protein-interactions

Trobe, M., Peters, M., Grimm, S., Wölfl, B. & Breinbauer, R., 2015.

Research output: Contribution to conferencePoster

A modular synthesis of teraryl-based α-helix mimetics for inhibition of protein-protein interactions

Trobe, M., Peters, M., Grimm, S., Wölfl, B. & Breinbauer, R., 2015.

Research output: Contribution to conferencePoster

A POWERFUL APPROACH TOWARDS C-GLYCOSYL TYPE IMINOALDITOL BUILDING BLOCKS FOR BIOLOGICAL APPLICATIONS

Zoidl, M., Gonzales-Santana, A., Hojnik, C., Schalli, M., Siriwardena, A., Stütz, A., Thonhofer, M., Torvisco Gomez, A., Wrodnigg, T. & Withers, S., 2015.

Research output: Contribution to conferencePoster

Characterization and therapeutic potential of DPP III knockout mice

Jha, S., Taschler, U., Ivkovic, J., Breinbauer, R., Zimmermann, R. & Macheroux, P., 3 Dec 2015.

Research output: Contribution to conferencePoster

Characterization of DPPIII knockout mice

Jha, S., Macheroux, P., Ivkovic, J., Taschler, U., Kumar, P., Gruber, K. & Zimmermann, R., 2015.

Research output: Contribution to conferencePoster

Characterization of DPP III knockout mice

Jha, S., Taschler, U., Ivkovic, J., Kumar, P., Gruber, K., Zimmermann, R. & Macheroux, P., 2015.

Research output: Contribution to conferencePoster

Design and Synthesis of Inhibitors of Dipeptidyl Peptidase-III

Lembacher-Fadum, C., Ivkovic, J., Jha, S., Kumar, P., Gruber, K., Macheroux, P. & Breinbauer, R., 3 Dec 2015.

Research output: Contribution to conferencePoster

Design and Synthesis of Inhibitors of Dipeptidyl Peptidase-III

Lembacher-Fadum, C., Ivkovic, J., Jha, S., Kumar, P., Gruber, K., Macheroux, P. & Breinbauer, R., 2015.

Research output: Contribution to conferencePoster

Design and Synthesis of Inhibitors of DPP3

Ivkovic, J., Kumar, P., Gruber, K., Macheroux, P. & Breinbauer, R., 2015.

Research output: Contribution to conferencePoster

Development of Inhibitors of PhzE - A New Target for Antibiotic Intervention

Guttenberger, N., Breinbauer, R. & Blankenfeldt, W., 2015.

Research output: Contribution to conferencePoster

Discovery and Characterization of Atglistatin – The First Inhibitor of ATGL (Adipose Triglyzeride Lipase)

Mayer, N., Schweiger, M., Romauch, M., Ivkovic, J., Fuchs, E., Doler, C. J., Lass, A., Höfler, G., Zechner, R., Zimmermann, R. & Breinbauer, R., 2015.

Research output: Contribution to conferencePoster

Elucidation of the structure and mechanism of CouO, a small molecule C-Methyltransferase from streptomyces rishiriensis

Faber, M., Pavkov-Keller, T., Steiner, K., Tengg, M., Schwab, H., Gruber, K. & Gruber, M., 26 Jul 2015.

Research output: Contribution to conferencePoster

GLYCOLIPID MIMETICS: FLUORINE CONTAINING ISOIMINOSUGARS AS CHEMICAL CHAPERONES FOR GM1 GANGLIOSIDOSIS AND FABRY´S DISEASE

Stütz, A., Fischer, R., Gonzalez Santana, A., Hojnik, C., Paschke, E., Schalli, M., Thonhofer, M., Torvisco Gomez, A., Withers, S. G., Wrodnigg, T. & Zoidl, M., 2015.

Research output: Contribution to conferencePoster

GLYCOLIPID MIMETICS: LIPOPHILIC 4-EPI-ISOFAGOMINE DERIVATIVES AS CHEMICAL CHAPERONES FOR GM1-GANGLIOSIDOSIS AND MORQUIO B

Thonhofer, M., Fischer, R., Gonzalez-Santana, A., Hojnik, C., Paschke, E., Schalli, M., Stütz, A., Weber, P., Withers, S. G., Wrodnigg, T. & Zoidl, M., 2015.

Research output: Contribution to conferencePoster

GLYCOLIPID MIMETICS: LIPOPHILIC CARBASUGARS AS INHIBITORS AND CHEMICAL CHAPERONES FOR GM1 GANGLIOSIDOSIS

Schalli, M., Fischer, R., Gonzalez Santana, A., Hojnik, C., Paschke, E., Stütz, A., Thonhofer, M., Withers, S. G., Wrodnigg, T. & Zoidl, M., 2015.

Research output: Contribution to conferencePoster

Identification and characterization of Tth-X and Pho-Y, novel members of the OYE family

Heckenbichler, K., Binter, A., Pavkov-Keller, T., Steinkellner, G., Steiner, K., Gruber, K. & Macheroux, P., 2015.

Research output: Contribution to conferencePoster

NAD(P)H:quinone oxidoreductase 1 as a crucial enzyme in human cancer development and treatment

Lienhart, W-D., Strandback, E. S., Gudipati, V., Uhl, M. K., Binter, A., Zangger, K., Breinbauer, R., Gruber, K. & Macheroux, P., 2015.

Research output: Contribution to conferencePoster

NAD(P)H:quinone oxidoreductase 1 as a crucial enzyme in human cancer development and treatment

Lienhart, W-D., Strandback, E. S., Gudipati, V., Uhl, M. K., Binter, A., Zangger, K., Breinbauer, R., Gruber, K. & Macheroux, P., 2015.

Research output: Contribution to conferencePoster

NAD( P)H:quinone oxidoreductase 1 as a crucial enzyme in human cancer development and treatment

Lienhart, W-D., Strandback, E. S., Zangger, K., Breinbauer, R., Gruber, K. & Macheroux, P., 2015.

Research output: Contribution to conferencePoster

ON THE REACTION MECHANISM OF THE ELIZABETHKINGIA MENINGOSEPTICA OLEATE HYDRATASE

Engleder, M., Pavkov-Keller, T., Emmerstorfer, A., Hromic, A., Schrempf, S., Steinkellner, G., Wriessnegger, T., Leitner, E., Strohmeier, G., Kaluzna, I., Mink, D., Schürmann, M., Wallner, S., Macheroux, P., Gruber, K. & Pichler, H., 2015.

Research output: Contribution to conferencePoster

Structure-Based Design and Synthesis of Inhibitors of Dipeptidylpeptidase III (DPP3)

Ivkovic, J., Kumar, P., Wallner, S., Macheroux, P., Gruber, K. & Breinbauer, R., 2015.

Research output: Contribution to conferencePoster