Research Output 1981 2019

2019

A Multi-Enzyme System for the In vitro Reduction of Carboxylic Acids to Aldehydes

Strohmeier, G., Schwarz, A., Eiteljörg, I., Kohrt, J., Howard, R. & Winkler, M., Jul 2019.

Research output: Contribution to conferencePosterResearch

Capsaicin Metabolite Synthesis by Fungal Cytochrome P450

Willim, M., Bachler, T., Schweda, B., Migglautsch, A. K., Glieder, A., Breinbauer, R. & Winkler, M., 14 Feb 2019.

Research output: Contribution to conferencePosterResearch

Carbohydrates@MOFs

Astria, E., Thonhofer, M., Ricco, R., Liang, W., Angela, C., Tarzia, A., Alt, K., Hagemeyer, C., Rattenberger, J., Schröttner, H., Wrodnigg, T. M., Amenitsch, H., Huang, D., Doonan, C. & Falcaro, P., 1 Jun 2019, In : Materials Horizons. 6, 5, p. 969-977 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Chemoselective Cysteine Bioconjugation via Palladium-Mediated Allylation

Schlatzer, T., Kriegesmann, J., Becker, C. F. W. & Breinbauer, R., 18 Jun 2019.

Research output: Contribution to conferencePosterResearchpeer-review

Co-factor demand and regeneration in the enzymatic one-step reduction of carboxylates to aldehydes in cell-free systems

Strohmeier, G., Schwarz, A., Andexer, J. N. & Winkler, M., 28 Oct 2019, (Accepted/In press) In : Journal of Biotechnology. 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Cell-Free System
Aldehydes
Regeneration
Adenosine Triphosphate
Sinorhizobium meliloti

Cytochrome P450 mediated hydroxylation of ibuprofen using Pichia pastoris as biocatalyst

Rinnofner, C., Kerschbaumer, B., Weber, H., Glieder, A. & Winkler, M., 2019, In : Biocatalysis and Agricultural Biotechnology. 17, p. 525-528 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
ibuprofen
Hydroxylation
Pichia pastoris
Biocatalysts
Pichia

Exploring the biocatalytic potential of a cytochrome P450 from Thermothelomyces thermophila

Fürst, M. J. L. J., Kerschbaumer, B., Rinnofner, C., Migglautsch, A. K., Winkler, M. & Fraaije, M. W., 2019, (Accepted/In press) In : Advanced Synthesis & Catalysis. p. 2487 2496 p.

Research output: Contribution to journalArticleResearchpeer-review

Festphasen- und Flowsynthese (Trendbericht, Organische Chemie 2018)

Breinbauer, R., 2019, In : Nachrichten aus der Chemie. 67, 3, p. 53-54

Research output: Contribution to journalArticleResearch

Iodonium-based Probes for the Activity-based Protein Profiling of Oxidoreductases

Breinbauer, R., Kljajic, M., Darnhofer, B., Schittmayer, M., Kollau, A., Mayer, B. & Birner-Grünberger, R., 25 Sep 2019.

Research output: Contribution to conferencePosterResearchpeer-review

Iodonium-based Probes for the Activity-based Protein Profiling of Oxidoreductases

Kljajic, M., Darnhofer, B., Schittmayer, M., Kollau, A., Mayer, B., Birner-Grünberger, R. & Breinbauer, R., 28 Mar 2019.

Research output: Contribution to conferencePosterResearchpeer-review

Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities

Unterhauser, K., Pöltl, L., Schneditz, G., Kienesberger, S., Glabonjat, R. A., Kitsera, M., Pletz, J., Josa-Prado, F., Dornisch, E., Lembacher-Fadum, C., Roier, S., Gorkiewicz, G., Lucena, D., Barasoain, I., Kroutil, W., Wiedner, M., Loizou, J. I., Breinbauer, R., Díaz, J. F., Schild, S. & 2 othersHögenauer, C. & Zechner, E. L., 26 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3774-3783 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Klebsiella oxytoca
Enterotoxins
Microtubules
Colitis
Intestines

Labeling and Natural Post-Translational Modification of Peptides and Proteins via Chemoselective Pd-Catalyzed Prenylation of Cysteine

Schlatzer, T., Kriegesmann, J., Schröder, H., Trobe, M., Lembacher-Fadum, C., Santner, S., Kravchuk, A., Becker, C. F. W. & Breinbauer, R., 2019, In : Journal of the American Chemical Society. 141, 37, p. 14931-14937

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Prenylation
Post Translational Protein Processing
Labeling
Peptides
Cysteine

Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans

Grabner, G. F., Fawzy, N., Pribasnig, M. A., Trieb, M., Taschler, U., Holzer, M., Schweiger, M., Wolinski, H., Kolb, D., Horvath, A., Breinbauer, R., Rülicke, T., Rabl, R., Lass, A., Stadlbauer, V., Hutter-Paier, B., Stauber, R. E., Fickert, P., Zechner, R., Marsche, G. & 2 othersEichmann, T. O. & Zimmermann, R., 1 Jan 2019, In : Journal of lipid research. 60, 5, p. 1020-1031 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolic Diseases
Metabolism
Liver
Hydrolases
Lipids

Pd/BIPHEPHOS is an Efficient Catalyst for the Pd‐Catalyzed S‐Allylation of Thiols with High n‐Selectivity

Schlatzer, T., Schröder, H., Trobe, M., Lembacher-Fadum, C., Stangl, S., Schlögl, C., Weber, H. & Breinbauer, R., 2019, In : Advanced Synthesis & Catalysis.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Nucleophiles
Antibiotics
Sulfhydryl Compounds
Functional groups
Catalysts

Selective Formation of 4,4′-Biphenols by Anodic Dehydrogenative Cross- and Homo-Coupling Reaction

Dahms, B., Kohlpaintner, P. J., Wiebe, A., Breinbauer, R., Schollmeyer, D. & Waldvogel, S. R., 21 Feb 2019, In : Chemistry - A European Journal. 25, 11, p. 2713-2716 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Phenols
Electricity
Chemical activation
Economics
Catalysts

Synthesis of 2-Pyrrolidinones by Palladium-Catalyzed [3+2] Cycloaddition of Isocyanates

Kljajic, M., Schlatzer, T. & Breinbauer, R., 2019, In : Synlett. 30, 5, p. 581-585 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Isocyanates
Cycloaddition
Palladium
Alkenes
Allylation

Synthesis of modified 1,5‑imino‑d‑xylitols as ligands for lysosomal β‑glucocerebrosidase

Zoidl, M., Wolfsgruber, A., Schalli, M., Nasseri, S. A., Weber, P., Stütz, A., Withers, S. G. & Wrodnigg, T. M., 2019, In : Monatshefte für Chemie = Chemical monthly. 150, 5, p. 831-842 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucosylceramidase
Substitution reactions
Glucosidases
Ligands
Xylitol

The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro

Pansy, K., Feichtinger, J., Ehall, B., Uhl, B., Sedej, M., Roula, D., Pursche, B., Wolf, A., Zoidl, M., Steinbauer, E., Gruber, V., Greinix, H. T., Prochazka, K. T., Thallinger, G. G., Heinemann, A., Beham-Schmid, C., Neumeister, P., Wrodnigg, T. M., Fechter, K. & Deutsch, A. J., 24 Sep 2019, In : International Journal of Molecular Sciences . 20, 19, 4740.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Lymphoma, Large B-Cell, Diffuse
Lymphoma
Cells
bone marrow
Bone

Towards a new panel of nitrile hydratases

Grill, B., Schwab, H., Glänzer, M., Steinkellner, G., Strohmeier, G., Pogorevcnik, U., Reicher, K., Gruber, K., Donsbach, K. & Winkler, M., 26 Jun 2019.

Research output: Contribution to conferencePosterResearch

Tris(2-Methoxyphenyl)bismuthine polymorphism characterized by nuclear quadrupole resonance spectroscopy

Scharfetter, H., Fischer, R., Krassnig, P., Thonhofer, M., Theyer, F. & Gösweiner, C., 1 Sep 2019, In : Crystals. 9, 9, 446.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Nuclear quadrupole resonance
nuclear quadrupole resonance
polymorphism
Polymorphism
Spectroscopy
2018

Aliphatic hydroxylation and epoxidation of capsaicin by Cytochrome P450 CYP505X

Migglautsch, A. K., Willim, M., Schweda, B., Glieder, A., Breinbauer, R. & Winkler, M., 31 Aug 2018, In : Tetrahedron. 74, p. 6199-6204

Research output: Contribution to journalArticleResearchpeer-review

Application of Threonine Aldolases for the Asymmetric Synthesis of α-Quaternary α-Amino Acids

Blesl, J., Trobe, M., Anderl, F., Breinbauer, R., Strohmeier, G. A. & Fesko, K., 21 Aug 2018, In : ChemCatChem. 10, 16, p. 3453-3458 6 p.

Research output: Contribution to journalArticleResearchpeer-review

aldolase
Glycine Hydroxymethyltransferase
amino acids
Amino acids
pseudomonas

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie / International Edition . 57, p. 7240 –7244

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Asymmetrische reduktive Carbocyclisierung durch modifizierte En‐Reduktasen

Heckenbichler, K., Schweiger, A. K., Brandner, L. A., Binter, A., Toplak, M., Macheroux, P., Gruber, K. & Breinbauer, R., 2018, In : Angewandte Chemie. 130, p. 7360-7364

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase

Parajuli, N., Takahara, S., Matsumura, N., Kim, T. T., Ferdaoussi, M., Migglautsch, A. K., Zechner, R., Breinbauer, R., Kershaw, E. E. & Dyck, J. R. B., 1 Oct 2018, In : American Journal of Physiology / Heart and Circulatory Physiology. 315, 4, p. H879-H884

Research output: Contribution to journalArticleResearchpeer-review

Lipase
Adipocytes
Heart Failure
Treatment Failure
atglistatin

Biochemical Characterization and Mechanistic Analysis of the Levoglucosan Kinase from Lipomyces starkeyi

Rother, C., Gutmann, A., Gudiminchi, R., Weber, H., Lepak, A. & Nidetzky, B., 16 Mar 2018, In : ChemBioChem. 19, 6, p. 596-603 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipomyces
Glucose-6-Phosphate
Phosphotransferases
Adenosine Diphosphate
Adenosine Triphosphate

Bioinformatic analysis of the fold type I PLP-dependent enzymes reveals determinants of reaction specificity in L-threonine aldolase from Aeromonas jandaei

Fesko, K., Suplatov, D. & Svedas, V., 8 May 2018, In : FEBS Open Bio. 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Glycine Hydroxymethyltransferase
Pyridoxal
Aeromonas
Pyridoxal Phosphate
Threonine

Catalytic and substrate promiscuity of engineered l-threonine aldolase

Fesko, K., 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Cyclopentanoid D-Galactosidase Inhibitors and potential Pharmacological Chaperones for GM1-Gangliosidosis

Weber, P., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W., Withers, S. G. & Wrodnigg, T. M., 2018.

Research output: Contribution to conferencePosterResearchpeer-review

CYCLOPENTANOID N-ACETYL-β-D-HEXOSAMINIDASE INHIBITORS

Weber, P., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W., Wolfsgruber, A. & Wrodnigg, T. M., 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Development of matrix metalloproteinase-13 inhibitors – A structure activity/structure-property relationship study

Fürst, R., Choi, J. Y., Knapinska, A. M., Smith, L., Cameron, M. D., Ruiz, C., Fields, G. B. & Roush, W. R., 15 Aug 2018, In : Bioorganic & Medicinal Chemistry. 26, 18, 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of Small-Molecule Inhibitors of Adipose Triglyceride Lipase (ATGL)

Migglautsch, A. K., Doler, C. J., Schweiger, M., Mayer, N., Fuchs, E., Grabner, G., Romauch, M., Zechner, R., Zimmermann, R. & Breinbauer, R., 6 Sep 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Festphasen- und Flowsynthese (Trendbericht, Organische Chemie 2017)

Breinbauer, R., 2018, In : Nachrichten aus der Chemie. 66, p. 256-257

Research output: Contribution to journalArticleResearchpeer-review

From a chelating, non-selective chemical probe to selective MMP-13 inhibitors for the treatment of osteoarthritis

Fürst, R., Choi, J. Y., Knapinska, A. M., Hart, P. J., Fields, G. B. & Roush, W. R., 30 Aug 2018.

Research output: Contribution to conferencePosterResearch

FURANOID CARBASUGARS AS GH 20 HEXOSAMINIDASE INHIBITORS AND POTENTIAL PHARMACOLOGICAL CHAPERONES

Wolfsgruber, A., Nasseri, S. A., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Torvisco Gomez, A., Müller, P., Tschernutter, M., Weber, P., Windischhofer, W., Withers, S. G. & Wrodnigg, T. M., 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Homogeneous cellulose thin films by regeneration of cellulose xanthate: properties and characterization

Weißl, M., Niegelhell, K., Reishofer, D., Zankel, A., Innerlohinger, J. & Spirk, S., 2018, In : Cellulose. 25, 1, p. 711-721 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Palladium-Mediated Allylation of Cysteine for Site-Selective Bioconjugation

Schlatzer, T., Kriegesmann, J., Becker, C. F. W. & Breinbauer, R., 18 Sep 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Palladium-Mediated Allylation of Cysteine for Site-Selective Bioconjugation

Schlatzer, T., Kriegesmann, J., Becker, C. F. W. & Breinbauer, R., 13 Dec 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Palladium-Mediated Allylation of Cysteine for Site-Selective Bioconjugation of Peptides and Proteins

Schlatzer, T., Kriegesmann, J., Schröder, H., Trobe, M., Becker, C. F. W. & Breinbauer, R., 29 Aug 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Pd-Mediated Allylation of Cysteine for Site-Selective Bioconjugation of Peptides and Proteins

Schlatzer, T., Kriegesmann, J., Schröder, H., Trobe, M., Lembacher-Fadum, C., Becker, C. F. W. & Breinbauer, R., 10 Sep 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Perdeuteration of cholesterol for neutron scattering applicatioins using recombinant Pichia pastoris

Mouline, M., Strohmeier, G., Hirz, M., Thompson, K., Rennie, A., Campbell, R. A., Pichler, H., Maric, S., Forsyth, T. & Haertlein, M., 5 Feb 2018, In : Chemistry and physics of lipids. 212, p. 80-87

Research output: Contribution to journalArticleResearchpeer-review

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Weber, P., Nasseri, S. A., Pabst, B., Torvisco Gomez, A., Müller, P., Paschke, E., Tschernutter, M., Windischhofer, W., Withers, S. G., Wrodnigg, T. M. & Stütz, A., 2018, In : Molecules . 23, 3, 11 p., 708.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Recombinant expression, purification and biochemical characterization of kievitone hydratase from Nectria haematococca

Engleder, M., Horvat, M., Emmerstorfer-Augustin, A., Wriessnegger, T., Gabriel, S., Strohmeier, G., Weber, H., Müller, M., Kaluzna, I., Mink, D., Schürmann, M. & Pichler, H., 8 Feb 2018, In : PLoS ONE.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Synthesis and Biological Characterization of Teraryl-based alpha-Helix-Mimetics

Blesl, J., Vareka, M., Trobe, M. & Breinbauer, R., 26 Jun 2018.

Research output: Contribution to conferencePosterResearch

Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention

Guttenberger, N., Schlatzer, T., Leypold, M., Tassoti, S. & Breinbauer, R., 2018, In : Monatshefte für Chemie = Chemical monthly. 149, p. 847-856 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition

Aschauer, P., Zimmermann, R., Breinbauer, R., Pavkov-Keller, T. & Oberer, M., 2018, In : Scientific reports. 8, 1, 8948.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The Impact of Deuteration on Natural and Synthetic Lipids: a Neutron Diffraction Study

Luchini, A., Delhom, R., Demé, B., Laux, V., Mouline, M., Haertlein, M., Pichler, H., Strohmeier, G., Wacklin, H. & Fragneto, G., 1 Aug 2018, In : Colloids and Surfaces / B. p. 126 - 133

Research output: Contribution to journalArticleResearchpeer-review

The monolignol oxidoreductase AtBBE-like protein 15: Characterization, rational engineering and biocatalytic applications.

Daniel, B., Messenlehner, J., Schrittwieser, J. H., Pils, S., Kroutil, W. & Macheroux, P., 28 Aug 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Total Syntheses of Tilivalline and Tilimycin, Cytotoxic Secondary Metabolites of Klebsiella Oxytoca

Lembacher-Fadum, C., Dornisch, E., Pletz, J., Glabonjat, R. A., Martin, F., Neger, M., Högenauer, C., Francesconi, K. A., Kroutil, W., Zangger, K., Zechner, E. L. & Breinbauer, R., 27 Aug 2018.

Research output: Contribution to conferencePosterResearchpeer-review

Whole-cell (+)-ambrein production in the yeast Pichia pastoris

Moser, S., Strohmeier, G., Leitner, E., Plocek, T. J., Vanhessche, K. & Pichler, H., Dec 2018, In : Metabolic Engineering Communications. 7, 9 p., e00077.

Research output: Contribution to journalArticleResearchpeer-review

Open Access