A DIFFERENT CROSS-LINKING APPROACH TO FABRICATE STABLE 3D SCAFFOLDS OF NANOCELLULOSE-ALGINATE

Activity: Talk or presentationTalk at conference or symposiumScience to science

Description

S01-O-04
Three-dimensional (3D) structures produced from the combination of nanofibrillated cellulose (NFC) and alginate (Alg) have been demonstrated to be suitable materials for various applications, including cell culturing1, 2. The mechanical properties and dimensional stability of such 3D printed structures of NFC/Alg were improved by cross-linking with various bivalent salts (CaCl2, Cu(NO3)2, FeCl3 )3. In this study, we prepared two types of inks: NFC/Al/CaCO3 (Ink 1) or NFC/Alg/CaCO3/photoacid generator (Ink 2). The 3D printed structures of Ink 1 and Ink 2 were ionically cross-linked with gluconolactone and UV-light.
Besides the rheological properties (viscose and elastic moduli) of the inks, the mechanical properties and dimensional stability of the printed structures were investigated as a function of concentration of the gluconolactone and UV irradiation intensity and exposure time. It is believed that the acidic proton generated by gluconolactone and PAG when dissolved in water or exposed to UV irradiation allows the dissociation of CaCO3, and consequently the release of Ca2+. This is capable to bind corresponding carboxyl functional groups of Alg and NFC. The scaffold materials with different microstructure and tunable properties obtained by this new, simple and water-based cross-linking approach should be suitable for various applications, such as cell growth, biocatalysis, etc.
Period11 Oct 2021
Event title7th EPNOE International Polysaccharide Conference
Event typeConference
LocationNantes, France
Degree of RecognitionInternational