ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Arpita Poddar; Suneela Pyreddy; Francesco Carraro; Sudip Dhakal; Andrea Rassell; Matthew R. Field; T. Srinivasa Reddy; Paolo Falcaro; Cara M. Doherty; Ravi Shukla

doi:10.1039/d0cc06241c

ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Arpita Poddar, Suneela Pyreddy, Francesco Carraro, Sudip Dhakal, Andrea Rassell, Matthew R. Field, T. Srinivasa Reddy, Paolo Falcaro, Cara M. Doherty, Ravi Shukla^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Physikalische und Theoretische Chemie (6350)

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Abstract

Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

Originalsprache	englisch
Seiten (von - bis)	15406-15409
Seitenumfang	4
Fachzeitschrift	Chemical Communications
Jahrgang	56
Ausgabenummer	98
DOIs	https://doi.org/10.1039/d0cc06241c
Publikationsstatus	Veröffentlicht - 21 Dez. 2020

ASJC Scopus subject areas

Keramische und Verbundwerkstoffe
Chemie (insg.)
Werkstoffchemie

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Zugriff auf Dokument

10.1039/d0cc06241c

Andere Dateien und Links

http://www.scopus.com/inward/record.url?scp=85098471731&partnerID=8YFLogxK

Dieses zitieren

@article{5f12cb81ca4546efbe5b690d0e2ef883,

title = "ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer",

abstract = "Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.",

author = "Arpita Poddar and Suneela Pyreddy and Francesco Carraro and Sudip Dhakal and Andrea Rassell and Field, {Matthew R.} and Reddy, {T. Srinivasa} and Paolo Falcaro and Doherty, {Cara M.} and Ravi Shukla",

year = "2020",

month = dec,

day = "21",

doi = "10.1039/d0cc06241c",

language = "English",

volume = "56",

pages = "15406--15409",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "98",

}

TY - JOUR

T1 - ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

AU - Poddar, Arpita

AU - Pyreddy, Suneela

AU - Carraro, Francesco

AU - Dhakal, Sudip

AU - Rassell, Andrea

AU - Field, Matthew R.

AU - Reddy, T. Srinivasa

AU - Falcaro, Paolo

AU - Doherty, Cara M.

AU - Shukla, Ravi

PY - 2020/12/21

Y1 - 2020/12/21

N2 - Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

AB - Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

UR - http://www.scopus.com/inward/record.url?scp=85098471731&partnerID=8YFLogxK

U2 - 10.1039/d0cc06241c

DO - 10.1039/d0cc06241c

M3 - Article

C2 - 33196071

AN - SCOPUS:85098471731

SN - 1359-7345

VL - 56

SP - 15406

EP - 15409

JO - Chemical Communications

JF - Chemical Communications

IS - 98

ER -

ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Abstract

ASJC Scopus subject areas

UN SDGs

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Dieses zitieren